Beta-adrenergic sensitivity in Parkinson's disease: effect of levodopa treatment.
Identifieur interne : 001681 ( PubMed/Checkpoint ); précédent : 001680; suivant : 001682Beta-adrenergic sensitivity in Parkinson's disease: effect of levodopa treatment.
Auteurs : G. Durrieu [France] ; Y. Rispail ; E. Chatelut ; M. Berlan ; A. Rascol ; J L Montastruc ; P. MontastrucSource :
- Clinical neuropharmacology [ 0362-5664 ] ; 1990.
English descriptors
- KwdEn :
- Aged, Dose-Response Relationship, Drug, Epinephrine (blood), Fatty Acids, Nonesterified (blood), Female, Heart Rate (drug effects), Humans, Isoproterenol (pharmacology), Kinetics, Levodopa (therapeutic use), Lymphocytes (chemistry), Male, Middle Aged, Norepinephrine (blood), Parkinson Disease (blood), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Radioligand Assay, Receptors, Adrenergic, beta (drug effects).
- MESH :
- chemical , blood : Epinephrine, Fatty Acids, Nonesterified, Norepinephrine.
- blood : Parkinson Disease.
- chemistry : Lymphocytes.
- drug effects : Heart Rate, Receptors, Adrenergic, beta.
- drug therapy : Parkinson Disease.
- chemical , pharmacology : Isoproterenol.
- physiopathology : Parkinson Disease.
- chemical , therapeutic use : Levodopa.
- Aged, Dose-Response Relationship, Drug, Female, Humans, Kinetics, Male, Middle Aged, Radioligand Assay.
Abstract
The beta-adrenergic sensitivity in never-treated and levodopa-treated patients with Parkinson's disease (PD) was studied through the evaluation of lymphocyte beta-adrenoceptor number ([125I]cyanopindolol binding sites) and chronotropic and metabolic (plasma nonesterified fatty acids--NEFA) responses to isoproterenol. No change was found in Bmax values or affinity constant Kd between never-treated patients, levodopa-treated patients with PD, and controls. At rest, no difference was observed in heart rate, plasma catecholamine, or NEFA levels between the three groups. Isoproterenol sensitivity (chronotropic response and plasma NEFA increase) was similar in never-treated and treated PD. The results suggest that peripheral beta-adrenergic sensitivity is unaffected either by the pathophysiological process of PD or by levodopa treatment.
PubMed: 2177376
Affiliations:
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pubmed:2177376Le document en format XML
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<front><div type="abstract" xml:lang="en">The beta-adrenergic sensitivity in never-treated and levodopa-treated patients with Parkinson's disease (PD) was studied through the evaluation of lymphocyte beta-adrenoceptor number ([125I]cyanopindolol binding sites) and chronotropic and metabolic (plasma nonesterified fatty acids--NEFA) responses to isoproterenol. No change was found in Bmax values or affinity constant Kd between never-treated patients, levodopa-treated patients with PD, and controls. At rest, no difference was observed in heart rate, plasma catecholamine, or NEFA levels between the three groups. Isoproterenol sensitivity (chronotropic response and plasma NEFA increase) was similar in never-treated and treated PD. The results suggest that peripheral beta-adrenergic sensitivity is unaffected either by the pathophysiological process of PD or by levodopa treatment.</div>
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