ParkinsonFranceV1, PubMed, Checkpoint, bibRecord, 000437

The pathogenesis of Pisa syndrome in Parkinson's disease.

Identifieur interne : 000437 ( PubMed/Checkpoint ); précédent : 000436; suivant : 000438

The pathogenesis of Pisa syndrome in Parkinson's disease.

Auteurs : Anna Castrioto [France] ; Céline Piscicelli ; Dominic Pérennou ; Paul Krack ; Bettina Debû

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:24909134

English descriptors

KwdEn :
- Animals, Basal Ganglia (pathology), Humans, Musculoskeletal System (physiopathology), Parkinson Disease (complications), Parkinson Disease (etiology), Postural Balance (physiology), Sensation Disorders (etiology), Sensation Disorders (pathology).
MESH :
- complications : Parkinson Disease.
- etiology : Parkinson Disease, Sensation Disorders.
- pathology : Basal Ganglia, Sensation Disorders.
- physiology : Postural Balance.
- physiopathology : Musculoskeletal System.
- Animals, Humans.

Abstract

Postural abnormalities such as postural deviations affect nearly all patients with advanced Parkinson's disease and represent an important source of disability. Although their existence has long been known, their management remains a challenge as they respond poorly to medication, brain surgery, or physiotherapy. Improving management strategies will require better understanding of the mechanisms underlying such postural deformities. In this review on the pathophysiology of Pisa syndrome, we examine the data supporting the central and peripheral hypotheses that attempt to explain these lateral trunk deviations. Although the pathophysiology is very probably multifactorial, the bulk of the data supports central, rather than peripheral, hypotheses. The central hypotheses that are best supported by both animal studies and clinical data include asymmetry of basal ganglia output and abnormalities in the central integration of sensory information. Further studies are needed to elucidate the pathophysiology underlying Pisa syndrome.

DOI: 10.1002/mds.25925
PubMed: 24909134

Affiliations:

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pubmed:24909134

Le document en format XML

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<term>Sensation Disorders (etiology)</term>
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<front><div type="abstract" xml:lang="en">Postural abnormalities such as postural deviations affect nearly all patients with advanced Parkinson's disease and represent an important source of disability. Although their existence has long been known, their management remains a challenge as they respond poorly to medication, brain surgery, or physiotherapy. Improving management strategies will require better understanding of the mechanisms underlying such postural deformities. In this review on the pathophysiology of Pisa syndrome, we examine the data supporting the central and peripheral hypotheses that attempt to explain these lateral trunk deviations. Although the pathophysiology is very probably multifactorial, the bulk of the data supports central, rather than peripheral, hypotheses. The central hypotheses that are best supported by both animal studies and clinical data include asymmetry of basal ganglia output and abnormalities in the central integration of sensory information. Further studies are needed to elucidate the pathophysiology underlying Pisa syndrome.</div>
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<Abstract><AbstractText>Postural abnormalities such as postural deviations affect nearly all patients with advanced Parkinson's disease and represent an important source of disability. Although their existence has long been known, their management remains a challenge as they respond poorly to medication, brain surgery, or physiotherapy. Improving management strategies will require better understanding of the mechanisms underlying such postural deformities. In this review on the pathophysiology of Pisa syndrome, we examine the data supporting the central and peripheral hypotheses that attempt to explain these lateral trunk deviations. Although the pathophysiology is very probably multifactorial, the bulk of the data supports central, rather than peripheral, hypotheses. The central hypotheses that are best supported by both animal studies and clinical data include asymmetry of basal ganglia output and abnormalities in the central integration of sensory information. Further studies are needed to elucidate the pathophysiology underlying Pisa syndrome.</AbstractText>
<CopyrightInformation>© 2014 International Parkinson and Movement Disorder Society.</CopyrightInformation>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

The pathogenesis of Pisa syndrome in Parkinson's disease.

The pathogenesis of Pisa syndrome in Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki