Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model.
Identifieur interne : 000730 ( PubMed/Checkpoint ); précédent : 000729; suivant : 000731Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model.
Auteurs : Daniel Alvarez-Fischer [France] ; Carmen Noelker ; Franca Vulinovi ; Anne Grünewald ; Caroline Chevarin ; Christine Klein ; Wolfgang H. Oertel ; Etienne C. Hirsch ; Patrick P. Michel ; Andreas HartmannSource :
- PloS one [ 1932-6203 ] ; 2013.
English descriptors
- KwdEn :
- Acupuncture Points, Animals, Apamin (pharmacology), Bee Venoms (pharmacology), Behavior, Animal (drug effects), Corpus Striatum (drug effects), Corpus Striatum (metabolism), Disease Models, Animal, Dopaminergic Neurons (drug effects), Exploratory Behavior (drug effects), MPTP Poisoning (prevention & control), Male, Mice, Mice, Inbred C57BL, Neuroprotective Agents (pharmacology), Parkinson Disease (prevention & control), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , metabolism : Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Apamin, Bee Venoms, Neuroprotective Agents.
- drug effects : Behavior, Animal, Corpus Striatum, Dopaminergic Neurons, Exploratory Behavior.
- metabolism : Corpus Striatum.
- prevention & control : MPTP Poisoning, Parkinson Disease.
- Acupuncture Points, Animals, Disease Models, Animal, Male, Mice, Mice, Inbred C57BL.
Abstract
Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom was protective in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. In particular, a specific component of bee venom, apamin, has previously been shown to have protective effects on dopaminergic neurons in vitro. However, no information regarding a potential protective action of apamin in animal models of PD is available to date. The specific goals of the present study were to (i) establish that the protective effect of bee venom for dopaminergic neurons is not restricted to acupoint stimulation, but can also be observed using a more conventional mode of administration and to (ii) demonstrate that apamin can mimic the protective effects of a bee venom treatment on dopaminergic neurons. Using the chronic mouse model of MPTP/probenecid, we show that bee venom provides sustained protection in an animal model that mimics the chronic degenerative process of PD. Apamin, however, reproduced these protective effects only partially, suggesting that other components of bee venom enhance the protective action of the peptide.
DOI: 10.1371/journal.pone.0061700
PubMed: 23637888
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:23637888Le document en format XML
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<term>Behavior, Animal (drug effects)</term>
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<front><div type="abstract" xml:lang="en">Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom was protective in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. In particular, a specific component of bee venom, apamin, has previously been shown to have protective effects on dopaminergic neurons in vitro. However, no information regarding a potential protective action of apamin in animal models of PD is available to date. The specific goals of the present study were to (i) establish that the protective effect of bee venom for dopaminergic neurons is not restricted to acupoint stimulation, but can also be observed using a more conventional mode of administration and to (ii) demonstrate that apamin can mimic the protective effects of a bee venom treatment on dopaminergic neurons. Using the chronic mouse model of MPTP/probenecid, we show that bee venom provides sustained protection in an animal model that mimics the chronic degenerative process of PD. Apamin, however, reproduced these protective effects only partially, suggesting that other components of bee venom enhance the protective action of the peptide.</div>
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<Abstract><AbstractText>Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom was protective in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. In particular, a specific component of bee venom, apamin, has previously been shown to have protective effects on dopaminergic neurons in vitro. However, no information regarding a potential protective action of apamin in animal models of PD is available to date. The specific goals of the present study were to (i) establish that the protective effect of bee venom for dopaminergic neurons is not restricted to acupoint stimulation, but can also be observed using a more conventional mode of administration and to (ii) demonstrate that apamin can mimic the protective effects of a bee venom treatment on dopaminergic neurons. Using the chronic mouse model of MPTP/probenecid, we show that bee venom provides sustained protection in an animal model that mimics the chronic degenerative process of PD. Apamin, however, reproduced these protective effects only partially, suggesting that other components of bee venom enhance the protective action of the peptide.</AbstractText>
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<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC3630120</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year>
<Month>07</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2013</Year>
<Month>03</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2013</Year>
<Month>5</Month>
<Day>3</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2013</Year>
<Month>5</Month>
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<PubMedPubDate PubStatus="medline"><Year>2013</Year>
<Month>12</Month>
<Day>27</Day>
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<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">23637888</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pone.0061700</ArticleId>
<ArticleId IdType="pii">PONE-D-12-20546</ArticleId>
<ArticleId IdType="pmc">PMC3630120</ArticleId>
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<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Chevarin, Caroline" sort="Chevarin, Caroline" uniqKey="Chevarin C" first="Caroline" last="Chevarin">Caroline Chevarin</name>
<name sortKey="Grunewald, Anne" sort="Grunewald, Anne" uniqKey="Grunewald A" first="Anne" last="Grünewald">Anne Grünewald</name>
<name sortKey="Hartmann, Andreas" sort="Hartmann, Andreas" uniqKey="Hartmann A" first="Andreas" last="Hartmann">Andreas Hartmann</name>
<name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name>
<name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<name sortKey="Michel, Patrick P" sort="Michel, Patrick P" uniqKey="Michel P" first="Patrick P" last="Michel">Patrick P. Michel</name>
<name sortKey="Noelker, Carmen" sort="Noelker, Carmen" uniqKey="Noelker C" first="Carmen" last="Noelker">Carmen Noelker</name>
<name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name>
<name sortKey="Vulinovi, Franca" sort="Vulinovi, Franca" uniqKey="Vulinovi F" first="Franca" last="Vulinovi">Franca Vulinovi</name>
</noCountry>
<country name="France"><region name="Île-de-France"><name sortKey="Alvarez Fischer, Daniel" sort="Alvarez Fischer, Daniel" uniqKey="Alvarez Fischer D" first="Daniel" last="Alvarez-Fischer">Daniel Alvarez-Fischer</name>
</region>
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