[Continuous subcutaneous infusion of apomorphine in Parkinson's disease: retrospective analysis of a series of 81 patients].
Identifieur interne : 000428 ( PubMed/Checkpoint ); précédent : 000427; suivant : 000429[Continuous subcutaneous infusion of apomorphine in Parkinson's disease: retrospective analysis of a series of 81 patients].
Auteurs : M. Rambour [France] ; C. Moreau [France] ; J. Salleron [France] ; D. Devos [France] ; A. Kreisler [France] ; E. Mutez [France] ; C. Simonin [France] ; A. Annic [France] ; K. Dujardin [France] ; A. Destée [France] ; L. Defebvre [France]Source :
- Revue neurologique [ 0035-3787 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Apomorphine (administration & dosage), Apomorphine (adverse effects), Apomorphine (therapeutic use), Dopamine Agonists (administration & dosage), Dopamine Agonists (adverse effects), Dopamine Agonists (therapeutic use), Drug Eruptions (etiology), Drug Evaluation, Female, Hallucinations (chemically induced), Humans, Infusions, Subcutaneous, Male, Middle Aged, Parkinson Disease (drug therapy), Patient Acceptance of Health Care, Quality of Life, Retrospective Studies, Severity of Illness Index, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Apomorphine, Dopamine Agonists.
- chemical , adverse effects : Antiparkinson Agents, Apomorphine, Dopamine Agonists.
- chemical , therapeutic use : Antiparkinson Agents, Apomorphine, Dopamine Agonists.
- chemically induced : Hallucinations.
- drug therapy : Parkinson Disease.
- etiology : Drug Eruptions.
- Adult, Aged, Drug Evaluation, Female, Humans, Infusions, Subcutaneous, Male, Middle Aged, Patient Acceptance of Health Care, Quality of Life, Retrospective Studies, Severity of Illness Index, Treatment Outcome.
Abstract
Continuous subcutaneous infusion of apomorphine (CAI) has shown efficacy in the treatment of motor fluctuations but its place in the therapeutic arsenal remains poorly defined in terms of indication, acceptability and long-term tolerance. Indeed, few studies have been carried out with a follow-up greater than 12 months. The main objective was to assess the quality of life of Parkinson's disease (PD) patients treated with CAI. We also evaluate the effectiveness on the motor fluctuations, the long-term tolerance of this treatment with its causes of discontinuation and the treatment regimens used.
DOI: 10.1016/j.neurol.2013.10.012
PubMed: 24594365
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Kreisler</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Mutez, E" sort="Mutez, E" uniqKey="Mutez E" first="E" last="Mutez">E. Mutez</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Simonin, C" sort="Simonin, C" uniqKey="Simonin C" first="C" last="Simonin">C. Simonin</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Annic, A" sort="Annic, A" uniqKey="Annic A" first="A" last="Annic">A. Annic</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Dujardin, K" sort="Dujardin, K" uniqKey="Dujardin K" first="K" last="Dujardin">K. Dujardin</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destée">A. Destée</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L" last="Defebvre">L. Defebvre</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24594365</idno><idno type="pmid">24594365</idno><idno type="doi">10.1016/j.neurol.2013.10.012</idno><idno type="wicri:Area/PubMed/Corpus">000611</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000611</idno><idno type="wicri:Area/PubMed/Curation">000589</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000589</idno><idno type="wicri:Area/PubMed/Checkpoint">000589</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000589</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Continuous subcutaneous infusion of apomorphine in Parkinson's disease: retrospective analysis of a series of 81 patients].</title><author><name sortKey="Rambour, M" sort="Rambour, M" uniqKey="Rambour M" first="M" last="Rambour">M. Rambour</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France. Electronic address: melie86@hotmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Moreau, C" sort="Moreau, C" uniqKey="Moreau C" first="C" last="Moreau">C. Moreau</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Salleron, J" sort="Salleron, J" uniqKey="Salleron J" first="J" last="Salleron">J. Salleron</name><affiliation wicri:level="3"><nlm:affiliation>EA 2694, service de biostatistiques, université Lille Nord de France, CHRU de Lille, rue Émile-Laine, 59037 Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA 2694, service de biostatistiques, université Lille Nord de France, CHRU de Lille, rue Émile-Laine, 59037 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Devos, D" sort="Devos, D" uniqKey="Devos D" first="D" last="Devos">D. Devos</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Kreisler, A" sort="Kreisler, A" uniqKey="Kreisler A" first="A" last="Kreisler">A. Kreisler</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Mutez, E" sort="Mutez, E" uniqKey="Mutez E" first="E" last="Mutez">E. Mutez</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Simonin, C" sort="Simonin, C" uniqKey="Simonin C" first="C" last="Simonin">C. Simonin</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Annic, A" sort="Annic, A" uniqKey="Annic A" first="A" last="Annic">A. Annic</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Dujardin, K" sort="Dujardin, K" uniqKey="Dujardin K" first="K" last="Dujardin">K. Dujardin</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destée">A. Destée</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L" last="Defebvre">L. Defebvre</name><affiliation wicri:level="3"><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">Revue neurologique</title><idno type="ISSN">0035-3787</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (adverse effects)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Apomorphine (administration & dosage)</term><term>Apomorphine (adverse effects)</term><term>Apomorphine (therapeutic use)</term><term>Dopamine Agonists (administration & dosage)</term><term>Dopamine Agonists (adverse effects)</term><term>Dopamine Agonists (therapeutic use)</term><term>Drug Eruptions (etiology)</term><term>Drug Evaluation</term><term>Female</term><term>Hallucinations (chemically induced)</term><term>Humans</term><term>Infusions, Subcutaneous</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Patient Acceptance of Health Care</term><term>Quality of Life</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Apomorphine</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Apomorphine</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Apomorphine</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Hallucinations</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Drug Eruptions</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Drug Evaluation</term><term>Female</term><term>Humans</term><term>Infusions, Subcutaneous</term><term>Male</term><term>Middle Aged</term><term>Patient Acceptance of Health Care</term><term>Quality of Life</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Continuous subcutaneous infusion of apomorphine (CAI) has shown efficacy in the treatment of motor fluctuations but its place in the therapeutic arsenal remains poorly defined in terms of indication, acceptability and long-term tolerance. Indeed, few studies have been carried out with a follow-up greater than 12 months. The main objective was to assess the quality of life of Parkinson's disease (PD) patients treated with CAI. We also evaluate the effectiveness on the motor fluctuations, the long-term tolerance of this treatment with its causes of discontinuation and the treatment regimens used.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24594365</PMID><DateCreated><Year>2014</Year><Month>04</Month><Day>04</Day></DateCreated><DateCompleted><Year>2014</Year><Month>11</Month><Day>24</Day></DateCompleted><DateRevised><Year>2014</Year><Month>04</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0035-3787</ISSN><JournalIssue CitedMedium="Internet"><Volume>170</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Revue neurologique</Title><ISOAbbreviation>Rev. Neurol. (Paris)</ISOAbbreviation></Journal><ArticleTitle>[Continuous subcutaneous infusion of apomorphine in Parkinson's disease: retrospective analysis of a series of 81 patients].</ArticleTitle><Pagination><MedlinePgn>205-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurol.2013.10.012</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0035-3787(14)00583-9</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Continuous subcutaneous infusion of apomorphine (CAI) has shown efficacy in the treatment of motor fluctuations but its place in the therapeutic arsenal remains poorly defined in terms of indication, acceptability and long-term tolerance. Indeed, few studies have been carried out with a follow-up greater than 12 months. The main objective was to assess the quality of life of Parkinson's disease (PD) patients treated with CAI. We also evaluate the effectiveness on the motor fluctuations, the long-term tolerance of this treatment with its causes of discontinuation and the treatment regimens used.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a retrospective study of 81 PD patients treated with CAI between April 2003 and June 2012. Data were collected from medical records. A repeated measures analysis of variance by the linear mixed model was used (significance level: 5%).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In August 2012, 27/81 patients were still treated with CAI with a mean duration of 28 months, 46/81 discontinued CAI (9 precociously), and 8 were lost to view. We didn't show improvement in the quality of life nor efficacy of CAI on the UPDRS IV score (P=0.54) and dyskinesia score (P=0.95). The CGI score patient also reflects this result with a majority response suggesting no significant change with CAI. We observed relative good cognitive and psychiatric tolerance. Adverse events were frequent but often benign. The average (±SD) rate of apomorphine was 3.15±1.71 mg/h and the oral dopaminergic treatment was decreased by 37.8%.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">The results are consistent with the literature except for the lack of efficiency on motor fluctuations which may be due to the use of too small doses of apomorphine. This seems to be a leading cause of discontinuation of CAI, especially when it is associated with side effects or important constraints. For better efficiency on motor fluctuations, we recommend the use of apomorphine at higher doses to obtain an optimal continuous dopaminergic stimulation.</AbstractText><CopyrightInformation>Copyright © 2014. Published by Elsevier Masson SAS.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rambour</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France. Electronic address: melie86@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreau</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salleron</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>EA 2694, service de biostatistiques, université Lille Nord de France, CHRU de Lille, rue Émile-Laine, 59037 Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Devos</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kreisler</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mutez</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simonin</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Annic</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dujardin</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Destée</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; Inserm, UMR 837, Team 6, JPArc, IRCL, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Defebvre</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Service de neurologie et pathologie du mouvement, hôpital Roger-Salengro, CHRU de Lille, rue Émile-Laine, 59037 Lille cedex, France; EA 4559, université Lille Nord de France, hôpital Roger-Salangro, rue Émile-Laine, 59037 Lille cedex, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Le traitement par apomorphine en perfusion continue sous-cutanée dans la maladie de Parkinson : analyse rétrospective d'une série de 81 patients.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Rev Neurol (Paris)</MedlineTA><NlmUniqueID>2984779R</NlmUniqueID><ISSNLinking>0035-3787</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018491">Dopamine Agonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>N21FAR7B4S</RegistryNumber><NameOfSubstance UI="D001058">Apomorphine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001058" MajorTopicYN="N">Apomorphine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018491" MajorTopicYN="N">Dopamine Agonists</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003875" MajorTopicYN="N">Drug Eruptions</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004341" MajorTopicYN="N">Drug Evaluation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006212" MajorTopicYN="N">Hallucinations</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055104" MajorTopicYN="N">Infusions, Subcutaneous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010342" MajorTopicYN="N">Patient Acceptance of Health Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Apomorphine</Keyword><Keyword MajorTopicYN="N">Maladie de Parkinson</Keyword><Keyword MajorTopicYN="N">Parkinson's Disease</Keyword><Keyword MajorTopicYN="N">Quality of life</Keyword><Keyword MajorTopicYN="N">Qualité de vie</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>05</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>09</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>10</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>3</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>3</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24594365</ArticleId><ArticleId IdType="pii">S0035-3787(14)00583-9</ArticleId><ArticleId IdType="doi">10.1016/j.neurol.2013.10.012</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Rambour, M" sort="Rambour, M" uniqKey="Rambour M" first="M" last="Rambour">M. Rambour</name></region><name sortKey="Annic, A" sort="Annic, A" uniqKey="Annic A" first="A" last="Annic">A. Annic</name><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L" last="Defebvre">L. Defebvre</name><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destée">A. Destée</name><name sortKey="Devos, D" sort="Devos, D" uniqKey="Devos D" first="D" last="Devos">D. Devos</name><name sortKey="Dujardin, K" sort="Dujardin, K" uniqKey="Dujardin K" first="K" last="Dujardin">K. Dujardin</name><name sortKey="Kreisler, A" sort="Kreisler, A" uniqKey="Kreisler A" first="A" last="Kreisler">A. Kreisler</name><name sortKey="Moreau, C" sort="Moreau, C" uniqKey="Moreau C" first="C" last="Moreau">C. Moreau</name><name sortKey="Mutez, E" sort="Mutez, E" uniqKey="Mutez E" first="E" last="Mutez">E. Mutez</name><name sortKey="Salleron, J" sort="Salleron, J" uniqKey="Salleron J" first="J" last="Salleron">J. Salleron</name><name sortKey="Simonin, C" sort="Simonin, C" uniqKey="Simonin C" first="C" last="Simonin">C. Simonin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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