Variable number tandem repeat dopamine transporter gene polymorphism and Parkinson's disease: no association found.
Identifieur interne : 001237 ( PubMed/Checkpoint ); précédent : 001236; suivant : 001238Variable number tandem repeat dopamine transporter gene polymorphism and Parkinson's disease: no association found.
Auteurs : G. Mercier [France] ; J C Turpin ; G. LucotteSource :
- Journal of neurology [ 0340-5354 ] ; 1999.
English descriptors
- KwdEn :
- Adult, Aged, Carrier Proteins (genetics), Dopamine Plasma Membrane Transport Proteins, Female, Genetic Markers, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Middle Aged, Minisatellite Repeats (genetics), Nerve Tissue Proteins, Parkinson Disease (blood), Parkinson Disease (genetics), Polymerase Chain Reaction, Polymorphism, Genetic (genetics).
- MESH :
- chemical , genetics : Carrier Proteins.
- blood : Parkinson Disease.
- genetics : Minisatellite Repeats, Parkinson Disease, Polymorphism, Genetic.
- Adult, Aged, Dopamine Plasma Membrane Transport Proteins, Female, Genetic Markers, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Middle Aged, Nerve Tissue Proteins, Polymerase Chain Reaction.
Abstract
We studied a variable number of tandem repeat polymorphisms in the dopamine transporter gene in search of an association with Parkinson's disease in a French population. Five alleles were detected, consisting of 7, 8, 9, 10 and 11 copies of the 40-base pair repeat sequence, of which the 10-copy allele was the most common. There was no significant difference between the patients and the control subjects in the distribution frequencies of the alleles or genotypes, or in ages at onset in patients between the main allelic classes.
PubMed: 9987713
Affiliations:
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pubmed:9987713Le document en format XML
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Mercier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Neurogénétique, Moléculaire (Service de Neurologie), Hôpital Maison Blanche, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neurogénétique, Moléculaire (Service de Neurologie), Hôpital Maison Blanche, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Turpin, J C" sort="Turpin, J C" uniqKey="Turpin J" first="J C" last="Turpin">J C Turpin</name></author><author><name sortKey="Lucotte, G" sort="Lucotte, G" uniqKey="Lucotte G" first="G" last="Lucotte">G. Lucotte</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:9987713</idno><idno type="pmid">9987713</idno><idno type="wicri:Area/PubMed/Corpus">001436</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001436</idno><idno type="wicri:Area/PubMed/Curation">001395</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001395</idno><idno type="wicri:Area/PubMed/Checkpoint">001395</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001395</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Variable number tandem repeat dopamine transporter gene polymorphism and Parkinson's disease: no association found.</title><author><name sortKey="Mercier, G" sort="Mercier, G" uniqKey="Mercier G" first="G" last="Mercier">G. Mercier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Neurogénétique, Moléculaire (Service de Neurologie), Hôpital Maison Blanche, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neurogénétique, Moléculaire (Service de Neurologie), Hôpital Maison Blanche, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Turpin, J C" sort="Turpin, J C" uniqKey="Turpin J" first="J C" last="Turpin">J C Turpin</name></author><author><name sortKey="Lucotte, G" sort="Lucotte, G" uniqKey="Lucotte G" first="G" last="Lucotte">G. Lucotte</name></author></analytic><series><title level="j">Journal of neurology</title><idno type="ISSN">0340-5354</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Carrier Proteins (genetics)</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Genetic Markers</term><term>Humans</term><term>Male</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins</term><term>Middle Aged</term><term>Minisatellite Repeats (genetics)</term><term>Nerve Tissue Proteins</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (genetics)</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Genetic (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Minisatellite Repeats</term><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Genetic Markers</term><term>Humans</term><term>Male</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins</term><term>Middle Aged</term><term>Nerve Tissue Proteins</term><term>Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied a variable number of tandem repeat polymorphisms in the dopamine transporter gene in search of an association with Parkinson's disease in a French population. Five alleles were detected, consisting of 7, 8, 9, 10 and 11 copies of the 40-base pair repeat sequence, of which the 10-copy allele was the most common. There was no significant difference between the patients and the control subjects in the distribution frequencies of the alleles or genotypes, or in ages at onset in patients between the main allelic classes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9987713</PMID><DateCreated><Year>1999</Year><Month>06</Month><Day>15</Day></DateCreated><DateCompleted><Year>1999</Year><Month>06</Month><Day>15</Day></DateCompleted><DateRevised><Year>2005</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-5354</ISSN><JournalIssue CitedMedium="Print"><Volume>246</Volume><Issue>1</Issue><PubDate><Year>1999</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of neurology</Title><ISOAbbreviation>J. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Variable number tandem repeat dopamine transporter gene polymorphism and Parkinson's disease: no association found.</ArticleTitle><Pagination><MedlinePgn>45-7</MedlinePgn></Pagination><Abstract><AbstractText>We studied a variable number of tandem repeat polymorphisms in the dopamine transporter gene in search of an association with Parkinson's disease in a French population. Five alleles were detected, consisting of 7, 8, 9, 10 and 11 copies of the 40-base pair repeat sequence, of which the 10-copy allele was the most common. There was no significant difference between the patients and the control subjects in the distribution frequencies of the alleles or genotypes, or in ages at onset in patients between the main allelic classes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mercier</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Laboratoire de Neurogénétique, Moléculaire (Service de Neurologie), Hôpital Maison Blanche, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turpin</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Lucotte</LastName><ForeName>G</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Neurol</MedlineTA><NlmUniqueID>0423161</NlmUniqueID><ISSNLinking>0340-5354</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050483">Dopamine Plasma Membrane Transport Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005819">Genetic Markers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D026901">Membrane Transport Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009419">Nerve Tissue Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050483" MajorTopicYN="N">Dopamine Plasma Membrane Transport Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005819" MajorTopicYN="N">Genetic Markers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008562" MajorTopicYN="Y">Membrane Glycoproteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D026901" MajorTopicYN="Y">Membrane Transport Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018598" MajorTopicYN="N">Minisatellite Repeats</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009419" MajorTopicYN="Y">Nerve Tissue Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>2</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>2</Month><Day>13</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>2</Month><Day>13</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9987713</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Champagne-Ardenne</li><li>Grand Est</li></region><settlement><li>Reims</li></settlement></list><tree><noCountry><name sortKey="Lucotte, G" sort="Lucotte, G" uniqKey="Lucotte G" first="G" last="Lucotte">G. Lucotte</name><name sortKey="Turpin, J C" sort="Turpin, J C" uniqKey="Turpin J" first="J C" last="Turpin">J C Turpin</name></noCountry><country name="France"><region name="Grand Est"><name sortKey="Mercier, G" sort="Mercier, G" uniqKey="Mercier G" first="G" last="Mercier">G. Mercier</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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