MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Identifieur interne : 000020 ( PubMed/Checkpoint ); précédent : 000019; suivant : 000021MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Auteurs : Wissem Deraredj Nadim ; Viorel Simion ; Helene Benedetti ; Chantal Pichon ; Patrick Baril ; Severine Morisset-Lopez [France]Source :
- Current neuropharmacology [ 1875-6190 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Antagomirs (pharmacology), Antagomirs (therapeutic use), Cognition Disorders (drug therapy), Cognition Disorders (genetics), Databases, Bibliographic (statistics & numerical data), Gene Expression Regulation (drug effects), Gene Expression Regulation (physiology), Humans, MicroRNAs (antagonists & inhibitors), MicroRNAs (genetics), MicroRNAs (metabolism), Neurodegenerative Diseases (drug therapy), Neuronal Plasticity (drug effects), Signal Transduction (drug effects).
- MESH :
- chemical , antagonists & inhibitors : MicroRNAs.
- chemical , genetics : MicroRNAs.
- chemical , metabolism : MicroRNAs.
- chemical , pharmacology : Antagomirs.
- chemical , therapeutic use : Antagomirs.
- drug effects : Gene Expression Regulation, Neuronal Plasticity, Signal Transduction.
- drug therapy : Cognition Disorders, Neurodegenerative Diseases.
- genetics : Cognition Disorders.
- physiology : Gene Expression Regulation.
- statistics & numerical data : Databases, Bibliographic.
- Animals, Humans.
Abstract
Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.
PubMed: 27396304
Affiliations:
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pubmed:27396304Le document en format XML
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<author><name sortKey="Simion, Viorel" sort="Simion, Viorel" uniqKey="Simion V" first="Viorel" last="Simion">Viorel Simion</name>
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<author><name sortKey="Benedetti, Helene" sort="Benedetti, Helene" uniqKey="Benedetti H" first="Helene" last="Benedetti">Helene Benedetti</name>
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<author><name sortKey="Baril, Patrick" sort="Baril, Patrick" uniqKey="Baril P" first="Patrick" last="Baril">Patrick Baril</name>
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<term>Cognition Disorders (drug therapy)</term>
<term>Cognition Disorders (genetics)</term>
<term>Databases, Bibliographic (statistics & numerical data)</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Gene Expression Regulation (physiology)</term>
<term>Humans</term>
<term>MicroRNAs (antagonists & inhibitors)</term>
<term>MicroRNAs (genetics)</term>
<term>MicroRNAs (metabolism)</term>
<term>Neurodegenerative Diseases (drug therapy)</term>
<term>Neuronal Plasticity (drug effects)</term>
<term>Signal Transduction (drug effects)</term>
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<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>MicroRNAs</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>MicroRNAs</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>MicroRNAs</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antagomirs</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antagomirs</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term>
<term>Neuronal Plasticity</term>
<term>Signal Transduction</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cognition Disorders</term>
<term>Neurodegenerative Diseases</term>
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<front><div type="abstract" xml:lang="en">Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.</div>
</front>
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<DateCreated><Year>2016</Year>
<Month>07</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>02</Month>
<Day>03</Day>
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<Month>02</Month>
<Day>03</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-6190</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<Issue>2</Issue>
<PubDate><Year>2017</Year>
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<Title>Current neuropharmacology</Title>
<ISOAbbreviation>Curr Neuropharmacol</ISOAbbreviation>
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<ArticleTitle>MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?</ArticleTitle>
<Pagination><MedlinePgn>260-275</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">From an extensive search in bibliographic databases of peer-reviewed research literature, we identified relevant published studies related to specific key words such as memory, cognition, neurodegenerative disorders, neurogenesis and miRNA. We then analysed, evaluated and summerized scientific evidences derived from these studies.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We first briefly summarize the basic molecular events involved in memory, a process inherent to cognitive disease, and then describe the role of miRNAs in neurodevelopment, synaptic plasticity and memory. Secondly, we provide an overview of the impact of miRNA dysregulation in the pathogenesis of different neurocognitive disorders, and lastly discuss the feasibility of miRNA-based therapeutics in the treatment of these disorders.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This review highlights the molecular basis of neurodegenerative and cognitive disorders by focusing on the impact of miRNAs dysregulation in these pathological phenotypes. Altogether, the published reports suggest that miRNAs-based therapy could be a viable therapeutic alternative to current treatment options in the future.</AbstractText>
</Abstract>
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<Author ValidYN="Y"><LastName>Simion</LastName>
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