Motor cortex plasticity can indicate vulnerability to motor fluctuation and high L-DOPA need in drug-naïve Parkinson's disease.
Identifieur interne : 000017 ( PubMed/Checkpoint ); précédent : 000016; suivant : 000018Motor cortex plasticity can indicate vulnerability to motor fluctuation and high L-DOPA need in drug-naïve Parkinson's disease.
Auteurs : Asha Kishore [Inde] ; Praveen James [Inde] ; Syam Krishnan [Inde] ; Lydia Yahia-Cherif [France] ; Sabine Meunier [France] ; Traian Popa [France]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2017.
Abstract
Motor cortex plasticity is reported to be decreased in Parkinson's disease in studies which pooled patients in various stages of the disease. Whether the early decrease in plasticity is related to the motor signs or is linked to the future development of motor complications of treatment is unclear. The aim of the study was to test if motor cortex plasticity and its cerebellar modulation are impaired in treatment-naïve Parkinson's disease, are related to the motor signs of the disease and predict occurrence of motor complications of treatment.
DOI: 10.1016/j.parkreldis.2016.12.005
PubMed: 28003105
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Electronic address: asha@sctimst.ac.in.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="James, Praveen" sort="James, Praveen" uniqKey="James P" first="Praveen" last="James">Praveen James</name><affiliation wicri:level="1"><nlm:affiliation>Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Krishnan, Syam" sort="Krishnan, Syam" uniqKey="Krishnan S" first="Syam" last="Krishnan">Syam Krishnan</name><affiliation wicri:level="1"><nlm:affiliation>Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Yahia Cherif, Lydia" sort="Yahia Cherif, Lydia" uniqKey="Yahia Cherif L" first="Lydia" last="Yahia-Cherif">Lydia Yahia-Cherif</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS 1127, Paris, France; CNRS, Centre MEG-EEG, UMR 7225, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS 1127, Paris, France; CNRS, Centre MEG-EEG, UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meunier, Sabine" sort="Meunier, Sabine" uniqKey="Meunier S" first="Sabine" last="Meunier">Sabine Meunier</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS 1127, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS 1127, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Popa, Traian" sort="Popa, Traian" uniqKey="Popa T" first="Traian" last="Popa">Traian Popa</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS 1127, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS 1127, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Motor cortex plasticity is reported to be decreased in Parkinson's disease in studies which pooled patients in various stages of the disease. Whether the early decrease in plasticity is related to the motor signs or is linked to the future development of motor complications of treatment is unclear. The aim of the study was to test if motor cortex plasticity and its cerebellar modulation are impaired in treatment-naïve Parkinson's disease, are related to the motor signs of the disease and predict occurrence of motor complications of treatment.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28003105</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>22</Day></DateCreated><DateRevised><Year>2017</Year><Month>01</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><PubDate><Year>2017</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Parkinsonism & related disorders</Title><ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation></Journal><ArticleTitle>Motor cortex plasticity can indicate vulnerability to motor fluctuation and high L-DOPA need in drug-naïve Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>55-62</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1353-8020(16)30486-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2016.12.005</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Motor cortex plasticity is reported to be decreased in Parkinson's disease in studies which pooled patients in various stages of the disease. Whether the early decrease in plasticity is related to the motor signs or is linked to the future development of motor complications of treatment is unclear. The aim of the study was to test if motor cortex plasticity and its cerebellar modulation are impaired in treatment-naïve Parkinson's disease, are related to the motor signs of the disease and predict occurrence of motor complications of treatment.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twenty-nine denovo patients with Parkinson's disease were longitudinally assessed for motor complications for four years. Using transcranial magnetic stimulation, the plasticity of the motor cortex and its cerebellar modulation were measured (response to paired-associative stimulation alone or preceded by 2 active cerebellar stimulation protocols), both in the untreated state and after a single dose of L-DOPA. Twenty-six matched, healthy volunteers were tested, only without L-DOPA.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Patients and healthy controls had similar proportions of responders and non-responders to plasticity induction. In the untreated state, the more efficient was the cerebellar modulation of motor cortex plasticity, the lower were the bradykinesia and rigidity scores. The extent of the individual plastic response to paired associative stimulation could indicate a vulnerability to develop early motor fluctuation but not dyskinesia.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Measuring motor cortex plasticity in denovo Parkinson's disease could be a neurophysiological parameter that may help identify patients with greater propensity for early motor fluctuations.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kishore</LastName><ForeName>Asha</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India. Electronic address: asha@sctimst.ac.in.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>James</LastName><ForeName>Praveen</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krishnan</LastName><ForeName>Syam</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yahia-Cherif</LastName><ForeName>Lydia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS 1127, Paris, France; CNRS, Centre MEG-EEG, UMR 7225, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meunier</LastName><ForeName>Sabine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS 1127, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Popa</LastName><ForeName>Traian</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière (ICM), Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS 1127, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>12</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parkinsonism Relat Disord</MedlineTA><NlmUniqueID>9513583</NlmUniqueID><ISSNLinking>1353-8020</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cerebellum</Keyword><Keyword MajorTopicYN="N">Motor cortex</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">Plasticity</Keyword><Keyword MajorTopicYN="N">Transcranial magnetic stimulation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>10</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28003105</ArticleId><ArticleId IdType="pii">S1353-8020(16)30486-2</ArticleId><ArticleId IdType="doi">10.1016/j.parkreldis.2016.12.005</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li><li>Inde</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Inde"><noRegion><name sortKey="Kishore, Asha" sort="Kishore, Asha" uniqKey="Kishore A" first="Asha" last="Kishore">Asha Kishore</name></noRegion><name sortKey="James, Praveen" sort="James, Praveen" uniqKey="James P" first="Praveen" last="James">Praveen James</name><name sortKey="Krishnan, Syam" sort="Krishnan, Syam" uniqKey="Krishnan S" first="Syam" last="Krishnan">Syam Krishnan</name></country><country name="France"><region name="Île-de-France"><name sortKey="Yahia Cherif, Lydia" sort="Yahia Cherif, Lydia" uniqKey="Yahia Cherif L" first="Lydia" last="Yahia-Cherif">Lydia Yahia-Cherif</name></region><name sortKey="Meunier, Sabine" sort="Meunier, Sabine" uniqKey="Meunier S" first="Sabine" last="Meunier">Sabine Meunier</name><name sortKey="Popa, Traian" sort="Popa, Traian" uniqKey="Popa T" first="Traian" last="Popa">Traian Popa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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