Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.
Identifieur interne : 000353 ( PubMed/Checkpoint ); précédent : 000352; suivant : 000354Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.
Auteurs : R S Desikan [États-Unis] ; A J Schork [États-Unis] ; Y. Wang [États-Unis] ; A. Witoelar [Norvège] ; M. Sharma [Allemagne] ; L K Mcevoy [États-Unis] ; D. Holland [États-Unis] ; J B Brewer [États-Unis] ; C-H Chen [États-Unis] ; W K Thompson [États-Unis] ; D. Harold [Royaume-Uni] ; J. Williams [Royaume-Uni] ; M J Owen [Royaume-Uni] ; M C O'Donovan [Royaume-Uni] ; M A Pericak-Vance [États-Unis] ; R. Mayeux [États-Unis] ; J L Haines [États-Unis] ; L A Farrer [États-Unis] ; G D Schellenberg [États-Unis] ; P. Heutink [Allemagne] ; A B Singleton [États-Unis] ; A. Brice [France] ; N W Wood [Royaume-Uni] ; J. Hardy [Royaume-Uni] ; M. Martinez [France] ; S H Choi [États-Unis] ; A. Destefano [États-Unis] ; M A Ikram [Pays-Bas] ; J C Bis [États-Unis] ; A. Smith [Islande] ; A L Fitzpatrick [États-Unis] ; L. Launer [États-Unis] ; C. Van Duijn [Pays-Bas] ; S. Seshadri [États-Unis] ; I D Ulstein [Norvège] ; D. Aarsland [Norvège] ; T. Fladby [Norvège] ; S. Djurovic [Norvège] ; B T Hyman [États-Unis] ; J. Snaedal [Islande] ; H. Stefansson [Islande] ; K. Stefansson [Islande] ; T. Gasser [Allemagne] ; O A Andreassen [Norvège] ; A M Dale [États-Unis]Source :
- Molecular psychiatry [ 1476-5578 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alleles, Alzheimer Disease (genetics), Apolipoproteins E (genetics), Brain (pathology), Chromosomes, Human, Pair 17, Female, Genetic Loci, Genetic Pleiotropy, Genome-Wide Association Study, Humans, Male, Middle Aged, Parkinson Disease (genetics), Polymorphism, Single Nucleotide, tau Proteins (genetics).
- MESH :
- chemical , genetics : Apolipoproteins E, tau Proteins.
- genetics : Alzheimer Disease, Parkinson Disease.
- pathology : Brain.
- Aged, Aged, 80 and over, Alleles, Chromosomes, Human, Pair 17, Female, Genetic Loci, Genetic Pleiotropy, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide.
Abstract
We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (total n=89 904 individuals), we sought to identify single nucleotide polymorphisms (SNPs) associating with both AD and PD. We found and replicated association of both AD and PD with the A allele of rs393152 within the extended MAPT region on chromosome 17 (meta analysis P-value across five independent AD cohorts=1.65 × 10(-7)). In independent datasets, we found a dose-dependent effect of the A allele of rs393152 on intra-cerebral MAPT transcript levels and volume loss within the entorhinal cortex and hippocampus. Our findings identify the tau-associated MAPT locus as a site of genetic overlap between AD and PD, and extending prior work, we show that the MAPT region increases risk of Alzheimer's neurodegeneration.
DOI: 10.1038/mp.2015.6
PubMed: 25687773
Affiliations:
- Allemagne, France, Islande, Norvège, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, Californie, District de Columbia, District de Tübingen, Floride, Grand Londres, Hollande-Méridionale, Maryland, Massachusetts, Midi-Pyrénées, Occitanie (région administrative), Pennsylvanie, Tennessee, Washington (État), État de New York, Île-de-France, Østlandet
- Londres, New York, Oslo, Paris, Rotterdam, Seattle, Toulouse, Tübingen
- Université Columbia, Université de Washington
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Wang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Witoelar, A" sort="Witoelar, A" uniqKey="Witoelar A" first="A" last="Witoelar">A. Witoelar</name><affiliation wicri:level="3"><nlm:affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Sharma, M" sort="Sharma, M" uniqKey="Sharma M" first="M" last="Sharma">M. Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen</wicri:regionArea><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion></affiliation></author><author><name sortKey="Mcevoy, L K" sort="Mcevoy, L K" uniqKey="Mcevoy L" first="L K" last="Mcevoy">L K Mcevoy</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Holland, D" sort="Holland, D" uniqKey="Holland D" first="D" last="Holland">D. Holland</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Brewer, J B" sort="Brewer, J B" uniqKey="Brewer J" first="J B" last="Brewer">J B Brewer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, C H" sort="Chen, C H" uniqKey="Chen C" first="C-H" last="Chen">C-H Chen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Thompson, W K" sort="Thompson, W K" uniqKey="Thompson W" first="W K" last="Thompson">W K Thompson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Harold, D" sort="Harold, D" uniqKey="Harold D" first="D" last="Harold">D. Harold</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Williams, J" sort="Williams, J" uniqKey="Williams J" first="J" last="Williams">J. Williams</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M J" last="Owen">M J Owen</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M C" last="O'Donovan">M C O'Donovan</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Pericak Vance, M A" sort="Pericak Vance, M A" uniqKey="Pericak Vance M" first="M A" last="Pericak-Vance">M A Pericak-Vance</name><affiliation wicri:level="2"><nlm:affiliation>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mayeux, R" sort="Mayeux, R" uniqKey="Mayeux R" first="R" last="Mayeux">R. Mayeux</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, and Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, and Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Haines, J L" sort="Haines, J L" uniqKey="Haines J" first="J L" last="Haines">J L Haines</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Farrer, L A" sort="Farrer, L A" uniqKey="Farrer L" first="L A" last="Farrer">L A Farrer</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Biostatistics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Biostatistics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schellenberg, G D" sort="Schellenberg, G D" uniqKey="Schellenberg G" first="G D" last="Schellenberg">G D Schellenberg</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P" last="Heutink">P. Heutink</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Paul-Ehrlich-Straße 15, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Paul-Ehrlich-Straße 15, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Singleton, A B" sort="Singleton, A B" uniqKey="Singleton A" first="A B" last="Singleton">A B Singleton</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name><affiliation wicri:level="3"><nlm:affiliation>Sorbonne Université, UPMC Univ Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Université, UPMC Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Wood, N W" sort="Wood, N W" uniqKey="Wood N" first="N W" last="Wood">N W Wood</name><affiliation wicri:level="3"><nlm:affiliation>UCL Genetics Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Genetics Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J" last="Hardy">J. Hardy</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Martinez, M" sort="Martinez, M" uniqKey="Martinez M" first="M" last="Martinez">M. Martinez</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMR1043, CPTP, CHU Purpan, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR1043, CPTP, CHU Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Choi, S H" sort="Choi, S H" uniqKey="Choi S" first="S H" last="Choi">S H Choi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, School of Public Health, Boston University, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Destefano, A" sort="Destefano, A" uniqKey="Destefano A" first="A" last="Destefano">A. Destefano</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, School of Public Health, Boston University, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name><affiliation wicri:level="3"><nlm:affiliation>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bis, J C" sort="Bis, J C" uniqKey="Bis J" first="J C" last="Bis">J C Bis</name><affiliation wicri:level="4"><nlm:affiliation>Deparment of Internal Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Deparment of Internal Medicine, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Smith, A" sort="Smith, A" uniqKey="Smith A" first="A" last="Smith">A. Smith</name><affiliation wicri:level="1"><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Fitzpatrick, A L" sort="Fitzpatrick, A L" uniqKey="Fitzpatrick A" first="A L" last="Fitzpatrick">A L Fitzpatrick</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Launer, L" sort="Launer, L" uniqKey="Launer L" first="L" last="Launer">L. Launer</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Van Duijn, C" sort="Van Duijn, C" uniqKey="Van Duijn C" first="C" last="Van Duijn">C. Van Duijn</name><affiliation wicri:level="3"><nlm:affiliation>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name><affiliation wicri:level="2"><nlm:affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ulstein, I D" sort="Ulstein, I D" uniqKey="Ulstein I" first="I D" last="Ulstein">I D Ulstein</name><affiliation wicri:level="3"><nlm:affiliation>Norwegian Centre for Dementia Research, Department of Old Age Psychiatry, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Norwegian Centre for Dementia Research, Department of Old Age Psychiatry, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D" last="Aarsland">D. Aarsland</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatric Psychiatry, Akershus University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Geriatric Psychiatry, Akershus University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Fladby, T" sort="Fladby, T" uniqKey="Fladby T" first="T" last="Fladby">T. Fladby</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Djurovic, S" sort="Djurovic, S" uniqKey="Djurovic S" first="S" last="Djurovic">S. Djurovic</name><affiliation wicri:level="3"><nlm:affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Hyman, B T" sort="Hyman, B T" uniqKey="Hyman B" first="B T" last="Hyman">B T Hyman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Massachusetts General Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Snaedal, J" sort="Snaedal, J" uniqKey="Snaedal J" first="J" last="Snaedal">J. Snaedal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Geriatric Medicine, University Hospital Reykjavik, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Geriatric Medicine, University Hospital Reykjavik, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, H" sort="Stefansson, H" uniqKey="Stefansson H" first="H" last="Stefansson">H. Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics/Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics/Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, K" sort="Stefansson, K" uniqKey="Stefansson K" first="K" last="Stefansson">K. Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics/Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics/Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name><affiliation wicri:level="1"><nlm:affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen</wicri:regionArea><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion></affiliation></author><author><name sortKey="Andreassen, O A" sort="Andreassen, O A" uniqKey="Andreassen O" first="O A" last="Andreassen">O A Andreassen</name><affiliation wicri:level="3"><nlm:affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Dale, A M" sort="Dale, A M" uniqKey="Dale A" first="A M" last="Dale">A M Dale</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25687773</idno><idno type="pmid">25687773</idno><idno type="doi">10.1038/mp.2015.6</idno><idno type="wicri:Area/PubMed/Corpus">000250</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000250</idno><idno type="wicri:Area/PubMed/Curation">000249</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000249</idno><idno type="wicri:Area/PubMed/Checkpoint">000249</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000249</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.</title><author><name sortKey="Desikan, R S" sort="Desikan, R S" uniqKey="Desikan R" first="R S" last="Desikan">R S Desikan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Schork, A J" sort="Schork, A J" uniqKey="Schork A" first="A J" last="Schork">A J Schork</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cognitive Science, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wang, Y" sort="Wang, Y" uniqKey="Wang Y" first="Y" last="Wang">Y. Wang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Witoelar, A" sort="Witoelar, A" uniqKey="Witoelar A" first="A" last="Witoelar">A. Witoelar</name><affiliation wicri:level="3"><nlm:affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Sharma, M" sort="Sharma, M" uniqKey="Sharma M" first="M" last="Sharma">M. Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen</wicri:regionArea><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion></affiliation></author><author><name sortKey="Mcevoy, L K" sort="Mcevoy, L K" uniqKey="Mcevoy L" first="L K" last="Mcevoy">L K Mcevoy</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Holland, D" sort="Holland, D" uniqKey="Holland D" first="D" last="Holland">D. Holland</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Brewer, J B" sort="Brewer, J B" uniqKey="Brewer J" first="J B" last="Brewer">J B Brewer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, C H" sort="Chen, C H" uniqKey="Chen C" first="C-H" last="Chen">C-H Chen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Thompson, W K" sort="Thompson, W K" uniqKey="Thompson W" first="W K" last="Thompson">W K Thompson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Harold, D" sort="Harold, D" uniqKey="Harold D" first="D" last="Harold">D. Harold</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Williams, J" sort="Williams, J" uniqKey="Williams J" first="J" last="Williams">J. Williams</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M J" last="Owen">M J Owen</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M C" last="O'Donovan">M C O'Donovan</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Pericak Vance, M A" sort="Pericak Vance, M A" uniqKey="Pericak Vance M" first="M A" last="Pericak-Vance">M A Pericak-Vance</name><affiliation wicri:level="2"><nlm:affiliation>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mayeux, R" sort="Mayeux, R" uniqKey="Mayeux R" first="R" last="Mayeux">R. Mayeux</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, and Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, and Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Haines, J L" sort="Haines, J L" uniqKey="Haines J" first="J L" last="Haines">J L Haines</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Physiology and Biophysics, Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Farrer, L A" sort="Farrer, L A" uniqKey="Farrer L" first="L A" last="Farrer">L A Farrer</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Biostatistics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Biostatistics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schellenberg, G D" sort="Schellenberg, G D" uniqKey="Schellenberg G" first="G D" last="Schellenberg">G D Schellenberg</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P" last="Heutink">P. Heutink</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Paul-Ehrlich-Straße 15, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Paul-Ehrlich-Straße 15, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Singleton, A B" sort="Singleton, A B" uniqKey="Singleton A" first="A B" last="Singleton">A B Singleton</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name><affiliation wicri:level="3"><nlm:affiliation>Sorbonne Université, UPMC Univ Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Université, UPMC Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Wood, N W" sort="Wood, N W" uniqKey="Wood N" first="N W" last="Wood">N W Wood</name><affiliation wicri:level="3"><nlm:affiliation>UCL Genetics Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Genetics Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J" last="Hardy">J. Hardy</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Martinez, M" sort="Martinez, M" uniqKey="Martinez M" first="M" last="Martinez">M. Martinez</name><affiliation wicri:level="3"><nlm:affiliation>INSERM UMR1043, CPTP, CHU Purpan, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR1043, CPTP, CHU Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Choi, S H" sort="Choi, S H" uniqKey="Choi S" first="S H" last="Choi">S H Choi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, School of Public Health, Boston University, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Destefano, A" sort="Destefano, A" uniqKey="Destefano A" first="A" last="Destefano">A. Destefano</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, School of Public Health, Boston University, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name><affiliation wicri:level="3"><nlm:affiliation>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bis, J C" sort="Bis, J C" uniqKey="Bis J" first="J C" last="Bis">J C Bis</name><affiliation wicri:level="4"><nlm:affiliation>Deparment of Internal Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Deparment of Internal Medicine, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Smith, A" sort="Smith, A" uniqKey="Smith A" first="A" last="Smith">A. Smith</name><affiliation wicri:level="1"><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Fitzpatrick, A L" sort="Fitzpatrick, A L" uniqKey="Fitzpatrick A" first="A L" last="Fitzpatrick">A L Fitzpatrick</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Launer, L" sort="Launer, L" uniqKey="Launer L" first="L" last="Launer">L. Launer</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Van Duijn, C" sort="Van Duijn, C" uniqKey="Van Duijn C" first="C" last="Van Duijn">C. Van Duijn</name><affiliation wicri:level="3"><nlm:affiliation>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name><affiliation wicri:level="2"><nlm:affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ulstein, I D" sort="Ulstein, I D" uniqKey="Ulstein I" first="I D" last="Ulstein">I D Ulstein</name><affiliation wicri:level="3"><nlm:affiliation>Norwegian Centre for Dementia Research, Department of Old Age Psychiatry, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Norwegian Centre for Dementia Research, Department of Old Age Psychiatry, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D" last="Aarsland">D. Aarsland</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatric Psychiatry, Akershus University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Geriatric Psychiatry, Akershus University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Fladby, T" sort="Fladby, T" uniqKey="Fladby T" first="T" last="Fladby">T. Fladby</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, University of Oslo, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Djurovic, S" sort="Djurovic, S" uniqKey="Djurovic S" first="S" last="Djurovic">S. Djurovic</name><affiliation wicri:level="3"><nlm:affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Hyman, B T" sort="Hyman, B T" uniqKey="Hyman B" first="B T" last="Hyman">B T Hyman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Massachusetts General Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Snaedal, J" sort="Snaedal, J" uniqKey="Snaedal J" first="J" last="Snaedal">J. Snaedal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Geriatric Medicine, University Hospital Reykjavik, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Geriatric Medicine, University Hospital Reykjavik, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, H" sort="Stefansson, H" uniqKey="Stefansson H" first="H" last="Stefansson">H. Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics/Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics/Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, K" sort="Stefansson, K" uniqKey="Stefansson K" first="K" last="Stefansson">K. Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE Genetics/Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE Genetics/Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name><affiliation wicri:level="1"><nlm:affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen</wicri:regionArea><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion></affiliation></author><author><name sortKey="Andreassen, O A" sort="Andreassen, O A" uniqKey="Andreassen O" first="O A" last="Andreassen">O A Andreassen</name><affiliation wicri:level="3"><nlm:affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Dale, A M" sort="Dale, A M" uniqKey="Dale A" first="A M" last="Dale">A M Dale</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Molecular psychiatry</title><idno type="eISSN">1476-5578</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Alzheimer Disease (genetics)</term><term>Apolipoproteins E (genetics)</term><term>Brain (pathology)</term><term>Chromosomes, Human, Pair 17</term><term>Female</term><term>Genetic Loci</term><term>Genetic Pleiotropy</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Single Nucleotide</term><term>tau Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Chromosomes, Human, Pair 17</term><term>Female</term><term>Genetic Loci</term><term>Genetic Pleiotropy</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (total n=89 904 individuals), we sought to identify single nucleotide polymorphisms (SNPs) associating with both AD and PD. We found and replicated association of both AD and PD with the A allele of rs393152 within the extended MAPT region on chromosome 17 (meta analysis P-value across five independent AD cohorts=1.65 × 10(-7)). In independent datasets, we found a dose-dependent effect of the A allele of rs393152 on intra-cerebral MAPT transcript levels and volume loss within the entorhinal cortex and hippocampus. Our findings identify the tau-associated MAPT locus as a site of genetic overlap between AD and PD, and extending prior work, we show that the MAPT region increases risk of Alzheimer's neurodegeneration.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25687773</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>20</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>29</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-5578</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>12</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Molecular psychiatry</Title><ISOAbbreviation>Mol. Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.</ArticleTitle><Pagination><MedlinePgn>1588-95</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/mp.2015.6</ELocationID><Abstract><AbstractText>We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (total n=89 904 individuals), we sought to identify single nucleotide polymorphisms (SNPs) associating with both AD and PD. We found and replicated association of both AD and PD with the A allele of rs393152 within the extended MAPT region on chromosome 17 (meta analysis P-value across five independent AD cohorts=1.65 × 10(-7)). In independent datasets, we found a dose-dependent effect of the A allele of rs393152 on intra-cerebral MAPT transcript levels and volume loss within the entorhinal cortex and hippocampus. Our findings identify the tau-associated MAPT locus as a site of genetic overlap between AD and PD, and extending prior work, we show that the MAPT region increases risk of Alzheimer's neurodegeneration.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Desikan</LastName><ForeName>R S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schork</LastName><ForeName>A J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witoelar</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McEvoy</LastName><ForeName>L K</ForeName><Initials>LK</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holland</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brewer</LastName><ForeName>J B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>C-H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>W K</ForeName><Initials>WK</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harold</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Owen</LastName><ForeName>M J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Donovan</LastName><ForeName>M C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Wales, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pericak-Vance</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayeux</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, and Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haines</LastName><ForeName>J L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Molecular Physiology and Biophysics, Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farrer</LastName><ForeName>L A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Biostatistics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schellenberg</LastName><ForeName>G D</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heutink</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Paul-Ehrlich-Straße 15, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singleton</LastName><ForeName>A B</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brice</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sorbonne Université, UPMC Univ Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wood</LastName><ForeName>N W</ForeName><Initials>NW</Initials><AffiliationInfo><Affiliation>UCL Genetics Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hardy</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martinez</LastName><ForeName>M</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2180-4537</Identifier><AffiliationInfo><Affiliation>INSERM UMR1043, CPTP, CHU Purpan, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>S H</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DeStefano</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ikram</LastName><ForeName>M A</ForeName><Initials>MA</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-0372-8585</Identifier><AffiliationInfo><Affiliation>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bis</LastName><ForeName>J C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Deparment of Internal Medicine, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kopavogur, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fitzpatrick</LastName><ForeName>A L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Launer</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Washington, DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Duijn</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Deparment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seshadri</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ulstein</LastName><ForeName>I D</ForeName><Initials>ID</Initials><AffiliationInfo><Affiliation>Norwegian Centre for Dementia Research, Department of Old Age Psychiatry, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aarsland</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Geriatric Psychiatry, Akershus University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Alzheimer's Disease Research Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fladby</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, University of Oslo, Oslo, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Akershus University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Djurovic</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hyman</LastName><ForeName>B T</ForeName><Initials>BT</Initials><AffiliationInfo><Affiliation>Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snaedal</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Geriatric Medicine, University Hospital Reykjavik, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stefansson</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>deCODE Genetics/Amgen, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stefansson</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>deCODE Genetics/Amgen, Reykjavik, Iceland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gasser</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of Tubingen, Tubingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andreassen</LastName><ForeName>O A</ForeName><Initials>OA</Initials><AffiliationInfo><Affiliation>NORMENT; Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dale</LastName><ForeName>A M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>ADNI, ADGC, GERAD, CHARGE and IPDGC Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 MH100351</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MR/K013041/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 AG031224</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 AG005131</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 GM104400</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 AG021886</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G-0907</GrantID><Agency>Parkinson's UK</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>K01AG029218</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AG032984</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AG031224</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 EB005970</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24-AG041689</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR001108</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K02NS067427</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 AG041689</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UO1AG032984</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG033193</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 AG025688</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K02 NS067427</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HD061414</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MR/L010305/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01HD061414</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K01 AG029218</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RC2 DA029475</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RC2DA029475</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AG049505</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>02</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mol Psychiatry</MedlineTA><NlmUniqueID>9607835</NlmUniqueID><ISSNLinking>1359-4184</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001057">Apolipoproteins E</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C054369">MAPT protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016875">tau Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2007 Mar;25(3):561-70</RefSource><PMID Version="1">17174556</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2009 Dec;41(12):1303-7</RefSource><PMID Version="1">19915576</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 1990 Feb 5;109(1-2):68-75</RefSource><PMID Version="1">2138261</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 1991;82(4):239-59</RefSource><PMID Version="1">1759558</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2005 Aug 15;14(16):2399-404</RefSource><PMID Version="1">16000317</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 2006 Apr;65(4):387-95</RefSource><PMID Version="1">16691119</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R188-95</RefSource><PMID Version="1">16987883</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2011 Oct;70(4):657-61</RefSource><PMID Version="1">22002658</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2012;28(2):377-87</RefSource><PMID Version="1">22027014</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2012 Apr;33(4):838.e7-11</RefSource><PMID Version="1">22221882</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2012 Mar 16;148(6):1204-22</RefSource><PMID Version="1">22424230</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2012;8(6):e1002707</RefSource><PMID Version="1">22685416</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2012 Aug 1;21(15):3500-12</RefSource><PMID Version="1">22556362</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2012 Aug 2;488(7409):96-9</RefSource><PMID Version="1">22801501</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2012 Jun;69(6):709-13</RefSource><PMID Version="1">22529247</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2012 Sep 15;21(18):4094-103</RefSource><PMID Version="1">22723018</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2013 Jan 10;368(2):107-16</RefSource><PMID Version="1">23150908</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2013;33(4):1009-19</RefSource><PMID Version="1">23064258</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2013 Feb 7;92(2):197-209</RefSource><PMID Version="1">23375658</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AJNR Am J Neuroradiol. 2013 Mar;34(3):505-10</RefSource><PMID Version="1">22976236</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2013 Apr;9(4):e1003455</RefSource><PMID Version="1">23637625</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2013 Jun;12(6):609-22</RefSource><PMID Version="1">23684085</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2013 Jun;45(6):670-5</RefSource><PMID Version="1">23603763</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2013 Dec;45(12):1452-8</RefSource><PMID Version="1">24162737</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA Neurol. 2013 Oct;70(10):1268-76</RefSource><PMID Version="1">23921447</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2003 Apr 3;348(14):1356-64</RefSource><PMID Version="1">12672864</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Genet. 2007;8:3</RefSource><PMID Version="1">17266761</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2009 Dec;41(12):1261-2</RefSource><PMID Version="1">19935760</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Med Genet B Neuropsychiatr Genet. 2009 Dec 5;150B(8):1152-5</RefSource><PMID Version="1">19308965</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2010 May 12;303(18):1832-40</RefSource><PMID Version="1">20460622</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2010 Sep 1;26(17):2190-1</RefSource><PMID Version="1">20616382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2011 Feb 19;377(9766):641-9</RefSource><PMID Version="1">21292315</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2011 Feb;7(2):e1001308</RefSource><PMID Version="1">21379329</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2011 May;43(5):436-41</RefSource><PMID Version="1">21460841</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2011;25(3):395-415</RefSource><PMID Version="1">21441655</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2007 Mar;64(3):343-9</RefSource><PMID Version="1">17210801</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stat Med. 2007 May 30;26(12):2465-78</RefSource><PMID Version="1">17054103</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2007 Aug 14;69(7):631-9</RefSource><PMID Version="1">17698783</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Hum Genet. 2009 Mar;17(3):287-94</RefSource><PMID Version="1">18854867</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2009 Apr;84(4):445-58</RefSource><PMID Version="1">19361613</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2009 Oct;41(10):1088-93</RefSource><PMID Version="1">19734902</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2009 Oct;41(10):1094-9</RefSource><PMID Version="1">19734903</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2009 Dec;41(12):1308-12</RefSource><PMID Version="1">19915575</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13790-4</RefSource><PMID Version="1">25201988</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" 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Williams</name><name sortKey="Wood, N W" sort="Wood, N W" uniqKey="Wood N" first="N W" last="Wood">N W Wood</name></country><country name="France"><region name="Île-de-France"><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name></region><name sortKey="Martinez, M" sort="Martinez, M" uniqKey="Martinez M" first="M" last="Martinez">M. Martinez</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name></region><name sortKey="Van Duijn, C" sort="Van Duijn, C" uniqKey="Van Duijn C" first="C" last="Van Duijn">C. Van Duijn</name></country><country name="Islande"><noRegion><name sortKey="Smith, A" sort="Smith, A" uniqKey="Smith A" first="A" last="Smith">A. Smith</name></noRegion><name sortKey="Snaedal, J" sort="Snaedal, J" uniqKey="Snaedal J" first="J" last="Snaedal">J. Snaedal</name><name sortKey="Stefansson, H" sort="Stefansson, H" uniqKey="Stefansson H" first="H" last="Stefansson">H. Stefansson</name><name sortKey="Stefansson, K" sort="Stefansson, K" uniqKey="Stefansson K" first="K" last="Stefansson">K. Stefansson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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