Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?
Identifieur interne : 000D71 ( PubMed/Checkpoint ); précédent : 000D70; suivant : 000D72Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?
Auteurs : A. Lannuzel [France] ; G U Höglinger ; P. Champy ; P P Michel ; E C Hirsch ; M. RubergSource :
- Journal of neural transmission. Supplementum [ 0303-6995 ] ; 2006.
English descriptors
- KwdEn :
- Adenosine Triphosphate (metabolism), Alkaloids (isolation & purification), Alkaloids (toxicity), Animals, Annonaceae (adverse effects), Cells, Cultured, Fruit, Furans (isolation & purification), Furans (toxicity), Herbal Medicine, Lactones (isolation & purification), Lactones (toxicity), Male, Mesencephalon (cytology), Neostriatum (pathology), Nerve Degeneration (chemically induced), Nerve Degeneration (pathology), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (epidemiology), Plant Extracts (adverse effects), Plant Leaves (chemistry), Rats, Rats, Inbred Lew, Substantia Nigra (pathology), West Indies (epidemiology).
- MESH :
- chemical , adverse effects : Plant Extracts.
- chemical , isolation & purification : Alkaloids, Furans, Lactones.
- chemical , metabolism : Adenosine Triphosphate.
- chemical , toxicity : Alkaloids, Furans, Lactones.
- geographic , epidemiology : West Indies.
- adverse effects : Annonaceae.
- chemically induced : Nerve Degeneration, Parkinson Disease, Secondary.
- chemistry : Plant Leaves.
- cytology : Mesencephalon.
- epidemiology : Parkinson Disease, Secondary.
- pathology : Neostriatum, Nerve Degeneration, Substantia Nigra.
- Animals, Cells, Cultured, Fruit, Herbal Medicine, Male, Rats, Rats, Inbred Lew.
Abstract
An abnormally frequent atypical levodopa-unresponsive, akinetic-rigid syndrome with some similarity to PSP was identified in the Caribbean island Guadeloupe, and was associated with the consumption of plants of the Annonacea family, especially Annona muricata (corossol, soursop) suggesting a possible toxic etiology. Annonaceae contain two groups of potential toxins, alkaloids and acetogenins. Both alkaloids and annonacin, the most abundant acetogenin, were toxic in vitro to dopaminergic and other neurons. However we have focused our work on annonacin for two reasons: (1) annonacin was toxic in nanomolar concentrations, whereas micromolar concentrations of the alkaloids were needed, (2) acetogenins are potent mitochondrial poisons, like other parkinsonism-inducing compounds. We have also shown that high concentrations of annonacin are present in the fruit or aqueous extracts of the leaves of A. muricata, can cross the blood brain barrier since it was detected in brain parenchyma of rats treated chronically with the molecule, and induced neurodegeneration of basal ganglia in these animals, similar to that observed in atypical parkinsonism. These studies reinforce the concept that consumption of Annonaceae may contribute to the pathogenesis of atypical parkinsonism in Guadeloupe.
PubMed: 17017523
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Champy</name></author><author><name sortKey="Michel, P P" sort="Michel, P P" uniqKey="Michel P" first="P P" last="Michel">P P Michel</name></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E C" last="Hirsch">E C Hirsch</name></author><author><name sortKey="Ruberg, M" sort="Ruberg, M" uniqKey="Ruberg M" first="M" last="Ruberg">M. 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Lannuzel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital, Pointe-a-Pitre, Guadeloupe, France. annie.lannuzel@wanadoo.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital, Pointe-a-Pitre, Guadeloupe</wicri:regionArea><wicri:noRegion>Guadeloupe</wicri:noRegion><wicri:noRegion>Guadeloupe</wicri:noRegion></affiliation></author><author><name sortKey="Hoglinger, G U" sort="Hoglinger, G U" uniqKey="Hoglinger G" first="G U" last="Höglinger">G U Höglinger</name></author><author><name sortKey="Champy, P" sort="Champy, P" uniqKey="Champy P" first="P" last="Champy">P. 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Annonaceae contain two groups of potential toxins, alkaloids and acetogenins. Both alkaloids and annonacin, the most abundant acetogenin, were toxic in vitro to dopaminergic and other neurons. However we have focused our work on annonacin for two reasons: (1) annonacin was toxic in nanomolar concentrations, whereas micromolar concentrations of the alkaloids were needed, (2) acetogenins are potent mitochondrial poisons, like other parkinsonism-inducing compounds. We have also shown that high concentrations of annonacin are present in the fruit or aqueous extracts of the leaves of A. muricata, can cross the blood brain barrier since it was detected in brain parenchyma of rats treated chronically with the molecule, and induced neurodegeneration of basal ganglia in these animals, similar to that observed in atypical parkinsonism. These studies reinforce the concept that consumption of Annonaceae may contribute to the pathogenesis of atypical parkinsonism in Guadeloupe.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17017523</PMID><DateCreated><Year>2006</Year><Month>10</Month><Day>04</Day></DateCreated><DateCompleted><Year>2006</Year><Month>10</Month><Day>24</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0303-6995</ISSN><JournalIssue CitedMedium="Print"><Issue>70</Issue><PubDate><Year>2006</Year></PubDate></JournalIssue><Title>Journal of neural transmission. Supplementum</Title><ISOAbbreviation>J. Neural Transm. Suppl.</ISOAbbreviation></Journal><ArticleTitle>Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?</ArticleTitle><Pagination><MedlinePgn>153-7</MedlinePgn></Pagination><Abstract><AbstractText>An abnormally frequent atypical levodopa-unresponsive, akinetic-rigid syndrome with some similarity to PSP was identified in the Caribbean island Guadeloupe, and was associated with the consumption of plants of the Annonacea family, especially Annona muricata (corossol, soursop) suggesting a possible toxic etiology. Annonaceae contain two groups of potential toxins, alkaloids and acetogenins. Both alkaloids and annonacin, the most abundant acetogenin, were toxic in vitro to dopaminergic and other neurons. However we have focused our work on annonacin for two reasons: (1) annonacin was toxic in nanomolar concentrations, whereas micromolar concentrations of the alkaloids were needed, (2) acetogenins are potent mitochondrial poisons, like other parkinsonism-inducing compounds. We have also shown that high concentrations of annonacin are present in the fruit or aqueous extracts of the leaves of A. muricata, can cross the blood brain barrier since it was detected in brain parenchyma of rats treated chronically with the molecule, and induced neurodegeneration of basal ganglia in these animals, similar to that observed in atypical parkinsonism. These studies reinforce the concept that consumption of Annonaceae may contribute to the pathogenesis of atypical parkinsonism in Guadeloupe.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lannuzel</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital, Pointe-a-Pitre, Guadeloupe, France. annie.lannuzel@wanadoo.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Höglinger</LastName><ForeName>G U</ForeName><Initials>GU</Initials></Author><Author ValidYN="Y"><LastName>Champy</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Michel</LastName><ForeName>P P</ForeName><Initials>PP</Initials></Author><Author ValidYN="Y"><LastName>Hirsch</LastName><ForeName>E C</ForeName><Initials>EC</Initials></Author><Author ValidYN="Y"><LastName>Ruberg</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Austria</Country><MedlineTA>J Neural Transm Suppl</MedlineTA><NlmUniqueID>0425126</NlmUniqueID><ISSNLinking>0303-6995</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000470">Alkaloids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005663">Furans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007783">Lactones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>111035-65-5</RegistryNumber><NameOfSubstance 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Leaves</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011917" MajorTopicYN="N">Rats, Inbred Lew</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013378" MajorTopicYN="N">Substantia Nigra</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014900" MajorTopicYN="N" Type="Geographic">West Indies</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>10</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>10</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>10</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17017523</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Champy, P" sort="Champy, P" uniqKey="Champy P" first="P" last="Champy">P. Champy</name><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E C" last="Hirsch">E C Hirsch</name><name sortKey="Hoglinger, G U" sort="Hoglinger, G U" uniqKey="Hoglinger G" first="G U" last="Höglinger">G U Höglinger</name><name sortKey="Michel, P P" sort="Michel, P P" uniqKey="Michel P" first="P P" last="Michel">P P Michel</name><name sortKey="Ruberg, M" sort="Ruberg, M" uniqKey="Ruberg M" first="M" last="Ruberg">M. Ruberg</name></noCountry><country name="France"><noRegion><name sortKey="Lannuzel, A" sort="Lannuzel, A" uniqKey="Lannuzel A" first="A" last="Lannuzel">A. Lannuzel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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