[Saccadic system plasticity mechanisms in Parkinson disease patients].
Identifieur interne : 000746 ( PubMed/Checkpoint ); précédent : 000745; suivant : 000747[Saccadic system plasticity mechanisms in Parkinson disease patients].
Auteurs : L. Abouaf [France] ; M. Panouillères ; S. Thobois ; V. Majerova ; A. Vighetto ; D. Pélisson ; C. TiliketeSource :
- Journal francais d'ophtalmologie [ 1773-0597 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- physiology : Adaptation, Physiological, Neuronal Plasticity, Saccades, Visual Perception.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Aged, Female, Humans, Individuality, Male, Middle Aged, Models, Biological, Reaction Time.
Abstract
Voluntary or reactive saccades predominate in rapid eye movements. Their goal is to preserve an active and optimal visual perception of the environment. Saccades cannot be guided once launched. Oculomotor plasticity, or saccadic adaptation, is still partially unknown, in particular the role played by the basal ganglia. New neuro-ophthalmological rehabilitation techniques require understanding the neurophysiological basis and demonstrating the neuronal structures involved in this plasticity.
DOI: 10.1016/j.jfo.2011.05.009
PubMed: 22018708
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Saccadic system plasticity mechanisms in Parkinson disease patients].</title><author><name sortKey="Abouaf, L" sort="Abouaf, L" uniqKey="Abouaf L" first="L" last="Abouaf">L. Abouaf</name><affiliation wicri:level="3"><nlm:affiliation>Inserm U1028, CNRS UMR5292, équipe Impact, centre de recherche en neurosciences de Lyon, 95, boulevard Pinel, 69500 Bron, France. lucieabouaf@gmail.com</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U1028, CNRS UMR5292, équipe Impact, centre de recherche en neurosciences de Lyon, 95, boulevard Pinel, 69500 Bron</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Bron</settlement></placeName></affiliation></author><author><name sortKey="Panouilleres, M" sort="Panouilleres, M" uniqKey="Panouilleres M" first="M" last="Panouillères">M. Panouillères</name></author><author><name sortKey="Thobois, S" sort="Thobois, S" uniqKey="Thobois S" first="S" last="Thobois">S. Thobois</name></author><author><name sortKey="Majerova, V" sort="Majerova, V" uniqKey="Majerova V" first="V" last="Majerova">V. Majerova</name></author><author><name sortKey="Vighetto, A" sort="Vighetto, A" uniqKey="Vighetto A" first="A" last="Vighetto">A. Vighetto</name></author><author><name sortKey="Pelisson, D" sort="Pelisson, D" uniqKey="Pelisson D" first="D" last="Pélisson">D. Pélisson</name></author><author><name sortKey="Tilikete, C" sort="Tilikete, C" uniqKey="Tilikete C" first="C" last="Tilikete">C. Tilikete</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22018708</idno><idno type="pmid">22018708</idno><idno type="doi">10.1016/j.jfo.2011.05.009</idno><idno type="wicri:Area/PubMed/Corpus">000883</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000883</idno><idno type="wicri:Area/PubMed/Curation">000847</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000847</idno><idno type="wicri:Area/PubMed/Checkpoint">000847</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000847</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Saccadic system plasticity mechanisms in Parkinson disease patients].</title><author><name sortKey="Abouaf, L" sort="Abouaf, L" uniqKey="Abouaf L" first="L" last="Abouaf">L. Abouaf</name><affiliation wicri:level="3"><nlm:affiliation>Inserm U1028, CNRS UMR5292, équipe Impact, centre de recherche en neurosciences de Lyon, 95, boulevard Pinel, 69500 Bron, France. lucieabouaf@gmail.com</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U1028, CNRS UMR5292, équipe Impact, centre de recherche en neurosciences de Lyon, 95, boulevard Pinel, 69500 Bron</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Bron</settlement></placeName></affiliation></author><author><name sortKey="Panouilleres, M" sort="Panouilleres, M" uniqKey="Panouilleres M" first="M" last="Panouillères">M. Panouillères</name></author><author><name sortKey="Thobois, S" sort="Thobois, S" uniqKey="Thobois S" first="S" last="Thobois">S. Thobois</name></author><author><name sortKey="Majerova, V" sort="Majerova, V" uniqKey="Majerova V" first="V" last="Majerova">V. Majerova</name></author><author><name sortKey="Vighetto, A" sort="Vighetto, A" uniqKey="Vighetto A" first="A" last="Vighetto">A. Vighetto</name></author><author><name sortKey="Pelisson, D" sort="Pelisson, D" uniqKey="Pelisson D" first="D" last="Pélisson">D. Pélisson</name></author><author><name sortKey="Tilikete, C" sort="Tilikete, C" uniqKey="Tilikete C" first="C" last="Tilikete">C. Tilikete</name></author></analytic><series><title level="j">Journal francais d'ophtalmologie</title><idno type="eISSN">1773-0597</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (physiology)</term><term>Aged</term><term>Female</term><term>Humans</term><term>Individuality</term><term>Male</term><term>Middle Aged</term><term>Models, Biological</term><term>Neuronal Plasticity (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Reaction Time</term><term>Saccades (physiology)</term><term>Visual Perception (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adaptation, Physiological</term><term>Neuronal Plasticity</term><term>Saccades</term><term>Visual Perception</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Individuality</term><term>Male</term><term>Middle Aged</term><term>Models, Biological</term><term>Reaction Time</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Voluntary or reactive saccades predominate in rapid eye movements. Their goal is to preserve an active and optimal visual perception of the environment. Saccades cannot be guided once launched. Oculomotor plasticity, or saccadic adaptation, is still partially unknown, in particular the role played by the basal ganglia. New neuro-ophthalmological rehabilitation techniques require understanding the neurophysiological basis and demonstrating the neuronal structures involved in this plasticity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22018708</PMID><DateCreated><Year>2012</Year><Month>04</Month><Day>02</Day></DateCreated><DateCompleted><Year>2012</Year><Month>07</Month><Day>16</Day></DateCompleted><DateRevised><Year>2012</Year><Month>04</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1773-0597</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>4</Issue><PubDate><Year>2012</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Journal francais d'ophtalmologie</Title><ISOAbbreviation>J Fr Ophtalmol</ISOAbbreviation></Journal><ArticleTitle>[Saccadic system plasticity mechanisms in Parkinson disease patients].</ArticleTitle><Pagination><MedlinePgn>242-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jfo.2011.05.009</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Voluntary or reactive saccades predominate in rapid eye movements. Their goal is to preserve an active and optimal visual perception of the environment. Saccades cannot be guided once launched. Oculomotor plasticity, or saccadic adaptation, is still partially unknown, in particular the role played by the basal ganglia. New neuro-ophthalmological rehabilitation techniques require understanding the neurophysiological basis and demonstrating the neuronal structures involved in this plasticity.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">This study assessed the reactive saccade adaptation in patients with idiopathic Parkinson disease, as a model of basal ganglia dysfunction. We predicted that saccadic adaptation would be preserved in this pathology.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Five patients with mild idiopathic hemi-Parkinson disease were included, as well as four age-matched controls. Reactive saccade adaptation was studied using the double-step target paradigm, in patients with OFF-Dopa treatment and in controls.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Group analysis demonstrated that patients had a lower level of adaptation than the controls (p<0.05). Individually, two patients did not adapt for bilateral saccades and one for ipsilateral (compared to Parkinson motor clinical syndrome) saccades. Two additional patients adapted on both sides but with a deficit in contralateral saccades when compared to the control group.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">These preliminary results suggest basal ganglia involvement in reactive saccadic adaptation, which remains to be clarified.</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Abouaf</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Inserm U1028, CNRS UMR5292, équipe Impact, centre de recherche en neurosciences de Lyon, 95, boulevard Pinel, 69500 Bron, France. lucieabouaf@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panouillères</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Thobois</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Majerova</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Vighetto</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Pélisson</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Tilikete</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D018848">Controlled Clinical Trial</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Mécanismes de plasticité saccadique chez les patients atteints de maladie de Parkinson.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2011</Year><Month>10</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>J Fr Ophtalmol</MedlineTA><NlmUniqueID>7804128</NlmUniqueID><ISSNLinking>0181-5512</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000222" MajorTopicYN="N">Adaptation, Physiological</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007206" MajorTopicYN="N">Individuality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009473" MajorTopicYN="N">Neuronal Plasticity</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011930" MajorTopicYN="N">Reaction Time</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012438" MajorTopicYN="N">Saccades</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014796" MajorTopicYN="N">Visual Perception</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>03</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>04</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>05</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22018708</ArticleId><ArticleId IdType="pii">S0181-5512(11)00318-4</ArticleId><ArticleId IdType="doi">10.1016/j.jfo.2011.05.009</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Bron</li></settlement></list><tree><noCountry><name sortKey="Majerova, V" sort="Majerova, V" uniqKey="Majerova V" first="V" last="Majerova">V. Majerova</name><name sortKey="Panouilleres, M" sort="Panouilleres, M" uniqKey="Panouilleres M" first="M" last="Panouillères">M. Panouillères</name><name sortKey="Pelisson, D" sort="Pelisson, D" uniqKey="Pelisson D" first="D" last="Pélisson">D. Pélisson</name><name sortKey="Thobois, S" sort="Thobois, S" uniqKey="Thobois S" first="S" last="Thobois">S. Thobois</name><name sortKey="Tilikete, C" sort="Tilikete, C" uniqKey="Tilikete C" first="C" last="Tilikete">C. Tilikete</name><name sortKey="Vighetto, A" sort="Vighetto, A" uniqKey="Vighetto A" first="A" last="Vighetto">A. Vighetto</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Abouaf, L" sort="Abouaf, L" uniqKey="Abouaf L" first="L" last="Abouaf">L. Abouaf</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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