Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation.
Identifieur interne : 000331 ( PubMed/Checkpoint ); précédent : 000330; suivant : 000332Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation.
Auteurs : Xavier Lévêque [France] ; Elodie Mathieux ; Véronique Nerrière-Daguin ; Reynald Thinard ; Laetitia Kermarrec ; Tony Durand ; Thomas Haudebourg ; Bernard Vanhove ; Laurent Lescaudron ; Isabelle Neveu ; Philippe NaveilhanSource :
- Journal of cellular and molecular medicine [ 1582-4934 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Antigens, CD11b (metabolism), Brain (immunology), Cell Survival, Chemokines (genetics), Chemokines (metabolism), Glial Fibrillary Acidic Protein (genetics), Glial Fibrillary Acidic Protein (metabolism), Graft Survival (immunology), Immunity, Immunity, Cellular, Immunocompetence, Male, Mesencephalon (cytology), Mesenchymal Stem Cell Transplantation, Mesenchymal Stromal Cells (cytology), Molecular Sequence Data, Motor Activity, Neurons (cytology), Neurons (metabolism), Neurons (transplantation), Oxidopamine, RNA, Messenger (genetics), RNA, Messenger (metabolism), Rats, Inbred Lew, Recovery of Function, Sus scrofa, Transplantation, Heterologous.
- MESH :
- chemical , genetics : Chemokines, Glial Fibrillary Acidic Protein, RNA, Messenger.
- chemical , metabolism : Antigens, CD11b, Chemokines, Glial Fibrillary Acidic Protein, RNA, Messenger.
- cytology : Mesencephalon, Mesenchymal Stromal Cells, Neurons.
- immunology : Brain, Graft Survival.
- metabolism : Neurons.
- transplantation : Neurons.
- Animals, Cell Survival, Immunity, Immunity, Cellular, Immunocompetence, Male, Mesenchymal Stem Cell Transplantation, Molecular Sequence Data, Motor Activity, Oxidopamine, Rats, Inbred Lew, Recovery of Function, Sus scrofa, Transplantation, Heterologous.
Abstract
Foetal pig neuroblasts are interesting candidates as a cell source for transplantation, but xenotransplantation in the brain requires the development of adapted immunosuppressive treatments. As systemic administration of high doses of cyclosporine A has side effects and does not protect xenotransplants forever, we focused our work on local control of the host immune responses. We studied the advantage of cotransplanting syngenic mesenchymal stem cells (MSC) with porcine neuroblasts (pNb) in immunocompetent rat striata. Two groups of animals were transplanted, either with pNb alone or with both MSC and pNb. At day 63, no porcine neurons were detected in the striata that received only pNb, while four of six rats transplanted with both pNb and MSC exhibited healthy porcine neurons. Interestingly, 50% of the cotransplanted rats displayed healthy grafts with pNF70+ and TH+ neurons at 120 days post-transplantation. qPCR analyses revealed a general dwindling of pro- and anti-inflammatory cytokines in the striata that received the cotransplants. Motor recovery was also observed following the transplantation of pNb and MSC in a rat model of Parkinson's disease. Taken together, the present data indicate that the immunosuppressive properties of MSC are of great interest for the long-term survival of xenogeneic neurons in the brain.
DOI: 10.1111/jcmm.12414
PubMed: 25310920
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:25310920Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation.</title><author><name sortKey="Leveque, Xavier" sort="Leveque, Xavier" uniqKey="Leveque X" first="Xavier" last="Lévêque">Xavier Lévêque</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, UMR 1064, Nantes, France; CHU de Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France; Faculté de Médecine, Université de Nantes, LUNAM Université, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR 1064, Nantes, France; CHU de Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France; Faculté de Médecine, Université de Nantes, LUNAM Université, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Mathieux, Elodie" sort="Mathieux, Elodie" uniqKey="Mathieux E" first="Elodie" last="Mathieux">Elodie Mathieux</name></author><author><name sortKey="Nerriere Daguin, Veronique" sort="Nerriere Daguin, Veronique" uniqKey="Nerriere Daguin V" first="Véronique" last="Nerrière-Daguin">Véronique Nerrière-Daguin</name></author><author><name sortKey="Thinard, Reynald" sort="Thinard, Reynald" uniqKey="Thinard R" first="Reynald" last="Thinard">Reynald Thinard</name></author><author><name sortKey="Kermarrec, Laetitia" sort="Kermarrec, Laetitia" uniqKey="Kermarrec L" first="Laetitia" last="Kermarrec">Laetitia Kermarrec</name></author><author><name sortKey="Durand, Tony" sort="Durand, Tony" uniqKey="Durand T" first="Tony" last="Durand">Tony Durand</name></author><author><name sortKey="Haudebourg, Thomas" sort="Haudebourg, Thomas" uniqKey="Haudebourg T" first="Thomas" last="Haudebourg">Thomas Haudebourg</name></author><author><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name></author><author><name sortKey="Lescaudron, Laurent" sort="Lescaudron, Laurent" uniqKey="Lescaudron L" first="Laurent" last="Lescaudron">Laurent Lescaudron</name></author><author><name sortKey="Neveu, Isabelle" sort="Neveu, Isabelle" uniqKey="Neveu I" first="Isabelle" last="Neveu">Isabelle Neveu</name></author><author><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25310920</idno><idno type="pmid">25310920</idno><idno type="doi">10.1111/jcmm.12414</idno><idno type="wicri:Area/PubMed/Corpus">000428</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000428</idno><idno type="wicri:Area/PubMed/Curation">000420</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000420</idno><idno type="wicri:Area/PubMed/Checkpoint">000420</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000420</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation.</title><author><name sortKey="Leveque, Xavier" sort="Leveque, Xavier" uniqKey="Leveque X" first="Xavier" last="Lévêque">Xavier Lévêque</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, UMR 1064, Nantes, France; CHU de Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France; Faculté de Médecine, Université de Nantes, LUNAM Université, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR 1064, Nantes, France; CHU de Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France; Faculté de Médecine, Université de Nantes, LUNAM Université, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Mathieux, Elodie" sort="Mathieux, Elodie" uniqKey="Mathieux E" first="Elodie" last="Mathieux">Elodie Mathieux</name></author><author><name sortKey="Nerriere Daguin, Veronique" sort="Nerriere Daguin, Veronique" uniqKey="Nerriere Daguin V" first="Véronique" last="Nerrière-Daguin">Véronique Nerrière-Daguin</name></author><author><name sortKey="Thinard, Reynald" sort="Thinard, Reynald" uniqKey="Thinard R" first="Reynald" last="Thinard">Reynald Thinard</name></author><author><name sortKey="Kermarrec, Laetitia" sort="Kermarrec, Laetitia" uniqKey="Kermarrec L" first="Laetitia" last="Kermarrec">Laetitia Kermarrec</name></author><author><name sortKey="Durand, Tony" sort="Durand, Tony" uniqKey="Durand T" first="Tony" last="Durand">Tony Durand</name></author><author><name sortKey="Haudebourg, Thomas" sort="Haudebourg, Thomas" uniqKey="Haudebourg T" first="Thomas" last="Haudebourg">Thomas Haudebourg</name></author><author><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name></author><author><name sortKey="Lescaudron, Laurent" sort="Lescaudron, Laurent" uniqKey="Lescaudron L" first="Laurent" last="Lescaudron">Laurent Lescaudron</name></author><author><name sortKey="Neveu, Isabelle" sort="Neveu, Isabelle" uniqKey="Neveu I" first="Isabelle" last="Neveu">Isabelle Neveu</name></author><author><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name></author></analytic><series><title level="j">Journal of cellular and molecular medicine</title><idno type="eISSN">1582-4934</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, CD11b (metabolism)</term><term>Brain (immunology)</term><term>Cell Survival</term><term>Chemokines (genetics)</term><term>Chemokines (metabolism)</term><term>Glial Fibrillary Acidic Protein (genetics)</term><term>Glial Fibrillary Acidic Protein (metabolism)</term><term>Graft Survival (immunology)</term><term>Immunity</term><term>Immunity, Cellular</term><term>Immunocompetence</term><term>Male</term><term>Mesencephalon (cytology)</term><term>Mesenchymal Stem Cell Transplantation</term><term>Mesenchymal Stromal Cells (cytology)</term><term>Molecular Sequence Data</term><term>Motor Activity</term><term>Neurons (cytology)</term><term>Neurons (metabolism)</term><term>Neurons (transplantation)</term><term>Oxidopamine</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Rats, Inbred Lew</term><term>Recovery of Function</term><term>Sus scrofa</term><term>Transplantation, Heterologous</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chemokines</term><term>Glial Fibrillary Acidic Protein</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD11b</term><term>Chemokines</term><term>Glial Fibrillary Acidic Protein</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mesencephalon</term><term>Mesenchymal Stromal Cells</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brain</term><term>Graft Survival</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Survival</term><term>Immunity</term><term>Immunity, Cellular</term><term>Immunocompetence</term><term>Male</term><term>Mesenchymal Stem Cell Transplantation</term><term>Molecular Sequence Data</term><term>Motor Activity</term><term>Oxidopamine</term><term>Rats, Inbred Lew</term><term>Recovery of Function</term><term>Sus scrofa</term><term>Transplantation, Heterologous</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Foetal pig neuroblasts are interesting candidates as a cell source for transplantation, but xenotransplantation in the brain requires the development of adapted immunosuppressive treatments. As systemic administration of high doses of cyclosporine A has side effects and does not protect xenotransplants forever, we focused our work on local control of the host immune responses. We studied the advantage of cotransplanting syngenic mesenchymal stem cells (MSC) with porcine neuroblasts (pNb) in immunocompetent rat striata. Two groups of animals were transplanted, either with pNb alone or with both MSC and pNb. At day 63, no porcine neurons were detected in the striata that received only pNb, while four of six rats transplanted with both pNb and MSC exhibited healthy porcine neurons. Interestingly, 50% of the cotransplanted rats displayed healthy grafts with pNF70+ and TH+ neurons at 120 days post-transplantation. qPCR analyses revealed a general dwindling of pro- and anti-inflammatory cytokines in the striata that received the cotransplants. Motor recovery was also observed following the transplantation of pNb and MSC in a rat model of Parkinson's disease. Taken together, the present data indicate that the immunosuppressive properties of MSC are of great interest for the long-term survival of xenogeneic neurons in the brain.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25310920</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>30</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1582-4934</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of cellular and molecular medicine</Title><ISOAbbreviation>J. Cell. Mol. Med.</ISOAbbreviation></Journal><ArticleTitle>Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation.</ArticleTitle><Pagination><MedlinePgn>124-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jcmm.12414</ELocationID><Abstract><AbstractText>Foetal pig neuroblasts are interesting candidates as a cell source for transplantation, but xenotransplantation in the brain requires the development of adapted immunosuppressive treatments. As systemic administration of high doses of cyclosporine A has side effects and does not protect xenotransplants forever, we focused our work on local control of the host immune responses. We studied the advantage of cotransplanting syngenic mesenchymal stem cells (MSC) with porcine neuroblasts (pNb) in immunocompetent rat striata. Two groups of animals were transplanted, either with pNb alone or with both MSC and pNb. At day 63, no porcine neurons were detected in the striata that received only pNb, while four of six rats transplanted with both pNb and MSC exhibited healthy porcine neurons. Interestingly, 50% of the cotransplanted rats displayed healthy grafts with pNF70+ and TH+ neurons at 120 days post-transplantation. qPCR analyses revealed a general dwindling of pro- and anti-inflammatory cytokines in the striata that received the cotransplants. Motor recovery was also observed following the transplantation of pNb and MSC in a rat model of Parkinson's disease. Taken together, the present data indicate that the immunosuppressive properties of MSC are of great interest for the long-term survival of xenogeneic neurons in the brain.</AbstractText><CopyrightInformation>© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lévêque</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>INSERM, UMR 1064, Nantes, France; CHU de Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France; Faculté de Médecine, Université de Nantes, LUNAM Université, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathieux</LastName><ForeName>Elodie</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Nerrière-Daguin</LastName><ForeName>Véronique</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Thinard</LastName><ForeName>Reynald</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Kermarrec</LastName><ForeName>Laetitia</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Durand</LastName><ForeName>Tony</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Haudebourg</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Vanhove</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Lescaudron</LastName><ForeName>Laurent</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Neveu</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Naveilhan</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>NM012583</AccessionNumber><AccessionNumber>NM012611</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>10</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Cell Mol Med</MedlineTA><NlmUniqueID>101083777</NlmUniqueID><ISSNLinking>1582-1838</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D039481">Antigens, CD11b</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018925">Chemokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005904">Glial Fibrillary Acidic Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>8HW4YBZ748</RegistryNumber><NameOfSubstance UI="D016627">Oxidopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Cell Transplant. 2000 Mar-Apr;9(2):273-8</RefSource><PMID Version="1">10811399</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Transplant. 2000 Mar-Apr;9(2):261-72</RefSource><PMID Version="1">10811398</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Xenotransplantation. 2001 May;8(2):136-48</RefSource><PMID Version="1">11328584</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci Res. 2002 May 1;68(3):284-92</RefSource><PMID Version="1">12111858</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 1989;77(2):329-36</RefSource><PMID Version="1">2571515</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1991 Jul 1;147(1):144-8</RefSource><PMID Version="1">1904899</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol. 1994 Sep;267(3 Pt 2):H931-7</RefSource><PMID Version="1">7522408</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 1996 Jul;140(1):1-13</RefSource><PMID Version="1">8682173</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 1996 Aug 1;88(3):1113-21</RefSource><PMID Version="1">8704222</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 1997 Mar;3(3):350-3</RefSource><PMID Version="1">9055867</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1998 Mar 15;160(6):2940-6</RefSource><PMID Version="1">9510198</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3908-13</RefSource><PMID Version="1">9520466</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2005 Sep 1;106(5):1755-61</RefSource><PMID Version="1">15905186</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Blood Marrow Transplant. 2005 Dec;11(12):1031-2</RefSource><PMID Version="1">16338626</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2006 Jan 1;107(1):367-72</RefSource><PMID Version="1">16141348</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2006 Nov;202(1):76-84</RefSource><PMID Version="1">16824519</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2007;2(1):e166</RefSource><PMID Version="1">17245442</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Immunol. 2007 May;28(5):219-26</RefSource><PMID Version="1">17400510</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Stem Cell. 2008 Feb 7;2(2):141-50</RefSource><PMID Version="1">18371435</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2008 Sep;8(9):726-36</RefSource><PMID Version="1">19172693</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Mol Med. 2009 Aug;13(8B):2547-58</RefSource><PMID Version="1">20141619</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Transplantation. 2010 Apr 15;89(7):816-23</RefSource><PMID Version="1">20216486</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Transgenic Res. 2010 Oct;19(5):745-63</RefSource><PMID Version="1">20094912</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2011 Jul;230(1):35-47</RefSource><PMID Version="1">20470774</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Methods Mol Biol. 2012;879:147-64</RefSource><PMID Version="1">22610559</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2000 Mar 14;54(5):1042-50</RefSource><PMID Version="1">10720272</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropharmacology. 2000 Mar 3;39(5):777-87</RefSource><PMID Version="1">10699444</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stem Cells. 2012 Oct;30(10):2342-53</RefSource><PMID Version="1">22888011</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Scand J Immunol. 2000 Sep;52(3):249-56</RefSource><PMID Version="1">10972900</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D039481" MajorTopicYN="N">Antigens, CD11b</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018925" MajorTopicYN="N">Chemokines</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005904" MajorTopicYN="N">Glial Fibrillary Acidic Protein</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006085" MajorTopicYN="N">Graft Survival</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007109" MajorTopicYN="Y">Immunity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007111" MajorTopicYN="N">Immunity, Cellular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007121" MajorTopicYN="N">Immunocompetence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008636" MajorTopicYN="N">Mesencephalon</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045164" MajorTopicYN="Y">Mesenchymal Stem Cell Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059630" MajorTopicYN="N">Mesenchymal Stromal Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009043" MajorTopicYN="N">Motor Activity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000637" MajorTopicYN="N">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016627" MajorTopicYN="N">Oxidopamine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011917" MajorTopicYN="N">Rats, Inbred Lew</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020127" MajorTopicYN="N">Recovery of Function</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D034421" MajorTopicYN="N">Sus scrofa</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014183" MajorTopicYN="Y">Transplantation, Heterologous</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4288356</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson</Keyword><Keyword MajorTopicYN="N">T cells</Keyword><Keyword MajorTopicYN="N">brain transplantation</Keyword><Keyword MajorTopicYN="N">immunosuppression</Keyword><Keyword MajorTopicYN="N">mesenchymal stem cells</Keyword><Keyword MajorTopicYN="N">rejection</Keyword><Keyword MajorTopicYN="N">restorative strategies</Keyword><Keyword MajorTopicYN="N">survival</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>02</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>07</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25310920</ArticleId><ArticleId IdType="doi">10.1111/jcmm.12414</ArticleId><ArticleId IdType="pmc">PMC4288356</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement><orgName><li>Université de Nantes</li></orgName></list><tree><noCountry><name sortKey="Durand, Tony" sort="Durand, Tony" uniqKey="Durand T" first="Tony" last="Durand">Tony Durand</name><name sortKey="Haudebourg, Thomas" sort="Haudebourg, Thomas" uniqKey="Haudebourg T" first="Thomas" last="Haudebourg">Thomas Haudebourg</name><name sortKey="Kermarrec, Laetitia" sort="Kermarrec, Laetitia" uniqKey="Kermarrec L" first="Laetitia" last="Kermarrec">Laetitia Kermarrec</name><name sortKey="Lescaudron, Laurent" sort="Lescaudron, Laurent" uniqKey="Lescaudron L" first="Laurent" last="Lescaudron">Laurent Lescaudron</name><name sortKey="Mathieux, Elodie" sort="Mathieux, Elodie" uniqKey="Mathieux E" first="Elodie" last="Mathieux">Elodie Mathieux</name><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name><name sortKey="Nerriere Daguin, Veronique" sort="Nerriere Daguin, Veronique" uniqKey="Nerriere Daguin V" first="Véronique" last="Nerrière-Daguin">Véronique Nerrière-Daguin</name><name sortKey="Neveu, Isabelle" sort="Neveu, Isabelle" uniqKey="Neveu I" first="Isabelle" last="Neveu">Isabelle Neveu</name><name sortKey="Thinard, Reynald" sort="Thinard, Reynald" uniqKey="Thinard R" first="Reynald" last="Thinard">Reynald Thinard</name><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name></noCountry><country name="France"><region name="Pays de la Loire"><name sortKey="Leveque, Xavier" sort="Leveque, Xavier" uniqKey="Leveque X" first="Xavier" last="Lévêque">Xavier Lévêque</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000331 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000331 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:25310920
|texte= Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:25310920" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |