Lessons from the analysis of nonhuman primates for understanding human aging and neurodegenerative diseases
Identifieur interne : 000949 ( Pmc/Curation ); précédent : 000948; suivant : 000950Lessons from the analysis of nonhuman primates for understanding human aging and neurodegenerative diseases
Auteurs : Jean-Michel Verdier [France] ; Isabelle Acquatella [France] ; Corinne Lautier [France] ; Gina Devau [France] ; Stéphanie Trouche [France] ; Christelle Lasbleiz [France] ; Nadine Mestre-Francés [France]Source :
- Frontiers in Neuroscience [ 1662-4548 ] ; 2015.
Abstract
Animal models are necessary tools for solving the most serious challenges facing medical research. In aging and neurodegenerative disease studies, rodents occupy a place of choice. However, the most challenging questions about longevity, the complexity and functioning of brain networks or social intelligence can almost only be investigated in nonhuman primates. Beside the fact that their brain structure is much closer to that of humans, they develop highly complex cognitive strategies and they are visually-oriented like humans. For these reasons, they deserve consideration, although their management and care are more complicated and the related costs much higher. Despite these caveats, considerable scientific advances have been possible using nonhuman primates. This review concisely summarizes their role in the study of aging and of the mechanisms involved in neurodegenerative disorders associated mainly with cognitive dysfunctions (Alzheimer's and prion diseases) or motor deficits (Parkinson's and related diseases).
Url:
DOI: 10.3389/fnins.2015.00064
PubMed: 25788873
PubMed Central: 4349082
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xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Neuroscience</title><idno type="ISSN">1662-4548</idno><idno type="eISSN">1662-453X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Animal models are necessary tools for solving the most serious challenges facing medical research. In aging and neurodegenerative disease studies, rodents occupy a place of choice. However, the most challenging questions about longevity, the complexity and functioning of brain networks or social intelligence can almost only be investigated in nonhuman primates. Beside the fact that their brain structure is much closer to that of humans, they develop highly complex cognitive strategies and they are visually-oriented like humans. For these reasons, they deserve consideration, although their management and care are more complicated and the related costs much higher. Despite these caveats, considerable scientific advances have been possible using nonhuman primates. This review concisely summarizes their role in the study of aging and of the mechanisms involved in neurodegenerative disorders associated mainly with cognitive dysfunctions (Alzheimer's and prion diseases) or motor deficits (Parkinson's and related diseases).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abdel Rassoul, R" uniqKey="Abdel Rassoul R">R. Abdel Rassoul</name></author><author><name sortKey="Alves, S" uniqKey="Alves S">S. Alves</name></author><author><name sortKey="Pantesco, V" uniqKey="Pantesco V">V. Pantesco</name></author><author><name sortKey="De Vos, J" uniqKey="De Vos J">J. De Vos</name></author><author><name sortKey="Michel, B" uniqKey="Michel B">B. Michel</name></author><author><name sortKey="Perret, M" uniqKey="Perret M">M. Perret</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abildgaard, C F" uniqKey="Abildgaard C">C. F. 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McDonald</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">Front Neurosci</journal-id><journal-id journal-id-type="publisher-id">Front. Neurosci.</journal-id><journal-title-group><journal-title>Frontiers in Neuroscience</journal-title></journal-title-group><issn pub-type="ppub">1662-4548</issn><issn pub-type="epub">1662-453X</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25788873</article-id><article-id pub-id-type="pmc">4349082</article-id><article-id pub-id-type="doi">10.3389/fnins.2015.00064</article-id><article-categories><subj-group subj-group-type="heading"><subject>Psychiatry</subject><subj-group><subject>Mini Review Article</subject></subj-group></subj-group></article-categories><title-group><article-title>Lessons from the analysis of nonhuman primates for understanding human aging and neurodegenerative diseases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Verdier</surname><given-names>Jean-Michel</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/9561"></uri></contrib><contrib contrib-type="author"><name><surname>Acquatella</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lautier</surname><given-names>Corinne</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/214136"></uri></contrib><contrib contrib-type="author"><name><surname>Devau</surname><given-names>Gina</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/214850"></uri></contrib><contrib contrib-type="author"><name><surname>Trouche</surname><given-names>Stéphanie</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/214780"></uri></contrib><contrib contrib-type="author"><name><surname>Lasbleiz</surname><given-names>Christelle</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/214776"></uri></contrib><contrib contrib-type="author"><name><surname>Mestre-Francés</surname><given-names>Nadine</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/14288"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Université de Montpellier</institution><country>Montpellier, France</country></aff><aff id="aff2"><sup>2</sup><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></aff><aff id="aff3"><sup>3</sup><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Patrick Lewis, University of Reading, UK</p></fn><fn fn-type="edited-by"><p>Reviewed by: Ricardo Insausti, University of Castilla -la Mancha, Spain; Varun Kesherwani, University of Nebraska Medical Center, USA</p></fn><corresp id="fn001">*Correspondence: Jean-Michel Verdier, University of Montpellier, Place Eugène Bataillon, CC105, 34095 Montpellier, France e-mail: <email xlink:type="simple">jean-michel.verdier@univ-montp2.fr</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience.</p></fn></author-notes><pub-date pub-type="epub"><day>04</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>9</volume><elocation-id>64</elocation-id><history><date date-type="received"><day>14</day><month>10</month><year>2014</year></date><date date-type="accepted"><day>13</day><month>2</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Verdier, Acquatella, Lautier, Devau, Trouche, Lasbleiz and Mestre-Francés.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Animal models are necessary tools for solving the most serious challenges facing medical research. In aging and neurodegenerative disease studies, rodents occupy a place of choice. However, the most challenging questions about longevity, the complexity and functioning of brain networks or social intelligence can almost only be investigated in nonhuman primates. Beside the fact that their brain structure is much closer to that of humans, they develop highly complex cognitive strategies and they are visually-oriented like humans. For these reasons, they deserve consideration, although their management and care are more complicated and the related costs much higher. Despite these caveats, considerable scientific advances have been possible using nonhuman primates. This review concisely summarizes their role in the study of aging and of the mechanisms involved in neurodegenerative disorders associated mainly with cognitive dysfunctions (Alzheimer's and prion diseases) or motor deficits (Parkinson's and related diseases).</p></abstract><kwd-group><kwd>neuroscience</kwd><kwd>brain</kwd><kwd>aging</kwd><kwd>neurodegenerative diseases</kwd><kwd>nonhuman primate</kwd></kwd-group><counts><fig-count count="0"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="79"></ref-count><page-count count="6"></page-count><word-count count="5660"></word-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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