Overactivity of cervical premotor neurons in Parkinson's disease.
Identifieur interne : 001329 ( PubMed/Checkpoint ); précédent : 001328; suivant : 001330Overactivity of cervical premotor neurons in Parkinson's disease.
Auteurs : S. Pol [France] ; M. Vidailhet ; S. Meunier ; D. Mazevet ; Yves Agid [France] ; E. Pierrot-DeseillignySource :
- Journal of neurology, neurosurgery, and psychiatry [ 0022-3050 ] ; 1998.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Brain (physiopathology), Electromyography (instrumentation), Humans, Middle Aged, Motor Neurons (physiology), Muscle Rigidity (diagnosis), Muscle Rigidity (physiopathology), Neural Pathways (physiology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Pyramidal Tracts (physiology), Severity of Illness Index, Synaptic Transmission (physiology), Tremor (diagnosis), Tremor (physiopathology), Wrist (innervation).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- diagnosis : Muscle Rigidity, Tremor.
- drug therapy : Parkinson Disease.
- innervation : Wrist.
- instrumentation : Electromyography.
- physiology : Motor Neurons, Neural Pathways, Pyramidal Tracts, Synaptic Transmission.
- physiopathology : Brain, Muscle Rigidity, Parkinson Disease, Tremor.
- Humans, Middle Aged, Severity of Illness Index.
Abstract
Cortical command to upper limb motor neurons is transmitted, in humans, not only through the monosynaptic corticomotor neuronal pathway, but also through cervical premotor neurons. Whether activity in this non-monosynaptic corticospinal pathway is modified in Parkinson's disease was explored.
PubMed: 9489525
Affiliations:
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pubmed:9489525Le document en format XML
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Meunier</name></author><author><name sortKey="Mazevet, D" sort="Mazevet, D" uniqKey="Mazevet D" first="D" last="Mazevet">D. Mazevet</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Pierrot Deseilligny, E" sort="Pierrot Deseilligny, E" uniqKey="Pierrot Deseilligny E" first="E" last="Pierrot-Deseilligny">E. Pierrot-Deseilligny</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9489525</idno><idno type="pmid">9489525</idno><idno type="wicri:Area/PubMed/Corpus">001486</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001486</idno><idno type="wicri:Area/PubMed/Curation">001445</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001445</idno><idno type="wicri:Area/PubMed/Checkpoint">001445</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001445</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Overactivity of cervical premotor neurons in Parkinson's disease.</title><author><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S" last="Pol">S. Pol</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Neurophysiologie Clinique, Réeducation, Hôpital de la Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neurophysiologie Clinique, Réeducation, Hôpital de la Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name></author><author><name sortKey="Meunier, S" sort="Meunier, S" uniqKey="Meunier S" first="S" last="Meunier">S. Meunier</name></author><author><name sortKey="Mazevet, D" sort="Mazevet, D" uniqKey="Mazevet D" first="D" last="Mazevet">D. Mazevet</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Pierrot Deseilligny, E" sort="Pierrot Deseilligny, E" uniqKey="Pierrot Deseilligny E" first="E" last="Pierrot-Deseilligny">E. Pierrot-Deseilligny</name></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Brain (physiopathology)</term><term>Electromyography (instrumentation)</term><term>Humans</term><term>Middle Aged</term><term>Motor Neurons (physiology)</term><term>Muscle Rigidity (diagnosis)</term><term>Muscle Rigidity (physiopathology)</term><term>Neural Pathways (physiology)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Pyramidal Tracts (physiology)</term><term>Severity of Illness Index</term><term>Synaptic Transmission (physiology)</term><term>Tremor (diagnosis)</term><term>Tremor (physiopathology)</term><term>Wrist (innervation)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Muscle Rigidity</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Wrist</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Neurons</term><term>Neural Pathways</term><term>Pyramidal Tracts</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Muscle Rigidity</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cortical command to upper limb motor neurons is transmitted, in humans, not only through the monosynaptic corticomotor neuronal pathway, but also through cervical premotor neurons. Whether activity in this non-monosynaptic corticospinal pathway is modified in Parkinson's disease was explored.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9489525</PMID><DateCreated><Year>1998</Year><Month>03</Month><Day>24</Day></DateCreated><DateCompleted><Year>1998</Year><Month>03</Month><Day>24</Day></DateCompleted><DateRevised><Year>2014</Year><Month>06</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3050</ISSN><JournalIssue CitedMedium="Print"><Volume>64</Volume><Issue>2</Issue><PubDate><Year>1998</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Journal of neurology, neurosurgery, and psychiatry</Title><ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation></Journal><ArticleTitle>Overactivity of cervical premotor neurons in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>166-71</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Cortical command to upper limb motor neurons is transmitted, in humans, not only through the monosynaptic corticomotor neuronal pathway, but also through cervical premotor neurons. Whether activity in this non-monosynaptic corticospinal pathway is modified in Parkinson's disease was explored.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Ongoing EMG activity recorded in wrist extensors during tonic extension of the wrist is suppressed by a volley evoked by stimulating the superficial radial nerve. It has been shown that this cutaneous induced suppression is due to inhibition of transmission of the cortical command at a premotor neuronal level. By comparing the cutaneous induced EMG depression between 45 de novo parkinsonian patients and 23 age matched controls it has been possible to appreciate if and to what extent the "non-monosynaptic" part of the cortical command is modified in these patients.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At the early stage of the illness the EMG depression, reflecting the "non-monosynaptic" part of the cortical command, was bilaterally increased despite very asymmetric clinical status. When the duration of the disease was more than 36 months, EMG depression returned to its control level. No correlation was found between the amount of the EMG depression and parkinsonian symptoms before and after levodopa treatment.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Increase of the relative "non-monosynaptic" part of the cortical command could reflect a compensatory motor mechanism elaborated upstream from the motor cortex.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pol</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratoire de Neurophysiologie Clinique, Réeducation, Hôpital de la Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vidailhet</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Meunier</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Mazevet</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Agid</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Pierrot-Deseilligny</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Neurol Neurosurg Psychiatry</MedlineTA><NlmUniqueID>2985191R</NlmUniqueID><ISSNLinking>0022-3050</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Adv Neurol. 1996;69:129-33</RefSource><PMID 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Version="1">8625879</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004576" MajorTopicYN="N">Electromyography</DescriptorName><QualifierName UI="Q000295" MajorTopicYN="N">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009046" MajorTopicYN="N">Motor Neurons</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009127" MajorTopicYN="N">Muscle Rigidity</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009434" MajorTopicYN="N">Neural Pathways</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011712" MajorTopicYN="N">Pyramidal Tracts</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009435" MajorTopicYN="N">Synaptic Transmission</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014202" MajorTopicYN="N">Tremor</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014953" MajorTopicYN="N">Wrist</DescriptorName><QualifierName UI="Q000294" MajorTopicYN="N">innervation</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC2169964</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>3</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>3</Month><Day>7</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>3</Month><Day>7</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9489525</ArticleId><ArticleId IdType="pmc">PMC2169964</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><noCountry><name sortKey="Mazevet, D" sort="Mazevet, D" uniqKey="Mazevet D" first="D" last="Mazevet">D. Mazevet</name><name sortKey="Meunier, S" sort="Meunier, S" uniqKey="Meunier S" first="S" last="Meunier">S. Meunier</name><name sortKey="Pierrot Deseilligny, E" sort="Pierrot Deseilligny, E" uniqKey="Pierrot Deseilligny E" first="E" last="Pierrot-Deseilligny">E. Pierrot-Deseilligny</name><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S" last="Pol">S. Pol</name></region><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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