Does HIV Infection Alter Parkinson Disease?
Identifieur interne : 000281 ( PubMed/Corpus ); précédent : 000280; suivant : 000282Does HIV Infection Alter Parkinson Disease?
Auteurs : Antoine Moulignier ; Antoine Gueguen ; François-Xavier Lescure ; Marc Ziegler ; Pierre-Marie Girard ; Bernard Cardon ; Gilles Pialoux ; Jean-Michel Molina ; Jean-Philippe Brandel ; Cédric LamirelSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1944-7884 ] ; 2015.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Anti-HIV Agents (therapeutic use), Antiparkinson Agents (therapeutic use), CD4 Lymphocyte Count, Case-Control Studies, Dogs, HIV Infections (complications), HIV Infections (drug therapy), Humans, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Retrospective Studies.
- MESH :
- chemical , therapeutic use : Anti-HIV Agents, Antiparkinson Agents.
- complications : HIV Infections, Parkinson Disease.
- drug therapy : HIV Infections, Parkinson Disease.
- Adolescent, Adult, Aged, Animals, CD4 Lymphocyte Count, Case-Control Studies, Dogs, Humans, Middle Aged, Retrospective Studies.
Abstract
To describe the clinical features, treatment(s), and outcomes of 15 HIV-infected patients with idiopathic Parkinson disease (PD) and sustained virus suppression and immunologic reconstitution, from a reference cohort of 9847 persons living with HIV (PLH).
DOI: 10.1097/QAI.0000000000000677
PubMed: 26371610
Links to Exploration step
pubmed:26371610Le document en format XML
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††Département d'Ophtalmologie, Fondation Adolphe de Rothschild, Paris, France; and ‡‡Service d'Ophtalmologie, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gueguen, Antoine" sort="Gueguen, Antoine" uniqKey="Gueguen A" first="Antoine" last="Gueguen">Antoine Gueguen</name></author><author><name sortKey="Lescure, Francois Xavier" sort="Lescure, Francois Xavier" uniqKey="Lescure F" first="François-Xavier" last="Lescure">François-Xavier Lescure</name></author><author><name sortKey="Ziegler, Marc" sort="Ziegler, Marc" uniqKey="Ziegler M" first="Marc" last="Ziegler">Marc Ziegler</name></author><author><name sortKey="Girard, Pierre Marie" sort="Girard, Pierre Marie" uniqKey="Girard P" first="Pierre-Marie" last="Girard">Pierre-Marie Girard</name></author><author><name sortKey="Cardon, Bernard" sort="Cardon, Bernard" uniqKey="Cardon B" first="Bernard" last="Cardon">Bernard Cardon</name></author><author><name sortKey="Pialoux, Gilles" sort="Pialoux, Gilles" uniqKey="Pialoux G" first="Gilles" last="Pialoux">Gilles Pialoux</name></author><author><name sortKey="Molina, Jean Michel" sort="Molina, Jean Michel" uniqKey="Molina J" first="Jean-Michel" last="Molina">Jean-Michel Molina</name></author><author><name sortKey="Brandel, Jean Philippe" sort="Brandel, Jean Philippe" uniqKey="Brandel J" first="Jean-Philippe" last="Brandel">Jean-Philippe Brandel</name></author><author><name sortKey="Lamirel, Cedric" sort="Lamirel, Cedric" uniqKey="Lamirel C" first="Cédric" last="Lamirel">Cédric Lamirel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26371610</idno><idno type="pmid">26371610</idno><idno type="doi">10.1097/QAI.0000000000000677</idno><idno type="wicri:Area/PubMed/Corpus">000281</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000281</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Does HIV Infection Alter Parkinson Disease?</title><author><name sortKey="Moulignier, Antoine" sort="Moulignier, Antoine" uniqKey="Moulignier A" first="Antoine" last="Moulignier">Antoine Moulignier</name><affiliation><nlm:affiliation>*Service de Neurologie, Fondation Adolphe de Rothschild, Paris, France; †Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Tenon, Paris, France; ‡Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Saint Louis, Paris, France; §Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France; ‖INSERM, IAME, UMR 1137, Paris, France; ¶Unité James Parkinson, Service de Neurologie, Fondation Adolphe de Rothschild, Paris, France; #Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Saint Antoine, Paris, France; **Université Pierre et Marie Curie, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), UMRS 975, Equipe "Alzheimer's and Prion Diseases," Paris, France; ††Département d'Ophtalmologie, Fondation Adolphe de Rothschild, Paris, France; and ‡‡Service d'Ophtalmologie, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gueguen, Antoine" sort="Gueguen, Antoine" uniqKey="Gueguen A" first="Antoine" last="Gueguen">Antoine Gueguen</name></author><author><name sortKey="Lescure, Francois Xavier" sort="Lescure, Francois Xavier" uniqKey="Lescure F" first="François-Xavier" last="Lescure">François-Xavier Lescure</name></author><author><name sortKey="Ziegler, Marc" sort="Ziegler, Marc" uniqKey="Ziegler M" first="Marc" last="Ziegler">Marc Ziegler</name></author><author><name sortKey="Girard, Pierre Marie" sort="Girard, Pierre Marie" uniqKey="Girard P" first="Pierre-Marie" last="Girard">Pierre-Marie Girard</name></author><author><name sortKey="Cardon, Bernard" sort="Cardon, Bernard" uniqKey="Cardon B" first="Bernard" last="Cardon">Bernard Cardon</name></author><author><name sortKey="Pialoux, Gilles" sort="Pialoux, Gilles" uniqKey="Pialoux G" first="Gilles" last="Pialoux">Gilles Pialoux</name></author><author><name sortKey="Molina, Jean Michel" sort="Molina, Jean Michel" uniqKey="Molina J" first="Jean-Michel" last="Molina">Jean-Michel Molina</name></author><author><name sortKey="Brandel, Jean Philippe" sort="Brandel, Jean Philippe" uniqKey="Brandel J" first="Jean-Philippe" last="Brandel">Jean-Philippe Brandel</name></author><author><name sortKey="Lamirel, Cedric" sort="Lamirel, Cedric" uniqKey="Lamirel C" first="Cédric" last="Lamirel">Cédric Lamirel</name></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="eISSN">1944-7884</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Anti-HIV Agents (therapeutic use)</term><term>Antiparkinson Agents (therapeutic use)</term><term>CD4 Lymphocyte Count</term><term>Case-Control Studies</term><term>Dogs</term><term>HIV Infections (complications)</term><term>HIV Infections (drug therapy)</term><term>Humans</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>CD4 Lymphocyte Count</term><term>Case-Control Studies</term><term>Dogs</term><term>Humans</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To describe the clinical features, treatment(s), and outcomes of 15 HIV-infected patients with idiopathic Parkinson disease (PD) and sustained virus suppression and immunologic reconstitution, from a reference cohort of 9847 persons living with HIV (PLH).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26371610</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>16</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>15</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1944-7884</ISSN><JournalIssue CitedMedium="Internet"><Volume>70</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Oct</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of acquired immune deficiency syndromes (1999)</Title><ISOAbbreviation>J. Acquir. Immune Defic. Syndr.</ISOAbbreviation></Journal><ArticleTitle>Does HIV Infection Alter Parkinson Disease?</ArticleTitle><Pagination><MedlinePgn>129-36</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/QAI.0000000000000677</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To describe the clinical features, treatment(s), and outcomes of 15 HIV-infected patients with idiopathic Parkinson disease (PD) and sustained virus suppression and immunologic reconstitution, from a reference cohort of 9847 persons living with HIV (PLH).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This retrospective, single-center matched case-control 1:2 study included PLH-PD patients evaluated over a 12-year period (2002-2013) with mean follow-up of 6.5 years. PD clinical features and dopamine replacement therapy (DRT) were compared, and biologically relevant HIV data were assessed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">PD prevalence in PLH was similar to that of the general population. At onset, clinical presentations and therapeutic management were similar for both groups. Rapidly effective DRT was well tolerated without combined antiretroviral therapy interactions or virus escape. At the end of the follow-up, compared with HIV-negative PD, PLH had a significantly lower median Unified Parkinson's Disease Rating Scale motor score (4 vs 14; P < 0.001), median Hoehn and Yahr stage (1 vs 2; P = 0.0005), and median Handipark scale score (2 vs 3; P = 0.0036) under the same daily DRT. One PLH underwent highly successful deep brain stimulation of the subthalamic nucleus.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">HIV-associated PD is similar to idiopathic PD with some features suggesting an HIV-induced functional adaptation of dopaminergic neurons that might counterbalance the PD-induced neuronal loss. Concurrent HIV infection does not compromise the outcome of idiopathic PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moulignier</LastName><ForeName>Antoine</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>*Service de Neurologie, Fondation Adolphe de Rothschild, Paris, France; †Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Tenon, Paris, France; ‡Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Saint Louis, Paris, France; §Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France; ‖INSERM, IAME, UMR 1137, Paris, France; ¶Unité James Parkinson, Service de Neurologie, Fondation Adolphe de Rothschild, Paris, France; #Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Saint Antoine, Paris, France; **Université Pierre et Marie Curie, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), UMRS 975, Equipe "Alzheimer's and Prion Diseases," Paris, France; ††Département d'Ophtalmologie, Fondation Adolphe de Rothschild, Paris, France; and ‡‡Service d'Ophtalmologie, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gueguen</LastName><ForeName>Antoine</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lescure</LastName><ForeName>François-Xavier</ForeName><Initials>FX</Initials></Author><Author ValidYN="Y"><LastName>Ziegler</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Girard</LastName><ForeName>Pierre-Marie</ForeName><Initials>PM</Initials></Author><Author ValidYN="Y"><LastName>Cardon</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Pialoux</LastName><ForeName>Gilles</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Molina</LastName><ForeName>Jean-Michel</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Brandel</LastName><ForeName>Jean-Philippe</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Lamirel</LastName><ForeName>Cédric</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Acquir Immune Defic Syndr</MedlineTA><NlmUniqueID>100892005</NlmUniqueID><ISSNLinking>1525-4135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018791" MajorTopicYN="N">CD4 Lymphocyte Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26371610</ArticleId><ArticleId IdType="doi">10.1097/QAI.0000000000000677</ArticleId><ArticleId IdType="pii">00126334-201510010-00004</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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