Low levels of ventricular CSF orexin/hypocretin in advanced PD.
Identifieur interne : 000F87 ( PubMed/Checkpoint ); précédent : 000F86; suivant : 000F88Low levels of ventricular CSF orexin/hypocretin in advanced PD.
Auteurs : X. Drouot [France] ; S. Moutereau ; J P Nguyen ; J P Lefaucheur ; A. Créange ; P. Remy ; F. Goldenberg ; M P D'OrthoSource :
- Neurology [ 1526-632X ] ; 2003.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Arousal (physiology), Carrier Proteins (cerebrospinal fluid), Cerebral Ventricles, Combined Modality Therapy, Disorders of Excessive Somnolence (cerebrospinal fluid), Disorders of Excessive Somnolence (etiology), Electric Stimulation Therapy, Female, Humans, Intracellular Signaling Peptides and Proteins, Male, Neuropeptides (cerebrospinal fluid), Neuropeptides (deficiency), Orexins, Parkinson Disease (cerebrospinal fluid), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (therapy).
- MESH :
- chemical , cerebrospinal fluid : Carrier Proteins, Neuropeptides.
- chemical , deficiency : Neuropeptides.
- chemical , therapeutic use : Antiparkinson Agents.
- cerebrospinal fluid : Disorders of Excessive Somnolence, Parkinson Disease.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease.
- etiology : Disorders of Excessive Somnolence.
- physiology : Arousal.
- therapy : Parkinson Disease.
- Cerebral Ventricles, Combined Modality Therapy, Electric Stimulation Therapy, Female, Humans, Intracellular Signaling Peptides and Proteins, Male, Orexins.
Abstract
The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.
PubMed: 12939433
Affiliations:
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Links to Exploration step
pubmed:12939433Le document en format XML
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<front><div type="abstract" xml:lang="en">The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.</div>
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<Abstract><AbstractText>The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.</AbstractText>
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