Effects of deep brain stimulation on balance and gait in patients with Parkinson's disease: A systematic neurophysiological review.
Identifieur interne : 000269 ( PubMed/Corpus ); précédent : 000268; suivant : 000270Effects of deep brain stimulation on balance and gait in patients with Parkinson's disease: A systematic neurophysiological review.
Auteurs : A. Collomb-Clerc ; M-L WelterSource :
- Neurophysiologie clinique = Clinical neurophysiology [ 1769-7131 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Deep Brain Stimulation (adverse effects), Deep Brain Stimulation (methods), Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (therapy), Globus Pallidus (physiopathology), Humans, Middle Aged, Parkinson Disease (complications), Parkinson Disease (therapy), Pars Reticulata (physiopathology), Pedunculopontine Tegmental Nucleus (physiopathology), Postural Balance, Posture, Subthalamic Nucleus (physiopathology), Treatment Outcome.
- MESH :
- adverse effects : Deep Brain Stimulation.
- complications : Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- methods : Deep Brain Stimulation.
- physiopathology : Globus Pallidus, Pars Reticulata, Pedunculopontine Tegmental Nucleus, Subthalamic Nucleus.
- therapy : Gait Disorders, Neurologic, Parkinson Disease.
- Aged, Humans, Middle Aged, Postural Balance, Posture, Treatment Outcome.
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and internal globus pallidus (GPi) deep brain stimulation (DBS) provides an efficient treatment for the alleviation of motor signs in patients with Parkinson's disease. The effects of DBS on gait and balance disorders are less successful and may even lead to an aggravation of freezing of gait and imbalance. The identification of a substantia nigra pars reticulata (SNr)-mesencephalic locomotor region (MLR) network in the control of locomotion and postural control and of its dysfunction/lesion in PD patients with gait and balance disorders led to suggestion that DBS should be targeting the SNr and the pedunculopontine nucleus (part of the MLR) for PD patients with these disabling axial motor signs. However, the clinical results to date have been disappointing. In this review, we discuss the effects of DBS of these basal ganglia and brainstem structures on the neurophysiological parameters of gait and balance control in PD patients. Overall, the data suggest that both STN and GPi-DBS improve gait parameters and quiet standing postural control in PD patients, but have no effect or may even aggravate dynamic postural control, in particular with STN-DBS. Conversely, DBS of the SNr and PPN has no effect on gait parameters but improves anticipatory postural adjustments and gait postural control.
DOI: 10.1016/j.neucli.2015.07.001
PubMed: 26319759
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Collomb-Clerc</name><affiliation><nlm:affiliation>AP-HP, hôpital de la Salpêtrière, département de neurologie, bâtiment Paul-Castaigne, groupe hospitalier de la Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Inserm, U1127, 75013 Paris, France; Sorbonne universités, UPMC université Paris 06, UMRS 1127, 75013 Paris, France; CNRS, UMR 7225, ICM, 75013 Paris, France; Institut du cerveau et de la moelle épinière, ICM, 75013 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M-L" last="Welter">M-L Welter</name><affiliation><nlm:affiliation>AP-HP, hôpital de la Salpêtrière, département de neurologie, bâtiment Paul-Castaigne, groupe hospitalier de la Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Inserm, U1127, 75013 Paris, France; Sorbonne universités, UPMC université Paris 06, UMRS 1127, 75013 Paris, France; CNRS, UMR 7225, ICM, 75013 Paris, France; Institut du cerveau et de la moelle épinière, ICM, 75013 Paris, France. 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Collomb-Clerc</name><affiliation><nlm:affiliation>AP-HP, hôpital de la Salpêtrière, département de neurologie, bâtiment Paul-Castaigne, groupe hospitalier de la Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Inserm, U1127, 75013 Paris, France; Sorbonne universités, UPMC université Paris 06, UMRS 1127, 75013 Paris, France; CNRS, UMR 7225, ICM, 75013 Paris, France; Institut du cerveau et de la moelle épinière, ICM, 75013 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M-L" last="Welter">M-L Welter</name><affiliation><nlm:affiliation>AP-HP, hôpital de la Salpêtrière, département de neurologie, bâtiment Paul-Castaigne, groupe hospitalier de la Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Inserm, U1127, 75013 Paris, France; Sorbonne universités, UPMC université Paris 06, UMRS 1127, 75013 Paris, France; CNRS, UMR 7225, ICM, 75013 Paris, France; Institut du cerveau et de la moelle épinière, ICM, 75013 Paris, France. Electronic address: marie-laure.welter@psl.aphp.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Neurophysiologie clinique = Clinical neurophysiology</title><idno type="eISSN">1769-7131</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation (adverse effects)</term><term>Deep Brain Stimulation (methods)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Gait Disorders, Neurologic (therapy)</term><term>Globus Pallidus (physiopathology)</term><term>Humans</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Pars Reticulata (physiopathology)</term><term>Pedunculopontine Tegmental Nucleus (physiopathology)</term><term>Postural Balance</term><term>Posture</term><term>Subthalamic Nucleus (physiopathology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term><term>Pars Reticulata</term><term>Pedunculopontine Tegmental Nucleus</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Middle Aged</term><term>Postural Balance</term><term>Posture</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and internal globus pallidus (GPi) deep brain stimulation (DBS) provides an efficient treatment for the alleviation of motor signs in patients with Parkinson's disease. The effects of DBS on gait and balance disorders are less successful and may even lead to an aggravation of freezing of gait and imbalance. The identification of a substantia nigra pars reticulata (SNr)-mesencephalic locomotor region (MLR) network in the control of locomotion and postural control and of its dysfunction/lesion in PD patients with gait and balance disorders led to suggestion that DBS should be targeting the SNr and the pedunculopontine nucleus (part of the MLR) for PD patients with these disabling axial motor signs. However, the clinical results to date have been disappointing. In this review, we discuss the effects of DBS of these basal ganglia and brainstem structures on the neurophysiological parameters of gait and balance control in PD patients. Overall, the data suggest that both STN and GPi-DBS improve gait parameters and quiet standing postural control in PD patients, but have no effect or may even aggravate dynamic postural control, in particular with STN-DBS. Conversely, DBS of the SNr and PPN has no effect on gait parameters but improves anticipatory postural adjustments and gait postural control.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26319759</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>30</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>14</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1769-7131</ISSN><JournalIssue CitedMedium="Internet"><Volume>45</Volume><Issue>4-5</Issue><PubDate><Year>2015</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Neurophysiologie clinique = Clinical neurophysiology</Title><ISOAbbreviation>Neurophysiol Clin</ISOAbbreviation></Journal><ArticleTitle>Effects of deep brain stimulation on balance and gait in patients with Parkinson's disease: A systematic neurophysiological review.</ArticleTitle><Pagination><MedlinePgn>371-88</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neucli.2015.07.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0987-7053(15)00040-4</ELocationID><Abstract><AbstractText>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and internal globus pallidus (GPi) deep brain stimulation (DBS) provides an efficient treatment for the alleviation of motor signs in patients with Parkinson's disease. The effects of DBS on gait and balance disorders are less successful and may even lead to an aggravation of freezing of gait and imbalance. The identification of a substantia nigra pars reticulata (SNr)-mesencephalic locomotor region (MLR) network in the control of locomotion and postural control and of its dysfunction/lesion in PD patients with gait and balance disorders led to suggestion that DBS should be targeting the SNr and the pedunculopontine nucleus (part of the MLR) for PD patients with these disabling axial motor signs. However, the clinical results to date have been disappointing. In this review, we discuss the effects of DBS of these basal ganglia and brainstem structures on the neurophysiological parameters of gait and balance control in PD patients. Overall, the data suggest that both STN and GPi-DBS improve gait parameters and quiet standing postural control in PD patients, but have no effect or may even aggravate dynamic postural control, in particular with STN-DBS. Conversely, DBS of the SNr and PPN has no effect on gait parameters but improves anticipatory postural adjustments and gait postural control.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Collomb-Clerc</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>AP-HP, hôpital de la Salpêtrière, département de neurologie, bâtiment Paul-Castaigne, groupe hospitalier de la Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Inserm, U1127, 75013 Paris, France; Sorbonne universités, UPMC université Paris 06, UMRS 1127, 75013 Paris, France; CNRS, UMR 7225, ICM, 75013 Paris, France; Institut du cerveau et de la moelle épinière, ICM, 75013 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Welter</LastName><ForeName>M-L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>AP-HP, hôpital de la Salpêtrière, département de neurologie, bâtiment Paul-Castaigne, groupe hospitalier de la Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Inserm, U1127, 75013 Paris, France; Sorbonne universités, UPMC université Paris 06, UMRS 1127, 75013 Paris, France; CNRS, UMR 7225, ICM, 75013 Paris, France; Institut du cerveau et de la moelle épinière, ICM, 75013 Paris, France. Electronic address: marie-laure.welter@psl.aphp.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>08</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Neurophysiol Clin</MedlineTA><NlmUniqueID>8804532</NlmUniqueID><ISSNLinking>0987-7053</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046690" MajorTopicYN="N">Deep Brain Stimulation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020233" MajorTopicYN="N">Gait Disorders, Neurologic</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005917" MajorTopicYN="N">Globus Pallidus</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065841" MajorTopicYN="N">Pars Reticulata</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045042" MajorTopicYN="N">Pedunculopontine Tegmental Nucleus</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004856" MajorTopicYN="Y">Postural Balance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011187" MajorTopicYN="N">Posture</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Balance</Keyword><Keyword MajorTopicYN="N">Deep brain stimulation</Keyword><Keyword MajorTopicYN="N">Gait</Keyword><Keyword MajorTopicYN="N">Maladie de Parkinson</Keyword><Keyword MajorTopicYN="N">Marche</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">Posture</Keyword><Keyword MajorTopicYN="N">Stimulation cérébrale profonde</Keyword><Keyword MajorTopicYN="N">Équilibre</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>06</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26319759</ArticleId><ArticleId IdType="pii">S0987-7053(15)00040-4</ArticleId><ArticleId IdType="doi">10.1016/j.neucli.2015.07.001</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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