Current Developments on Optical Feedback Interferometry as an All-Optical Sensor for Biomedical Applications.
Identifieur interne : 000143 ( PubMed/Corpus ); précédent : 000142; suivant : 000144Current Developments on Optical Feedback Interferometry as an All-Optical Sensor for Biomedical Applications.
Auteurs : Julien Perchoux ; Adam Quotb ; Reza Atashkhooei ; Francisco J. Azcona ; Evelio E. Ramírez-Miquet ; Olivier Bernal ; Ajit Jha ; Antonio Luna-Arriaga ; Carlos Yanez ; Jesus Caum ; Thierry Bosch ; Santiago RoyoSource :
- Sensors (Basel, Switzerland) [ 1424-8220 ] ; 2016.
Abstract
Optical feedback interferometry (OFI) sensors are experiencing a consistent increase in their applications to biosensing due to their contactless nature, low cost and compactness, features that fit very well with current biophotonics research and market trends. The present paper is a review of the work in progress at UPC-CD6 and LAAS-CNRS related to the application of OFI to different aspects of biosensing, both in vivo and ex vivo. This work is intended to present the variety of opportunities and potential applications related to OFI that are available in the field. The activities presented are divided into two main sensing strategies: The measurement of optical path changes and the monitoring of flows, which correspond to sensing strategies linked to the reconstruction of changes of amplitude from the interferometric signal, and to classical Doppler frequency measurements, respectively. For optical path change measurements, measurements of transient pulses, usual in biosensing, together with the measurement of large displacements applied to designing palliative care instrumentation for Parkinson disease are discussed. Regarding the Doppler-based approach, progress in flow-related signal processing and applications in real-time monitoring of non-steady flows, human blood flow monitoring and OFI pressure myograph sensing will be presented. In all cases, experimental setups are discussed and results presented, showing the versatility of the technique. The described applications show the wide capabilities in biosensing of the OFI sensor, showing it as an enabler of low-cost, all-optical, high accuracy biomedical applications.
DOI: 10.3390/s16050694
PubMed: 27187406
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Azcona</name><affiliation><nlm:affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. francisco.javier.azcona@cd6.upc.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Ramirez Miquet, Evelio E" sort="Ramirez Miquet, Evelio E" uniqKey="Ramirez Miquet E" first="Evelio E" last="Ramírez-Miquet">Evelio E. Ramírez-Miquet</name><affiliation><nlm:affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. ermiquet@ceaden.edu.cu.</nlm:affiliation></affiliation></author><author><name sortKey="Bernal, Olivier" sort="Bernal, Olivier" uniqKey="Bernal O" first="Olivier" last="Bernal">Olivier Bernal</name><affiliation><nlm:affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. olivier.bernal@enseeiht.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Jha, Ajit" sort="Jha, Ajit" uniqKey="Jha A" first="Ajit" last="Jha">Ajit Jha</name><affiliation><nlm:affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. ajit.jha@cd6.upc.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Luna Arriaga, Antonio" sort="Luna Arriaga, Antonio" uniqKey="Luna Arriaga A" first="Antonio" last="Luna-Arriaga">Antonio Luna-Arriaga</name><affiliation><nlm:affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. antonio.lunaarriaga@enseeiht.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Yanez, Carlos" sort="Yanez, Carlos" uniqKey="Yanez C" first="Carlos" last="Yanez">Carlos Yanez</name><affiliation><nlm:affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. carlos.yanez@cd6.upc.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Caum, Jesus" sort="Caum, Jesus" uniqKey="Caum J" first="Jesus" last="Caum">Jesus Caum</name><affiliation><nlm:affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. caum@oo.upc.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Bosch, Thierry" sort="Bosch, Thierry" uniqKey="Bosch T" first="Thierry" last="Bosch">Thierry Bosch</name><affiliation><nlm:affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. thierry.bosch@enseeiht.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Royo, Santiago" sort="Royo, Santiago" uniqKey="Royo S" first="Santiago" last="Royo">Santiago Royo</name><affiliation><nlm:affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. santiago.royo@upc.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Sensors (Basel, Switzerland)</title><idno type="eISSN">1424-8220</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Optical feedback interferometry (OFI) sensors are experiencing a consistent increase in their applications to biosensing due to their contactless nature, low cost and compactness, features that fit very well with current biophotonics research and market trends. The present paper is a review of the work in progress at UPC-CD6 and LAAS-CNRS related to the application of OFI to different aspects of biosensing, both in vivo and ex vivo. This work is intended to present the variety of opportunities and potential applications related to OFI that are available in the field. The activities presented are divided into two main sensing strategies: The measurement of optical path changes and the monitoring of flows, which correspond to sensing strategies linked to the reconstruction of changes of amplitude from the interferometric signal, and to classical Doppler frequency measurements, respectively. For optical path change measurements, measurements of transient pulses, usual in biosensing, together with the measurement of large displacements applied to designing palliative care instrumentation for Parkinson disease are discussed. Regarding the Doppler-based approach, progress in flow-related signal processing and applications in real-time monitoring of non-steady flows, human blood flow monitoring and OFI pressure myograph sensing will be presented. In all cases, experimental setups are discussed and results presented, showing the versatility of the technique. The described applications show the wide capabilities in biosensing of the OFI sensor, showing it as an enabler of low-cost, all-optical, high accuracy biomedical applications.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27187406</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>18</Day></DateCreated><DateRevised><Year>2016</Year><Month>05</Month><Day>29</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1424-8220</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>5</Issue><PubDate><Year>2016</Year><Month>May</Month><Day>13</Day></PubDate></JournalIssue><Title>Sensors (Basel, Switzerland)</Title><ISOAbbreviation>Sensors (Basel)</ISOAbbreviation></Journal><ArticleTitle>Current Developments on Optical Feedback Interferometry as an All-Optical Sensor for Biomedical Applications.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.3390/s16050694</ELocationID><ELocationID EIdType="pii" ValidYN="Y">E694</ELocationID><Abstract><AbstractText>Optical feedback interferometry (OFI) sensors are experiencing a consistent increase in their applications to biosensing due to their contactless nature, low cost and compactness, features that fit very well with current biophotonics research and market trends. The present paper is a review of the work in progress at UPC-CD6 and LAAS-CNRS related to the application of OFI to different aspects of biosensing, both in vivo and ex vivo. This work is intended to present the variety of opportunities and potential applications related to OFI that are available in the field. The activities presented are divided into two main sensing strategies: The measurement of optical path changes and the monitoring of flows, which correspond to sensing strategies linked to the reconstruction of changes of amplitude from the interferometric signal, and to classical Doppler frequency measurements, respectively. For optical path change measurements, measurements of transient pulses, usual in biosensing, together with the measurement of large displacements applied to designing palliative care instrumentation for Parkinson disease are discussed. Regarding the Doppler-based approach, progress in flow-related signal processing and applications in real-time monitoring of non-steady flows, human blood flow monitoring and OFI pressure myograph sensing will be presented. In all cases, experimental setups are discussed and results presented, showing the versatility of the technique. The described applications show the wide capabilities in biosensing of the OFI sensor, showing it as an enabler of low-cost, all-optical, high accuracy biomedical applications.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Perchoux</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. julien.perchoux@enseeiht.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quotb</LastName><ForeName>Adam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. adam.quotb@enseeiht.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Atashkhooei</LastName><ForeName>Reza</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. reza.atashkhooei@cd6.upc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azcona</LastName><ForeName>Francisco J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. francisco.javier.azcona@cd6.upc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramírez-Miquet</LastName><ForeName>Evelio E</ForeName><Initials>EE</Initials><AffiliationInfo><Affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. ermiquet@ceaden.edu.cu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, Calle 30, No. 502, Miramar, La Habana 11300, Cuba. ermiquet@ceaden.edu.cu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bernal</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. olivier.bernal@enseeiht.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jha</LastName><ForeName>Ajit</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. ajit.jha@cd6.upc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luna-Arriaga</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. antonio.lunaarriaga@enseeiht.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yanez</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. carlos.yanez@cd6.upc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caum</LastName><ForeName>Jesus</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. caum@oo.upc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bosch</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France. thierry.bosch@enseeiht.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Royo</LastName><ForeName>Santiago</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain. santiago.royo@upc.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>05</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Sensors (Basel)</MedlineTA><NlmUniqueID>101204366</NlmUniqueID><ISSNLinking>1424-8220</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Invest Ophthalmol. 1972 Nov;11(11):936-44</RefSource><PMID 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Version="1">25606963</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Appl Opt. 2015 Dec 1;54(34):10106-13</RefSource><PMID Version="1">26836667</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2889-96</RefSource><PMID Version="1">21979438</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC4883385</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">biophotonics</Keyword><Keyword MajorTopicYN="N">biosensors</Keyword><Keyword MajorTopicYN="N">flowmetry</Keyword><Keyword MajorTopicYN="N">metrology</Keyword><Keyword MajorTopicYN="N">optical feedback interferometry</Keyword><Keyword MajorTopicYN="N">vibrometry</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>01</Day></PubMedPubDate><PubMedPubDate 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