[Therapeutic potential of optogenetic neuromodulation].
Identifieur interne : 000231 ( PubMed/Checkpoint ); précédent : 000230; suivant : 000232[Therapeutic potential of optogenetic neuromodulation].
Auteurs : Marie Vandecasteele [France] ; Yann-Suhan Senova [France] ; Stéphane Palfi [France] ; Guillaume P. Dugué [France]Source :
- Medecine sciences : M/S [ 0767-0974 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Epilepsy (therapy), Genetic Vectors, Humans, Light, Mental Disorders (therapy), Mice, Mice, Transgenic, Nerve Tissue (metabolism), Nerve Tissue (radiation effects), Neurotransmitter Agents (genetics), Neurotransmitter Agents (therapeutic use), Optogenetics (methods), Parkinson Disease (therapy), Viruses (genetics).
- MESH :
- chemical , genetics : Neurotransmitter Agents.
- genetics : Viruses.
- metabolism : Nerve Tissue.
- methods : Optogenetics.
- radiation effects : Nerve Tissue.
- chemical , therapeutic use : Neurotransmitter Agents.
- therapy : Epilepsy, Mental Disorders, Parkinson Disease.
- Animals, Genetic Vectors, Humans, Light, Mice, Mice, Transgenic.
Abstract
Optogenetic neuromodulation techniques, which have emerged during the last 15 years, have considerably enhanced our ability to probe the functioning of neural circuits by allowing the excitation and inhibition of genetically-defined neuronal populations using light. Having gained tremendous popularity in the field of fundamental neuroscience, these techniques are now opening new therapeutic avenues. Optogenetic neuromodulation is a method of choice for studying the physiopathology of neurological and neuropsychiatric disorders in a range of animal models, and could accelerate the discovery of new therapeutic strategies. New therapeutic protocols employing optogenetic neuromodulation may also emerge in the near future, offering promising alternative approaches for disorders which lack appropriate treatments, such as pharmacoresistant epilepsy and inherited retinal degeneration.
DOI: 10.1051/medsci/20153104015
PubMed: 25958759
Affiliations:
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pubmed:25958759Le document en format XML
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Dugué</name><affiliation wicri:level="3"><nlm:affiliation>CNRS UMR 8197, Inserm U1024, institut de biologie de l'école normale supérieure, 46, rue d'Ulm, 75005 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8197, Inserm U1024, institut de biologie de l'école normale supérieure, 46, rue d'Ulm, 75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Medecine sciences : M/S</title><idno type="ISSN">0767-0974</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Epilepsy (therapy)</term><term>Genetic Vectors</term><term>Humans</term><term>Light</term><term>Mental Disorders (therapy)</term><term>Mice</term><term>Mice, Transgenic</term><term>Nerve Tissue (metabolism)</term><term>Nerve Tissue (radiation effects)</term><term>Neurotransmitter Agents (genetics)</term><term>Neurotransmitter Agents (therapeutic use)</term><term>Optogenetics (methods)</term><term>Parkinson Disease (therapy)</term><term>Viruses (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Neurotransmitter Agents</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Nerve Tissue</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Optogenetics</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Nerve Tissue</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Neurotransmitter Agents</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Epilepsy</term><term>Mental Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genetic Vectors</term><term>Humans</term><term>Light</term><term>Mice</term><term>Mice, Transgenic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Optogenetic neuromodulation techniques, which have emerged during the last 15 years, have considerably enhanced our ability to probe the functioning of neural circuits by allowing the excitation and inhibition of genetically-defined neuronal populations using light. Having gained tremendous popularity in the field of fundamental neuroscience, these techniques are now opening new therapeutic avenues. Optogenetic neuromodulation is a method of choice for studying the physiopathology of neurological and neuropsychiatric disorders in a range of animal models, and could accelerate the discovery of new therapeutic strategies. New therapeutic protocols employing optogenetic neuromodulation may also emerge in the near future, offering promising alternative approaches for disorders which lack appropriate treatments, such as pharmacoresistant epilepsy and inherited retinal degeneration.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25958759</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>11</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>10</Day></DateCompleted><DateRevised><Year>2015</Year><Month>05</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0767-0974</ISSN><JournalIssue CitedMedium="Print"><Volume>31</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Medecine sciences : M/S</Title><ISOAbbreviation>Med Sci (Paris)</ISOAbbreviation></Journal><ArticleTitle>[Therapeutic potential of optogenetic neuromodulation].</ArticleTitle><Pagination><MedlinePgn>404-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1051/medsci/20153104015</ELocationID><Abstract><AbstractText>Optogenetic neuromodulation techniques, which have emerged during the last 15 years, have considerably enhanced our ability to probe the functioning of neural circuits by allowing the excitation and inhibition of genetically-defined neuronal populations using light. Having gained tremendous popularity in the field of fundamental neuroscience, these techniques are now opening new therapeutic avenues. Optogenetic neuromodulation is a method of choice for studying the physiopathology of neurological and neuropsychiatric disorders in a range of animal models, and could accelerate the discovery of new therapeutic strategies. New therapeutic protocols employing optogenetic neuromodulation may also emerge in the near future, offering promising alternative approaches for disorders which lack appropriate treatments, such as pharmacoresistant epilepsy and inherited retinal degeneration.</AbstractText><CopyrightInformation>© 2015 médecine/sciences – Inserm.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vandecasteele</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Équipe dynamique et pathophysiologie des réseaux neuronaux, centre interdisciplinaire de recherche en biologie, CNRS UMR 7241, Inserm U1050, Collège de France, 11, place Marcelin Berthelot, 75005 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Senova</LastName><ForeName>Yann-Suhan</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>AP-HP, hôpital Henri Mondor, service de neurochirurgie, 94000 Créteil, France - Inserm, U955, équipe 14, 94000 Créteil, France - Université Paris Est, faculté de médecine, 94000 Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palfi</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>AP-HP, hôpital Henri Mondor, service de neurochirurgie, 94000 Créteil, France - Inserm, U955, équipe 14, 94000 Créteil, France - Université Paris Est, faculté de médecine, 94000 Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dugué</LastName><ForeName>Guillaume P</ForeName><Initials>GP</Initials><AffiliationInfo><Affiliation>CNRS UMR 8197, Inserm U1024, institut de biologie de l'école normale supérieure, 46, rue d'Ulm, 75005 Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><VernacularTitle>Potentiel thérapeutique de la neuromodulation optogénétique.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Med Sci (Paris)</MedlineTA><NlmUniqueID>8710980</NlmUniqueID><ISSNLinking>0767-0974</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018377">Neurotransmitter Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004827" MajorTopicYN="N">Epilepsy</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005822" MajorTopicYN="N">Genetic Vectors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008027" MajorTopicYN="N">Light</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001523" MajorTopicYN="N">Mental Disorders</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009417" MajorTopicYN="N">Nerve Tissue</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018377" MajorTopicYN="N">Neurotransmitter Agents</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062308" MajorTopicYN="N">Optogenetics</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25958759</ArticleId><ArticleId IdType="doi">10.1051/medsci/20153104015</ArticleId><ArticleId IdType="pii">medsci20153104p404</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Vandecasteele, Marie" sort="Vandecasteele, Marie" uniqKey="Vandecasteele M" first="Marie" last="Vandecasteele">Marie Vandecasteele</name></region><name sortKey="Dugue, Guillaume P" sort="Dugue, Guillaume P" uniqKey="Dugue G" first="Guillaume P" last="Dugué">Guillaume P. Dugué</name><name sortKey="Palfi, Stephane" sort="Palfi, Stephane" uniqKey="Palfi S" first="Stéphane" last="Palfi">Stéphane Palfi</name><name sortKey="Senova, Yann Suhan" sort="Senova, Yann Suhan" uniqKey="Senova Y" first="Yann-Suhan" last="Senova">Yann-Suhan Senova</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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