Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease.
Identifieur interne : 001242 ( PubMed/Checkpoint ); précédent : 001241; suivant : 001243Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease.
Auteurs : S. Chalon [France] ; P. Emond ; S. Bodard ; M P Vilar ; C. Thiercelin ; J C Besnard ; D. GuilloteauSource :
- Synapse (New York, N.Y.) [ 0887-4476 ] ; 1999.
English descriptors
- KwdEn :
- Animals, Benzamides, Carrier Proteins (metabolism), Corpus Striatum (diagnostic imaging), Dopamine (pharmacokinetics), Dopamine Antagonists (pharmacokinetics), Dopamine Plasma Membrane Transport Proteins, Iodine Radioisotopes (pharmacokinetics), Male, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Nortropanes (pharmacokinetics), Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Pyrrolidines, Radiopharmaceuticals (pharmacokinetics), Rats, Rats, Wistar, Receptors, Dopamine D2 (biosynthesis), Time Factors, Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , biosynthesis : Receptors, Dopamine D2.
- chemical , metabolism : Carrier Proteins.
- chemical , pharmacokinetics : Dopamine, Dopamine Antagonists, Iodine Radioisotopes, Nortropanes, Radiopharmaceuticals.
- chemical : Benzamides, Dopamine Plasma Membrane Transport Proteins, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Pyrrolidines.
- diagnostic imaging : Corpus Striatum, Parkinson Disease.
- metabolism : Parkinson Disease.
- Animals, Male, Rats, Rats, Wistar, Time Factors, Tomography, Emission-Computed, Single-Photon.
Abstract
The time course of the loss in presynaptic dopamine transporters (DAT) and of the increase in postsynaptic dopamine D2 receptors (D2R) was studied in a rat model of Parkinson's disease. For this, in vitro autoradiographic experiments were performed in the striatum using (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methy lphenyl) nortropane (PE2I), a new single photon emission tomography (SPET) ligand for DAT, and iodobenzamide (IBZM), a SPET ligand for D2R. A significant decrease in [125I]PE2I binding was observed as early as 24 h after 6-hydroxydopamine lesion, whereas no change occurred in [125I]IBZM binding. At 48 h postlesion, PE2I binding was 50% decreased, while IBZM binding was 30% increased. Between 3 and 14 days postlesion, PE2I binding had almost totally disappeared and IBZM binding remained increased by around 40-50%. From these animal experiments, it can be assumed that PE2I would be very efficient for the detection of a reduction in the number of DAT reflecting neuronal loss, thus allowing early diagnosis of Parkinson's disease. The exploration of both DAT and D2R would improve follow-up of this disease.
DOI: 10.1002/(SICI)1098-2396(199902)31:2<134::AID-SYN6>3.0.CO;2-V
PubMed: 10024010
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:10024010Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease.</title>
<author><name sortKey="Chalon, S" sort="Chalon, S" uniqKey="Chalon S" first="S" last="Chalon">S. Chalon</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U316, Laboratoire de Biophysique Médicale et Pharmaceutique, Tours, France. chalon@balzac.univ-tours.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U316, Laboratoire de Biophysique Médicale et Pharmaceutique, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Emond, P" sort="Emond, P" uniqKey="Emond P" first="P" last="Emond">P. Emond</name>
</author>
<author><name sortKey="Bodard, S" sort="Bodard, S" uniqKey="Bodard S" first="S" last="Bodard">S. Bodard</name>
</author>
<author><name sortKey="Vilar, M P" sort="Vilar, M P" uniqKey="Vilar M" first="M P" last="Vilar">M P Vilar</name>
</author>
<author><name sortKey="Thiercelin, C" sort="Thiercelin, C" uniqKey="Thiercelin C" first="C" last="Thiercelin">C. Thiercelin</name>
</author>
<author><name sortKey="Besnard, J C" sort="Besnard, J C" uniqKey="Besnard J" first="J C" last="Besnard">J C Besnard</name>
</author>
<author><name sortKey="Guilloteau, D" sort="Guilloteau, D" uniqKey="Guilloteau D" first="D" last="Guilloteau">D. Guilloteau</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1999">1999</date>
<idno type="RBID">pubmed:10024010</idno>
<idno type="pmid">10024010</idno>
<idno type="doi">10.1002/(SICI)1098-2396(199902)31:2<134::AID-SYN6>3.0.CO;2-V</idno>
<idno type="wicri:Area/PubMed/Corpus">001420</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001420</idno>
<idno type="wicri:Area/PubMed/Curation">001379</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001379</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001379</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001379</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease.</title>
<author><name sortKey="Chalon, S" sort="Chalon, S" uniqKey="Chalon S" first="S" last="Chalon">S. Chalon</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U316, Laboratoire de Biophysique Médicale et Pharmaceutique, Tours, France. chalon@balzac.univ-tours.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U316, Laboratoire de Biophysique Médicale et Pharmaceutique, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Emond, P" sort="Emond, P" uniqKey="Emond P" first="P" last="Emond">P. Emond</name>
</author>
<author><name sortKey="Bodard, S" sort="Bodard, S" uniqKey="Bodard S" first="S" last="Bodard">S. Bodard</name>
</author>
<author><name sortKey="Vilar, M P" sort="Vilar, M P" uniqKey="Vilar M" first="M P" last="Vilar">M P Vilar</name>
</author>
<author><name sortKey="Thiercelin, C" sort="Thiercelin, C" uniqKey="Thiercelin C" first="C" last="Thiercelin">C. Thiercelin</name>
</author>
<author><name sortKey="Besnard, J C" sort="Besnard, J C" uniqKey="Besnard J" first="J C" last="Besnard">J C Besnard</name>
</author>
<author><name sortKey="Guilloteau, D" sort="Guilloteau, D" uniqKey="Guilloteau D" first="D" last="Guilloteau">D. Guilloteau</name>
</author>
</analytic>
<series><title level="j">Synapse (New York, N.Y.)</title>
<idno type="ISSN">0887-4476</idno>
<imprint><date when="1999" type="published">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Benzamides</term>
<term>Carrier Proteins (metabolism)</term>
<term>Corpus Striatum (diagnostic imaging)</term>
<term>Dopamine (pharmacokinetics)</term>
<term>Dopamine Antagonists (pharmacokinetics)</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Iodine Radioisotopes (pharmacokinetics)</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Nerve Tissue Proteins</term>
<term>Nortropanes (pharmacokinetics)</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Pyrrolidines</term>
<term>Radiopharmaceuticals (pharmacokinetics)</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Receptors, Dopamine D2 (biosynthesis)</term>
<term>Time Factors</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carrier Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Dopamine</term>
<term>Dopamine Antagonists</term>
<term>Iodine Radioisotopes</term>
<term>Nortropanes</term>
<term>Radiopharmaceuticals</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Benzamides</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Nerve Tissue Proteins</term>
<term>Pyrrolidines</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Corpus Striatum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Time Factors</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The time course of the loss in presynaptic dopamine transporters (DAT) and of the increase in postsynaptic dopamine D2 receptors (D2R) was studied in a rat model of Parkinson's disease. For this, in vitro autoradiographic experiments were performed in the striatum using (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methy lphenyl) nortropane (PE2I), a new single photon emission tomography (SPET) ligand for DAT, and iodobenzamide (IBZM), a SPET ligand for D2R. A significant decrease in [125I]PE2I binding was observed as early as 24 h after 6-hydroxydopamine lesion, whereas no change occurred in [125I]IBZM binding. At 48 h postlesion, PE2I binding was 50% decreased, while IBZM binding was 30% increased. Between 3 and 14 days postlesion, PE2I binding had almost totally disappeared and IBZM binding remained increased by around 40-50%. From these animal experiments, it can be assumed that PE2I would be very efficient for the detection of a reduction in the number of DAT reflecting neuronal loss, thus allowing early diagnosis of Parkinson's disease. The exploration of both DAT and D2R would improve follow-up of this disease.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10024010</PMID>
<DateCreated><Year>1999</Year>
<Month>07</Month>
<Day>12</Day>
</DateCreated>
<DateCompleted><Year>1999</Year>
<Month>07</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>11</Month>
<Day>24</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0887-4476</ISSN>
<JournalIssue CitedMedium="Print"><Volume>31</Volume>
<Issue>2</Issue>
<PubDate><Year>1999</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Synapse (New York, N.Y.)</Title>
<ISOAbbreviation>Synapse</ISOAbbreviation>
</Journal>
<ArticleTitle>Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>134-9</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The time course of the loss in presynaptic dopamine transporters (DAT) and of the increase in postsynaptic dopamine D2 receptors (D2R) was studied in a rat model of Parkinson's disease. For this, in vitro autoradiographic experiments were performed in the striatum using (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methy lphenyl) nortropane (PE2I), a new single photon emission tomography (SPET) ligand for DAT, and iodobenzamide (IBZM), a SPET ligand for D2R. A significant decrease in [125I]PE2I binding was observed as early as 24 h after 6-hydroxydopamine lesion, whereas no change occurred in [125I]IBZM binding. At 48 h postlesion, PE2I binding was 50% decreased, while IBZM binding was 30% increased. Between 3 and 14 days postlesion, PE2I binding had almost totally disappeared and IBZM binding remained increased by around 40-50%. From these animal experiments, it can be assumed that PE2I would be very efficient for the detection of a reduction in the number of DAT reflecting neuronal loss, thus allowing early diagnosis of Parkinson's disease. The exploration of both DAT and D2R would improve follow-up of this disease.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chalon</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>INSERM U316, Laboratoire de Biophysique Médicale et Pharmaceutique, Tours, France. chalon@balzac.univ-tours.fr</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Emond</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bodard</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Vilar</LastName>
<ForeName>M P</ForeName>
<Initials>MP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Thiercelin</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Besnard</LastName>
<ForeName>J C</ForeName>
<Initials>JC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Guilloteau</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Synapse</MedlineTA>
<NlmUniqueID>8806914</NlmUniqueID>
<ISSNLinking>0887-4476</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001549">Benzamides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018492">Dopamine Antagonists</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050483">Dopamine Plasma Membrane Transport Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007457">Iodine Radioisotopes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D026901">Membrane Transport Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C113010">N-(3-iodoprop-2-enyl)-2-beta-carbomethoxy-3-(4-methylphenyl)nortropane</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009419">Nerve Tissue Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009662">Nortropanes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011759">Pyrrolidines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017448">Receptors, Dopamine D2</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C493216">Slc6a3 protein, rat</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>84226-06-2</RegistryNumber>
<NameOfSubstance UI="C055743">3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber>
<NameOfSubstance UI="D004298">Dopamine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001549" MajorTopicYN="N">Benzamides</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004298" MajorTopicYN="N">Dopamine</DescriptorName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018492" MajorTopicYN="Y">Dopamine Antagonists</DescriptorName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050483" MajorTopicYN="N">Dopamine Plasma Membrane Transport Proteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007457" MajorTopicYN="N">Iodine Radioisotopes</DescriptorName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008562" MajorTopicYN="Y">Membrane Glycoproteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D026901" MajorTopicYN="Y">Membrane Transport Proteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009419" MajorTopicYN="Y">Nerve Tissue Proteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009662" MajorTopicYN="Y">Nortropanes</DescriptorName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011759" MajorTopicYN="N">Pyrrolidines</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019275" MajorTopicYN="Y">Radiopharmaceuticals</DescriptorName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017448" MajorTopicYN="N">Receptors, Dopamine D2</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015899" MajorTopicYN="N">Tomography, Emission-Computed, Single-Photon</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year>
<Month>2</Month>
<Day>19</Day>
<Hour>4</Hour>
<Minute>31</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2000</Year>
<Month>6</Month>
<Day>20</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1999</Year>
<Month>2</Month>
<Day>19</Day>
<Hour>4</Hour>
<Minute>31</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">10024010</ArticleId>
<ArticleId IdType="pii">10.1002/(SICI)1098-2396(199902)31:2<134::AID-SYN6>3.0.CO;2-V</ArticleId>
<ArticleId IdType="doi">10.1002/(SICI)1098-2396(199902)31:2<134::AID-SYN6>3.0.CO;2-V</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Centre-Val de Loire</li>
<li>Région Centre</li>
</region>
<settlement><li>Tours</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Besnard, J C" sort="Besnard, J C" uniqKey="Besnard J" first="J C" last="Besnard">J C Besnard</name>
<name sortKey="Bodard, S" sort="Bodard, S" uniqKey="Bodard S" first="S" last="Bodard">S. Bodard</name>
<name sortKey="Emond, P" sort="Emond, P" uniqKey="Emond P" first="P" last="Emond">P. Emond</name>
<name sortKey="Guilloteau, D" sort="Guilloteau, D" uniqKey="Guilloteau D" first="D" last="Guilloteau">D. Guilloteau</name>
<name sortKey="Thiercelin, C" sort="Thiercelin, C" uniqKey="Thiercelin C" first="C" last="Thiercelin">C. Thiercelin</name>
<name sortKey="Vilar, M P" sort="Vilar, M P" uniqKey="Vilar M" first="M P" last="Vilar">M P Vilar</name>
</noCountry>
<country name="France"><region name="Centre-Val de Loire"><name sortKey="Chalon, S" sort="Chalon, S" uniqKey="Chalon S" first="S" last="Chalon">S. Chalon</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001242 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001242 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:10024010 |texte= Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:10024010" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |