Multimodal MRI assessment of nigro-striatal pathway in multiple system atrophy and Parkinson disease.
Identifieur interne : 000186 ( PubMed/Corpus ); précédent : 000185; suivant : 000187Multimodal MRI assessment of nigro-striatal pathway in multiple system atrophy and Parkinson disease.
Auteurs : Gaetano Barbagallo ; Maria Sierra-Pe A ; Federico Nemmi ; Anne Pavy-Le Traon ; Wassilios G. Meissner ; Olivier Rascol ; Patrice PéranSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
English descriptors
- KwdEn :
- Adult, Aged, Corpus Striatum (pathology), Corpus Striatum (physiopathology), Humans, Magnetic Resonance Imaging, Middle Aged, Multiple System Atrophy (diagnostic imaging), Multiple System Atrophy (physiopathology), Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Putamen (diagnostic imaging), Putamen (physiopathology).
- MESH :
- diagnostic imaging : Multiple System Atrophy, Parkinson Disease, Putamen.
- pathology : Corpus Striatum.
- physiopathology : Corpus Striatum, Multiple System Atrophy, Parkinson Disease, Putamen.
- Adult, Aged, Humans, Magnetic Resonance Imaging, Middle Aged.
Abstract
Parkinson's disease (PD) and multiple system atrophy (MSA) are two neurodegenerative alpha-synucleinopathies characterized by severe impairment of the nigro-striatal pathway. Based on T1-, T2*-, and diffusion-weighted magnetic resonance imaging (MRI), macro-structural and micro-structural abnormalities in these diseases can be detected.
DOI: 10.1002/mds.26471
PubMed: 26676922
Links to Exploration step
pubmed:26676922Le document en format XML
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Meissner</name><affiliation><nlm:affiliation>Centre de Référence Atrophie Multisystématisée, Centre Hospitalier Universitaire de Bordeaux, Pessac, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation><nlm:affiliation>INSERM, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Peran, Patrice" sort="Peran, Patrice" uniqKey="Peran P" first="Patrice" last="Péran">Patrice Péran</name><affiliation><nlm:affiliation>INSERM, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059, Toulouse, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26676922</idno><idno type="pmid">26676922</idno><idno type="doi">10.1002/mds.26471</idno><idno type="wicri:Area/PubMed/Corpus">000186</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000186</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Multimodal MRI assessment of nigro-striatal pathway in multiple system atrophy and Parkinson disease.</title><author><name sortKey="Barbagallo, Gaetano" sort="Barbagallo, Gaetano" uniqKey="Barbagallo G" first="Gaetano" last="Barbagallo">Gaetano Barbagallo</name><affiliation><nlm:affiliation>INSERM, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sierra Pe A, Maria" sort="Sierra Pe A, Maria" uniqKey="Sierra Pe A M" first="Maria" last="Sierra-Pe A">Maria Sierra-Pe A</name><affiliation><nlm:affiliation>Service of Neurology, University Hospital "Marqués de Valdecilla (IFIMAV)," University of Cantabria and "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED),", Santander, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Nemmi, Federico" sort="Nemmi, Federico" uniqKey="Nemmi F" first="Federico" last="Nemmi">Federico Nemmi</name><affiliation><nlm:affiliation>Neuroscience Department, Retzius vag 8, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Traon, Anne Pavy Le" sort="Traon, Anne Pavy Le" uniqKey="Traon A" first="Anne Pavy-Le" last="Traon">Anne Pavy-Le Traon</name><affiliation><nlm:affiliation>Centre de Référence Atrophie Multisystématisée, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name><affiliation><nlm:affiliation>Centre de Référence Atrophie Multisystématisée, Centre Hospitalier Universitaire de Bordeaux, Pessac, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation><nlm:affiliation>INSERM, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Peran, Patrice" sort="Peran, Patrice" uniqKey="Peran P" first="Patrice" last="Péran">Patrice Péran</name><affiliation><nlm:affiliation>INSERM, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059, Toulouse, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Corpus Striatum (pathology)</term><term>Corpus Striatum (physiopathology)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term><term>Multiple System Atrophy (diagnostic imaging)</term><term>Multiple System Atrophy (physiopathology)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (physiopathology)</term><term>Putamen (diagnostic imaging)</term><term>Putamen (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) and multiple system atrophy (MSA) are two neurodegenerative alpha-synucleinopathies characterized by severe impairment of the nigro-striatal pathway. Based on T1-, T2*-, and diffusion-weighted magnetic resonance imaging (MRI), macro-structural and micro-structural abnormalities in these diseases can be detected.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26676922</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>08</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>15</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Multimodal MRI assessment of nigro-striatal pathway in multiple system atrophy and Parkinson disease.</ArticleTitle><Pagination><MedlinePgn>325-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26471</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Parkinson's disease (PD) and multiple system atrophy (MSA) are two neurodegenerative alpha-synucleinopathies characterized by severe impairment of the nigro-striatal pathway. Based on T1-, T2*-, and diffusion-weighted magnetic resonance imaging (MRI), macro-structural and micro-structural abnormalities in these diseases can be detected.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">This study was undertaken to compare the nigro-striatal changes that occur in patients with PD with those in patients with both variants of MSA (the parkinsonian variant, MSA-P, and the cerebellar variant, MSA-C), and to explore correlations between different MRI parameters and clinical data.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We simultaneously measured volume, T2* relaxation rates, and mean diffusivity in nigro-striatal structures (substantia nigra, caudate nucleus, and putamen) of 26 patients with PD and 29 patients with MSA (16 with MSA-P and 13 with MSA-C).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Significant changes in the putamina in patients with MSA were observed compared with patients with PD. Patients with MSA-P had higher mean diffusivity values in their putamina than did patients with PD or MSA-C. The putamina of both subgroups of MSA had higher T2* relaxation rates values than PD. Remarkably, discriminant analysis showed that using two measurements of microstructural damage (T2* relaxation rates and mean diffusivity in the putamen) allowed 96% accuracy to distinguish patients with PD from those with MSA-P. Correlation analyses between MRI findings and clinical variables revealed that patients with PD showed significant correlations only at the nigra. In patients with MSA, clinical variables correlated with MRI findings in both the nigra and striatum.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Multimodal MRI reveals different pattern of nigro-striatal involvement in patients with PD and patients with MSA.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barbagallo</LastName><ForeName>Gaetano</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>INSERM, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059, Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université de Toulouse (UPS), Imagerie Cérébrale et Handicaps Neurologiques, Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Neurology, University Magna Graecia, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sierra-Peña</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Service of Neurology, University Hospital "Marqués de Valdecilla (IFIMAV)," University of Cantabria and "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED),", Santander, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nemmi</LastName><ForeName>Federico</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Neuroscience Department, Retzius vag 8, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Traon</LastName><ForeName>Anne Pavy-Le</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Centre de Référence Atrophie Multisystématisée, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meissner</LastName><ForeName>Wassilios G</ForeName><Initials>WG</Initials><AffiliationInfo><Affiliation>Centre de Référence Atrophie Multisystématisée, Centre Hospitalier Universitaire de Bordeaux, Pessac, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie, Centre Hospitalier Universitaire de Bordeaux, Pessac, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Institut des Maladies Neurodégénératives, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rascol</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>INSERM, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059, Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université de Toulouse (UPS), Imagerie Cérébrale et Handicaps Neurologiques, Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre de Référence Atrophie Multisystématisée, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Département de Pharmacologie Clinique, INSERM CIC1436, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Péran</LastName><ForeName>Patrice</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INSERM, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059, Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université de Toulouse (UPS), Imagerie Cérébrale et Handicaps Neurologiques, Toulouse, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="Y">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019578" MajorTopicYN="N">Multiple System Atrophy</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011699" MajorTopicYN="N">Putamen</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">multimodal MRI</Keyword><Keyword MajorTopicYN="N">multiple system atrophy</Keyword><Keyword MajorTopicYN="N">nigro-striatal pathway</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>10</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>10</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26676922</ArticleId><ArticleId IdType="doi">10.1002/mds.26471</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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