Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial.
Identifieur interne : 000C72 ( PubMed/Checkpoint ); précédent : 000C71; suivant : 000C73Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial.
Auteurs : W M M. Schüpbach [France] ; D. Maltête ; J L Houeto ; S Tezenas Du Montcel ; L. Mallet ; M L Welter ; M. Gargiulo ; C. Béhar ; A M Bonnet ; V. Czernecki ; B. Pidoux ; S. Navarro ; D. Dormont ; P. Cornu ; Yves Agid [France]Source :
- Neurology [ 1526-632X ] ; 2007.
English descriptors
- KwdEn :
- Activities of Daily Living (psychology), Adult, Antiparkinson Agents (therapeutic use), Deep Brain Stimulation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurosurgical Procedures (methods), Parkinson Disease (epidemiology), Parkinson Disease (psychology), Parkinson Disease (therapy), Prospective Studies, Quality of Life (psychology), Subthalamic Nucleus (physiology), Time Factors.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- epidemiology : Parkinson Disease.
- methods : Neurosurgical Procedures.
- physiology : Subthalamic Nucleus.
- psychology : Activities of Daily Living, Parkinson Disease, Quality of Life.
- therapy : Parkinson Disease.
- Adult, Deep Brain Stimulation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Time Factors.
Abstract
Stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson disease (PD) and is currently performed after a mean disease duration of 14 years, when severe motor complications have resulted in marked loss of quality of life. We examined whether surgery at an early stage would maintain quality of life as well as improve motor function.
DOI: 10.1212/01.wnl.0000250253.03919.fb
PubMed: 17151341
Affiliations:
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pubmed:17151341Le document en format XML
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Béhar</name></author><author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name></author><author><name sortKey="Czernecki, V" sort="Czernecki, V" uniqKey="Czernecki V" first="V" last="Czernecki">V. Czernecki</name></author><author><name sortKey="Pidoux, B" sort="Pidoux, B" uniqKey="Pidoux B" first="B" last="Pidoux">B. Pidoux</name></author><author><name sortKey="Navarro, S" sort="Navarro, S" uniqKey="Navarro S" first="S" last="Navarro">S. Navarro</name></author><author><name sortKey="Dormont, D" sort="Dormont, D" uniqKey="Dormont D" first="D" last="Dormont">D. Dormont</name></author><author><name sortKey="Cornu, P" sort="Cornu, P" uniqKey="Cornu P" first="P" last="Cornu">P. 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Schüpbach</name><affiliation wicri:level="3"><nlm:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Maltete, D" sort="Maltete, D" uniqKey="Maltete D" first="D" last="Maltête">D. Maltête</name></author><author><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J L" last="Houeto">J L Houeto</name></author><author><name sortKey="Du Montcel, S Tezenas" sort="Du Montcel, S Tezenas" uniqKey="Du Montcel S" first="S Tezenas" last="Du Montcel">S Tezenas Du Montcel</name></author><author><name sortKey="Mallet, L" sort="Mallet, L" uniqKey="Mallet L" first="L" last="Mallet">L. Mallet</name></author><author><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M L" last="Welter">M L Welter</name></author><author><name sortKey="Gargiulo, M" sort="Gargiulo, M" uniqKey="Gargiulo M" first="M" last="Gargiulo">M. Gargiulo</name></author><author><name sortKey="Behar, C" sort="Behar, C" uniqKey="Behar C" first="C" last="Béhar">C. Béhar</name></author><author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name></author><author><name sortKey="Czernecki, V" sort="Czernecki, V" uniqKey="Czernecki V" first="V" last="Czernecki">V. Czernecki</name></author><author><name sortKey="Pidoux, B" sort="Pidoux, B" uniqKey="Pidoux B" first="B" last="Pidoux">B. Pidoux</name></author><author><name sortKey="Navarro, S" sort="Navarro, S" uniqKey="Navarro S" first="S" last="Navarro">S. Navarro</name></author><author><name sortKey="Dormont, D" sort="Dormont, D" uniqKey="Dormont D" first="D" last="Dormont">D. Dormont</name></author><author><name sortKey="Cornu, P" sort="Cornu, P" uniqKey="Cornu P" first="P" last="Cornu">P. Cornu</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (psychology)</term><term>Adult</term><term>Antiparkinson Agents (therapeutic use)</term><term>Deep Brain Stimulation</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurosurgical Procedures (methods)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Prospective Studies</term><term>Quality of Life (psychology)</term><term>Subthalamic Nucleus (physiology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurosurgical Procedures</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Activities of Daily Living</term><term>Parkinson Disease</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Deep Brain Stimulation</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson disease (PD) and is currently performed after a mean disease duration of 14 years, when severe motor complications have resulted in marked loss of quality of life. We examined whether surgery at an early stage would maintain quality of life as well as improve motor function.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17151341</PMID><DateCreated><Year>2007</Year><Month>01</Month><Day>23</Day></DateCreated><DateCompleted><Year>2007</Year><Month>02</Month><Day>21</Day></DateCompleted><DateRevised><Year>2007</Year><Month>09</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>68</Volume><Issue>4</Issue><PubDate><Year>2007</Year><Month>Jan</Month><Day>23</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial.</ArticleTitle><Pagination><MedlinePgn>267-71</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson disease (PD) and is currently performed after a mean disease duration of 14 years, when severe motor complications have resulted in marked loss of quality of life. We examined whether surgery at an early stage would maintain quality of life as well as improve motor function.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twenty patients with PD of short duration (time elapsed since first symptom +/- SD: 6.8 +/- 1.0 years) with mild to moderate motor signs (Unified Parkinson's Disease Rating Scale III "off" medication: 29 +/- 12) who responded well to levodopa treatment were included in pairs, matched for age, duration and severity of disease, and impairment in socioprofessional functioning. Patients were prospectively randomized to undergo bilateral subthalamic nucleus stimulation (n = 10) or receive optimized medical treatment (n = 10). Parkinsonian motor scores, quality of life, cognition, and psychiatric morbidity were assessed at inclusion and at 6, 12, and 18 months after randomization.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Quality of life was improved by 24% in surgical and 0% in nonsurgical patients (p < 0.05). After 18 months, the severity of parkinsonian motor signs "off" medication, levodopa-induced motor complications, and daily levodopa dose were reduced by 69%, 83%, and 57% in operated patients and increased by 29%, 15%, and 12% in the group with medical treatment only (p < 0.001). Adverse events were mild or transient, and overall psychiatric morbidity and anxiety improved in the surgical group.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Subthalamic nucleus stimulation should be considered a therapeutic option early in the course of Parkinson disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schüpbach</LastName><ForeName>W M M</ForeName><Initials>WM</Initials><AffiliationInfo><Affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maltête</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Houeto</LastName><ForeName>J L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>du Montcel</LastName><ForeName>S Tezenas</ForeName><Initials>ST</Initials></Author><Author ValidYN="Y"><LastName>Mallet</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Welter</LastName><ForeName>M L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Gargiulo</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Béhar</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Bonnet</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Czernecki</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Pidoux</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Navarro</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Dormont</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Cornu</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Agid</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2006</Year><Month>12</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Neurology. 2007 Jan 23;68(4):252-3</RefSource><PMID Version="1">17242330</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Neurology. 2007 Aug 21;69(8):811-2; author reply 812</RefSource><PMID Version="1">17709721</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000203" MajorTopicYN="N">Activities of Daily Living</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D046690" MajorTopicYN="N">Deep Brain Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019635" MajorTopicYN="N">Neurosurgical Procedures</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>12</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>2</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>12</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17151341</ArticleId><ArticleId IdType="pii">01.wnl.0000250253.03919.fb</ArticleId><ArticleId IdType="doi">10.1212/01.wnl.0000250253.03919.fb</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><noCountry><name sortKey="Behar, C" sort="Behar, C" uniqKey="Behar C" first="C" last="Béhar">C. Béhar</name><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name><name sortKey="Cornu, P" sort="Cornu, P" uniqKey="Cornu P" first="P" last="Cornu">P. Cornu</name><name sortKey="Czernecki, V" sort="Czernecki, V" uniqKey="Czernecki V" first="V" last="Czernecki">V. Czernecki</name><name sortKey="Dormont, D" sort="Dormont, D" uniqKey="Dormont D" first="D" last="Dormont">D. Dormont</name><name sortKey="Du Montcel, S Tezenas" sort="Du Montcel, S Tezenas" uniqKey="Du Montcel S" first="S Tezenas" last="Du Montcel">S Tezenas Du Montcel</name><name sortKey="Gargiulo, M" sort="Gargiulo, M" uniqKey="Gargiulo M" first="M" last="Gargiulo">M. Gargiulo</name><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J L" last="Houeto">J L Houeto</name><name sortKey="Mallet, L" sort="Mallet, L" uniqKey="Mallet L" first="L" last="Mallet">L. Mallet</name><name sortKey="Maltete, D" sort="Maltete, D" uniqKey="Maltete D" first="D" last="Maltête">D. Maltête</name><name sortKey="Navarro, S" sort="Navarro, S" uniqKey="Navarro S" first="S" last="Navarro">S. Navarro</name><name sortKey="Pidoux, B" sort="Pidoux, B" uniqKey="Pidoux B" first="B" last="Pidoux">B. Pidoux</name><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M L" last="Welter">M L Welter</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Schupbach, W M M" sort="Schupbach, W M M" uniqKey="Schupbach W" first="W M M" last="Schüpbach">W M M. Schüpbach</name></region><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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