Supplementary motor area activation is impaired in severe traumatic brain injury parkinsonism.
Identifieur interne : 000441 ( PubMed/Checkpoint ); précédent : 000440; suivant : 000442Supplementary motor area activation is impaired in severe traumatic brain injury parkinsonism.
Auteurs : Patrice Péran [France] ; Sheila Catani ; Chiara Falletta Caravasso ; Federico Nemmi ; Umberto Sabatini ; Rita FormisanoSource :
- Journal of neurotrauma [ 1557-9042 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Brain Injuries.
- etiology : Parkinsonian Disorders.
- physiopathology : Brain Injuries, Motor Cortex, Parkinsonian Disorders.
- Adult, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Young Adult.
Abstract
A high percentage of survivors of severe traumatic brain injury present diffuse axonal injury and extrapyramidal symptoms. The association between diffuse cerebral damage and parkinsonian symptoms is probably because of the interruption of nigro-striato-frontal pathways. While functional magnetic resonance imaging (fMRI) has been widely used to investigate parkinsonism in idiopathic Parkinson disease, little is known about functional brain modifications related to post-traumatic parkinsonism (PTP). The aim of this study is to assess cerebral activity of the action-related network in patients with PTP comparing these patients to matched healthy controls. In the fMRI scanner, we proposed to 12 PTP patients and 12 healthy control participants a continuum of tasks involving action-related word production, mental simulation of action, and miming of action triggered by external stimuli such as drawings of objects. Patients with PTP showed a main effect similar to that of healthy controls in all the tasks. Direct comparison revealed hypoactivation of areas in the action-related network in patients with PTP for all the tasks. During the mime of action, which involved actual movement, the hypoactivation was localized to the motor network. Our results suggest that patients with PTP showed a cerebral reorganization for motor tasks in agreement with the cerebral reorganization observed in idiopathic Parkinson disease. For patients with PTP, supplementary motor area impairment seems to play a central role in parkinsonism, in line with the brain reorganization of action-related tasks.
DOI: 10.1089/neu.2013.3103
PubMed: 24168468
Affiliations:
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Formisano</name></author></analytic><series><title level="j">Journal of neurotrauma</title><idno type="eISSN">1557-9042</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain Injuries (complications)</term><term>Brain Injuries (physiopathology)</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Parkinsonian Disorders (etiology)</term><term>Parkinsonian Disorders (physiopathology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Brain Injuries</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Injuries</term><term>Motor Cortex</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A high percentage of survivors of severe traumatic brain injury present diffuse axonal injury and extrapyramidal symptoms. The association between diffuse cerebral damage and parkinsonian symptoms is probably because of the interruption of nigro-striato-frontal pathways. While functional magnetic resonance imaging (fMRI) has been widely used to investigate parkinsonism in idiopathic Parkinson disease, little is known about functional brain modifications related to post-traumatic parkinsonism (PTP). The aim of this study is to assess cerebral activity of the action-related network in patients with PTP comparing these patients to matched healthy controls. In the fMRI scanner, we proposed to 12 PTP patients and 12 healthy control participants a continuum of tasks involving action-related word production, mental simulation of action, and miming of action triggered by external stimuli such as drawings of objects. Patients with PTP showed a main effect similar to that of healthy controls in all the tasks. Direct comparison revealed hypoactivation of areas in the action-related network in patients with PTP for all the tasks. During the mime of action, which involved actual movement, the hypoactivation was localized to the motor network. Our results suggest that patients with PTP showed a cerebral reorganization for motor tasks in agreement with the cerebral reorganization observed in idiopathic Parkinson disease. For patients with PTP, supplementary motor area impairment seems to play a central role in parkinsonism, in line with the brain reorganization of action-related tasks.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24168468</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>21</Day></DateCreated><DateCompleted><Year>2014</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2014</Year><Month>03</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1557-9042</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>7</Issue><PubDate><Year>2014</Year><Month>Apr</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of neurotrauma</Title><ISOAbbreviation>J. Neurotrauma</ISOAbbreviation></Journal><ArticleTitle>Supplementary motor area activation is impaired in severe traumatic brain injury parkinsonism.</ArticleTitle><Pagination><MedlinePgn>642-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/neu.2013.3103</ELocationID><Abstract><AbstractText>A high percentage of survivors of severe traumatic brain injury present diffuse axonal injury and extrapyramidal symptoms. The association between diffuse cerebral damage and parkinsonian symptoms is probably because of the interruption of nigro-striato-frontal pathways. While functional magnetic resonance imaging (fMRI) has been widely used to investigate parkinsonism in idiopathic Parkinson disease, little is known about functional brain modifications related to post-traumatic parkinsonism (PTP). The aim of this study is to assess cerebral activity of the action-related network in patients with PTP comparing these patients to matched healthy controls. In the fMRI scanner, we proposed to 12 PTP patients and 12 healthy control participants a continuum of tasks involving action-related word production, mental simulation of action, and miming of action triggered by external stimuli such as drawings of objects. Patients with PTP showed a main effect similar to that of healthy controls in all the tasks. Direct comparison revealed hypoactivation of areas in the action-related network in patients with PTP for all the tasks. During the mime of action, which involved actual movement, the hypoactivation was localized to the motor network. Our results suggest that patients with PTP showed a cerebral reorganization for motor tasks in agreement with the cerebral reorganization observed in idiopathic Parkinson disease. For patients with PTP, supplementary motor area impairment seems to play a central role in parkinsonism, in line with the brain reorganization of action-related tasks.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Péran</LastName><ForeName>Patrice</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>1 INSERM, Imagerie Cérébrale et Handicaps Neurologiques, Centre Hospitalier Universitaire de Toulouse , Toulouse, France .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Catani</LastName><ForeName>Sheila</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Falletta Caravasso</LastName><ForeName>Chiara</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Nemmi</LastName><ForeName>Federico</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Sabatini</LastName><ForeName>Umberto</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Formisano</LastName><ForeName>Rita</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Neurotrauma</MedlineTA><NlmUniqueID>8811626</NlmUniqueID><ISSNLinking>0897-7151</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001930" MajorTopicYN="N">Brain Injuries</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009044" MajorTopicYN="N">Motor Cortex</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020734" MajorTopicYN="N">Parkinsonian Disorders</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>10</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>10</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24168468</ArticleId><ArticleId IdType="doi">10.1089/neu.2013.3103</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement></list><tree><noCountry><name sortKey="Catani, Sheila" sort="Catani, Sheila" uniqKey="Catani S" first="Sheila" last="Catani">Sheila Catani</name><name sortKey="Falletta Caravasso, Chiara" sort="Falletta Caravasso, Chiara" uniqKey="Falletta Caravasso C" first="Chiara" last="Falletta Caravasso">Chiara Falletta Caravasso</name><name sortKey="Formisano, Rita" sort="Formisano, Rita" uniqKey="Formisano R" first="Rita" last="Formisano">Rita Formisano</name><name sortKey="Nemmi, Federico" sort="Nemmi, Federico" uniqKey="Nemmi F" first="Federico" last="Nemmi">Federico Nemmi</name><name sortKey="Sabatini, Umberto" sort="Sabatini, Umberto" uniqKey="Sabatini U" first="Umberto" last="Sabatini">Umberto Sabatini</name></noCountry><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Peran, Patrice" sort="Peran, Patrice" uniqKey="Peran P" first="Patrice" last="Péran">Patrice Péran</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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