Low levels of ventricular CSF orexin/hypocretin in advanced PD.
Identifieur interne : 000F87 ( PubMed/Checkpoint ); précédent : 000F86; suivant : 000F88Low levels of ventricular CSF orexin/hypocretin in advanced PD.
Auteurs : X. Drouot [France] ; S. Moutereau ; J P Nguyen ; J P Lefaucheur ; A. Créange ; P. Remy ; F. Goldenberg ; M P D'OrthoSource :
- Neurology [ 1526-632X ] ; 2003.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Arousal (physiology), Carrier Proteins (cerebrospinal fluid), Cerebral Ventricles, Combined Modality Therapy, Disorders of Excessive Somnolence (cerebrospinal fluid), Disorders of Excessive Somnolence (etiology), Electric Stimulation Therapy, Female, Humans, Intracellular Signaling Peptides and Proteins, Male, Neuropeptides (cerebrospinal fluid), Neuropeptides (deficiency), Orexins, Parkinson Disease (cerebrospinal fluid), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (therapy).
- MESH :
- chemical , cerebrospinal fluid : Carrier Proteins, Neuropeptides.
- chemical , deficiency : Neuropeptides.
- chemical , therapeutic use : Antiparkinson Agents.
- cerebrospinal fluid : Disorders of Excessive Somnolence, Parkinson Disease.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease.
- etiology : Disorders of Excessive Somnolence.
- physiology : Arousal.
- therapy : Parkinson Disease.
- Cerebral Ventricles, Combined Modality Therapy, Electric Stimulation Therapy, Female, Humans, Intracellular Signaling Peptides and Proteins, Male, Orexins.
Abstract
The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.
PubMed: 12939433
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:12939433Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Low levels of ventricular CSF orexin/hypocretin in advanced PD.</title><author><name sortKey="Drouot, X" sort="Drouot, X" uniqKey="Drouot X" first="X" last="Drouot">X. Drouot</name><affiliation wicri:level="3"><nlm:affiliation>Service de Physiologie-Explorations Fonctionnelles, Unité Inserm U421-Université Paris XII, Faculté de Médecine de Créteil, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France. xavier.drouot@hmn.ap-hop-paris.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Physiologie-Explorations Fonctionnelles, Unité Inserm U421-Université Paris XII, Faculté de Médecine de Créteil, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Moutereau, S" sort="Moutereau, S" uniqKey="Moutereau S" first="S" last="Moutereau">S. Moutereau</name></author><author><name sortKey="Nguyen, J P" sort="Nguyen, J P" uniqKey="Nguyen J" first="J P" last="Nguyen">J P Nguyen</name></author><author><name sortKey="Lefaucheur, J P" sort="Lefaucheur, J P" uniqKey="Lefaucheur J" first="J P" last="Lefaucheur">J P Lefaucheur</name></author><author><name sortKey="Creange, A" sort="Creange, A" uniqKey="Creange A" first="A" last="Créange">A. Créange</name></author><author><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P" last="Remy">P. Remy</name></author><author><name sortKey="Goldenberg, F" sort="Goldenberg, F" uniqKey="Goldenberg F" first="F" last="Goldenberg">F. Goldenberg</name></author><author><name sortKey="D Ortho, M P" sort="D Ortho, M P" uniqKey="D Ortho M" first="M P" last="D'Ortho">M P D'Ortho</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12939433</idno><idno type="pmid">12939433</idno><idno type="wicri:Area/PubMed/Corpus">001085</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001085</idno><idno type="wicri:Area/PubMed/Curation">001044</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001044</idno><idno type="wicri:Area/PubMed/Checkpoint">001044</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001044</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Low levels of ventricular CSF orexin/hypocretin in advanced PD.</title><author><name sortKey="Drouot, X" sort="Drouot, X" uniqKey="Drouot X" first="X" last="Drouot">X. Drouot</name><affiliation wicri:level="3"><nlm:affiliation>Service de Physiologie-Explorations Fonctionnelles, Unité Inserm U421-Université Paris XII, Faculté de Médecine de Créteil, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France. xavier.drouot@hmn.ap-hop-paris.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Physiologie-Explorations Fonctionnelles, Unité Inserm U421-Université Paris XII, Faculté de Médecine de Créteil, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Moutereau, S" sort="Moutereau, S" uniqKey="Moutereau S" first="S" last="Moutereau">S. Moutereau</name></author><author><name sortKey="Nguyen, J P" sort="Nguyen, J P" uniqKey="Nguyen J" first="J P" last="Nguyen">J P Nguyen</name></author><author><name sortKey="Lefaucheur, J P" sort="Lefaucheur, J P" uniqKey="Lefaucheur J" first="J P" last="Lefaucheur">J P Lefaucheur</name></author><author><name sortKey="Creange, A" sort="Creange, A" uniqKey="Creange A" first="A" last="Créange">A. Créange</name></author><author><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P" last="Remy">P. Remy</name></author><author><name sortKey="Goldenberg, F" sort="Goldenberg, F" uniqKey="Goldenberg F" first="F" last="Goldenberg">F. Goldenberg</name></author><author><name sortKey="D Ortho, M P" sort="D Ortho, M P" uniqKey="D Ortho M" first="M P" last="D'Ortho">M P D'Ortho</name></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Arousal (physiology)</term><term>Carrier Proteins (cerebrospinal fluid)</term><term>Cerebral Ventricles</term><term>Combined Modality Therapy</term><term>Disorders of Excessive Somnolence (cerebrospinal fluid)</term><term>Disorders of Excessive Somnolence (etiology)</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Humans</term><term>Intracellular Signaling Peptides and Proteins</term><term>Male</term><term>Neuropeptides (cerebrospinal fluid)</term><term>Neuropeptides (deficiency)</term><term>Orexins</term><term>Parkinson Disease (cerebrospinal fluid)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Carrier Proteins</term><term>Neuropeptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Neuropeptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Disorders of Excessive Somnolence</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Arousal</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cerebral Ventricles</term><term>Combined Modality Therapy</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Humans</term><term>Intracellular Signaling Peptides and Proteins</term><term>Male</term><term>Orexins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12939433</PMID><DateCreated><Year>2003</Year><Month>08</Month><Day>26</Day></DateCreated><DateCompleted><Year>2004</Year><Month>01</Month><Day>29</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><Issue>4</Issue><PubDate><Year>2003</Year><Month>Aug</Month><Day>26</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Low levels of ventricular CSF orexin/hypocretin in advanced PD.</ArticleTitle><Pagination><MedlinePgn>540-3</MedlinePgn></Pagination><Abstract><AbstractText>The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Drouot</LastName><ForeName>X</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Service de Physiologie-Explorations Fonctionnelles, Unité Inserm U421-Université Paris XII, Faculté de Médecine de Créteil, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France. xavier.drouot@hmn.ap-hop-paris.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moutereau</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>J P</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Lefaucheur</LastName><ForeName>J P</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Créange</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Remy</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Goldenberg</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>d'Ortho</LastName><ForeName>M P</ForeName><Initials>MP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000596229">HCRT protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047908">Intracellular Signaling Peptides and Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009479">Neuropeptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000068797">Orexins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Sleep Med. 2004 Jan;5(1):91-2</RefSource><PMID Version="1">14725834</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001143" MajorTopicYN="N">Arousal</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName><QualifierName UI="Q000134" MajorTopicYN="N">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002552" MajorTopicYN="N">Cerebral Ventricles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006970" MajorTopicYN="N">Disorders of Excessive Somnolence</DescriptorName><QualifierName UI="Q000134" MajorTopicYN="N">cerebrospinal fluid</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004599" MajorTopicYN="N">Electric Stimulation Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D047908" MajorTopicYN="Y">Intracellular Signaling Peptides and Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009479" MajorTopicYN="N">Neuropeptides</DescriptorName><QualifierName UI="Q000134" MajorTopicYN="N">cerebrospinal fluid</QualifierName><QualifierName UI="Q000172" MajorTopicYN="Y">deficiency</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000068797" MajorTopicYN="N">Orexins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000134" MajorTopicYN="N">cerebrospinal fluid</QualifierName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>8</Month><Day>27</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>1</Month><Day>30</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>8</Month><Day>27</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12939433</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Créteil</li></settlement></list><tree><noCountry><name sortKey="Creange, A" sort="Creange, A" uniqKey="Creange A" first="A" last="Créange">A. Créange</name><name sortKey="D Ortho, M P" sort="D Ortho, M P" uniqKey="D Ortho M" first="M P" last="D'Ortho">M P D'Ortho</name><name sortKey="Goldenberg, F" sort="Goldenberg, F" uniqKey="Goldenberg F" first="F" last="Goldenberg">F. Goldenberg</name><name sortKey="Lefaucheur, J P" sort="Lefaucheur, J P" uniqKey="Lefaucheur J" first="J P" last="Lefaucheur">J P Lefaucheur</name><name sortKey="Moutereau, S" sort="Moutereau, S" uniqKey="Moutereau S" first="S" last="Moutereau">S. Moutereau</name><name sortKey="Nguyen, J P" sort="Nguyen, J P" uniqKey="Nguyen J" first="J P" last="Nguyen">J P Nguyen</name><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P" last="Remy">P. Remy</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Drouot, X" sort="Drouot, X" uniqKey="Drouot X" first="X" last="Drouot">X. Drouot</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000F87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:12939433
|texte= Low levels of ventricular CSF orexin/hypocretin in advanced PD.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:12939433" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |