Memory for spatial location in 'de novo' parkinsonian patients.
Identifieur interne : 001393 ( PubMed/Checkpoint ); précédent : 001392; suivant : 001394Memory for spatial location in 'de novo' parkinsonian patients.
Auteurs : B. Pillon [France] ; S. Ertle ; B. Deweer ; A M Bonnet ; M. Vidailhet ; B. DuboisSource :
- Neuropsychologia [ 0028-3932 ] ; 1997.
English descriptors
- KwdEn :
- Analysis of Variance, Case-Control Studies, Corpus Striatum (physiopathology), Frontal Lobe (physiopathology), Humans, Learning (physiology), Memory Disorders (etiology), Memory Disorders (physiopathology), Mental Recall (physiology), Middle Aged, Parkinson Disease (complications), Parkinson Disease (physiopathology), Space Perception (physiology), Time Factors, Verbal Learning (physiology).
- MESH :
- complications : Parkinson Disease.
- etiology : Memory Disorders.
- physiology : Learning, Mental Recall, Space Perception, Verbal Learning.
- physiopathology : Corpus Striatum, Frontal Lobe, Memory Disorders, Parkinson Disease.
- Analysis of Variance, Case-Control Studies, Humans, Middle Aged, Time Factors.
Abstract
A deficit in memory for spatial location was recently reported in typical non-demented parkinsonian patients ('standard'). Is this deficit related to dopamine depletion? Such an association would reinforce the suggestion that striato-frontal neuronal circuits are implicated in memory for item-specific spatial coordinates. To answer this question, we compared the performance of 10 recently diagnosed and not yet treated parkinsonian patients ('de novo'), in which the neurobiochemical deficit is considered to involve mainly the nigrostriatal dopaminergic system, to that of 14 controls matched for age, global cognitive efficiency and mood, on a visuospatial learning test. The task required little motor or constructive functions and was designed to allow control of encoding and comparison of free recall, cued recall and recognition. Compared to controls, 'de novo' patients displayed a lower performance in memory for visuospatial location of pictures, contrasting with relative preservation of verbal memory, perceptive visuospatial and executive functions. These results confirm the sensitivity of visuospatial memory even at an early stage of Parkinson's disease and suggest the implication of the nigrostriatal dopaminergic system, and associated striato-frontal neuronal circuits, in executive processes needed for spatial location learning.
PubMed: 9051671
Affiliations:
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Deweer</name></author><author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name></author><author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. 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Pillon</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U 289, Hôpital de la Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 289, Hôpital de la Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ertle, S" sort="Ertle, S" uniqKey="Ertle S" first="S" last="Ertle">S. Ertle</name></author><author><name sortKey="Deweer, B" sort="Deweer, B" uniqKey="Deweer B" first="B" last="Deweer">B. Deweer</name></author><author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name></author><author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name></author></analytic><series><title level="j">Neuropsychologia</title><idno type="ISSN">0028-3932</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Corpus Striatum (physiopathology)</term><term>Frontal Lobe (physiopathology)</term><term>Humans</term><term>Learning (physiology)</term><term>Memory Disorders (etiology)</term><term>Memory Disorders (physiopathology)</term><term>Mental Recall (physiology)</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term><term>Space Perception (physiology)</term><term>Time Factors</term><term>Verbal Learning (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Learning</term><term>Mental Recall</term><term>Space Perception</term><term>Verbal Learning</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Frontal Lobe</term><term>Memory Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Humans</term><term>Middle Aged</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A deficit in memory for spatial location was recently reported in typical non-demented parkinsonian patients ('standard'). Is this deficit related to dopamine depletion? Such an association would reinforce the suggestion that striato-frontal neuronal circuits are implicated in memory for item-specific spatial coordinates. To answer this question, we compared the performance of 10 recently diagnosed and not yet treated parkinsonian patients ('de novo'), in which the neurobiochemical deficit is considered to involve mainly the nigrostriatal dopaminergic system, to that of 14 controls matched for age, global cognitive efficiency and mood, on a visuospatial learning test. The task required little motor or constructive functions and was designed to allow control of encoding and comparison of free recall, cued recall and recognition. Compared to controls, 'de novo' patients displayed a lower performance in memory for visuospatial location of pictures, contrasting with relative preservation of verbal memory, perceptive visuospatial and executive functions. These results confirm the sensitivity of visuospatial memory even at an early stage of Parkinson's disease and suggest the implication of the nigrostriatal dopaminergic system, and associated striato-frontal neuronal circuits, in executive processes needed for spatial location learning.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9051671</PMID><DateCreated><Year>1997</Year><Month>05</Month><Day>27</Day></DateCreated><DateCompleted><Year>1997</Year><Month>05</Month><Day>27</Day></DateCompleted><DateRevised><Year>2009</Year><Month>11</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3932</ISSN><JournalIssue CitedMedium="Print"><Volume>35</Volume><Issue>3</Issue><PubDate><Year>1997</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Neuropsychologia</Title><ISOAbbreviation>Neuropsychologia</ISOAbbreviation></Journal><ArticleTitle>Memory for spatial location in 'de novo' parkinsonian patients.</ArticleTitle><Pagination><MedlinePgn>221-8</MedlinePgn></Pagination><Abstract><AbstractText>A deficit in memory for spatial location was recently reported in typical non-demented parkinsonian patients ('standard'). Is this deficit related to dopamine depletion? Such an association would reinforce the suggestion that striato-frontal neuronal circuits are implicated in memory for item-specific spatial coordinates. To answer this question, we compared the performance of 10 recently diagnosed and not yet treated parkinsonian patients ('de novo'), in which the neurobiochemical deficit is considered to involve mainly the nigrostriatal dopaminergic system, to that of 14 controls matched for age, global cognitive efficiency and mood, on a visuospatial learning test. The task required little motor or constructive functions and was designed to allow control of encoding and comparison of free recall, cued recall and recognition. Compared to controls, 'de novo' patients displayed a lower performance in memory for visuospatial location of pictures, contrasting with relative preservation of verbal memory, perceptive visuospatial and executive functions. 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Deweer</name><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name><name sortKey="Ertle, S" sort="Ertle, S" uniqKey="Ertle S" first="S" last="Ertle">S. Ertle</name><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B" last="Pillon">B. Pillon</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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