Quality of life in Parkinson's disease improved by apomorphine pump: the OPTIPUMP cohort study.
Identifieur interne : 000135 ( PubMed/Corpus ); précédent : 000134; suivant : 000136Quality of life in Parkinson's disease improved by apomorphine pump: the OPTIPUMP cohort study.
Auteurs : Sophie Drapier ; Alexandre Eusebio ; Bertrand Degos ; Marc Vérin ; Franck Durif ; Jean Philippe Azulay ; François Viallet ; Tiphaine Rouaud ; Caroline Moreau ; Luc Defebvre ; Valerie Fraix ; Christine Tranchant ; Karine Andre ; Christine Brefel Courbon ; Emmanuel Roze ; David DevosSource :
- Journal of neurology [ 1432-1459 ] ; 2016.
Abstract
To report on OPTIPUMP, a cohort study, investigating the impact in real-life clinical settings of continuous subcutaneous apomorphine infusion (CSAI) on the quality of life (HRQoL) of patients with Parkinson's disease. OPTIPUMP was a prospective, open-label, observational cohort study involving 30 investigational sites in France. CSAI was proposed as part of routine clinical care to patients aged ≥18 years, in absence of dementia, with a PD diagnosis and based on the presence of motor fluctuations not controlled by oral treatments. The impact of APO-pump on quality of life was evaluated as the difference in PDQ-39 scores between the initiation treatment and the follow-up visit after 6 months' treatment. All adverse events were recorded. Hyper- and hypodopaminergic behavioral tolerance was assessed on the Ardouin Scale of Behavior in Parkinson's Disease. Between September 2011 and January 2013, we enrolled 142 patients: 42 patients were withdrawn due to pump removal (33), death (4), lost of follow-up (4), no available data (1). 100 completed the study. At 6 months, their HRQoL had significantly improved (p = 0.011), as had their total UPDRS score (p < 0.001). Regarding the safety profile, Ardouin scale scores indicated that their hyperdopaminergic behaviors had not increased. CSAI had a favorable impact on HRQoL, with benefits outweighing risks. The analysis of the withdrawn patients highlights the heterogeneity of the use of the pump having an impact on its efficacy and tolerability.
DOI: 10.1007/s00415-016-8106-3
PubMed: 27060084
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Roze</name><affiliation><nlm:affiliation>Department of Neurology, Assistance Publique Hôpitaux de Paris, Inserm, U 1127, CNRS, UMR 7225, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Sorbonne Universités, 47-83 boulevard de l'Hôpital, 75013, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation><nlm:affiliation>Department of Medical Pharmacology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27060084</idno><idno type="pmid">27060084</idno><idno type="doi">10.1007/s00415-016-8106-3</idno><idno type="wicri:Area/PubMed/Corpus">000135</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000135</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quality of life in Parkinson's disease improved by apomorphine pump: the OPTIPUMP cohort study.</title><author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name><affiliation><nlm:affiliation>Department of Neurology, EA 4712, University Rennes 1, CHU Pontchaillou, 2 Henri Le Guilloux, 35000, Rennes, France. sophie.drapier@chu-rennes.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation><nlm:affiliation>Department of Neurology and Movement Disorders, APHM Timone University Hospital and Institut de Neurosciences de la Timone, AMU-CNRS UMR 7289, Marseilles, France.</nlm:affiliation></affiliation></author><author><name sortKey="Degos, Bertrand" sort="Degos, Bertrand" uniqKey="Degos B" first="Bertrand" last="Degos">Bertrand Degos</name><affiliation><nlm:affiliation>Department of Neurology, Centre Expert et Inter-Régional de Coordination de la Maladie de Parkinson, Hôpital de la Pitié-Salpêtrière, APHP, 47-83 boulevard de l'Hôpital, 75013, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><affiliation><nlm:affiliation>Department of Neurology, EA 4712, University Rennes 1, CHU Pontchaillou, 2 Henri Le Guilloux, 35000, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><affiliation><nlm:affiliation>Department of Movement Disorders and Neurology, CHU Clermont-Ferrand, 58 rue Montalembert, 63003, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean Philippe" last="Azulay">Jean Philippe Azulay</name><affiliation><nlm:affiliation>Department of Neurology and Movement Disorders, APHM Timone University Hospital and Institut de Neurosciences de la Timone, AMU-CNRS UMR 7289, Marseilles, France.</nlm:affiliation></affiliation></author><author><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><affiliation><nlm:affiliation>Department of Neurology, University Hospital, Avenue des Tamaris, 13616, Aix-En-Provence, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name><affiliation><nlm:affiliation>Department of Neurology, CHU Nantes, boulevard Jacques-Monod-Saint-Herblain, 44093, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><affiliation><nlm:affiliation>Department of Movement Disorders and Neurology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><nlm:affiliation>Department of Movement Disorders and Neurology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation><nlm:affiliation>Department of Psychiatry and Neurology, CHU Grenoble, Avenue Maquis du Grésivaudan, 38700, La Tronche, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tranchant, Christine" sort="Tranchant, Christine" uniqKey="Tranchant C" first="Christine" last="Tranchant">Christine Tranchant</name><affiliation><nlm:affiliation>Department of Movement Disorders and Neurology, CHU Strasbourg, 1 Place de L Hôpital, 67000, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Andre, Karine" sort="Andre, Karine" uniqKey="Andre K" first="Karine" last="Andre">Karine Andre</name><affiliation><nlm:affiliation>CLINACT Groupe, Sèvre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Courbon, Christine Brefel" sort="Courbon, Christine Brefel" uniqKey="Courbon C" first="Christine Brefel" last="Courbon">Christine Brefel Courbon</name><affiliation><nlm:affiliation>Department of Clinical Pharmacology and Neurosciences, UMR 825 Inserm, University Hospital Toulouse III, 31059, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name><affiliation><nlm:affiliation>Department of Neurology, Assistance Publique Hôpitaux de Paris, Inserm, U 1127, CNRS, UMR 7225, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Sorbonne Universités, 47-83 boulevard de l'Hôpital, 75013, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation><nlm:affiliation>Department of Medical Pharmacology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of neurology</title><idno type="eISSN">1432-1459</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To report on OPTIPUMP, a cohort study, investigating the impact in real-life clinical settings of continuous subcutaneous apomorphine infusion (CSAI) on the quality of life (HRQoL) of patients with Parkinson's disease. OPTIPUMP was a prospective, open-label, observational cohort study involving 30 investigational sites in France. CSAI was proposed as part of routine clinical care to patients aged ≥18 years, in absence of dementia, with a PD diagnosis and based on the presence of motor fluctuations not controlled by oral treatments. The impact of APO-pump on quality of life was evaluated as the difference in PDQ-39 scores between the initiation treatment and the follow-up visit after 6 months' treatment. All adverse events were recorded. Hyper- and hypodopaminergic behavioral tolerance was assessed on the Ardouin Scale of Behavior in Parkinson's Disease. Between September 2011 and January 2013, we enrolled 142 patients: 42 patients were withdrawn due to pump removal (33), death (4), lost of follow-up (4), no available data (1). 100 completed the study. At 6 months, their HRQoL had significantly improved (p = 0.011), as had their total UPDRS score (p < 0.001). Regarding the safety profile, Ardouin scale scores indicated that their hyperdopaminergic behaviors had not increased. CSAI had a favorable impact on HRQoL, with benefits outweighing risks. The analysis of the withdrawn patients highlights the heterogeneity of the use of the pump having an impact on its efficacy and tolerability.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27060084</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>06</Day></DateCreated><DateRevised><Year>2016</Year><Month>12</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1459</ISSN><JournalIssue CitedMedium="Internet"><Volume>263</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of neurology</Title><ISOAbbreviation>J. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Quality of life in Parkinson's disease improved by apomorphine pump: the OPTIPUMP cohort study.</ArticleTitle><Pagination><MedlinePgn>1111-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00415-016-8106-3</ELocationID><Abstract><AbstractText>To report on OPTIPUMP, a cohort study, investigating the impact in real-life clinical settings of continuous subcutaneous apomorphine infusion (CSAI) on the quality of life (HRQoL) of patients with Parkinson's disease. OPTIPUMP was a prospective, open-label, observational cohort study involving 30 investigational sites in France. CSAI was proposed as part of routine clinical care to patients aged ≥18 years, in absence of dementia, with a PD diagnosis and based on the presence of motor fluctuations not controlled by oral treatments. The impact of APO-pump on quality of life was evaluated as the difference in PDQ-39 scores between the initiation treatment and the follow-up visit after 6 months' treatment. All adverse events were recorded. Hyper- and hypodopaminergic behavioral tolerance was assessed on the Ardouin Scale of Behavior in Parkinson's Disease. Between September 2011 and January 2013, we enrolled 142 patients: 42 patients were withdrawn due to pump removal (33), death (4), lost of follow-up (4), no available data (1). 100 completed the study. At 6 months, their HRQoL had significantly improved (p = 0.011), as had their total UPDRS score (p < 0.001). Regarding the safety profile, Ardouin scale scores indicated that their hyperdopaminergic behaviors had not increased. CSAI had a favorable impact on HRQoL, with benefits outweighing risks. The analysis of the withdrawn patients highlights the heterogeneity of the use of the pump having an impact on its efficacy and tolerability.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Drapier</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, EA 4712, University Rennes 1, CHU Pontchaillou, 2 Henri Le Guilloux, 35000, Rennes, France. sophie.drapier@chu-rennes.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neurology Department, University Hospital, 2 rue Henri Le Guilloux, 35200, Rennes, France. sophie.drapier@chu-rennes.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eusebio</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology and Movement Disorders, APHM Timone University Hospital and Institut de Neurosciences de la Timone, AMU-CNRS UMR 7289, Marseilles, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Degos</LastName><ForeName>Bertrand</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Neurology, Centre Expert et Inter-Régional de Coordination de la Maladie de Parkinson, Hôpital de la Pitié-Salpêtrière, APHP, 47-83 boulevard de l'Hôpital, 75013, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vérin</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, EA 4712, University Rennes 1, CHU Pontchaillou, 2 Henri Le Guilloux, 35000, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durif</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, CHU Clermont-Ferrand, 58 rue Montalembert, 63003, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azulay</LastName><ForeName>Jean Philippe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Neurology and Movement Disorders, APHM Timone University Hospital and Institut de Neurosciences de la Timone, AMU-CNRS UMR 7289, Marseilles, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viallet</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital, Avenue des Tamaris, 13616, Aix-En-Provence, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouaud</LastName><ForeName>Tiphaine</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology, CHU Nantes, boulevard Jacques-Monod-Saint-Herblain, 44093, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreau</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Defebvre</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraix</LastName><ForeName>Valerie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Neurology, CHU Grenoble, Avenue Maquis du Grésivaudan, 38700, La Tronche, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tranchant</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, CHU Strasbourg, 1 Place de L Hôpital, 67000, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andre</LastName><ForeName>Karine</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>CLINACT Groupe, Sèvre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Courbon</LastName><ForeName>Christine Brefel</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Department of Clinical Pharmacology and Neurosciences, UMR 825 Inserm, University Hospital Toulouse III, 31059, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roze</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Neurology, Assistance Publique Hôpitaux de Paris, Inserm, U 1127, CNRS, UMR 7225, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Sorbonne Universités, 47-83 boulevard de l'Hôpital, 75013, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Devos</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Medical Pharmacology, INSERM U1171, Lille University, CHU Lille, 2, avenue Oscar Lambret, 59037, Lille, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Neurol</MedlineTA><NlmUniqueID>0423161</NlmUniqueID><ISSNLinking>0340-5354</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Apomorphine pump</Keyword><Keyword MajorTopicYN="N">Parkinson’s disease</Keyword><Keyword MajorTopicYN="N">Quality of life</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>11</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>03</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>03</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27060084</ArticleId><ArticleId 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