Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond.
Identifieur interne : 000233 ( PubMed/Corpus ); précédent : 000232; suivant : 000234Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond.
Auteurs : L. Calder N-Garcidue As ; E. Leray ; P. Heydarpour ; R. Torres-Jard N ; J. ReisSource :
- Revue neurologique [ 0035-3787 ] ; 2016.
English descriptors
- KwdEn :
- Air Pollution (adverse effects), Alzheimer Disease (etiology), Child, Cognition Disorders (epidemiology), Cognition Disorders (etiology), Humans, Multiple Sclerosis (etiology), Neuritis (epidemiology), Neuritis (etiology), Neurodegenerative Diseases (epidemiology), Neurodegenerative Diseases (etiology), Parkinson Disease (etiology), Risk Factors.
- MESH :
- adverse effects : Air Pollution.
- epidemiology : Cognition Disorders, Neuritis, Neurodegenerative Diseases.
- etiology : Alzheimer Disease, Cognition Disorders, Multiple Sclerosis, Neuritis, Neurodegenerative Diseases, Parkinson Disease.
- Child, Humans, Risk Factors.
Abstract
Air pollution (indoors and outdoors) is a major issue in public health as epidemiological studies have highlighted its numerous detrimental health consequences (notably, respiratory and cardiovascular pathological conditions). Over the past 15 years, air pollution has also been considered a potent environmental risk factor for neurological diseases and neuropathology. This review examines the impact of air pollution on children's brain development and the clinical, cognitive, brain structural and metabolic consequences. Long-term potential consequences for adults' brains and the effects on multiple sclerosis (MS) are also discussed. One challenge is to assess the effects of lifetime exposures to outdoor and indoor environmental pollutants, including occupational exposures: how much, for how long and what type. Diffuse neuroinflammation, damage to the neurovascular unit, and the production of autoantibodies to neural and tight-junction proteins are worrisome findings in children chronically exposed to concentrations above the current standards for ozone and fine particulate matter (PM2.5), and may constitute significant risk factors for the development of Alzheimer's disease later in life. Finally, data supporting the role of air pollution as a risk factor for MS are reviewed, focusing on the effects of PM10 and nitrogen oxides.
DOI: 10.1016/j.neurol.2015.10.008
PubMed: 26718591
Links to Exploration step
pubmed:26718591Le document en format XML
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Heydarpour</name><affiliation><nlm:affiliation>MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Torres Jard N, R" sort="Torres Jard N, R" uniqKey="Torres Jard N R" first="R" last="Torres-Jard N">R. Torres-Jard N</name><affiliation><nlm:affiliation>Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Mexico City, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Reis, J" sort="Reis, J" uniqKey="Reis J" first="J" last="Reis">J. Reis</name><affiliation><nlm:affiliation>Service de Neurologie, Centre Hospitalier Universitaire, Hôpital de Hautepierre, 1, avenue Molière, 67200 Strasbourg, France. 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Calder N-Garcidue As</name><affiliation><nlm:affiliation>The University of Montana, Missoula, MT, 59812, USA; Universidad del Valle de México, Mexico City 04850, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Leray, E" sort="Leray, E" uniqKey="Leray E" first="E" last="Leray">E. Leray</name><affiliation><nlm:affiliation>EHESP Sorbonne Paris Cité, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Heydarpour, P" sort="Heydarpour, P" uniqKey="Heydarpour P" first="P" last="Heydarpour">P. Heydarpour</name><affiliation><nlm:affiliation>MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Torres Jard N, R" sort="Torres Jard N, R" uniqKey="Torres Jard N R" first="R" last="Torres-Jard N">R. Torres-Jard N</name><affiliation><nlm:affiliation>Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Mexico City, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Reis, J" sort="Reis, J" uniqKey="Reis J" first="J" last="Reis">J. Reis</name><affiliation><nlm:affiliation>Service de Neurologie, Centre Hospitalier Universitaire, Hôpital de Hautepierre, 1, avenue Molière, 67200 Strasbourg, France. Electronic address: Jacques.reis@wanadoo.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Revue neurologique</title><idno type="ISSN">0035-3787</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Air Pollution (adverse effects)</term><term>Alzheimer Disease (etiology)</term><term>Child</term><term>Cognition Disorders (epidemiology)</term><term>Cognition Disorders (etiology)</term><term>Humans</term><term>Multiple Sclerosis (etiology)</term><term>Neuritis (epidemiology)</term><term>Neuritis (etiology)</term><term>Neurodegenerative Diseases (epidemiology)</term><term>Neurodegenerative Diseases (etiology)</term><term>Parkinson Disease (etiology)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Air Pollution</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognition Disorders</term><term>Neuritis</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Alzheimer Disease</term><term>Cognition Disorders</term><term>Multiple Sclerosis</term><term>Neuritis</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Humans</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Air pollution (indoors and outdoors) is a major issue in public health as epidemiological studies have highlighted its numerous detrimental health consequences (notably, respiratory and cardiovascular pathological conditions). Over the past 15 years, air pollution has also been considered a potent environmental risk factor for neurological diseases and neuropathology. This review examines the impact of air pollution on children's brain development and the clinical, cognitive, brain structural and metabolic consequences. Long-term potential consequences for adults' brains and the effects on multiple sclerosis (MS) are also discussed. One challenge is to assess the effects of lifetime exposures to outdoor and indoor environmental pollutants, including occupational exposures: how much, for how long and what type. Diffuse neuroinflammation, damage to the neurovascular unit, and the production of autoantibodies to neural and tight-junction proteins are worrisome findings in children chronically exposed to concentrations above the current standards for ozone and fine particulate matter (PM2.5), and may constitute significant risk factors for the development of Alzheimer's disease later in life. Finally, data supporting the role of air pollution as a risk factor for MS are reviewed, focusing on the effects of PM10 and nitrogen oxides.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26718591</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>24</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>15</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0035-3787</ISSN><JournalIssue CitedMedium="Internet"><Volume>172</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Revue neurologique</Title><ISOAbbreviation>Rev. Neurol. (Paris)</ISOAbbreviation></Journal><ArticleTitle>Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond.</ArticleTitle><Pagination><MedlinePgn>69-80</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurol.2015.10.008</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0035-3787(15)00923-6</ELocationID><Abstract><AbstractText>Air pollution (indoors and outdoors) is a major issue in public health as epidemiological studies have highlighted its numerous detrimental health consequences (notably, respiratory and cardiovascular pathological conditions). Over the past 15 years, air pollution has also been considered a potent environmental risk factor for neurological diseases and neuropathology. This review examines the impact of air pollution on children's brain development and the clinical, cognitive, brain structural and metabolic consequences. Long-term potential consequences for adults' brains and the effects on multiple sclerosis (MS) are also discussed. One challenge is to assess the effects of lifetime exposures to outdoor and indoor environmental pollutants, including occupational exposures: how much, for how long and what type. Diffuse neuroinflammation, damage to the neurovascular unit, and the production of autoantibodies to neural and tight-junction proteins are worrisome findings in children chronically exposed to concentrations above the current standards for ozone and fine particulate matter (PM2.5), and may constitute significant risk factors for the development of Alzheimer's disease later in life. Finally, data supporting the role of air pollution as a risk factor for MS are reviewed, focusing on the effects of PM10 and nitrogen oxides.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Calderón-Garcidueñas</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>The University of Montana, Missoula, MT, 59812, USA; Universidad del Valle de México, Mexico City 04850, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leray</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>EHESP Sorbonne Paris Cité, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heydarpour</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torres-Jardón</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Mexico City, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reis</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Service de Neurologie, Centre Hospitalier Universitaire, Hôpital de Hautepierre, 1, avenue Molière, 67200 Strasbourg, France. Electronic address: Jacques.reis@wanadoo.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Rev Neurol (Paris)</MedlineTA><NlmUniqueID>2984779R</NlmUniqueID><ISSNLinking>0035-3787</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000397" MajorTopicYN="N">Air Pollution</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003072" MajorTopicYN="N">Cognition Disorders</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009443" MajorTopicYN="N">Neuritis</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019636" MajorTopicYN="N">Neurodegenerative Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Air pollution</Keyword><Keyword MajorTopicYN="N">Alzheimer's disease</Keyword><Keyword MajorTopicYN="N">Children's brain development</Keyword><Keyword MajorTopicYN="N">Multiple sclerosis</Keyword><Keyword MajorTopicYN="N">Neurodegeneration</Keyword><Keyword MajorTopicYN="N">Nitrogen oxide gases</Keyword><Keyword MajorTopicYN="N">Ozone</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">Particulate matter</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>04</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>10</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>10</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26718591</ArticleId><ArticleId IdType="pii">S0035-3787(15)00923-6</ArticleId><ArticleId IdType="doi">10.1016/j.neurol.2015.10.008</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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