The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.
Identifieur interne : 000025 ( PubMed/Corpus ); précédent : 000024; suivant : 000026The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.
Auteurs : John M. Lee ; Pascal Derkinderen ; Jeffrey H. Kordower ; Roy Freeman ; David G. Munoz ; Thomas Kremer ; Wagner Zago ; Samantha J. Hutten ; Charles H. Adler ; Geidy E. Serrano ; Thomas G. BeachSource :
- Journal of neuropathology and experimental neurology [ 1554-6578 ] ; 2017.
Abstract
The neuropathological hallmark of Parkinson disease (PD) is abnormal accumulation of α-synuclein (α-syn). Demonstrating pathological α-syn in live patients would be useful for identifying and monitoring PD patients. To date, however, imaging and biofluid approaches have not permitted premortem assessment of pathological α-syn. α-syn pathology in the peripheral nervous system of patients with PD has been demonstrated in studies dating back more than 40 years. More recent work suggests that colon, submandibular gland and skin biopsies could be useful as expedient biomarkers but histological differentiation of pathological and normal peripheral α-syn has been challenging and multiple research groups have reported variable results. A variety of immunohistochemical methods have been employed but almost all studies to date originated at single centers with no independent, blinded replication. To address these issues, the Michael J. Fox Foundation for Parkinson's Research sponsored a series of meetings and investigations by several research groups with relevant experience. The major finding reported herein was that biopsies can be used to distinguish PD patients from normal subjects. However, full assessment of the clinical potential of biopsy will only be achieved through large, multicenter trials in which both the initial detection methodology and histology have been assessed by blinded panels of pathologists.
DOI: 10.1093/jnen/nlw103
PubMed: 28069931
Links to Exploration step
pubmed:28069931Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.</title>
<author><name sortKey="Lee, John M" sort="Lee, John M" uniqKey="Lee J" first="John M" last="Lee">John M. Lee</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Freeman, Roy" sort="Freeman, Roy" uniqKey="Freeman R" first="Roy" last="Freeman">Roy Freeman</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G" last="Munoz">David G. Munoz</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kremer, Thomas" sort="Kremer, Thomas" uniqKey="Kremer T" first="Thomas" last="Kremer">Thomas Kremer</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zago, Wagner" sort="Zago, Wagner" uniqKey="Zago W" first="Wagner" last="Zago">Wagner Zago</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hutten, Samantha J" sort="Hutten, Samantha J" uniqKey="Hutten S" first="Samantha J" last="Hutten">Samantha J. Hutten</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Serrano, Geidy E" sort="Serrano, Geidy E" uniqKey="Serrano G" first="Geidy E" last="Serrano">Geidy E. Serrano</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); thomas.beach@bannerhealth.com.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28069931</idno>
<idno type="pmid">28069931</idno>
<idno type="doi">10.1093/jnen/nlw103</idno>
<idno type="wicri:Area/PubMed/Corpus">000025</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000025</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.</title>
<author><name sortKey="Lee, John M" sort="Lee, John M" uniqKey="Lee J" first="John M" last="Lee">John M. Lee</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Freeman, Roy" sort="Freeman, Roy" uniqKey="Freeman R" first="Roy" last="Freeman">Roy Freeman</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G" last="Munoz">David G. Munoz</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kremer, Thomas" sort="Kremer, Thomas" uniqKey="Kremer T" first="Thomas" last="Kremer">Thomas Kremer</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zago, Wagner" sort="Zago, Wagner" uniqKey="Zago W" first="Wagner" last="Zago">Wagner Zago</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hutten, Samantha J" sort="Hutten, Samantha J" uniqKey="Hutten S" first="Samantha J" last="Hutten">Samantha J. Hutten</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Serrano, Geidy E" sort="Serrano, Geidy E" uniqKey="Serrano G" first="Geidy E" last="Serrano">Geidy E. Serrano</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name>
<affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); thomas.beach@bannerhealth.com.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of neuropathology and experimental neurology</title>
<idno type="eISSN">1554-6578</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The neuropathological hallmark of Parkinson disease (PD) is abnormal accumulation of α-synuclein (α-syn). Demonstrating pathological α-syn in live patients would be useful for identifying and monitoring PD patients. To date, however, imaging and biofluid approaches have not permitted premortem assessment of pathological α-syn. α-syn pathology in the peripheral nervous system of patients with PD has been demonstrated in studies dating back more than 40 years. More recent work suggests that colon, submandibular gland and skin biopsies could be useful as expedient biomarkers but histological differentiation of pathological and normal peripheral α-syn has been challenging and multiple research groups have reported variable results. A variety of immunohistochemical methods have been employed but almost all studies to date originated at single centers with no independent, blinded replication. To address these issues, the Michael J. Fox Foundation for Parkinson's Research sponsored a series of meetings and investigations by several research groups with relevant experience. The major finding reported herein was that biopsies can be used to distinguish PD patients from normal subjects. However, full assessment of the clinical potential of biopsy will only be achieved through large, multicenter trials in which both the initial detection methodology and histology have been assessed by blinded panels of pathologists.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28069931</PMID>
<DateCreated><Year>2017</Year>
<Month>01</Month>
<Day>10</Day>
</DateCreated>
<DateRevised><Year>2017</Year>
<Month>01</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1554-6578</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year>
<Month>Jan</Month>
<Day>09</Day>
</PubDate>
</JournalIssue>
<Title>Journal of neuropathology and experimental neurology</Title>
<ISOAbbreviation>J. Neuropathol. Exp. Neurol.</ISOAbbreviation>
</Journal>
<ArticleTitle>The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">nlw103</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/jnen/nlw103</ELocationID>
<Abstract><AbstractText NlmCategory="UNASSIGNED">The neuropathological hallmark of Parkinson disease (PD) is abnormal accumulation of α-synuclein (α-syn). Demonstrating pathological α-syn in live patients would be useful for identifying and monitoring PD patients. To date, however, imaging and biofluid approaches have not permitted premortem assessment of pathological α-syn. α-syn pathology in the peripheral nervous system of patients with PD has been demonstrated in studies dating back more than 40 years. More recent work suggests that colon, submandibular gland and skin biopsies could be useful as expedient biomarkers but histological differentiation of pathological and normal peripheral α-syn has been challenging and multiple research groups have reported variable results. A variety of immunohistochemical methods have been employed but almost all studies to date originated at single centers with no independent, blinded replication. To address these issues, the Michael J. Fox Foundation for Parkinson's Research sponsored a series of meetings and investigations by several research groups with relevant experience. The major finding reported herein was that biopsies can be used to distinguish PD patients from normal subjects. However, full assessment of the clinical potential of biopsy will only be achieved through large, multicenter trials in which both the initial detection methodology and histology have been assessed by blinded panels of pathologists.</AbstractText>
<CopyrightInformation>© 2017 American Association of Neuropathologists, Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>John M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Derkinderen</LastName>
<ForeName>Pascal</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kordower</LastName>
<ForeName>Jeffrey H</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Freeman</LastName>
<ForeName>Roy</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Munoz</LastName>
<ForeName>David G</ForeName>
<Initials>DG</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kremer</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zago</LastName>
<ForeName>Wagner</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hutten</LastName>
<ForeName>Samantha J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Adler</LastName>
<ForeName>Charles H</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Serrano</LastName>
<ForeName>Geidy E</ForeName>
<Initials>GE</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA).</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Beach</LastName>
<ForeName>Thomas G</ForeName>
<Initials>TG</Initials>
<AffiliationInfo><Affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Prothena Biosciences, Inc., South San Francisco, California (WZ); thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB) thomas.beach@bannerhealth.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="">Review</PublicationType>
<PublicationType UI="">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>01</Month>
<Day>09</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Neuropathol Exp Neurol</MedlineTA>
<NlmUniqueID>2985192R</NlmUniqueID>
<ISSNLinking>0022-3069</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Biomarker</Keyword>
<Keyword MajorTopicYN="N">Colon</Keyword>
<Keyword MajorTopicYN="N">Diagnosis</Keyword>
<Keyword MajorTopicYN="N">Lewy body</Keyword>
<Keyword MajorTopicYN="N">Prognosis</Keyword>
<Keyword MajorTopicYN="N">Skin</Keyword>
<Keyword MajorTopicYN="N">Submandibular gland.</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>1</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>1</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>1</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28069931</ArticleId>
<ArticleId IdType="pii">nlw103</ArticleId>
<ArticleId IdType="doi">10.1093/jnen/nlw103</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000025 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000025 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:28069931 |texte= The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:28069931" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |