ParkinsonFranceV1, PubMed, Corpus, bibRecord, 000319

EIF4G1 mutations do not cause Parkinson's disease.

Identifieur interne : 000319 ( PubMed/Corpus ); précédent : 000318; suivant : 000320

EIF4G1 mutations do not cause Parkinson's disease.

Auteurs : Noah Nichols ; Jose M. Bras ; Dena G. Hernandez ; Iris E. Jansen ; Suzanne Lesage ; Steven Lubbe ; Andrew B. Singleton

Source :

Neurobiology of aging [ 1558-1497 ] ; 2015.

RBID : pubmed:26022768

English descriptors

KwdEn :
- Eukaryotic Initiation Factor-4G (genetics), Gene Frequency, Genetic Association Studies, Humans, Mutation, Parkinson Disease (genetics).
MESH :
- chemical , genetics : Eukaryotic Initiation Factor-4G.
- genetics : Parkinson Disease.
- Gene Frequency, Genetic Association Studies, Humans, Mutation.

Abstract

EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.

DOI: 10.1016/j.neurobiolaging.2015.04.017
PubMed: 26022768

Links to Exploration step

pubmed:26022768

Le document en format XML

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<author><name sortKey="Bras, Jose M" sort="Bras, Jose M" uniqKey="Bras J" first="Jose M" last="Bras">Jose M. Bras</name>
<affiliation><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G" last="Hernandez">Dena G. Hernandez</name>
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<author><name sortKey="Jansen, Iris E" sort="Jansen, Iris E" uniqKey="Jansen I" first="Iris E" last="Jansen">Iris E. Jansen</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, VU University Medical Center (VUmc), Amsterdam, the Netherlands; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</nlm:affiliation>
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<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
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<author><name sortKey="Lubbe, Steven" sort="Lubbe, Steven" uniqKey="Lubbe S" first="Steven" last="Lubbe">Steven Lubbe</name>
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<author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name>
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<front><div type="abstract" xml:lang="en">EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.</div>
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<CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2014 Jun;20(6):659-61</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Neuron. 2015 Jan 7;85(1):76-87</RefSource>
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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

EIF4G1 mutations do not cause Parkinson's disease.

EIF4G1 mutations do not cause Parkinson's disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki