Neurological Adverse Effects of Antipsychotics in Children and Adolescents.
Identifieur interne : 000245 ( PubMed/Corpus ); précédent : 000244; suivant : 000246Neurological Adverse Effects of Antipsychotics in Children and Adolescents.
Auteurs : Margarita Garcia-Amador ; Jessica Merchán-Naranjo ; Cecilia Tapia ; Carmen Moreno ; Josefina Castro-Fornieles ; Inmaculada Baeza ; Elena De La Serna ; José A. Alda ; Daniel Mu Oz ; Patricia Andrés Nestares ; Carmen Martínez Cantarero ; Celso ArangoSource :
- Journal of clinical psychopharmacology [ 1533-712X ] ; 2015.
English descriptors
- KwdEn :
- Adolescent, Antipsychotic Agents (adverse effects), Benzodiazepines (adverse effects), Child, Child, Preschool, Drug-Related Side Effects and Adverse Reactions (epidemiology), Dyskinesia, Drug-Induced (epidemiology), Dyskinesia, Drug-Induced (etiology), Female, Follow-Up Studies, Humans, Male, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (epidemiology), Quetiapine Fumarate (adverse effects), Risperidone (adverse effects).
- MESH :
- chemical , adverse effects : Antipsychotic Agents, Benzodiazepines, Quetiapine Fumarate, Risperidone.
- chemically induced : Parkinson Disease, Secondary.
- epidemiology : Drug-Related Side Effects and Adverse Reactions, Dyskinesia, Drug-Induced, Parkinson Disease, Secondary.
- etiology : Dyskinesia, Drug-Induced.
- Adolescent, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Male.
Abstract
The aim of this study was to evaluate demographic, clinical, and treatment factors that may impact on neurological adverse effects in naive and quasi-naive children and adolescents treated with antipsychotics.
DOI: 10.1097/JCP.0000000000000419
PubMed: 26505569
Links to Exploration step
pubmed:26505569Le document en format XML
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Alda</name></author><author><name sortKey="Mu Oz, Daniel" sort="Mu Oz, Daniel" uniqKey="Mu Oz D" first="Daniel" last="Mu Oz">Daniel Mu Oz</name></author><author><name sortKey="Andres Nestares, Patricia" sort="Andres Nestares, Patricia" uniqKey="Andres Nestares P" first="Patricia" last="Andrés Nestares">Patricia Andrés Nestares</name></author><author><name sortKey="Cantarero, Carmen Martinez" sort="Cantarero, Carmen Martinez" uniqKey="Cantarero C" first="Carmen Martínez" last="Cantarero">Carmen Martínez Cantarero</name></author><author><name sortKey="Arango, Celso" sort="Arango, Celso" uniqKey="Arango C" first="Celso" last="Arango">Celso Arango</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26505569</idno><idno type="pmid">26505569</idno><idno type="doi">10.1097/JCP.0000000000000419</idno><idno type="wicri:Area/PubMed/Corpus">000245</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000245</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neurological Adverse Effects of Antipsychotics in Children and Adolescents.</title><author><name sortKey="Garcia Amador, Margarita" sort="Garcia Amador, Margarita" uniqKey="Garcia Amador M" first="Margarita" last="Garcia-Amador">Margarita Garcia-Amador</name><affiliation><nlm:affiliation>From the *Child and Adolescent Psychiatry Department, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, CIBERSAM, Madrid; †Clinique Marigny, Groupe ORPEA-CLINEA, Toulouse, France; ‡Child and Adolescent Psychiatry and Psychology Department, Hospital Clínic Barcelona; IDIBAPS; and SGR-1119, Department of Psychiatry and Psychobiology, University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona; and §Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM; and ║Child and Adolescent Psychiatry and Psychology Section, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Merchan Naranjo, Jessica" sort="Merchan Naranjo, Jessica" uniqKey="Merchan Naranjo J" first="Jessica" last="Merchán-Naranjo">Jessica Merchán-Naranjo</name></author><author><name sortKey="Tapia, Cecilia" sort="Tapia, Cecilia" uniqKey="Tapia C" first="Cecilia" last="Tapia">Cecilia Tapia</name></author><author><name sortKey="Moreno, Carmen" sort="Moreno, Carmen" uniqKey="Moreno C" first="Carmen" last="Moreno">Carmen Moreno</name></author><author><name sortKey="Castro Fornieles, Josefina" sort="Castro Fornieles, Josefina" uniqKey="Castro Fornieles J" first="Josefina" last="Castro-Fornieles">Josefina Castro-Fornieles</name></author><author><name sortKey="Baeza, Inmaculada" sort="Baeza, Inmaculada" uniqKey="Baeza I" first="Inmaculada" last="Baeza">Inmaculada Baeza</name></author><author><name sortKey="De La Serna, Elena" sort="De La Serna, Elena" uniqKey="De La Serna E" first="Elena" last="De La Serna">Elena De La Serna</name></author><author><name sortKey="Alda, Jose A" sort="Alda, Jose A" uniqKey="Alda J" first="José A" last="Alda">José A. Alda</name></author><author><name sortKey="Mu Oz, Daniel" sort="Mu Oz, Daniel" uniqKey="Mu Oz D" first="Daniel" last="Mu Oz">Daniel Mu Oz</name></author><author><name sortKey="Andres Nestares, Patricia" sort="Andres Nestares, Patricia" uniqKey="Andres Nestares P" first="Patricia" last="Andrés Nestares">Patricia Andrés Nestares</name></author><author><name sortKey="Cantarero, Carmen Martinez" sort="Cantarero, Carmen Martinez" uniqKey="Cantarero C" first="Carmen Martínez" last="Cantarero">Carmen Martínez Cantarero</name></author><author><name sortKey="Arango, Celso" sort="Arango, Celso" uniqKey="Arango C" first="Celso" last="Arango">Celso Arango</name></author></analytic><series><title level="j">Journal of clinical psychopharmacology</title><idno type="eISSN">1533-712X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Antipsychotic Agents (adverse effects)</term><term>Benzodiazepines (adverse effects)</term><term>Child</term><term>Child, Preschool</term><term>Drug-Related Side Effects and Adverse Reactions (epidemiology)</term><term>Dyskinesia, Drug-Induced (epidemiology)</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (epidemiology)</term><term>Quetiapine Fumarate (adverse effects)</term><term>Risperidone (adverse effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antipsychotic Agents</term><term>Benzodiazepines</term><term>Quetiapine Fumarate</term><term>Risperidone</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to evaluate demographic, clinical, and treatment factors that may impact on neurological adverse effects in naive and quasi-naive children and adolescents treated with antipsychotics.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26505569</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>03</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>30</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1533-712X</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of clinical psychopharmacology</Title><ISOAbbreviation>J Clin Psychopharmacol</ISOAbbreviation></Journal><ArticleTitle>Neurological Adverse Effects of Antipsychotics in Children and Adolescents.</ArticleTitle><Pagination><MedlinePgn>686-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/JCP.0000000000000419</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The aim of this study was to evaluate demographic, clinical, and treatment factors that may impact on neurological adverse effects in naive and quasi-naive children and adolescents treated with antipsychotics.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a 1-year, multicenter, observational study of a naive and quasi-naive pediatric population receiving antipsychotic treatment. Two subanalyses were run using the subsample of subjects taking the 3 most used antipsychotics and the subsample of antipsychotic-naive subjects. Total dyskinesia score (DyskinesiaS) and total Parkinson score (ParkinsonS) were calculated from the Maryland Psychiatric Research Center Involuntary Movement Scale, total UKU-Cognition score was calculated from the UKU Side Effect Rating Scale. Risk factors for tardive dyskinesias (TDs) defined after Schooler-Kaine criteria were studied using a logistic regression.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Two hundred sixty-five subjects (mean age, 14.4 [SD, 2.9] years) with different Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I disorders were recruited. DyskinesiaS (P < 0.001) and ParkinsonS (P < 0.001) increased at 1-year follow-up. Risperidone was associated with higher increases in DyskinesiaS compared with quetiapine (P < 0.001). Higher increases in ParkinsonS were found with risperidone (P < 0.001) and olanzapine (P = 0.02) compared with quetiapine. Total UKU-Cognition Score decreased at follow-up. Findings were also significant when analyzing antipsychotic-naive subjects. Fifteen subjects (5.8%) fulfilled Schooler-Kane criteria for TD at follow-up. Younger age, history of psychotic symptoms, and higher cumulative exposure time were associated with TD at follow-up.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Antipsychotics increased neurological adverse effects in a naive and quasi-naive pediatric population and should be carefully monitored. Risperidone presented higher scores in symptoms of dyskinesia and parkinsonism. Quetiapine was the antipsychotic with less neurological adverse effects. Younger subjects, psychosis, and treatment factors predicted an increased risk of TD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Garcia-Amador</LastName><ForeName>Margarita</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>From the *Child and Adolescent Psychiatry Department, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, CIBERSAM, Madrid; †Clinique Marigny, Groupe ORPEA-CLINEA, Toulouse, France; ‡Child and Adolescent Psychiatry and Psychology Department, Hospital Clínic Barcelona; IDIBAPS; and SGR-1119, Department of Psychiatry and Psychobiology, University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona; and §Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM; and ║Child and Adolescent Psychiatry and Psychology Section, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merchán-Naranjo</LastName><ForeName>Jessica</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Tapia</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Moreno</LastName><ForeName>Carmen</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Castro-Fornieles</LastName><ForeName>Josefina</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Baeza</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>de la Serna</LastName><ForeName>Elena</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Alda</LastName><ForeName>José A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Muñoz</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Andrés Nestares</LastName><ForeName>Patricia</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Cantarero</LastName><ForeName>Carmen Martínez</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Arango</LastName><ForeName>Celso</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Psychopharmacol</MedlineTA><NlmUniqueID>8109496</NlmUniqueID><ISSNLinking>0271-0749</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014150">Antipsychotic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>12794-10-4</RegistryNumber><NameOfSubstance UI="D001569">Benzodiazepines</NameOfSubstance></Chemical><Chemical><RegistryNumber>2S3PL1B6UJ</RegistryNumber><NameOfSubstance UI="D000069348">Quetiapine Fumarate</NameOfSubstance></Chemical><Chemical><RegistryNumber>L6UH7ZF8HC</RegistryNumber><NameOfSubstance UI="D018967">Risperidone</NameOfSubstance></Chemical><Chemical><RegistryNumber>N7U69T4SZR</RegistryNumber><NameOfSubstance UI="C076029">olanzapine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014150" MajorTopicYN="N">Antipsychotic Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001569" MajorTopicYN="N">Benzodiazepines</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064420" MajorTopicYN="N">Drug-Related Side Effects and Adverse Reactions</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004409" MajorTopicYN="N">Dyskinesia, Drug-Induced</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010302" MajorTopicYN="N">Parkinson Disease, Secondary</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000069348" MajorTopicYN="N">Quetiapine Fumarate</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018967" MajorTopicYN="N">Risperidone</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>10</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>10</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26505569</ArticleId><ArticleId IdType="doi">10.1097/JCP.0000000000000419</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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