Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.
Identifieur interne : 000297 ( PubMed/Corpus ); précédent : 000296; suivant : 000298Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.
Auteurs : Assunta Pelosi ; Jean-Antoine Girault ; Denis HervéSource :
- PloS one [ 1932-6203 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Dopamine Agents, Levodopa.
- pathology : Dopaminergic Neurons, Medial Forebrain Bundle, Parkinson Disease, Secondary.
- psychology : Parkinson Disease, Secondary.
- Animals, Functional Laterality, Grooming, Male, Mice, Inbred C57BL.
Abstract
Grooming behaviour is the most common innate behaviour in animals. In rodents, it consists of sequences of movements organized in four phases, executed symmetrically on both sides of the animal and creating a syntactic chain of behavioural events. The grooming syntax can be altered by stress and novelty, as well as by several mutations and brain lesions. Grooming behaviour is known to be affected by alterations of the dopamine system, including dopamine receptor modulation, dopamine alteration in genetically modified animals, and after brain lesion. While a lot is known about the initiation and syntactic modifications of this refined sequence of movements, effects of unilateral lesion of dopamine neurons are unclear particularly regarding the symmetry of syntactic chains. In the present work we studied grooming in mice unilaterally lesioned in the medial forebrain bundle by 6-hydroxydopamine. We found a reduction in completion of grooming bouts, associated with reduction in number of transitions between grooming phases. The data also revealed the development of asymmetry in grooming behaviour, with reduced tendency to groom the contralateral side to the lesion. Symmetry was recovered following treatment with L-DOPA. Thus, the present work shows that unilateral lesion of dopamine neurons reduces self-grooming behaviour by affecting duration and numbers of events. It produces premature discontinuation of grooming chains but the sequence syntax remains correct. This deficient grooming could be considered as an intrinsic symptom of Parkinson's disease in animal models and could present some similarities with abnormalities of motor movement sequencing seen in patients. Our study also suggests grooming analysis as an additional method to screen parkinsonism in animal models.
DOI: 10.1371/journal.pone.0137185
PubMed: 26397369
Links to Exploration step
pubmed:26397369Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.</title><author><name sortKey="Pelosi, Assunta" sort="Pelosi, Assunta" uniqKey="Pelosi A" first="Assunta" last="Pelosi">Assunta Pelosi</name><affiliation><nlm:affiliation>Inserm UMR-S 839, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC, Paris-6), Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Girault, Jean Antoine" sort="Girault, Jean Antoine" uniqKey="Girault J" first="Jean-Antoine" last="Girault">Jean-Antoine Girault</name><affiliation><nlm:affiliation>Inserm UMR-S 839, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC, Paris-6), Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Herve, Denis" sort="Herve, Denis" uniqKey="Herve D" first="Denis" last="Hervé">Denis Hervé</name><affiliation><nlm:affiliation>Inserm UMR-S 839, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC, Paris-6), Paris, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26397369</idno><idno type="pmid">26397369</idno><idno type="doi">10.1371/journal.pone.0137185</idno><idno type="wicri:Area/PubMed/Corpus">000297</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000297</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.</title><author><name sortKey="Pelosi, Assunta" sort="Pelosi, Assunta" uniqKey="Pelosi A" first="Assunta" last="Pelosi">Assunta Pelosi</name><affiliation><nlm:affiliation>Inserm UMR-S 839, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC, Paris-6), Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Girault, Jean Antoine" sort="Girault, Jean Antoine" uniqKey="Girault J" first="Jean-Antoine" last="Girault">Jean-Antoine Girault</name><affiliation><nlm:affiliation>Inserm UMR-S 839, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC, Paris-6), Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Herve, Denis" sort="Herve, Denis" uniqKey="Herve D" first="Denis" last="Hervé">Denis Hervé</name><affiliation><nlm:affiliation>Inserm UMR-S 839, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC, Paris-6), Paris, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dopamine Agents (pharmacology)</term><term>Dopaminergic Neurons (pathology)</term><term>Functional Laterality</term><term>Grooming</term><term>Levodopa (pharmacology)</term><term>Male</term><term>Medial Forebrain Bundle (pathology)</term><term>Mice, Inbred C57BL</term><term>Parkinson Disease, Secondary (pathology)</term><term>Parkinson Disease, Secondary (psychology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dopaminergic Neurons</term><term>Medial Forebrain Bundle</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Functional Laterality</term><term>Grooming</term><term>Male</term><term>Mice, Inbred C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Grooming behaviour is the most common innate behaviour in animals. In rodents, it consists of sequences of movements organized in four phases, executed symmetrically on both sides of the animal and creating a syntactic chain of behavioural events. The grooming syntax can be altered by stress and novelty, as well as by several mutations and brain lesions. Grooming behaviour is known to be affected by alterations of the dopamine system, including dopamine receptor modulation, dopamine alteration in genetically modified animals, and after brain lesion. While a lot is known about the initiation and syntactic modifications of this refined sequence of movements, effects of unilateral lesion of dopamine neurons are unclear particularly regarding the symmetry of syntactic chains. In the present work we studied grooming in mice unilaterally lesioned in the medial forebrain bundle by 6-hydroxydopamine. We found a reduction in completion of grooming bouts, associated with reduction in number of transitions between grooming phases. The data also revealed the development of asymmetry in grooming behaviour, with reduced tendency to groom the contralateral side to the lesion. Symmetry was recovered following treatment with L-DOPA. Thus, the present work shows that unilateral lesion of dopamine neurons reduces self-grooming behaviour by affecting duration and numbers of events. It produces premature discontinuation of grooming chains but the sequence syntax remains correct. This deficient grooming could be considered as an intrinsic symptom of Parkinson's disease in animal models and could present some similarities with abnormalities of motor movement sequencing seen in patients. Our study also suggests grooming analysis as an additional method to screen parkinsonism in animal models.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26397369</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>24</Day></DateCreated><DateCompleted><Year>2016</Year><Month>05</Month><Day>25</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>02</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>9</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.</ArticleTitle><Pagination><MedlinePgn>e0137185</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0137185</ELocationID><Abstract><AbstractText>Grooming behaviour is the most common innate behaviour in animals. In rodents, it consists of sequences of movements organized in four phases, executed symmetrically on both sides of the animal and creating a syntactic chain of behavioural events. The grooming syntax can be altered by stress and novelty, as well as by several mutations and brain lesions. Grooming behaviour is known to be affected by alterations of the dopamine system, including dopamine receptor modulation, dopamine alteration in genetically modified animals, and after brain lesion. While a lot is known about the initiation and syntactic modifications of this refined sequence of movements, effects of unilateral lesion of dopamine neurons are unclear particularly regarding the symmetry of syntactic chains. In the present work we studied grooming in mice unilaterally lesioned in the medial forebrain bundle by 6-hydroxydopamine. We found a reduction in completion of grooming bouts, associated with reduction in number of transitions between grooming phases. The data also revealed the development of asymmetry in grooming behaviour, with reduced tendency to groom the contralateral side to the lesion. Symmetry was recovered following treatment with L-DOPA. Thus, the present work shows that unilateral lesion of dopamine neurons reduces self-grooming behaviour by affecting duration and numbers of events. It produces premature discontinuation of grooming chains but the sequence syntax remains correct. This deficient grooming could be considered as an intrinsic symptom of Parkinson's disease in animal models and could present some similarities with abnormalities of motor movement sequencing seen in patients. Our study also suggests grooming analysis as an additional method to screen parkinsonism in animal models.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pelosi</LastName><ForeName>Assunta</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Inserm UMR-S 839, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC, Paris-6), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girault</LastName><ForeName>Jean-Antoine</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Inserm UMR-S 839, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC, Paris-6), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hervé</LastName><ForeName>Denis</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Inserm UMR-S 839, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC, Paris-6), Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>09</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015259">Dopamine Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">Dopamine Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059290" MajorTopicYN="N">Dopaminergic Neurons</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007839" MajorTopicYN="N">Functional Laterality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006120" MajorTopicYN="Y">Grooming</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008474" MajorTopicYN="N">Medial Forebrain Bundle</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010302" MajorTopicYN="N">Parkinson Disease, Secondary</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4580614</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>08</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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