A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation.
Identifieur interne : 000266 ( PubMed/Corpus ); précédent : 000265; suivant : 000267A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation.
Auteurs : Aude Gesquière-Dando ; Eric Guedj ; Anderson Loundou ; Romain Carron ; Tatiana Witjas ; Frédérique Fluchère ; Marie Delfini ; Laura Mundler ; Jean Regis ; Jean-Philippe Azulay ; Alexandre EusebioSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Apathy (physiology), Brain (diagnostic imaging), Brain (drug effects), Brain (metabolism), Deep Brain Stimulation, Female, Fluorodeoxyglucose F18 (pharmacokinetics), Humans, Image Processing, Computer-Assisted, Logistic Models, Male, Middle Aged, Parkinsonian Disorders (diagnostic imaging), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (therapy), Positron-Emission Tomography, Subthalamic Nucleus (physiology), Treatment Outcome.
- MESH :
- chemical , pharmacokinetics : Fluorodeoxyglucose F18.
- diagnostic imaging : Brain, Parkinsonian Disorders.
- drug effects : Brain.
- metabolism : Brain, Parkinsonian Disorders.
- physiology : Apathy, Subthalamic Nucleus.
- therapy : Parkinsonian Disorders.
- Aged, Deep Brain Stimulation, Female, Humans, Image Processing, Computer-Assisted, Logistic Models, Male, Middle Aged, Positron-Emission Tomography, Treatment Outcome.
Abstract
Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) has been associated with the development of postoperative apathy. Debate on the causes of postoperative apathy continues, and the dominant hypothesis is that stimulation or dopaminergic drug reductions are causal in its development. We hypothesized that a preoperative predisposition to apathy also could exist. To this end, we sought to identify a preoperative metabolic pattern using [(18)]Fluorodeoxyglucose Positron Emission Tomography (PET), which could be associated with the occurrence of postoperative apathy after STN-DBS for PD.
DOI: 10.1002/mds.26349
PubMed: 26228098
Links to Exploration step
pubmed:26228098Le document en format XML
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France.</nlm:affiliation></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26228098</idno><idno type="pmid">26228098</idno><idno type="doi">10.1002/mds.26349</idno><idno type="wicri:Area/PubMed/Corpus">000266</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000266</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation.</title><author><name sortKey="Gesquiere Dando, Aude" sort="Gesquiere Dando, Aude" uniqKey="Gesquiere Dando A" first="Aude" last="Gesquière-Dando">Aude Gesquière-Dando</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Guedj, Eric" sort="Guedj, Eric" uniqKey="Guedj E" first="Eric" last="Guedj">Eric Guedj</name><affiliation><nlm:affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Loundou, Anderson" sort="Loundou, Anderson" uniqKey="Loundou A" first="Anderson" last="Loundou">Anderson Loundou</name><affiliation><nlm:affiliation>APHM, CHU Timone, Unité d'Aide méthodologique à la Recherche Clinique et Epidémiologique, DRRC, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Carron, Romain" sort="Carron, Romain" uniqKey="Carron R" first="Romain" last="Carron">Romain Carron</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fluchere, Frederique" sort="Fluchere, Frederique" uniqKey="Fluchere F" first="Frédérique" last="Fluchère">Frédérique Fluchère</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Delfini, Marie" sort="Delfini, Marie" uniqKey="Delfini M" first="Marie" last="Delfini">Marie Delfini</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mundler, Laura" sort="Mundler, Laura" uniqKey="Mundler L" first="Laura" last="Mundler">Laura Mundler</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Regis, Jean" sort="Regis, Jean" uniqKey="Regis J" first="Jean" last="Regis">Jean Regis</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Apathy (physiology)</term><term>Brain (diagnostic imaging)</term><term>Brain (drug effects)</term><term>Brain (metabolism)</term><term>Deep Brain Stimulation</term><term>Female</term><term>Fluorodeoxyglucose F18 (pharmacokinetics)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Parkinsonian Disorders (diagnostic imaging)</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (therapy)</term><term>Positron-Emission Tomography</term><term>Subthalamic Nucleus (physiology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apathy</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) has been associated with the development of postoperative apathy. Debate on the causes of postoperative apathy continues, and the dominant hypothesis is that stimulation or dopaminergic drug reductions are causal in its development. We hypothesized that a preoperative predisposition to apathy also could exist. To this end, we sought to identify a preoperative metabolic pattern using [(18)]Fluorodeoxyglucose Positron Emission Tomography (PET), which could be associated with the occurrence of postoperative apathy after STN-DBS for PD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26228098</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>15</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>12</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>13</Issue><PubDate><Year>2015</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation.</ArticleTitle><Pagination><MedlinePgn>1767-76</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26349</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) has been associated with the development of postoperative apathy. Debate on the causes of postoperative apathy continues, and the dominant hypothesis is that stimulation or dopaminergic drug reductions are causal in its development. We hypothesized that a preoperative predisposition to apathy also could exist. To this end, we sought to identify a preoperative metabolic pattern using [(18)]Fluorodeoxyglucose Positron Emission Tomography (PET), which could be associated with the occurrence of postoperative apathy after STN-DBS for PD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Thirty-four patients with PD, not clinically apathetic, underwent an [(18)]Fluorodeoxyglucose-PET scan before surgery of STN-DBS, and were tested for the occurrence of apathy 1 y after surgery. Whole-brain voxel-based PET intergroup comparison (P < 0.005; corrected for the cluster) was evaluated between patients who developed apathy at 1 y and those who did not.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eight patients (23.5%) became apathetic after surgery. Motor improvement and decrease in dopaminergic treatment were similar in both postoperative apathy and non-apathy groups. We found a cluster of significantly greater metabolism in the postoperative apathy group within the cerebellum, brainstem (in particular ventral tegmental area), temporal lobe, insula, amygdala, lentiform nucleus, subgenual anterior cingulate, and inferior frontal gyrus. A metabolic value above 68 could discriminate patients who would develop postoperative apathy with 100% sensitivity and 88.5% specificity.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We describe a preoperative metabolic pattern associated with the development of apathy after STN-DBS in PD. This suggests the existence of a predisposition to apathy, which may further be triggered by perioperative drug modifications.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gesquière-Dando</LastName><ForeName>Aude</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guedj</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>APHM, CHU Timone, Service Central de Biophysique et Médecine Nucléaire, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CERIMED, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loundou</LastName><ForeName>Anderson</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Unité d'Aide méthodologique à la Recherche Clinique et Epidémiologique, DRRC, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carron</LastName><ForeName>Romain</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witjas</LastName><ForeName>Tatiana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fluchère</LastName><ForeName>Frédérique</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delfini</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mundler</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Regis</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azulay</LastName><ForeName>Jean-Philippe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eusebio</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber><NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057565" MajorTopicYN="N">Apathy</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D046690" MajorTopicYN="Y">Deep Brain Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019788" MajorTopicYN="N">Fluorodeoxyglucose F18</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020734" MajorTopicYN="N">Parkinsonian Disorders</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">FDG PET</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">apathy</Keyword><Keyword MajorTopicYN="N">predictive marker</Keyword><Keyword MajorTopicYN="N">subthalamic nucleus stimulation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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