[Pathophysiology of Parkinson's disease: an update].
Identifieur interne : 000949 ( PubMed/Checkpoint ); précédent : 000948; suivant : 000950[Pathophysiology of Parkinson's disease: an update].
Auteurs : Léon Tremblay [France]Source :
- Bulletin de l'Academie nationale de medecine [ 0001-4079 ] ; 2010.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Biomedical Research (methods), Biomedical Research (trends), Disease Models, Animal, Haplorhini, Humans, Nerve Net (pathology), Nerve Net (physiopathology), Neurotoxins, Parkinson Disease (etiology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (pathology), Parkinsonian Disorders (physiopathology), Parkinsonian Disorders (psychology).
- MESH :
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neurotoxins.
- chemically induced : Parkinsonian Disorders.
- etiology : Parkinson Disease.
- methods : Biomedical Research.
- pathology : Nerve Net, Parkinson Disease, Parkinsonian Disorders.
- physiopathology : Nerve Net, Parkinson Disease, Parkinsonian Disorders.
- psychology : Parkinsonian Disorders.
- trends : Biomedical Research.
- Animals, Disease Models, Animal, Haplorhini, Humans.
Abstract
Considerable progress has been made in the pathophysiology of Parkinson's disease in the last 25 years. To better understand the nature and diversity of the symptoms of Parkinson's disease it is necessary to integrate clinical knowledge on 1) the role of dopamine, 2) the anatomical and functional organization of the basal ganglia, and 3) the dysfunctions observed in MPTP-treated monkeys. This article reviews the principal discoveries in these three research fields and their contribution to our understanding of the pathophysiology of Parkinson's disease.
PubMed: 22043627
Affiliations:
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pubmed:22043627Le document en format XML
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To better understand the nature and diversity of the symptoms of Parkinson's disease it is necessary to integrate clinical knowledge on 1) the role of dopamine, 2) the anatomical and functional organization of the basal ganglia, and 3) the dysfunctions observed in MPTP-treated monkeys. This article reviews the principal discoveries in these three research fields and their contribution to our understanding of the pathophysiology of Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22043627</PMID><DateCreated><Year>2011</Year><Month>11</Month><Day>02</Day></DateCreated><DateCompleted><Year>2011</Year><Month>11</Month><Day>29</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-4079</ISSN><JournalIssue CitedMedium="Print"><Volume>194</Volume><Issue>7</Issue><PubDate><Year>2010</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Bulletin de l'Academie nationale de medecine</Title><ISOAbbreviation>Bull. Acad. Natl. Med.</ISOAbbreviation></Journal><ArticleTitle>[Pathophysiology of Parkinson's disease: an update].</ArticleTitle><Pagination><MedlinePgn>1321-31; discussion 1331-2</MedlinePgn></Pagination><Abstract><AbstractText>Considerable progress has been made in the pathophysiology of Parkinson's disease in the last 25 years. To better understand the nature and diversity of the symptoms of Parkinson's disease it is necessary to integrate clinical knowledge on 1) the role of dopamine, 2) the anatomical and functional organization of the basal ganglia, and 3) the dysfunctions observed in MPTP-treated monkeys. This article reviews the principal discoveries in these three research fields and their contribution to our understanding of the pathophysiology of Parkinson's disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tremblay</LastName><ForeName>Léon</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre de Neurosciences Cognitives, UMR-5229 CNRS-Université Lyon 1, Bron, F69675, France. tremblay-leon@yahoo.fr</Affiliation></AffiliationInfo></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><VernacularTitle>Où en sommes-nous sur la physiopathologie de la maladie de Parkinson?</VernacularTitle></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Bull Acad Natl Med</MedlineTA><NlmUniqueID>7503383</NlmUniqueID><ISSNLinking>0001-4079</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009498">Neurotoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>9P21XSP91P</RegistryNumber><NameOfSubstance UI="D015632">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015632" MajorTopicYN="N">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D035843" MajorTopicYN="N">Biomedical Research</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000639" MajorTopicYN="Y">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000882" MajorTopicYN="N">Haplorhini</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009415" MajorTopicYN="N">Nerve Net</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009498" MajorTopicYN="N">Neurotoxins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020734" MajorTopicYN="N">Parkinsonian Disorders</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>11</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>11</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>12</Month><Day>13</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22043627</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Tremblay, Leon" sort="Tremblay, Leon" uniqKey="Tremblay L" first="Léon" last="Tremblay">Léon Tremblay</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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