Lithium enhances remyelination of peripheral nerves
Identifieur interne : 000538 ( Pmc/Curation ); précédent : 000537; suivant : 000539Lithium enhances remyelination of peripheral nerves
Auteurs : Joelle Makoukji [France] ; Martin Belle [France] ; Delphine Meffre [France] ; Ruth Stassart [Allemagne] ; Julien Grenier [France] ; Ghjuvan'Ghjacumu Shackleford [France] ; Robert Fledrich [Allemagne] ; Cosima Fonte [France] ; Julien Branchu [France] ; Marie Goulard [France] ; Catherine De Waele [France] ; Frédéric Charbonnier [France] ; Michael W. Sereda [Allemagne] ; Etienne-Emile Baulieu [France] ; Michael Schumacher [France] ; Sophie Bernard [France] ; Charbel Massaad [France]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2012.
Abstract
Glycogen synthase kinase 3β (GSK3β) inhibitors, especially the mood stabilizer lithium chloride, are also used as neuroprotective or anti-inflammatory agents. We studied the influence of LiCl on the remyelination of peripheral nerves. We showed that the treatment of adult mice with LiCl after facial nerve crush injury stimulated the expression of myelin genes, restored the myelin structure, and accelerated the recovery of whisker movements. LiCl treatment also promoted remyelination of the sciatic nerve after crush. We also demonstrated that peripheral myelin gene MPZ and PMP22 promoter activities, transcripts, and protein levels are stimulated by GSK3β inhibitors (LiCl and SB216763) in Schwann cells as well as in sciatic and facial nerves. LiCl exerts its action in Schwann cells by increasing the amount of β-catenin and provoking its nuclear localization. We showed by ChIP experiments that LiCl treatment drives β-catenin to bind to T-cell factor/lymphoid-enhancer factor response elements identified in myelin genes. Taken together, our findings open perspectives in the treatment of nerve demyelination by administering GSK3β inhibitors such as lithium.
Url:
DOI: 10.1073/pnas.1121367109
PubMed: 22355115
PubMed Central: 3309729
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000541
Links to Exploration step
PMC:3309729Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lithium enhances remyelination of peripheral nerves</title><author><name sortKey="Makoukji, Joelle" sort="Makoukji, Joelle" uniqKey="Makoukji J" first="Joelle" last="Makoukji">Joelle Makoukji</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Belle, Martin" sort="Belle, Martin" uniqKey="Belle M" first="Martin" last="Belle">Martin Belle</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meffre, Delphine" sort="Meffre, Delphine" uniqKey="Meffre D" first="Delphine" last="Meffre">Delphine Meffre</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stassart, Ruth" sort="Stassart, Ruth" uniqKey="Stassart R" first="Ruth" last="Stassart">Ruth Stassart</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurogenetics,<institution>Max Planck Institute of Experimental Medicine</institution>, 37075 Goettingen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grenier, Julien" sort="Grenier, Julien" uniqKey="Grenier J" first="Julien" last="Grenier">Julien Grenier</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shackleford, Ghjuvan Ghjacumu" sort="Shackleford, Ghjuvan Ghjacumu" uniqKey="Shackleford G" first="Ghjuvan'Ghjacumu" last="Shackleford">Ghjuvan'Ghjacumu Shackleford</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fledrich, Robert" sort="Fledrich, Robert" uniqKey="Fledrich R" first="Robert" last="Fledrich">Robert Fledrich</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurogenetics,<institution>Max Planck Institute of Experimental Medicine</institution>, 37075 Goettingen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fonte, Cosima" sort="Fonte, Cosima" uniqKey="Fonte C" first="Cosima" last="Fonte">Cosima Fonte</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale, Institut Fédératif de Recherche de Bicêtre 93,<institution>University Paris-Sud 11</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Branchu, Julien" sort="Branchu, Julien" uniqKey="Branchu J" first="Julien" last="Branchu">Julien Branchu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goulard, Marie" sort="Goulard, Marie" uniqKey="Goulard M" first="Marie" last="Goulard">Marie Goulard</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Waele, Catherine" sort="De Waele, Catherine" uniqKey="De Waele C" first="Catherine" last="De Waele">Catherine De Waele</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Charbonnier, Frederic" sort="Charbonnier, Frederic" uniqKey="Charbonnier F" first="Frédéric" last="Charbonnier">Frédéric Charbonnier</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sereda, Michael W" sort="Sereda, Michael W" uniqKey="Sereda M" first="Michael W." last="Sereda">Michael W. Sereda</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurogenetics,<institution>Max Planck Institute of Experimental Medicine</institution>, 37075 Goettingen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Clinical Neurophysiology,<institution>University of Goettingen</institution>, 37075 Goettingen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baulieu, Etienne Emile" sort="Baulieu, Etienne Emile" uniqKey="Baulieu E" first="Etienne-Emile" last="Baulieu">Etienne-Emile Baulieu</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale, Institut Fédératif de Recherche de Bicêtre 93,<institution>University Paris-Sud 11</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schumacher, Michael" sort="Schumacher, Michael" uniqKey="Schumacher M" first="Michael" last="Schumacher">Michael Schumacher</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale, Institut Fédératif de Recherche de Bicêtre 93,<institution>University Paris-Sud 11</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bernard, Sophie" sort="Bernard, Sophie" uniqKey="Bernard S" first="Sophie" last="Bernard">Sophie Bernard</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Massaad, Charbel" sort="Massaad, Charbel" uniqKey="Massaad C" first="Charbel" last="Massaad">Charbel Massaad</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22355115</idno><idno type="pmc">3309729</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309729</idno><idno type="RBID">PMC:3309729</idno><idno type="doi">10.1073/pnas.1121367109</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000541</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000541</idno><idno type="wicri:Area/Pmc/Curation">000538</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000538</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lithium enhances remyelination of peripheral nerves</title><author><name sortKey="Makoukji, Joelle" sort="Makoukji, Joelle" uniqKey="Makoukji J" first="Joelle" last="Makoukji">Joelle Makoukji</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Belle, Martin" sort="Belle, Martin" uniqKey="Belle M" first="Martin" last="Belle">Martin Belle</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meffre, Delphine" sort="Meffre, Delphine" uniqKey="Meffre D" first="Delphine" last="Meffre">Delphine Meffre</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stassart, Ruth" sort="Stassart, Ruth" uniqKey="Stassart R" first="Ruth" last="Stassart">Ruth Stassart</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurogenetics,<institution>Max Planck Institute of Experimental Medicine</institution>, 37075 Goettingen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grenier, Julien" sort="Grenier, Julien" uniqKey="Grenier J" first="Julien" last="Grenier">Julien Grenier</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shackleford, Ghjuvan Ghjacumu" sort="Shackleford, Ghjuvan Ghjacumu" uniqKey="Shackleford G" first="Ghjuvan'Ghjacumu" last="Shackleford">Ghjuvan'Ghjacumu Shackleford</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fledrich, Robert" sort="Fledrich, Robert" uniqKey="Fledrich R" first="Robert" last="Fledrich">Robert Fledrich</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurogenetics,<institution>Max Planck Institute of Experimental Medicine</institution>, 37075 Goettingen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fonte, Cosima" sort="Fonte, Cosima" uniqKey="Fonte C" first="Cosima" last="Fonte">Cosima Fonte</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale, Institut Fédératif de Recherche de Bicêtre 93,<institution>University Paris-Sud 11</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Branchu, Julien" sort="Branchu, Julien" uniqKey="Branchu J" first="Julien" last="Branchu">Julien Branchu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goulard, Marie" sort="Goulard, Marie" uniqKey="Goulard M" first="Marie" last="Goulard">Marie Goulard</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Waele, Catherine" sort="De Waele, Catherine" uniqKey="De Waele C" first="Catherine" last="De Waele">Catherine De Waele</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Charbonnier, Frederic" sort="Charbonnier, Frederic" uniqKey="Charbonnier F" first="Frédéric" last="Charbonnier">Frédéric Charbonnier</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sereda, Michael W" sort="Sereda, Michael W" uniqKey="Sereda M" first="Michael W." last="Sereda">Michael W. Sereda</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurogenetics,<institution>Max Planck Institute of Experimental Medicine</institution>, 37075 Goettingen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Clinical Neurophysiology,<institution>University of Goettingen</institution>, 37075 Goettingen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baulieu, Etienne Emile" sort="Baulieu, Etienne Emile" uniqKey="Baulieu E" first="Etienne-Emile" last="Baulieu">Etienne-Emile Baulieu</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale, Institut Fédératif de Recherche de Bicêtre 93,<institution>University Paris-Sud 11</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schumacher, Michael" sort="Schumacher, Michael" uniqKey="Schumacher M" first="Michael" last="Schumacher">Michael Schumacher</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale, Institut Fédératif de Recherche de Bicêtre 93,<institution>University Paris-Sud 11</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bernard, Sophie" sort="Bernard, Sophie" uniqKey="Bernard S" first="Sophie" last="Bernard">Sophie Bernard</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Massaad, Charbel" sort="Massaad, Charbel" uniqKey="Massaad C" first="Charbel" last="Massaad">Charbel Massaad</name><affiliation wicri:level="1"><nlm:aff id="aff1">Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Glycogen synthase kinase 3β (GSK3β) inhibitors, especially the mood stabilizer lithium chloride, are also used as neuroprotective or anti-inflammatory agents. We studied the influence of LiCl on the remyelination of peripheral nerves. We showed that the treatment of adult mice with LiCl after facial nerve crush injury stimulated the expression of myelin genes, restored the myelin structure, and accelerated the recovery of whisker movements. LiCl treatment also promoted remyelination of the sciatic nerve after crush. We also demonstrated that peripheral myelin gene MPZ and PMP22 promoter activities, transcripts, and protein levels are stimulated by GSK3β inhibitors (LiCl and SB216763) in Schwann cells as well as in sciatic and facial nerves. LiCl exerts its action in Schwann cells by increasing the amount of β-catenin and provoking its nuclear localization. We showed by ChIP experiments that LiCl treatment drives β-catenin to bind to T-cell factor/lymphoid-enhancer factor response elements identified in myelin genes. Taken together, our findings open perspectives in the treatment of nerve demyelination by administering GSK3β inhibitors such as lithium.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="iso-abbrev">Proc. Natl. Acad. Sci. U.S.A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22355115</article-id><article-id pub-id-type="pmc">3309729</article-id><article-id pub-id-type="publisher-id">201121367</article-id><article-id pub-id-type="doi">10.1073/pnas.1121367109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Neuroscience</subject></subj-group></subj-group></article-categories><title-group><article-title>Lithium enhances remyelination of peripheral nerves</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Makoukji</surname><given-names>Joelle</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Belle</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Meffre</surname><given-names>Delphine</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stassart</surname><given-names>Ruth</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Grenier</surname><given-names>Julien</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shackleford</surname><given-names>Ghjuvan'Ghjacumu</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fledrich</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fonte</surname><given-names>Cosima</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Branchu</surname><given-names>Julien</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Goulard</surname><given-names>Marie</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>de Waele</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Charbonnier</surname><given-names>Frédéric</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sereda</surname><given-names>Michael W.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baulieu</surname><given-names>Etienne-Emile</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref><xref ref-type="corresp" rid="cor1"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schumacher</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bernard</surname><given-names>Sophie</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Massaad</surname><given-names>Charbel</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>2</sup></xref></contrib><aff id="aff1"><sup>a</sup>Unité Mixte de Recherche 8194, Centre National de la Recherche Scientifique, Centre d'Etude de la Sensori Motricité,<institution>University Paris Descartes</institution>, 75270 Paris Cedex 06,<country>France</country>;</aff><aff id="aff2"><sup>b</sup>Department of Neurogenetics,<institution>Max Planck Institute of Experimental Medicine</institution>, 37075 Goettingen,<country>Germany</country>;</aff><aff id="aff3"><sup>c</sup>Unité Mixte de Recherche 788, Institut National de la Santé et de la Recherche Médicale, Institut Fédératif de Recherche de Bicêtre 93,<institution>University Paris-Sud 11</institution>, 94276 Le Kremlin-Bicêtre Cedex,<country>France</country>; and</aff><aff id="aff4"><sup>d</sup>Department of Clinical Neurophysiology,<institution>University of Goettingen</institution>, 37075 Goettingen,<country>Germany</country></aff></contrib-group><author-notes><corresp id="cor1"><sup>2</sup>To whom correspondence may be addressed. E-mail: <email>etienne.baulieu@inserm.fr</email> or <email>charbel.massaad@parisdescartes.fr</email>.</corresp><fn fn-type="edited-by"><p>Contributed by Etienne-Emile Baulieu, December 27, 2011 (sent for review November 24, 2011)</p></fn><fn fn-type="con"><p>Author contributions: R.S., C.d.W., F.C., M.W.S., S.B., and C.M. designed research; J.M., M.B., D.M., R.S., J.G., G.S., R.F., C.F., J.B., M.G., C.d.W., and S.B. performed research; J.M., C.d.W., F.C., M.W.S., M.S., S.B., and C.M. analyzed data; and E.-E.B., M.S., and C.M. wrote the paper.</p></fn><fn fn-type="equal" id="fn1"><p><sup>1</sup>J.M. and M.B. contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><day>6</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>21</day><month>2</month><year>2012</year></pub-date><volume>109</volume><issue>10</issue><fpage>3973</fpage><lpage>3978</lpage><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="pnas.201121367.pdf"></self-uri><abstract><p>Glycogen synthase kinase 3β (GSK3β) inhibitors, especially the mood stabilizer lithium chloride, are also used as neuroprotective or anti-inflammatory agents. We studied the influence of LiCl on the remyelination of peripheral nerves. We showed that the treatment of adult mice with LiCl after facial nerve crush injury stimulated the expression of myelin genes, restored the myelin structure, and accelerated the recovery of whisker movements. LiCl treatment also promoted remyelination of the sciatic nerve after crush. We also demonstrated that peripheral myelin gene MPZ and PMP22 promoter activities, transcripts, and protein levels are stimulated by GSK3β inhibitors (LiCl and SB216763) in Schwann cells as well as in sciatic and facial nerves. LiCl exerts its action in Schwann cells by increasing the amount of β-catenin and provoking its nuclear localization. We showed by ChIP experiments that LiCl treatment drives β-catenin to bind to T-cell factor/lymphoid-enhancer factor response elements identified in myelin genes. Taken together, our findings open perspectives in the treatment of nerve demyelination by administering GSK3β inhibitors such as lithium.</p></abstract><kwd-group><kwd>Wnt/β-catenin</kwd><kwd>neuropathy</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000538 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000538 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:3309729
|texte= Lithium enhances remyelination of peripheral nerves
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:22355115" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |