Modeling depression in Parkinson disease: disease-specific and nonspecific risk factors.
Identifieur interne : 000679 ( PubMed/Checkpoint ); précédent : 000678; suivant : 000680Modeling depression in Parkinson disease: disease-specific and nonspecific risk factors.
Auteurs : Albert F G. Leentjens [Australie] ; Anja J H. Moonen ; Kathy Dujardin ; Laura Marsh ; Pablo Martinez-Martin ; Irene H. Richard ; Sergio E. Starkstein ; Sebastian KöhlerSource :
- Neurology [ 1526-632X ] ; 2013.
English descriptors
- KwdEn :
- Activities of Daily Living (psychology), Aged, Cross-Sectional Studies, Depression (etiology), Depression (psychology), Female, Humans, Male, Middle Aged, Models, Neurological, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), Risk Factors, Severity of Illness Index.
- MESH :
- complications : Parkinson Disease.
- etiology : Depression.
- psychology : Activities of Daily Living, Depression, Parkinson Disease.
- Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Models, Neurological, Neuropsychological Tests, Risk Factors, Severity of Illness Index.
Abstract
To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model.
DOI: 10.1212/WNL.0b013e3182a4a503
PubMed: 23946309
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:23946309Le document en format XML
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<term>Depression (psychology)</term>
<term>Female</term>
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<term>Male</term>
<term>Middle Aged</term>
<term>Models, Neurological</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (psychology)</term>
<term>Risk Factors</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Activities of Daily Living</term>
<term>Depression</term>
<term>Parkinson Disease</term>
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<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Neurological</term>
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<front><div type="abstract" xml:lang="en">To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model.</div>
</front>
</TEI>
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<Title>Neurology</Title>
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<ArticleTitle>Modeling depression in Parkinson disease: disease-specific and nonspecific risk factors.</ArticleTitle>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Structural equation modeling of direct and indirect associations of risk factors with the latent depression outcome using a cross-sectional dataset of 342 patients with PD.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A model with acceptable fit was generated that explained 41% of the variance in depression. In the final model, 3 PD-specific variables (increased disease duration, more severe motor symptoms, the use of levodopa) and 6 nonspecific variables (female sex, history of anxiety and/or depression, family history of depression, worse functioning on activities of daily living, and worse cognitive status) were maintained and significantly associated with depression. Nonspecific risk factors had a 3-times-higher influence in the model than PD-specific risk factors.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In this cross-sectional study, we showed that nonspecific factors may be more prominent markers of depression than PD-specific factors. Accordingly, research on depression in PD should focus not only on factors associated with or specific for PD, but should also examine a wider scope of factors including general risk factors for depression, not specific for PD.</AbstractText>
</Abstract>
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