Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson's disease.
Identifieur interne : 000176 ( PubMed/Checkpoint ); précédent : 000175; suivant : 000177Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson's disease.
Auteurs : Affif Zaccaria [Suisse] ; Ali Bouamrani [France] ; Stephan Chabardès [France] ; Michèle El Atifi [France] ; Eric Seigneuret [France] ; Johannes A. Lobrinus [Suisse] ; Michel Dubois-Dauphin [Suisse] ; François Berger [France] ; Pierre R. Burkhard [Suisse]Source :
- Molecular neurodegeneration [ 1750-1326 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- physiology : Neurons.
- therapy : Parkinson Disease.
- Adult, Aged, Deep Brain Stimulation, Female, Globus Pallidus, Humans, Male, Middle Aged, Proteomics, Subthalamic Nucleus.
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) has been established as a highly effective symptomatic therapy for Parkinson's disease (PD). An intriguing biological aspect related to the DBS procedure is that a temporary contact establishes between surgical instruments and the surrounding brain tissue. In this exploratory study, we took advantage of this unique context to harvest brain material adhering to the stylet routinely used during surgery, and to examine the biological value of these samples, here referred to as "brain tissue imprints" (BTIs).
DOI: 10.1186/s13024-016-0077-4
PubMed: 26822202
Affiliations:
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Affif.Zaccaria@unige.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>NeuroProteomics Group, University Medical Center, Faculty of Medicine, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Bouamrani, Ali" sort="Bouamrani, Ali" uniqKey="Bouamrani A" first="Ali" last="Bouamrani">Ali Bouamrani</name><affiliation wicri:level="3"><nlm:affiliation>CEA-LETI, Clinatec, Edmond J. Safra Biomedical Research Center, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-LETI, Clinatec, Edmond J. 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Safra Biomedical Research Center, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-LETI, Clinatec, Edmond J. Safra Biomedical Research Center, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name><affiliation wicri:level="3"><nlm:affiliation>Clinique de neurochirurgie, CHU de Grenoble, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Clinique de neurochirurgie, CHU de Grenoble, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Lobrinus, Johannes A" sort="Lobrinus, Johannes A" uniqKey="Lobrinus J" first="Johannes A" last="Lobrinus">Johannes A. Lobrinus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Pathology, Geneva University Hospitals, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Dubois Dauphin, Michel" sort="Dubois Dauphin, Michel" uniqKey="Dubois Dauphin M" first="Michel" last="Dubois-Dauphin">Michel Dubois-Dauphin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Immunology, University Medical Center, Faculty of Medicine, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Pathology and Immunology, University Medical Center, Faculty of Medicine, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Berger, Francois" sort="Berger, Francois" uniqKey="Berger F" first="François" last="Berger">François Berger</name><affiliation wicri:level="3"><nlm:affiliation>Inserm UA01, Clinatec, Edmond J. Safra Biomedical Research Center, CEA, Grenoble CHU, Univ. Grenoble Alpes, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm UA01, Clinatec, Edmond J. Safra Biomedical Research Center, CEA, Grenoble CHU, Univ. Grenoble Alpes, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Burkhard, Pierre R" sort="Burkhard, Pierre R" uniqKey="Burkhard P" first="Pierre R" last="Burkhard">Pierre R. Burkhard</name><affiliation wicri:level="1"><nlm:affiliation>NeuroProteomics Group, University Medical Center, Faculty of Medicine, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>NeuroProteomics Group, University Medical Center, Faculty of Medicine, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular neurodegeneration</title><idno type="eISSN">1750-1326</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Female</term><term>Globus Pallidus</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurons (physiology)</term><term>Parkinson Disease (therapy)</term><term>Proteomics</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Female</term><term>Globus Pallidus</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Proteomics</term><term>Subthalamic Nucleus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) has been established as a highly effective symptomatic therapy for Parkinson's disease (PD). An intriguing biological aspect related to the DBS procedure is that a temporary contact establishes between surgical instruments and the surrounding brain tissue. In this exploratory study, we took advantage of this unique context to harvest brain material adhering to the stylet routinely used during surgery, and to examine the biological value of these samples, here referred to as "brain tissue imprints" (BTIs).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26822202</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>29</Day></DateCreated><DateCompleted><Year>2016</Year><Month>11</Month><Day>08</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1750-1326</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><PubDate><Year>2016</Year><Month>Jan</Month><Day>28</Day></PubDate></JournalIssue><Title>Molecular neurodegeneration</Title><ISOAbbreviation>Mol Neurodegener</ISOAbbreviation></Journal><ArticleTitle>Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13024-016-0077-4</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) has been established as a highly effective symptomatic therapy for Parkinson's disease (PD). An intriguing biological aspect related to the DBS procedure is that a temporary contact establishes between surgical instruments and the surrounding brain tissue. In this exploratory study, we took advantage of this unique context to harvest brain material adhering to the stylet routinely used during surgery, and to examine the biological value of these samples, here referred to as "brain tissue imprints" (BTIs).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Nineteen BTIs from 12 STN- or GPi-electrode implanted patients were obtained in vivo during DBS surgery, without any modification of the surgical procedure. Immunofluorescence analyses confirmed that our approach allowed the harvesting of many neural cells including neurons harboring distinct neurotransmitter markers. Shotgun proteomic and transcriptomic analyses provided for the first time molecular information from DBS-associated brain samples, and confirmed the compatibility of this new type of sample with poly-omic approaches. The method appears to be safe and results consistent.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We here propose BTIs as original and highly valuable brain samples, and DBS-related brain imprinting as a new conceptual approach to biological research in living patients with PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zaccaria</LastName><ForeName>Affif</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>NeuroProteomics Group, University Medical Center, Faculty of Medicine, Geneva, Switzerland. Affif.Zaccaria@unige.ch.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre Medical Universitaire (CMU), Rue Michel Servet 1, CH-1211, Genève 4, Switzerland. Affif.Zaccaria@unige.ch.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouamrani</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CEA-LETI, Clinatec, Edmond J. Safra Biomedical Research Center, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chabardès</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Clinique de neurochirurgie, CHU de Grenoble, Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, U836, Grenoble Institut des Neurosciences, Univ. Grenoble Alpes, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El Atifi</LastName><ForeName>Michèle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>CEA-LETI, Clinatec, Edmond J. Safra Biomedical Research Center, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seigneuret</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Clinique de neurochirurgie, CHU de Grenoble, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lobrinus</LastName><ForeName>Johannes A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Pathology, Geneva University Hospitals, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubois-Dauphin</LastName><ForeName>Michel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology and Immunology, University Medical Center, Faculty of Medicine, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Inserm UA01, Clinatec, Edmond J. Safra Biomedical Research Center, CEA, Grenoble CHU, Univ. Grenoble Alpes, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burkhard</LastName><ForeName>Pierre R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>NeuroProteomics Group, University Medical Center, Faculty of Medicine, Geneva, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Geneva University Hospitals, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mol 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MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046690" MajorTopicYN="Y">Deep Brain Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005917" MajorTopicYN="N">Globus Pallidus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D040901" MajorTopicYN="Y">Proteomics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4730746</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>09</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>01</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26822202</ArticleId><ArticleId IdType="doi">10.1186/s13024-016-0077-4</ArticleId><ArticleId IdType="pii">10.1186/s13024-016-0077-4</ArticleId><ArticleId IdType="pmc">PMC4730746</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li><li>Suisse</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement></list><tree><country name="Suisse"><noRegion><name sortKey="Zaccaria, Affif" sort="Zaccaria, Affif" uniqKey="Zaccaria A" first="Affif" last="Zaccaria">Affif Zaccaria</name></noRegion><name sortKey="Burkhard, Pierre R" sort="Burkhard, Pierre R" uniqKey="Burkhard P" first="Pierre R" last="Burkhard">Pierre R. Burkhard</name><name sortKey="Dubois Dauphin, Michel" sort="Dubois Dauphin, Michel" uniqKey="Dubois Dauphin M" first="Michel" last="Dubois-Dauphin">Michel Dubois-Dauphin</name><name sortKey="Lobrinus, Johannes A" sort="Lobrinus, Johannes A" uniqKey="Lobrinus J" first="Johannes A" last="Lobrinus">Johannes A. Lobrinus</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Bouamrani, Ali" sort="Bouamrani, Ali" uniqKey="Bouamrani A" first="Ali" last="Bouamrani">Ali Bouamrani</name></region><name sortKey="Berger, Francois" sort="Berger, Francois" uniqKey="Berger F" first="François" last="Berger">François Berger</name><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardès">Stephan Chabardès</name><name sortKey="El Atifi, Michele" sort="El Atifi, Michele" uniqKey="El Atifi M" first="Michèle" last="El Atifi">Michèle El Atifi</name><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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