EIF4G1 mutations do not cause Parkinson's disease.
Identifieur interne : 000319 ( PubMed/Corpus ); précédent : 000318; suivant : 000320EIF4G1 mutations do not cause Parkinson's disease.
Auteurs : Noah Nichols ; Jose M. Bras ; Dena G. Hernandez ; Iris E. Jansen ; Suzanne Lesage ; Steven Lubbe ; Andrew B. SingletonSource :
- Neurobiology of aging [ 1558-1497 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Eukaryotic Initiation Factor-4G.
- genetics : Parkinson Disease.
- Gene Frequency, Genetic Association Studies, Humans, Mutation.
Abstract
EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.
DOI: 10.1016/j.neurobiolaging.2015.04.017
PubMed: 26022768
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pubmed:26022768Le document en format XML
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<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
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<front><div type="abstract" xml:lang="en">EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.</div>
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<CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2014 Jun;20(6):659-61</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Neuron. 2015 Jan 7;85(1):76-87</RefSource>
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