Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue.
Identifieur interne : 000F53 ( PubMed/Checkpoint ); précédent : 000F52; suivant : 000F54Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue.
Auteurs : Valérie Cochen [France] ; Maria-Joao Ribeiro ; Jean-Paul Nguyen ; Jean-Marc Gurruchaga ; Gabriel Villafane ; Christian Loc'H ; Gilles Defer ; Yves Samson ; Marc Peschanski ; Philippe Hantraye ; Pierre Cesaro ; Philippe RemySource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Aged, Corpus Striatum (metabolism), Dopamine Plasma Membrane Transport Proteins, Female, Fetal Tissue Transplantation (methods), Fluorodeoxyglucose F18 (pharmacokinetics), Graft Rejection (prevention & control), Humans, Immunosuppressive Agents (therapeutic use), Male, Membrane Glycoproteins, Membrane Transport Proteins (metabolism), Mesencephalon (embryology), Mesencephalon (metabolism), Mesencephalon (transplantation), Middle Aged, Nerve Tissue Proteins, Parkinson Disease (diagnosis), Parkinson Disease (surgery), Radiopharmaceuticals (pharmacokinetics), Tomography, Emission-Computed.
- MESH :
- chemical , metabolism : Membrane Transport Proteins.
- chemical , pharmacokinetics : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- chemical , therapeutic use : Immunosuppressive Agents.
- chemical : Dopamine Plasma Membrane Transport Proteins, Membrane Glycoproteins, Nerve Tissue Proteins.
- diagnosis : Parkinson Disease.
- embryology : Mesencephalon.
- metabolism : Corpus Striatum, Mesencephalon.
- methods : Fetal Tissue Transplantation.
- prevention & control : Graft Rejection.
- surgery : Parkinson Disease.
- transplantation : Mesencephalon.
- Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed.
Abstract
We compared the striatal uptake of [(18)F]fluorodopa with [(76)Br]-FE-CBT, a positron emission tomography (PET) ligand of the dopamine transporter (DAT), which estimates the density of dopamine nerve terminals, in 6 patients with Parkinson's disease grafted with fetal mesencephalic cells. There was no change in DAT ligand binding in the grafted putamen, despite a significant increase of [(18)F]fluorodopa uptake. This finding suggests that the clinical benefit induced by the graft is more related to increased dopaminergic activity than improved dopaminergic innervation in the host striatum and, therefore, that [(18)F]fluorodopa remains the optimal tracer to evaluate grafted PD patients. Further analysis showed that the clinical and [(18)F]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation.
DOI: 10.1002/mds.10463
PubMed: 12889084
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:12889084Le document en format XML
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<front><div type="abstract" xml:lang="en">We compared the striatal uptake of [(18)F]fluorodopa with [(76)Br]-FE-CBT, a positron emission tomography (PET) ligand of the dopamine transporter (DAT), which estimates the density of dopamine nerve terminals, in 6 patients with Parkinson's disease grafted with fetal mesencephalic cells. There was no change in DAT ligand binding in the grafted putamen, despite a significant increase of [(18)F]fluorodopa uptake. This finding suggests that the clinical benefit induced by the graft is more related to increased dopaminergic activity than improved dopaminergic innervation in the host striatum and, therefore, that [(18)F]fluorodopa remains the optimal tracer to evaluate grafted PD patients. Further analysis showed that the clinical and [(18)F]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation.</div>
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