Accuracy and cutoff values of delayed heart to mediastinum ratio with (123)I-metaiodobenzylguanidine cardiac scintigraphy for Lewy body disease diagnoses.
Identifieur interne : 000415 ( PubMed/Checkpoint ); précédent : 000414; suivant : 000416Accuracy and cutoff values of delayed heart to mediastinum ratio with (123)I-metaiodobenzylguanidine cardiac scintigraphy for Lewy body disease diagnoses.
Auteurs : Guillaume Lamotte [France] ; Rémy Morello [France] ; Adrien Lebasnier [France] ; Denis Agostini [France] ; Gilles L. Defer [France]Source :
- BMC neurology [ 1471-2377 ] ; 2015.
English descriptors
- KwdEn :
- 3-Iodobenzylguanidine (chemistry), Aged, Brain (diagnostic imaging), Female, Heart (diagnostic imaging), Humans, Lewy Body Disease (diagnostic imaging), Male, Mediastinum (diagnostic imaging), Middle Aged, Parkinson Disease (diagnostic imaging), Parkinsonian Disorders (diagnostic imaging), ROC Curve, Radiopharmaceuticals (chemistry), Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , chemistry : 3-Iodobenzylguanidine, Radiopharmaceuticals.
- diagnostic imaging : Brain, Heart, Lewy Body Disease, Mediastinum, Parkinson Disease, Parkinsonian Disorders.
- Aged, Female, Humans, Male, Middle Aged, ROC Curve, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon.
Abstract
Different studies have found diminished cardiac metaiodobenzylguanidine (MIBG) uptake in Lewy body (LB) related conditions (Parkinson's disease (PD) and Lewy body dementia (LBD)). However, delayed heart/mediastinum (d-H/M) ratio diagnostic cutoff points are debated in parkinsonian syndromes.
DOI: 10.1186/s12883-015-0338-9
PubMed: 25971430
Affiliations:
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pubmed:25971430Le document en format XML
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Defer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital of Caen, Avenue Côte de Nacre, 14033, Caen, Basse Normandie, France. defer-g@chu-caen.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital of Caen, Avenue Côte de Nacre, 14033, Caen, Basse Normandie</wicri:regionArea><wicri:noRegion>Basse Normandie</wicri:noRegion><wicri:noRegion>Basse Normandie</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC neurology</title><idno type="eISSN">1471-2377</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3-Iodobenzylguanidine (chemistry)</term><term>Aged</term><term>Brain (diagnostic imaging)</term><term>Female</term><term>Heart (diagnostic imaging)</term><term>Humans</term><term>Lewy Body Disease (diagnostic imaging)</term><term>Male</term><term>Mediastinum (diagnostic imaging)</term><term>Middle Aged</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinsonian Disorders (diagnostic imaging)</term><term>ROC Curve</term><term>Radiopharmaceuticals (chemistry)</term><term>Reproducibility of Results</term><term>Retrospective Studies</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>3-Iodobenzylguanidine</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Heart</term><term>Lewy Body Disease</term><term>Mediastinum</term><term>Parkinson Disease</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>ROC Curve</term><term>Reproducibility of Results</term><term>Retrospective Studies</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Different studies have found diminished cardiac metaiodobenzylguanidine (MIBG) uptake in Lewy body (LB) related conditions (Parkinson's disease (PD) and Lewy body dementia (LBD)). However, delayed heart/mediastinum (d-H/M) ratio diagnostic cutoff points are debated in parkinsonian syndromes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25971430</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>30</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2377</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><PubDate><Year>2015</Year><Month>May</Month><Day>15</Day></PubDate></JournalIssue><Title>BMC neurology</Title><ISOAbbreviation>BMC Neurol</ISOAbbreviation></Journal><ArticleTitle>Accuracy and cutoff values of delayed heart to mediastinum ratio with (123)I-metaiodobenzylguanidine cardiac scintigraphy for Lewy body disease diagnoses.</ArticleTitle><Pagination><MedlinePgn>83</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12883-015-0338-9</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Different studies have found diminished cardiac metaiodobenzylguanidine (MIBG) uptake in Lewy body (LB) related conditions (Parkinson's disease (PD) and Lewy body dementia (LBD)). However, delayed heart/mediastinum (d-H/M) ratio diagnostic cutoff points are debated in parkinsonian syndromes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We performed a monocentric retrospective analysis on 62 consecutive parkinsonian patients who underwent an (123)I-MIBG scintigraphy, brain imaging and dopaminergic imaging using (123)I-Ioflupane single photon emission computed tomography (SPECT) from 2009 to 2013. The optimal d-H/M ratio was determined from a Receiver Operating Characteristic (ROC) curve and the sensitivity (Se), specificity (Sp) and likelihood ratios (LR) were calculated. 42 patients were diagnosed with LB diseases (20 PD, 22 LBD) and 20 patients with other diseases.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">(123)I-MIBG scintigraphy helped to distinguish PD (p < 0.001) and LBD (p = 0.03) from other diseases. The optimal d-H/M ratio was 1.48 (0.85 area under the ROC curve). Se and Sp were 83.3 %, and 85 % respectively with positive and negative LR of 5.5 and 0.2 respectively. Patients with LBD had a lower d-H/M ratio than patients with PD (result not statistically significant) and a cutoff point at 1.2 could help to differentiate the two diseases. We did not find any correlation between the d-H/M ratio and clinical or (123)I-Ioflupane SPECT data.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">According to our population, the d-H/M ratio at 1.48 led to the best performance diagnosis with good Se, Sp and accuracy. In addition, a d-H/M ratio cutoff at 1.2 could help to differentiate PD from LBD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lamotte</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital of Caen, Avenue Côte de Nacre, 14033, Caen, Basse Normandie, France. guillaumelamotte14@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morello</LastName><ForeName>Rémy</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Statistics and Clinical Research, University Hospital of Caen, Caen, France. morello-r@chu-caen.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lebasnier</LastName><ForeName>Adrien</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine, University Hospital of Caen, Caen, EA 4650, France. adrien.lebasnier@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agostini</LastName><ForeName>Denis</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine, University Hospital of Caen, Caen, EA 4650, France. agostini-de@chu-caen.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Defer</LastName><ForeName>Gilles L</ForeName><Initials>GL</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital of Caen, Avenue Côte de Nacre, 14033, Caen, Basse Normandie, France. defer-g@chu-caen.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unité INSERM U 919, Sérine protéase et physiopathologie de l'Unité Neurovasculaire, GIP Cycéron, Université Caen Basse-Normandie, Caen, France. defer-g@chu-caen.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Neurol</MedlineTA><NlmUniqueID>100968555</NlmUniqueID><ISSNLinking>1471-2377</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>35MRW7B4AD</RegistryNumber><NameOfSubstance UI="D019797">3-Iodobenzylguanidine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Eur J Nucl Med Mol Imaging. 2010 Jan;37(1):3-11</RefSource><PMID Version="1">19626324</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2009 Nov;15(9):706-8</RefSource><PMID 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Version="1">18725592</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurol. 2009 Feb;16(2):174-82</RefSource><PMID Version="1">19146639</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Nucl Med Mol Imaging. 2010 Aug;37(9):1802-12</RefSource><PMID Version="1">20577740</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D019797" MajorTopicYN="N">3-Iodobenzylguanidine</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006321" MajorTopicYN="N">Heart</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020961" MajorTopicYN="N">Lewy Body Disease</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008482" MajorTopicYN="N">Mediastinum</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic 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IdType="pmc">PMC4448316</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Basse-Normandie</li><li>Région Normandie</li></region><settlement><li>Caen</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Lamotte, Guillaume" sort="Lamotte, Guillaume" uniqKey="Lamotte G" first="Guillaume" last="Lamotte">Guillaume Lamotte</name></noRegion><name sortKey="Agostini, Denis" sort="Agostini, Denis" uniqKey="Agostini D" first="Denis" last="Agostini">Denis Agostini</name><name sortKey="Defer, Gilles L" sort="Defer, Gilles L" uniqKey="Defer G" first="Gilles L" last="Defer">Gilles L. Defer</name><name sortKey="Lebasnier, Adrien" sort="Lebasnier, Adrien" uniqKey="Lebasnier A" first="Adrien" last="Lebasnier">Adrien Lebasnier</name><name sortKey="Morello, Remy" sort="Morello, Remy" uniqKey="Morello R" first="Rémy" last="Morello">Rémy Morello</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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