[10 years of substitution therapy for neurodegenerative diseases using fetal neuron grafts: a positive outcome but with questions for the future].
Identifieur interne : 001110 ( PubMed/Checkpoint ); précédent : 001109; suivant : 001111[10 years of substitution therapy for neurodegenerative diseases using fetal neuron grafts: a positive outcome but with questions for the future].
Auteurs : M. PeschanskiSource :
- Journal de la Societe de biologie [ 1295-0661 ] ; 2001.
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Animals, Brain Tissue Transplantation, Cells, Cultured (transplantation), Combined Modality Therapy, Cricetinae, Fetal Tissue Transplantation, Forecasting, France, Humans, Huntington Disease (therapy), Levodopa (therapeutic use), Neurodegenerative Diseases (therapy), Neurons (transplantation), Parkinson Disease (drug therapy), Parkinson Disease (therapy), Rabbits, Rats, Species Specificity, Stem Cell Transplantation, Swine, Tissue and Organ Procurement, Transplantation, Heterologous, Transplantation, Homologous, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Levodopa.
- geographic : France.
- drug therapy : Parkinson Disease.
- therapy : Huntington Disease, Neurodegenerative Diseases, Parkinson Disease.
- transplantation : Cells, Cultured, Neurons.
- Animals, Brain Tissue Transplantation, Combined Modality Therapy, Cricetinae, Fetal Tissue Transplantation, Forecasting, Humans, Rabbits, Rats, Species Specificity, Stem Cell Transplantation, Swine, Tissue and Organ Procurement, Transplantation, Heterologous, Transplantation, Homologous, Treatment Outcome.
Abstract
Fetal neural allografts have already proven their therapeutic value in several hundreds of patients with Parkinson's disease, and have very recently provided promising results for patients with Huntington's disease in our center. Fetal neurons integrate readily into the neural parenchyma of the adult hosts, differentiate into mature neurons and substitute, anatomically and functionally for lost host neurons. Notable clinical improvements have been obtained using this procedure. Nevertheless, a major obstacle hampers the development of the technique, that provoked by the logistic difficulty in retrieving and preparing the tissue. Indeed, this requires, for each surgical session, the organization of a chain of expertise which cannot be taken up by an external provider (e.g. a biotech company). This is difficult to organize outside of specialized research centers. The future of the technique relies, therefore, upon the design of alternative sources of tissue. Two different ways are currently explored very actively, namely xenografting of neurons of porcine origin and human stem cells, in particular derived from ES cells. In both cases, but in different ways, the goal of both techniques is to allow the organisation of cell banking systems, relieving the constraints of obtaining the collaboration of specialized obstetricians and biologists. Obstacles foreseen for these two alternative ways of fetal neurons to be are identified and research laboratories are actively exploring ways to overcome them.
PubMed: 11530501
Affiliations:
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pubmed:11530501Le document en format XML
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<front><div type="abstract" xml:lang="en">Fetal neural allografts have already proven their therapeutic value in several hundreds of patients with Parkinson's disease, and have very recently provided promising results for patients with Huntington's disease in our center. Fetal neurons integrate readily into the neural parenchyma of the adult hosts, differentiate into mature neurons and substitute, anatomically and functionally for lost host neurons. Notable clinical improvements have been obtained using this procedure. Nevertheless, a major obstacle hampers the development of the technique, that provoked by the logistic difficulty in retrieving and preparing the tissue. Indeed, this requires, for each surgical session, the organization of a chain of expertise which cannot be taken up by an external provider (e.g. a biotech company). This is difficult to organize outside of specialized research centers. The future of the technique relies, therefore, upon the design of alternative sources of tissue. Two different ways are currently explored very actively, namely xenografting of neurons of porcine origin and human stem cells, in particular derived from ES cells. In both cases, but in different ways, the goal of both techniques is to allow the organisation of cell banking systems, relieving the constraints of obtaining the collaboration of specialized obstetricians and biologists. Obstacles foreseen for these two alternative ways of fetal neurons to be are identified and research laboratories are actively exploring ways to overcome them.</div>
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<Abstract><AbstractText>Fetal neural allografts have already proven their therapeutic value in several hundreds of patients with Parkinson's disease, and have very recently provided promising results for patients with Huntington's disease in our center. Fetal neurons integrate readily into the neural parenchyma of the adult hosts, differentiate into mature neurons and substitute, anatomically and functionally for lost host neurons. Notable clinical improvements have been obtained using this procedure. Nevertheless, a major obstacle hampers the development of the technique, that provoked by the logistic difficulty in retrieving and preparing the tissue. Indeed, this requires, for each surgical session, the organization of a chain of expertise which cannot be taken up by an external provider (e.g. a biotech company). This is difficult to organize outside of specialized research centers. The future of the technique relies, therefore, upon the design of alternative sources of tissue. Two different ways are currently explored very actively, namely xenografting of neurons of porcine origin and human stem cells, in particular derived from ES cells. In both cases, but in different ways, the goal of both techniques is to allow the organisation of cell banking systems, relieving the constraints of obtaining the collaboration of specialized obstetricians and biologists. Obstacles foreseen for these two alternative ways of fetal neurons to be are identified and research laboratories are actively exploring ways to overcome them.</AbstractText>
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