Evidence for deficiencies in perceptual and semantic olfactory processes in Parkinson's disease.
Identifieur interne : 001000 ( PubMed/Checkpoint ); précédent : 000F99; suivant : 001001Evidence for deficiencies in perceptual and semantic olfactory processes in Parkinson's disease.
Auteurs : Julie Hudry [France] ; Stéphane Thobois ; Emmanuel Broussolle ; Patrice Adeleine ; Jean-Pierre RoyetSource :
- Chemical senses [ 0379-864X ] ; 2003.
English descriptors
- KwdEn :
- Age Factors, Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Female, Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Odorants, Olfaction Disorders (psychology), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Perception, Semantics, Sensory Thresholds, Smell (physiology), Task Performance and Analysis.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- physiology : Smell.
- psychology : Olfaction Disorders, Parkinson Disease.
- Age Factors, Aged, Female, Humans, Male, Middle Aged, Odorants, Perception, Semantics, Sensory Thresholds, Task Performance and Analysis.
Abstract
Olfactory deficits have been reported in Parkinson's disease (PD) and are thought to represent a sensitive marker of the disease. The aim of the present study was to examine the differential contribution in olfactory dysfunction of perceptual and semantic processes of odours in PD patients. Twenty-four PD patients (12 males and 12 females) and 24 control subjects (12 males and 12 females) were tested. The experiment included two sessions. Initially, 12 odorants were delivered, one per minute. For each odour, subjects were asked to rate intensity, pleasantness, familiarity and edibility using linear rating scales. The odorants were again presented and the subjects were asked to identify them. The four olfactory judgements and odour identification were severely disturbed in PD patients when compared to control subjects. These findings demonstrate major deficits for all cognitive tasks of olfactory judgement in PD, and suggest that PD is associated with disruption of olfactory areas situated in the temporal lobes and also in the prefrontal cortex.
PubMed: 12907591
Affiliations:
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type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name></author><author><name sortKey="Adeleine, Patrice" sort="Adeleine, Patrice" uniqKey="Adeleine P" first="Patrice" last="Adeleine">Patrice Adeleine</name></author><author><name sortKey="Royet, Jean Pierre" sort="Royet, Jean Pierre" uniqKey="Royet J" first="Jean-Pierre" last="Royet">Jean-Pierre Royet</name></author></analytic><series><title level="j">Chemical senses</title><idno type="ISSN">0379-864X</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age 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The aim of the present study was to examine the differential contribution in olfactory dysfunction of perceptual and semantic processes of odours in PD patients. Twenty-four PD patients (12 males and 12 females) and 24 control subjects (12 males and 12 females) were tested. The experiment included two sessions. Initially, 12 odorants were delivered, one per minute. For each odour, subjects were asked to rate intensity, pleasantness, familiarity and edibility using linear rating scales. The odorants were again presented and the subjects were asked to identify them. The four olfactory judgements and odour identification were severely disturbed in PD patients when compared to control subjects. These findings demonstrate major deficits for all cognitive tasks of olfactory judgement in PD, and suggest that PD is associated with disruption of olfactory areas situated in the temporal lobes and also in the prefrontal cortex.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12907591</PMID><DateCreated><Year>2003</Year><Month>08</Month><Day>08</Day></DateCreated><DateCompleted><Year>2004</Year><Month>07</Month><Day>09</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0379-864X</ISSN><JournalIssue CitedMedium="Print"><Volume>28</Volume><Issue>6</Issue><PubDate><Year>2003</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Chemical senses</Title><ISOAbbreviation>Chem. 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The four olfactory judgements and odour identification were severely disturbed in PD patients when compared to control subjects. 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MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013647" MajorTopicYN="N">Task Performance and Analysis</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>8</Month><Day>9</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>7</Month><Day>10</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>8</Month><Day>9</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12907591</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><noCountry><name sortKey="Adeleine, Patrice" sort="Adeleine, Patrice" uniqKey="Adeleine P" first="Patrice" last="Adeleine">Patrice Adeleine</name><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><name sortKey="Royet, Jean Pierre" sort="Royet, Jean Pierre" uniqKey="Royet J" first="Jean-Pierre" last="Royet">Jean-Pierre Royet</name><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Hudry, Julie" sort="Hudry, Julie" uniqKey="Hudry J" first="Julie" last="Hudry">Julie Hudry</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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