Profile of Neuropsychiatric Symptoms in Parkinson's Disease: Surgical Candidates Compared to Controls.
Identifieur interne : 000224 ( PubMed/Corpus ); précédent : 000223; suivant : 000225Profile of Neuropsychiatric Symptoms in Parkinson's Disease: Surgical Candidates Compared to Controls.
Auteurs : Valérie M J. Lamberti ; Bruno Pereira ; Eugénie Lhommée ; Amélie Bichon ; Emmanuelle Schmitt ; Pierre Pelissier ; Andrea Kistner ; Valérie Fraix ; Anna Castrioto ; Rianne A J. Esselink ; Frank Durif ; Paul KrackSource :
- Journal of Parkinson's disease [ 1877-718X ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- psychology : Parkinson Disease.
- surgery : Parkinson Disease.
- Cohort Studies, Cross-Sectional Studies, Deep Brain Stimulation, Female, Humans, Male, Middle Aged.
Abstract
Subthalamic nucleus deep brain stimulation (STN-DBS) improves motor symptoms of Parkinson's disease (PD) and motor complications of dopaminergic treatment. Whether STN-DBS should be considered when PD patients experience neuropsychiatric symptoms is controversial. Lack of systematic behavioral evaluation at baseline hampers the understanding of postoperative neuropsychiatric outcomes.
DOI: 10.3233/JPD-150698
PubMed: 26889631
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Lamberti</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pereira, Bruno" sort="Pereira, Bruno" uniqKey="Pereira B" first="Bruno" last="Pereira">Bruno Pereira</name><affiliation><nlm:affiliation>CHU Clermont-Ferrand, DRCI, Biostatistics Unit, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lhommee, Eugenie" sort="Lhommee, Eugenie" uniqKey="Lhommee E" first="Eugénie" last="Lhommée">Eugénie Lhommée</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bichon, Amelie" sort="Bichon, Amelie" uniqKey="Bichon A" first="Amélie" last="Bichon">Amélie Bichon</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schmitt, Emmanuelle" sort="Schmitt, Emmanuelle" uniqKey="Schmitt E" first="Emmanuelle" last="Schmitt">Emmanuelle Schmitt</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pelissier, Pierre" sort="Pelissier, Pierre" uniqKey="Pelissier P" first="Pierre" last="Pelissier">Pierre Pelissier</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kistner, Andrea" sort="Kistner, Andrea" uniqKey="Kistner A" first="Andrea" last="Kistner">Andrea Kistner</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Esselink, Rianne A J" sort="Esselink, Rianne A J" uniqKey="Esselink R" first="Rianne A J" last="Esselink">Rianne A J. Esselink</name><affiliation><nlm:affiliation>Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Durif, Frank" sort="Durif, Frank" uniqKey="Durif F" first="Frank" last="Durif">Frank Durif</name><affiliation><nlm:affiliation>CHU Clermont-Ferrand, Neurology Department; CHU Gabriel Montpied, and Université Clermont 1, UFR Medecine, EA7280, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26889631</idno><idno type="pmid">26889631</idno><idno type="doi">10.3233/JPD-150698</idno><idno type="wicri:Area/PubMed/Corpus">000224</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000224</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Profile of Neuropsychiatric Symptoms in Parkinson's Disease: Surgical Candidates Compared to Controls.</title><author><name sortKey="Lamberti, Valerie M J" sort="Lamberti, Valerie M J" uniqKey="Lamberti V" first="Valérie M J" last="Lamberti">Valérie M J. Lamberti</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pereira, Bruno" sort="Pereira, Bruno" uniqKey="Pereira B" first="Bruno" last="Pereira">Bruno Pereira</name><affiliation><nlm:affiliation>CHU Clermont-Ferrand, DRCI, Biostatistics Unit, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lhommee, Eugenie" sort="Lhommee, Eugenie" uniqKey="Lhommee E" first="Eugénie" last="Lhommée">Eugénie Lhommée</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bichon, Amelie" sort="Bichon, Amelie" uniqKey="Bichon A" first="Amélie" last="Bichon">Amélie Bichon</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schmitt, Emmanuelle" sort="Schmitt, Emmanuelle" uniqKey="Schmitt E" first="Emmanuelle" last="Schmitt">Emmanuelle Schmitt</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pelissier, Pierre" sort="Pelissier, Pierre" uniqKey="Pelissier P" first="Pierre" last="Pelissier">Pierre Pelissier</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kistner, Andrea" sort="Kistner, Andrea" uniqKey="Kistner A" first="Andrea" last="Kistner">Andrea Kistner</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Esselink, Rianne A J" sort="Esselink, Rianne A J" uniqKey="Esselink R" first="Rianne A J" last="Esselink">Rianne A J. Esselink</name><affiliation><nlm:affiliation>Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Durif, Frank" sort="Durif, Frank" uniqKey="Durif F" first="Frank" last="Durif">Frank Durif</name><affiliation><nlm:affiliation>CHU Clermont-Ferrand, Neurology Department; CHU Gabriel Montpied, and Université Clermont 1, UFR Medecine, EA7280, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of Parkinson's disease</title><idno type="eISSN">1877-718X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cohort Studies</term><term>Cross-Sectional Studies</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (surgery)</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term><term>Cross-Sectional Studies</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus deep brain stimulation (STN-DBS) improves motor symptoms of Parkinson's disease (PD) and motor complications of dopaminergic treatment. Whether STN-DBS should be considered when PD patients experience neuropsychiatric symptoms is controversial. Lack of systematic behavioral evaluation at baseline hampers the understanding of postoperative neuropsychiatric outcomes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26889631</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>01</Day></DateCreated><DateCompleted><Year>2017</Year><Month>01</Month><Day>17</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1877-718X</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>1</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Journal of Parkinson's disease</Title><ISOAbbreviation>J Parkinsons Dis</ISOAbbreviation></Journal><ArticleTitle>Profile of Neuropsychiatric Symptoms in Parkinson's Disease: Surgical Candidates Compared to Controls.</ArticleTitle><Pagination><MedlinePgn>133-42</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3233/JPD-150698</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Subthalamic nucleus deep brain stimulation (STN-DBS) improves motor symptoms of Parkinson's disease (PD) and motor complications of dopaminergic treatment. Whether STN-DBS should be considered when PD patients experience neuropsychiatric symptoms is controversial. Lack of systematic behavioral evaluation at baseline hampers the understanding of postoperative neuropsychiatric outcomes.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">This study compares the behavioral profile of a surgical population to that in general PD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Single center data from 234 PD surgical candidates were compared to data from 260 non-demented PD patients consulting in 13 PD expert centers at different stages of disease. The latter were considered representative of the general PD population. Neuropsychiatric symptoms were assessed using the Ardouin Scale of Behavior in PD, a guided interview quantifying changes in severity of 21 neuropsychiatric symptoms, classified into psychic non-motor fluctuations, hypo- and hyperdopaminergic behaviors. Multivariate analyses were performed to study differences in behavioral items between the two groups.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Surgical candidates were younger, had longer disease duration and used significantly higher doses of dopaminergic drugs. After adjustment for covariates, dopaminergic addiction (OR 10.83; p = 0.002), nocturnal hyperactivity (OR 1.87; p = 0.04), excessive hobbyism (OR 2.37; p = 0.008), "excess in motivation" (OR 4.02; p < .001), psychic OFF (2.87; p < 0.001) and psychic ON (2.10; p = 0.001) fluctuations were more frequent in the surgical candidates. Depressed mood prevailed in the general PD population (OR 0.53; p = 0.045).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Behavioral complications of dopaminergic treatment are frequent in PD patients candidates for STN-DBS. They cannot be considered as contraindications for STN-DBS but must be taken into account in postoperative management.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lamberti</LastName><ForeName>Valérie M J</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pereira</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>CHU Clermont-Ferrand, DRCI, Biostatistics Unit, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lhommée</LastName><ForeName>Eugénie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, U1216, F-38000 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bichon</LastName><ForeName>Amélie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, U1216, F-38000 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmitt</LastName><ForeName>Emmanuelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, U1216, F-38000 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pelissier</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, U1216, F-38000 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kistner</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, U1216, F-38000 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraix</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, U1216, F-38000 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castrioto</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, U1216, F-38000 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esselink</LastName><ForeName>Rianne A J</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durif</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>CHU Clermont-Ferrand, Neurology Department; CHU Gabriel Montpied, and Université Clermont 1, UFR Medecine, EA7280, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krack</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Psychiatry Neurology and Neurological Rehabilitation, CHU Grenoble Alpes, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, U1216, F-38000 Grenoble, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Parkinsons Dis</MedlineTA><NlmUniqueID>101567362</NlmUniqueID><ISSNLinking>1877-7171</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046690" MajorTopicYN="Y">Deep Brain Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson disease</Keyword><Keyword MajorTopicYN="N">deep brain stimulation</Keyword><Keyword MajorTopicYN="N">dopamine</Keyword><Keyword MajorTopicYN="N">impulse control disorders</Keyword><Keyword MajorTopicYN="N">subthalamic nucleus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26889631</ArticleId><ArticleId IdType="pii">JPD150698</ArticleId><ArticleId IdType="doi">10.3233/JPD-150698</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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