Metabotropic glutamate receptors: From the workbench to the bedside
Identifieur interne : 000571 ( Pmc/Curation ); précédent : 000570; suivant : 000572Metabotropic glutamate receptors: From the workbench to the bedside
Auteurs : F. Nicoletti [Italie] ; J. Bockaert [France] ; G. L. Collingridge [Royaume-Uni] ; P. J. Conn [États-Unis] ; F. Ferraguti [Autriche] ; D. D. Schoepp [États-Unis] ; J. T. Wroblewski [États-Unis] ; J. P. Pin [France]Source :
- Neuropharmacology [ 0028-3908 ] ; 2010.
Abstract
Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 articles have been published since then, and subtype-selective mGlu receptor ligands are now under clinical development for the treatment of a variety of disorders such as Fragile-X syndrome, schizophrenia, Parkinson’s disease and L-DOPA-induced dyskinesias, generalized anxiety disorder, chronic pain, and gastroesophageal reflux disorder. Prof. Erminio Costa was linked to the early times of the mGlu receptor history, when a few research groups challenged the general belief that glutamate could only activate ionotropic receptors and all metabolic responses to glutamate were secondary to calcium entry. This review moves from those nostalgic times to the most recent advances in the physiology and pharmacology of mGlu receptors, and highlights the role of individual mGlu receptor subtypes in the pathophysiology of human disorders. This article is part of a Special Issue entitled ‘Trends in Neuropharmacology: In Memory of Erminio Costa’.
Url:
DOI: 10.1016/j.neuropharm.2010.10.022
PubMed: 21036182
PubMed Central: 3787883
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Nicoletti</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Physiology and Pharmacology, University of Rome, Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiology and Pharmacology, University of Rome, Sapienza, Piazzale Aldo Moro 5, 00185 Rome</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">I.N.M. Neuromed, Pozzilli, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>I.N.M. Neuromed, Pozzilli</wicri:regionArea></affiliation></author><author><name sortKey="Bockaert, J" sort="Bockaert, J" uniqKey="Bockaert J" first="J." last="Bockaert">J. Bockaert</name><affiliation wicri:level="1"><nlm:aff id="A3">Institute of Functional Genomics, CNRS UMR 5203, INSERM U661, University of Montpellier 1 & 2, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institute of Functional Genomics, CNRS UMR 5203, INSERM U661, University of Montpellier 1 & 2, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Collingridge, G L" sort="Collingridge, G L" uniqKey="Collingridge G" first="G. L." last="Collingridge">G. L. Collingridge</name><affiliation wicri:level="1"><nlm:aff id="A4">MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Conn, P J" sort="Conn, P J" uniqKey="Conn P" first="P. J." last="Conn">P. J. 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Pin</name><affiliation wicri:level="1"><nlm:aff id="A3">Institute of Functional Genomics, CNRS UMR 5203, INSERM U661, University of Montpellier 1 & 2, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institute of Functional Genomics, CNRS UMR 5203, INSERM U661, University of Montpellier 1 & 2, Montpellier</wicri:regionArea></affiliation></author></analytic><series><title level="j">Neuropharmacology</title><idno type="ISSN">0028-3908</idno><idno type="eISSN">1873-7064</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 articles have been published since then, and subtype-selective mGlu receptor ligands are now under clinical development for the treatment of a variety of disorders such as Fragile-X syndrome, schizophrenia, Parkinson’s disease and L-DOPA-induced dyskinesias, generalized anxiety disorder, chronic pain, and gastroesophageal reflux disorder. Prof. Erminio Costa was linked to the early times of the mGlu receptor history, when a few research groups challenged the general belief that glutamate could only activate ionotropic receptors and all metabolic responses to glutamate were secondary to calcium entry. This review moves from those nostalgic times to the most recent advances in the physiology and pharmacology of mGlu receptors, and highlights the role of individual mGlu receptor subtypes in the pathophysiology of human disorders. This article is part of a Special Issue entitled ‘Trends in Neuropharmacology: In Memory of Erminio Costa’.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0236217</journal-id><journal-id journal-id-type="pubmed-jr-id">6077</journal-id><journal-id journal-id-type="nlm-ta">Neuropharmacology</journal-id><journal-id journal-id-type="iso-abbrev">Neuropharmacology</journal-id><journal-title-group><journal-title>Neuropharmacology</journal-title></journal-title-group><issn pub-type="ppub">0028-3908</issn><issn pub-type="epub">1873-7064</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21036182</article-id><article-id pub-id-type="pmc">3787883</article-id><article-id pub-id-type="doi">10.1016/j.neuropharm.2010.10.022</article-id><article-id pub-id-type="manuscript">NIHMS280608</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Metabotropic glutamate receptors: From the workbench to the bedside</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Nicoletti</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Bockaert</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Collingridge</surname><given-names>G.L.</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Conn</surname><given-names>P.J.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Ferraguti</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Schoepp</surname><given-names>D.D.</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Wroblewski</surname><given-names>J.T.</given-names></name><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Pin</surname><given-names>J.P.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Physiology and Pharmacology, University of Rome, Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy</aff><aff id="A2"><label>b</label>I.N.M. Neuromed, Pozzilli, Italy</aff><aff id="A3"><label>c</label>Institute of Functional Genomics, CNRS UMR 5203, INSERM U661, University of Montpellier 1 & 2, Montpellier, France</aff><aff id="A4"><label>d</label>MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, UK</aff><aff id="A5"><label>e</label>Department of Pharmacology, Vanderbilt Program in Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, USA</aff><aff id="A6"><label>f</label>Department of Pharmacology, Innsbruck Medical University, Innsbruck, Austria</aff><aff id="A7"><label>g</label>Neuroscience, Merck and Company Inc., North Wales, NJ, USA</aff><aff id="A8"><label>h</label>Department of Pharmacology, Georgetown University Medical Centre, Washington, DC, USA</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author. Department of Physiology and Pharmacology, University of Rome, Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy. Tel.: +39 06 49912969; fax: +39 0865 927575, <email>ferdinandonicoletti@hotmail.com</email> (F. Nicoletti)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>9</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>29</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2013</year></pub-date><volume>60</volume><issue>0</issue><fpage>1017</fpage><lpage>1041</lpage><permissions><copyright-statement>© 2010 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P1">Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 articles have been published since then, and subtype-selective mGlu receptor ligands are now under clinical development for the treatment of a variety of disorders such as Fragile-X syndrome, schizophrenia, Parkinson’s disease and L-DOPA-induced dyskinesias, generalized anxiety disorder, chronic pain, and gastroesophageal reflux disorder. Prof. Erminio Costa was linked to the early times of the mGlu receptor history, when a few research groups challenged the general belief that glutamate could only activate ionotropic receptors and all metabolic responses to glutamate were secondary to calcium entry. This review moves from those nostalgic times to the most recent advances in the physiology and pharmacology of mGlu receptors, and highlights the role of individual mGlu receptor subtypes in the pathophysiology of human disorders. This article is part of a Special Issue entitled ‘Trends in Neuropharmacology: In Memory of Erminio Costa’.</p></abstract><kwd-group><kwd>Metabotropic glutamate receptors</kwd><kwd>Receptor structure</kwd><kwd>mGlu receptor ligands</kwd><kwd>Clinical studies</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS037436-08 || NS</award-id></award-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS037436 || NS</award-id></award-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS031373 || NS</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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