Has removal of excess cysteine led to the evolution of pheomelanin? Pheomelanogenesis as an excretory mechanism for cysteine.
Identifieur interne : 000803 ( PubMed/Checkpoint ); précédent : 000802; suivant : 000804Has removal of excess cysteine led to the evolution of pheomelanin? Pheomelanogenesis as an excretory mechanism for cysteine.
Auteurs : Ismael Galván [France] ; Ghanem Ghanem ; Anders P. M LlerSource :
- BioEssays : news and reviews in molecular, cellular and developmental biology [ 1521-1878 ] ; 2012.
English descriptors
- KwdEn :
- Alzheimer Disease (metabolism), Alzheimer Disease (physiopathology), Cysteine (metabolism), Cysteine Dioxygenase (metabolism), Diet, Evolution, Molecular, Glutathione (metabolism), Humans, Melanins (genetics), Melanins (metabolism), Melanocytes (cytology), Melanocytes (metabolism), Oxidative Stress, Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Selection, Genetic, Temperature, Ultraviolet Rays (adverse effects).
- MESH :
- chemical , genetics : Melanins.
- chemical , metabolism : Cysteine, Cysteine Dioxygenase, Glutathione, Melanins.
- adverse effects : Ultraviolet Rays.
- cytology : Melanocytes.
- metabolism : Alzheimer Disease, Melanocytes, Parkinson Disease.
- physiopathology : Alzheimer Disease, Parkinson Disease.
- Diet, Evolution, Molecular, Humans, Oxidative Stress, Selection, Genetic, Temperature.
Abstract
Pheomelanogenesis may have evolved as an excretory mechanism to remove excess cysteine, and in humans this might potentially confer a greater ability to avoid disease such as Parkinson's and Alzheimer's disease, in which excess cysteine is a contributory cause.
DOI: 10.1002/bies.201200017
PubMed: 22442057
Affiliations:
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pubmed:22442057Le document en format XML
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<front><div type="abstract" xml:lang="en">Pheomelanogenesis may have evolved as an excretory mechanism to remove excess cysteine, and in humans this might potentially confer a greater ability to avoid disease such as Parkinson's and Alzheimer's disease, in which excess cysteine is a contributory cause.</div>
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