Rewiring the brain with cell transplantation in Parkinson's disease.
Identifieur interne : 000874 ( PubMed/Checkpoint ); précédent : 000873; suivant : 000875Rewiring the brain with cell transplantation in Parkinson's disease.
Auteurs : Afsaneh Gaillard [France] ; Mohamed JaberSource :
- Trends in neurosciences [ 1878-108X ] ; 2011.
English descriptors
- KwdEn :
- Animals, Brain Tissue Transplantation (methods), Brain Tissue Transplantation (trends), Humans, Neural Stem Cells (cytology), Neural Stem Cells (physiology), Neural Stem Cells (transplantation), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Stem Cell Transplantation (methods), Stem Cell Transplantation (trends).
- MESH :
- cytology : Neural Stem Cells.
- methods : Brain Tissue Transplantation, Stem Cell Transplantation.
- physiology : Neural Stem Cells.
- physiopathology : Parkinson Disease.
- surgery : Parkinson Disease.
- transplantation : Neural Stem Cells.
- trends : Brain Tissue Transplantation, Stem Cell Transplantation.
- Animals, Humans.
Abstract
Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought to constitute a non-permissive environment for long distance axonal outgrowth of transplanted neuroblasts. Here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of PD. Such findings have raised new hopes and opened new avenues for cell replacement therapy in patients with PD.
DOI: 10.1016/j.tins.2011.01.003
PubMed: 21316770
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:21316770Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rewiring the brain with cell transplantation in Parkinson's disease.</title>
<author><name sortKey="Gaillard, Afsaneh" sort="Gaillard, Afsaneh" uniqKey="Gaillard A" first="Afsaneh" last="Gaillard">Afsaneh Gaillard</name>
<affiliation wicri:level="4"><nlm:affiliation>Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Centre National de la Recherche Scientifique (CNRS), 1 rue Georges Bonnet, Poitiers, F-86022, France. Afsaneh.Gaillard@univ-poitiers.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Centre National de la Recherche Scientifique (CNRS), 1 rue Georges Bonnet, Poitiers, F-86022</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Poitou-Charentes</region>
</placeName>
<orgName type="university">Université de Poitiers</orgName>
</affiliation>
</author>
<author><name sortKey="Jaber, Mohamed" sort="Jaber, Mohamed" uniqKey="Jaber M" first="Mohamed" last="Jaber">Mohamed Jaber</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:21316770</idno>
<idno type="pmid">21316770</idno>
<idno type="doi">10.1016/j.tins.2011.01.003</idno>
<idno type="wicri:Area/PubMed/Corpus">000995</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000995</idno>
<idno type="wicri:Area/PubMed/Curation">000955</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000955</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000955</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000955</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Rewiring the brain with cell transplantation in Parkinson's disease.</title>
<author><name sortKey="Gaillard, Afsaneh" sort="Gaillard, Afsaneh" uniqKey="Gaillard A" first="Afsaneh" last="Gaillard">Afsaneh Gaillard</name>
<affiliation wicri:level="4"><nlm:affiliation>Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Centre National de la Recherche Scientifique (CNRS), 1 rue Georges Bonnet, Poitiers, F-86022, France. Afsaneh.Gaillard@univ-poitiers.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Centre National de la Recherche Scientifique (CNRS), 1 rue Georges Bonnet, Poitiers, F-86022</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Poitou-Charentes</region>
</placeName>
<orgName type="university">Université de Poitiers</orgName>
</affiliation>
</author>
<author><name sortKey="Jaber, Mohamed" sort="Jaber, Mohamed" uniqKey="Jaber M" first="Mohamed" last="Jaber">Mohamed Jaber</name>
</author>
</analytic>
<series><title level="j">Trends in neurosciences</title>
<idno type="eISSN">1878-108X</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Brain Tissue Transplantation (methods)</term>
<term>Brain Tissue Transplantation (trends)</term>
<term>Humans</term>
<term>Neural Stem Cells (cytology)</term>
<term>Neural Stem Cells (physiology)</term>
<term>Neural Stem Cells (transplantation)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Stem Cell Transplantation (methods)</term>
<term>Stem Cell Transplantation (trends)</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Neural Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Brain Tissue Transplantation</term>
<term>Stem Cell Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neural Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neural Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Brain Tissue Transplantation</term>
<term>Stem Cell Transplantation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought to constitute a non-permissive environment for long distance axonal outgrowth of transplanted neuroblasts. Here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of PD. Such findings have raised new hopes and opened new avenues for cell replacement therapy in patients with PD.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21316770</PMID>
<DateCreated><Year>2011</Year>
<Month>03</Month>
<Day>08</Day>
</DateCreated>
<DateCompleted><Year>2012</Year>
<Month>01</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2011</Year>
<Month>03</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1878-108X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>34</Volume>
<Issue>3</Issue>
<PubDate><Year>2011</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Trends in neurosciences</Title>
<ISOAbbreviation>Trends Neurosci.</ISOAbbreviation>
</Journal>
<ArticleTitle>Rewiring the brain with cell transplantation in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>124-33</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.tins.2011.01.003</ELocationID>
<Abstract><AbstractText>Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought to constitute a non-permissive environment for long distance axonal outgrowth of transplanted neuroblasts. Here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of PD. Such findings have raised new hopes and opened new avenues for cell replacement therapy in patients with PD.</AbstractText>
<CopyrightInformation>Copyright © 2011 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gaillard</LastName>
<ForeName>Afsaneh</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Centre National de la Recherche Scientifique (CNRS), 1 rue Georges Bonnet, Poitiers, F-86022, France. Afsaneh.Gaillard@univ-poitiers.fr</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jaber</LastName>
<ForeName>Mohamed</ForeName>
<Initials>M</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Trends Neurosci</MedlineTA>
<NlmUniqueID>7808616</NlmUniqueID>
<ISSNLinking>0166-2236</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016380" MajorTopicYN="N">Brain Tissue Transplantation</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058953" MajorTopicYN="N">Neural Stem Cells</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
<QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D033581" MajorTopicYN="N">Stem Cell Transplantation</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year>
<Month>06</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2010</Year>
<Month>12</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2011</Year>
<Month>01</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2011</Year>
<Month>2</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2011</Year>
<Month>2</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2012</Year>
<Month>1</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">21316770</ArticleId>
<ArticleId IdType="pii">S0166-2236(11)00004-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.tins.2011.01.003</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Nouvelle-Aquitaine</li>
<li>Poitou-Charentes</li>
</region>
<orgName><li>Université de Poitiers</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Jaber, Mohamed" sort="Jaber, Mohamed" uniqKey="Jaber M" first="Mohamed" last="Jaber">Mohamed Jaber</name>
</noCountry>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Gaillard, Afsaneh" sort="Gaillard, Afsaneh" uniqKey="Gaillard A" first="Afsaneh" last="Gaillard">Afsaneh Gaillard</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000874 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000874 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:21316770 |texte= Rewiring the brain with cell transplantation in Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:21316770" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |