A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson's disease.
Identifieur interne : 000843 ( PubMed/Checkpoint ); précédent : 000842; suivant : 000844A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson's disease.
Auteurs : H. Pouclet [France] ; T. Lebouvier ; E. Coron ; S B Des Varannes ; M. Neunlist ; P. DerkinderenSource :
- Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society [ 1365-2982 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- pathology : Colon, Intestinal Mucosa, Lewy Bodies, Neurites, Parkinson Disease, Submucous Plexus.
- Adult, Aged, Female, Humans, Immunohistochemistry, Male, Microdissection, Middle Aged.
Abstract
Lewy bodies and neurites (LN), the two pathological hallmarks of Parkinson's disease (PD), are found in the enteric nervous system (ENS). Previously, we have shown that whole mounts of submucosa obtained after microdissection of colonic biopsies can be used for the detection of LN in the submucosal plexus (SMP) of PD patients. Recent reports suggest that Lewy pathology may extend beyond the submucosa to involve the digestive mucosa. The aim of the present research was to determine whether the analysis of the mucosa obtained after microdissection may help improve the sensitivity of colonic biopsies to detect Lewy pathology in the colon of PD patients.
DOI: 10.1111/j.1365-2982.2012.01887.x
PubMed: 22292943
Affiliations:
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Coron</name></author><author><name sortKey="Des Varannes, S B" sort="Des Varannes, S B" uniqKey="Des Varannes S" first="S B" last="Des Varannes">S B Des Varannes</name></author><author><name sortKey="Neunlist, M" sort="Neunlist, M" uniqKey="Neunlist M" first="M" last="Neunlist">M. Neunlist</name></author><author><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P" last="Derkinderen">P. Derkinderen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22292943</idno><idno type="pmid">22292943</idno><idno type="doi">10.1111/j.1365-2982.2012.01887.x</idno><idno type="wicri:Area/PubMed/Corpus">000884</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000884</idno><idno type="wicri:Area/PubMed/Curation">000848</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000848</idno><idno type="wicri:Area/PubMed/Checkpoint">000848</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000848</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson's disease.</title><author><name sortKey="Pouclet, H" sort="Pouclet, H" uniqKey="Pouclet H" first="H" last="Pouclet">H. Pouclet</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U913, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U913, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Lebouvier, T" sort="Lebouvier, T" uniqKey="Lebouvier T" first="T" last="Lebouvier">T. Lebouvier</name></author><author><name sortKey="Coron, E" sort="Coron, E" uniqKey="Coron E" first="E" last="Coron">E. Coron</name></author><author><name sortKey="Des Varannes, S B" sort="Des Varannes, S B" uniqKey="Des Varannes S" first="S B" last="Des Varannes">S B Des Varannes</name></author><author><name sortKey="Neunlist, M" sort="Neunlist, M" uniqKey="Neunlist M" first="M" last="Neunlist">M. Neunlist</name></author><author><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P" last="Derkinderen">P. Derkinderen</name></author></analytic><series><title level="j">Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society</title><idno type="eISSN">1365-2982</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Colon (pathology)</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Intestinal Mucosa (pathology)</term><term>Lewy Bodies (pathology)</term><term>Male</term><term>Microdissection</term><term>Middle Aged</term><term>Neurites (pathology)</term><term>Parkinson Disease (pathology)</term><term>Submucous Plexus (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colon</term><term>Intestinal Mucosa</term><term>Lewy Bodies</term><term>Neurites</term><term>Parkinson Disease</term><term>Submucous Plexus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Microdissection</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> Lewy bodies and neurites (LN), the two pathological hallmarks of Parkinson's disease (PD), are found in the enteric nervous system (ENS). Previously, we have shown that whole mounts of submucosa obtained after microdissection of colonic biopsies can be used for the detection of LN in the submucosal plexus (SMP) of PD patients. Recent reports suggest that Lewy pathology may extend beyond the submucosa to involve the digestive mucosa. The aim of the present research was to determine whether the analysis of the mucosa obtained after microdissection may help improve the sensitivity of colonic biopsies to detect Lewy pathology in the colon of PD patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22292943</PMID><DateCreated><Year>2012</Year><Month>03</Month><Day>14</Day></DateCreated><DateCompleted><Year>2012</Year><Month>07</Month><Day>30</Day></DateCompleted><DateRevised><Year>2012</Year><Month>03</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2982</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>4</Issue><PubDate><Year>2012</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society</Title><ISOAbbreviation>Neurogastroenterol. Motil.</ISOAbbreviation></Journal><ArticleTitle>A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>e202-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1365-2982.2012.01887.x</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND"> Lewy bodies and neurites (LN), the two pathological hallmarks of Parkinson's disease (PD), are found in the enteric nervous system (ENS). Previously, we have shown that whole mounts of submucosa obtained after microdissection of colonic biopsies can be used for the detection of LN in the submucosal plexus (SMP) of PD patients. Recent reports suggest that Lewy pathology may extend beyond the submucosa to involve the digestive mucosa. The aim of the present research was to determine whether the analysis of the mucosa obtained after microdissection may help improve the sensitivity of colonic biopsies to detect Lewy pathology in the colon of PD patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS"> Nine PD patients and 10 controls were included. Four biopsies were taken from the sigmoid/descending colon junction during the course of a rectosigmoidoscopy (short colonoscopy) in PD patients and during a total colonoscopy for colorectal screening in controls. Biopsies were microdissected, the mucosa was separated from the submucosa and both structures were analyzed by immunohistochemistry. Immunohistochemical analysis was performed using antibodies against phosphorylated alpha-synuclein to detect LN and neurofilaments NF200 kDa to label the neuronal structures.</AbstractText><AbstractText Label="KEY RESULTS" NlmCategory="RESULTS"> Lewy neurites were present in the SMP of four patients and in the mucosa of three patients. Remarkably, among the patients who displayed LN within their mucosa, one was devoid of Lewy pathology in his SMP. No LN were observed in the mucosa and the SMP of controls.</AbstractText><AbstractText Label="CONCLUSIONS & INFERENCES" NlmCategory="CONCLUSIONS"> The parallel analysis of colonic mucosa, along with the SMP, can help detect Lewy pathology in PD.</AbstractText><CopyrightInformation>© 2012 Blackwell Publishing Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pouclet</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Inserm, U913, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lebouvier</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Coron</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Des Varannes</LastName><ForeName>S B</ForeName><Initials>SB</Initials></Author><Author ValidYN="Y"><LastName>Neunlist</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Derkinderen</LastName><ForeName>P</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>01</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neurogastroenterol Motil</MedlineTA><NlmUniqueID>9432572</NlmUniqueID><ISSNLinking>1350-1925</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003106" MajorTopicYN="N">Colon</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007413" MajorTopicYN="N">Intestinal Mucosa</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016631" MajorTopicYN="N">Lewy Bodies</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042282" MajorTopicYN="N">Microdissection</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016501" MajorTopicYN="N">Neurites</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013368" MajorTopicYN="N">Submucous Plexus</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22292943</ArticleId><ArticleId IdType="doi">10.1111/j.1365-2982.2012.01887.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement></list><tree><noCountry><name sortKey="Coron, E" sort="Coron, E" uniqKey="Coron E" first="E" last="Coron">E. Coron</name><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P" last="Derkinderen">P. Derkinderen</name><name sortKey="Des Varannes, S B" sort="Des Varannes, S B" uniqKey="Des Varannes S" first="S B" last="Des Varannes">S B Des Varannes</name><name sortKey="Lebouvier, T" sort="Lebouvier, T" uniqKey="Lebouvier T" first="T" last="Lebouvier">T. Lebouvier</name><name sortKey="Neunlist, M" sort="Neunlist, M" uniqKey="Neunlist M" first="M" last="Neunlist">M. Neunlist</name></noCountry><country name="France"><region name="Pays de la Loire"><name sortKey="Pouclet, H" sort="Pouclet, H" uniqKey="Pouclet H" first="H" last="Pouclet">H. Pouclet</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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