Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic.
Identifieur interne : 000914 ( PubMed/Checkpoint ); précédent : 000913; suivant : 000915Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic.
Auteurs : Olivier Clément [France] ; Emilie Sapin ; Anne Bérod ; Patrice Fort ; Pierre-Hervé LuppiSource :
- Sleep [ 1550-9109 ] ; 2011.
English descriptors
- KwdEn :
- Amino Acid Transport System X-AG (physiology), Animals, Brain Stem (anatomy & histology), Brain Stem (physiology), Electroencephalography, Electromyography, Glucose Transporter Type 2 (physiology), In Situ Hybridization, Neurons (physiology), Rats, Receptors, Glutamate (physiology), Sleep, REM (physiology).
- MESH :
- chemical , physiology : Amino Acid Transport System X-AG, Glucose Transporter Type 2, Receptors, Glutamate.
- anatomy & histology : Brain Stem.
- physiology : Brain Stem, Neurons, Sleep, REM.
- Animals, Electroencephalography, Electromyography, In Situ Hybridization, Rats.
Abstract
To determine whether sublaterodorsal tegmental nucleus (SLD) neurons triggering paradoxical (REM) sleep (PS) are glutamatergic.
PubMed: 21461384
Affiliations:
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Links to Exploration step
pubmed:21461384Le document en format XML
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nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Sapin, Emilie" sort="Sapin, Emilie" uniqKey="Sapin E" first="Emilie" last="Sapin">Emilie Sapin</name></author><author><name sortKey="Berod, Anne" sort="Berod, Anne" uniqKey="Berod A" first="Anne" last="Bérod">Anne Bérod</name></author><author><name sortKey="Fort, Patrice" sort="Fort, Patrice" uniqKey="Fort P" first="Patrice" last="Fort">Patrice Fort</name></author><author><name sortKey="Luppi, Pierre Herve" sort="Luppi, Pierre Herve" uniqKey="Luppi P" first="Pierre-Hervé" last="Luppi">Pierre-Hervé Luppi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21461384</idno><idno type="pmid">21461384</idno><idno type="wicri:Area/PubMed/Corpus">000989</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000989</idno><idno type="wicri:Area/PubMed/Curation">000949</idno><idno 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Neuroscience, Research Center, Lyon, F-69372</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Sapin, Emilie" sort="Sapin, Emilie" uniqKey="Sapin E" first="Emilie" last="Sapin">Emilie Sapin</name></author><author><name sortKey="Berod, Anne" sort="Berod, Anne" uniqKey="Berod A" first="Anne" last="Bérod">Anne Bérod</name></author><author><name sortKey="Fort, Patrice" sort="Fort, Patrice" uniqKey="Fort P" first="Patrice" last="Fort">Patrice Fort</name></author><author><name sortKey="Luppi, Pierre Herve" sort="Luppi, Pierre Herve" uniqKey="Luppi P" first="Pierre-Hervé" last="Luppi">Pierre-Hervé Luppi</name></author></analytic><series><title level="j">Sleep</title><idno type="eISSN">1550-9109</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Transport System X-AG (physiology)</term><term>Animals</term><term>Brain Stem (anatomy & histology)</term><term>Brain Stem (physiology)</term><term>Electroencephalography</term><term>Electromyography</term><term>Glucose Transporter Type 2 (physiology)</term><term>In Situ Hybridization</term><term>Neurons (physiology)</term><term>Rats</term><term>Receptors, Glutamate (physiology)</term><term>Sleep, REM (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Amino Acid Transport System X-AG</term><term>Glucose Transporter Type 2</term><term>Receptors, Glutamate</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Brain Stem</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain Stem</term><term>Neurons</term><term>Sleep, REM</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electroencephalography</term><term>Electromyography</term><term>In Situ Hybridization</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine whether sublaterodorsal tegmental nucleus (SLD) neurons triggering paradoxical (REM) sleep (PS) are glutamatergic.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21461384</PMID><DateCreated><Year>2011</Year><Month>04</Month><Day>04</Day></DateCreated><DateCompleted><Year>2011</Year><Month>08</Month><Day>16</Day></DateCompleted><DateRevised><Year>2015</Year><Month>02</Month><Day>04</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1550-9109</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>4</Issue><PubDate><Year>2011</Year><Month>Apr</Month><Day>01</Day></PubDate></JournalIssue><Title>Sleep</Title><ISOAbbreviation>Sleep</ISOAbbreviation></Journal><ArticleTitle>Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic.</ArticleTitle><Pagination><MedlinePgn>419-23</MedlinePgn></Pagination><Abstract><AbstractText Label="STUDY OBJECTIVES" NlmCategory="OBJECTIVE">To determine whether sublaterodorsal tegmental nucleus (SLD) neurons triggering paradoxical (REM) sleep (PS) are glutamatergic.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Three groups of rats were used: controls, rats deprived of PS for 72 h, and rats allowed to recover for 3 h after deprivation. Brain sections were processed for double labeling combining Fos immunohistochemistry and vesicular glutamate transporter 2 (vGLUT2) in situ hybridization.</AbstractText><AbstractText Label="MEASUREMENTS AND RESULTS" NlmCategory="RESULTS">The number of single Fos+ and Fos/vGLUT2+ double-labeled neurons was counted for each experimental condition. A very large number of Fos+ neurons expressing vGLUT2 mRNA specifically after PS hypersomnia was counted in the SLD. These double-labeled cells accounted for 84% of the total number of Fos+ cells.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This finding adds further evidence to the concept that PS-on neurons of the SLD generating PS are of small size and glutamatergic in nature. By means of their descending projections to medullary and/or spinal glycinergic/GABAergic premotoneurons, they may be especially important for the induction of muscle atonia during PS, a disturbed phenomenon in narcolepsy and REM sleep behavior disorder.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Clément</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Physiopathology of the Neuronal Network Responsible for the Sleep-Waking Cycle Team, CNRS UMR5292, INSERM U1028, Lyon Neuroscience, Research Center, Lyon, F-69372, France. luppi@sommeil.univ-lyon1.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sapin</LastName><ForeName>Emilie</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Bérod</LastName><ForeName>Anne</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Fort</LastName><ForeName>Patrice</ForeName><Initials>P</Initials></Author><Author 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PubStatus="entrez"><Year>2011</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>8</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21461384</ArticleId><ArticleId IdType="pmc">PMC3064553</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region></list><tree><noCountry><name sortKey="Berod, Anne" sort="Berod, Anne" uniqKey="Berod A" first="Anne" last="Bérod">Anne Bérod</name><name sortKey="Fort, Patrice" sort="Fort, Patrice" uniqKey="Fort P" first="Patrice" last="Fort">Patrice Fort</name><name sortKey="Luppi, Pierre Herve" sort="Luppi, Pierre Herve" uniqKey="Luppi P" first="Pierre-Hervé" last="Luppi">Pierre-Hervé Luppi</name><name sortKey="Sapin, Emilie" sort="Sapin, Emilie" uniqKey="Sapin E" first="Emilie" last="Sapin">Emilie Sapin</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Clement, Olivier" sort="Clement, Olivier" uniqKey="Clement O" first="Olivier" last="Clément">Olivier Clément</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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