Is pineal melatonin released in the third ventricle in humans? A study in movement disorders.
Identifieur interne : 001750 ( PubMed/Checkpoint ); précédent : 001749; suivant : 001751Is pineal melatonin released in the third ventricle in humans? A study in movement disorders.
Auteurs : J. Leston [France] ; C. Harthé [France] ; C. Mottolese [France] ; P. Mertens [France] ; M. Sindou [France] ; B. Claustrat [France]Source :
- Neuro-Chirurgie [ 1773-0619 ]
English descriptors
- KwdEn :
- Adult, Aged, Female, Humans, Lateral Ventricles (metabolism), Male, Melatonin (analogs & derivatives), Melatonin (blood), Melatonin (cerebrospinal fluid), Melatonin (pharmacology), Middle Aged, Movement Disorders (blood), Movement Disorders (cerebrospinal fluid), Movement Disorders (diagnosis), Pineal Gland (metabolism), Third Ventricle (metabolism).
- MESH :
- chemical , analogs & derivatives : Melatonin.
- chemical , blood : Melatonin.
- chemical , cerebrospinal fluid : Melatonin.
- blood : Movement Disorders.
- cerebrospinal fluid : Movement Disorders.
- diagnosis : Movement Disorders.
- metabolism : Lateral Ventricles, Pineal Gland, Third Ventricle.
- chemical , pharmacology : Melatonin.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75±2.75pg/mL vs. 3.20±0.33pg/mL, P=0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5pg/mL. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.
DOI: 10.1016/j.neuchi.2013.04.004
PubMed: 24975205
Affiliations:
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A study in movement disorders.</title><author><name sortKey="Leston, J" sort="Leston, J" uniqKey="Leston J" first="J" last="Leston">J. Leston</name><affiliation wicri:level="1"><nlm:affiliation>Neurosurgical Unit A, P.-Wertheimer Hospital, Bron, France; Inserm, U846, Department of Chronobiology, Stem Cell and Brain Research Institute, Bron, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neurosurgical Unit A, P.-Wertheimer Hospital, Bron, France; Inserm, U846, Department of Chronobiology, Stem Cell and Brain Research Institute, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Harthe, C" sort="Harthe, C" uniqKey="Harthe C" first="C" last="Harthé">C. Harthé</name><affiliation wicri:level="3"><nlm:affiliation>Hormone Laboratory, Centre of Nuclear Medicine, Department of Chronobiology, Stem Cell and Brain Research Institute, Groupement Hospitalier Est, 59, boulevard Pinel, 69677 Bron, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hormone Laboratory, Centre of Nuclear Medicine, Department of Chronobiology, Stem Cell and Brain Research Institute, Groupement Hospitalier Est, 59, boulevard Pinel, 69677 Bron</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Bron</settlement></placeName></affiliation></author><author><name sortKey="Mottolese, C" sort="Mottolese, C" uniqKey="Mottolese C" first="C" last="Mottolese">C. 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Sindou</name><affiliation wicri:level="1"><nlm:affiliation>Neurosurgical Unit A, P.-Wertheimer Hospital, Bron, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neurosurgical Unit A, P.-Wertheimer Hospital, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Claustrat, B" sort="Claustrat, B" uniqKey="Claustrat B" first="B" last="Claustrat">B. Claustrat</name><affiliation wicri:level="1"><nlm:affiliation>Hormone Laboratory, Centre of Nuclear Medicine, Department of Chronobiology, Stem Cell and Brain Research Institute, Groupement Hospitalier Est, 59, boulevard Pinel, 69677 Bron, France; Inserm, U846, Department of Chronobiology, Stem Cell and Brain Research Institute, Bron, France. Electronic address: bruno.claustrat@chu-lyon.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hormone Laboratory, Centre of Nuclear Medicine, Department of Chronobiology, Stem Cell and Brain Research Institute, Groupement Hospitalier Est, 59, boulevard Pinel, 69677 Bron, France; Inserm, U846, Department of Chronobiology, Stem Cell and Brain Research Institute, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neuro-Chirurgie</title><idno type="eISSN">1773-0619</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Lateral Ventricles (metabolism)</term><term>Male</term><term>Melatonin (analogs & derivatives)</term><term>Melatonin (blood)</term><term>Melatonin (cerebrospinal fluid)</term><term>Melatonin (pharmacology)</term><term>Middle Aged</term><term>Movement Disorders (blood)</term><term>Movement Disorders (cerebrospinal fluid)</term><term>Movement Disorders (diagnosis)</term><term>Pineal Gland (metabolism)</term><term>Third Ventricle (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Melatonin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Melatonin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Melatonin</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lateral Ventricles</term><term>Pineal Gland</term><term>Third Ventricle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Melatonin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75±2.75pg/mL vs. 3.20±0.33pg/mL, P=0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5pg/mL. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24975205</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>22</Day></DateCreated><DateCompleted><Year>2016</Year><Month>03</Month><Day>11</Day></DateCompleted><DateRevised><Year>2016</Year><Month>04</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1773-0619</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><Issue>2-3</Issue><PubDate><MedlineDate>2015 Apr-Jun</MedlineDate></PubDate></JournalIssue><Title>Neuro-Chirurgie</Title><ISOAbbreviation>Neurochirurgie</ISOAbbreviation></Journal><ArticleTitle>Is pineal melatonin released in the third ventricle in humans? A study in movement disorders.</ArticleTitle><Pagination><MedlinePgn>85-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neuchi.2013.04.004</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0028-3770(13)00035-0</ELocationID><Abstract><AbstractText>In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75±2.75pg/mL vs. 3.20±0.33pg/mL, P=0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5pg/mL. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Leston</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Neurosurgical Unit A, P.-Wertheimer Hospital, Bron, France; Inserm, U846, Department of Chronobiology, Stem Cell and Brain Research Institute, Bron, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harthé</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hormone Laboratory, Centre of Nuclear Medicine, Department of Chronobiology, Stem Cell and Brain Research Institute, Groupement Hospitalier Est, 59, boulevard Pinel, 69677 Bron, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mottolese</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Neurosurgical Unit B, P.-Wertheimer Hospital, Bron, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mertens</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Neurosurgical Unit A, P.-Wertheimer Hospital, Bron, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sindou</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Neurosurgical Unit A, P.-Wertheimer Hospital, Bron, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Claustrat</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Hormone Laboratory, Centre of Nuclear Medicine, Department of Chronobiology, Stem Cell and Brain Research Institute, Groupement Hospitalier Est, 59, boulevard Pinel, 69677 Bron, France; Inserm, U846, Department of Chronobiology, Stem Cell and Brain Research Institute, Bron, France. Electronic address: bruno.claustrat@chu-lyon.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>06</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Neurochirurgie</MedlineTA><NlmUniqueID>0401057</NlmUniqueID><ISSNLinking>0028-3770</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>2208-40-4</RegistryNumber><NameOfSubstance UI="C054513">6-sulfatoxymelatonin</NameOfSubstance></Chemical><Chemical><RegistryNumber>JL5DK93RCL</RegistryNumber><NameOfSubstance UI="D008550">Melatonin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020547" MajorTopicYN="N">Lateral Ventricles</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008550" MajorTopicYN="N">Melatonin</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000134" MajorTopicYN="Y">cerebrospinal fluid</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009069" MajorTopicYN="N">Movement Disorders</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000134" MajorTopicYN="Y">cerebrospinal fluid</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010870" MajorTopicYN="N">Pineal Gland</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020542" MajorTopicYN="N">Third Ventricle</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AMT6S</Keyword><Keyword MajorTopicYN="N">Cerebrospinal fluid</Keyword><Keyword MajorTopicYN="N">Human</Keyword><Keyword MajorTopicYN="N">LCS</Keyword><Keyword MajorTopicYN="N">Melatonin</Keyword><Keyword MajorTopicYN="N">Mélatonine</Keyword><Keyword MajorTopicYN="N">Parkinson</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>04</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>04</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24975205</ArticleId><ArticleId IdType="pii">S0028-3770(13)00035-0</ArticleId><ArticleId IdType="doi">10.1016/j.neuchi.2013.04.004</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Bron</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Leston, J" sort="Leston, J" uniqKey="Leston J" first="J" last="Leston">J. Leston</name></noRegion><name sortKey="Claustrat, B" sort="Claustrat, B" uniqKey="Claustrat B" first="B" last="Claustrat">B. Claustrat</name><name sortKey="Harthe, C" sort="Harthe, C" uniqKey="Harthe C" first="C" last="Harthé">C. Harthé</name><name sortKey="Mertens, P" sort="Mertens, P" uniqKey="Mertens P" first="P" last="Mertens">P. Mertens</name><name sortKey="Mottolese, C" sort="Mottolese, C" uniqKey="Mottolese C" first="C" last="Mottolese">C. Mottolese</name><name sortKey="Sindou, M" sort="Sindou, M" uniqKey="Sindou M" first="M" last="Sindou">M. Sindou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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