MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Identifieur interne : 000020 ( PubMed/Checkpoint ); précédent : 000019; suivant : 000021MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Auteurs : Wissem Deraredj Nadim ; Viorel Simion ; Helene Benedetti ; Chantal Pichon ; Patrick Baril ; Severine Morisset-Lopez [France]Source :
- Current neuropharmacology [ 1875-6190 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Antagomirs (pharmacology), Antagomirs (therapeutic use), Cognition Disorders (drug therapy), Cognition Disorders (genetics), Databases, Bibliographic (statistics & numerical data), Gene Expression Regulation (drug effects), Gene Expression Regulation (physiology), Humans, MicroRNAs (antagonists & inhibitors), MicroRNAs (genetics), MicroRNAs (metabolism), Neurodegenerative Diseases (drug therapy), Neuronal Plasticity (drug effects), Signal Transduction (drug effects).
- MESH :
- chemical , antagonists & inhibitors : MicroRNAs.
- chemical , genetics : MicroRNAs.
- chemical , metabolism : MicroRNAs.
- chemical , pharmacology : Antagomirs.
- chemical , therapeutic use : Antagomirs.
- drug effects : Gene Expression Regulation, Neuronal Plasticity, Signal Transduction.
- drug therapy : Cognition Disorders, Neurodegenerative Diseases.
- genetics : Cognition Disorders.
- physiology : Gene Expression Regulation.
- statistics & numerical data : Databases, Bibliographic.
- Animals, Humans.
Abstract
Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.
PubMed: 27396304
Affiliations:
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uniqKey="Morisset Lopez S" first="Severine" last="Morisset-Lopez">Severine Morisset-Lopez</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Biophysique Moleculaire, CNRS UPR4301, Universite d'Orleans France, 45071 Orleans Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Biophysique Moleculaire, CNRS UPR4301, Universite d'Orleans France, 45071 Orleans Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Orleans</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27396304</idno><idno type="pmid">27396304</idno><idno type="wicri:Area/PubMed/Corpus">000027</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000027</idno><idno 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first="Chantal" last="Pichon">Chantal Pichon</name></author><author><name sortKey="Baril, Patrick" sort="Baril, Patrick" uniqKey="Baril P" first="Patrick" last="Baril">Patrick Baril</name></author><author><name sortKey="Morisset Lopez, Severine" sort="Morisset Lopez, Severine" uniqKey="Morisset Lopez S" first="Severine" last="Morisset-Lopez">Severine Morisset-Lopez</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Biophysique Moleculaire, CNRS UPR4301, Universite d'Orleans France, 45071 Orleans Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Biophysique Moleculaire, CNRS UPR4301, Universite d'Orleans France, 45071 Orleans Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Orleans</settlement></placeName></affiliation></author></analytic><series><title level="j">Current neuropharmacology</title><idno type="eISSN">1875-6190</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antagomirs (pharmacology)</term><term>Antagomirs (therapeutic use)</term><term>Cognition Disorders (drug therapy)</term><term>Cognition Disorders (genetics)</term><term>Databases, Bibliographic (statistics & numerical data)</term><term>Gene Expression Regulation (drug effects)</term><term>Gene Expression Regulation (physiology)</term><term>Humans</term><term>MicroRNAs (antagonists & inhibitors)</term><term>MicroRNAs (genetics)</term><term>MicroRNAs (metabolism)</term><term>Neurodegenerative Diseases (drug therapy)</term><term>Neuronal Plasticity (drug effects)</term><term>Signal Transduction (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>MicroRNAs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>MicroRNAs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>MicroRNAs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antagomirs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antagomirs</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term><term>Neuronal Plasticity</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cognition Disorders</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression Regulation</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Databases, Bibliographic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27396304</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>11</Day></DateCreated><DateCompleted><Year>2017</Year><Month>02</Month><Day>03</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-6190</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>2</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Current neuropharmacology</Title><ISOAbbreviation>Curr Neuropharmacol</ISOAbbreviation></Journal><ArticleTitle>MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?</ArticleTitle><Pagination><MedlinePgn>260-275</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">From an extensive search in bibliographic databases of peer-reviewed research literature, we identified relevant published studies related to specific key words such as memory, cognition, neurodegenerative disorders, neurogenesis and miRNA. We then analysed, evaluated and summerized scientific evidences derived from these studies.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We first briefly summarize the basic molecular events involved in memory, a process inherent to cognitive disease, and then describe the role of miRNAs in neurodevelopment, synaptic plasticity and memory. Secondly, we provide an overview of the impact of miRNA dysregulation in the pathogenesis of different neurocognitive disorders, and lastly discuss the feasibility of miRNA-based therapeutics in the treatment of these disorders.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This review highlights the molecular basis of neurodegenerative and cognitive disorders by focusing on the impact of miRNAs dysregulation in these pathological phenotypes. Altogether, the published reports suggest that miRNAs-based therapy could be a viable therapeutic alternative to current treatment options in the future.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nadim</LastName><ForeName>Wissem Deraredj</ForeName><Initials>WD</Initials></Author><Author ValidYN="Y"><LastName>Simion</LastName><ForeName>Viorel</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Benedetti</LastName><ForeName>Helene</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Pichon</LastName><ForeName>Chantal</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Baril</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Morisset-Lopez</LastName><ForeName>Severine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre de Biophysique Moleculaire, CNRS UPR4301, Universite d'Orleans France, 45071 Orleans Cedex, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United Arab Emirates</Country><MedlineTA>Curr Neuropharmacol</MedlineTA><NlmUniqueID>101157239</NlmUniqueID><ISSNLinking>1570-159X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000070416">Antagomirs</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D035683">MicroRNAs</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000070416" MajorTopicYN="N">Antagomirs</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003072" MajorTopicYN="N">Cognition Disorders</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016206" MajorTopicYN="N">Databases, Bibliographic</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D035683" MajorTopicYN="N">MicroRNAs</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019636" MajorTopicYN="N">Neurodegenerative Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009473" MajorTopicYN="N">Neuronal Plasticity</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate 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Centre</li></region><settlement><li>Orleans</li></settlement></list><tree><noCountry><name sortKey="Baril, Patrick" sort="Baril, Patrick" uniqKey="Baril P" first="Patrick" last="Baril">Patrick Baril</name><name sortKey="Benedetti, Helene" sort="Benedetti, Helene" uniqKey="Benedetti H" first="Helene" last="Benedetti">Helene Benedetti</name><name sortKey="Nadim, Wissem Deraredj" sort="Nadim, Wissem Deraredj" uniqKey="Nadim W" first="Wissem Deraredj" last="Nadim">Wissem Deraredj Nadim</name><name sortKey="Pichon, Chantal" sort="Pichon, Chantal" uniqKey="Pichon C" first="Chantal" last="Pichon">Chantal Pichon</name><name sortKey="Simion, Viorel" sort="Simion, Viorel" uniqKey="Simion V" first="Viorel" last="Simion">Viorel Simion</name></noCountry><country name="France"><region name="Centre-Val de Loire"><name sortKey="Morisset Lopez, Severine" sort="Morisset Lopez, Severine" uniqKey="Morisset Lopez S" first="Severine" last="Morisset-Lopez">Severine 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