A Case–Control Study on the Origin of Atypical Scrapie in Sheep, France
Identifieur interne : 000387 ( Pmc/Curation ); précédent : 000386; suivant : 000388A Case–Control Study on the Origin of Atypical Scrapie in Sheep, France
Auteurs : Alexandre Fediaevsky ; Eric Morignat ; Christian Ducrot ; Didier CalavasSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2009.
Abstract
Risk factors for this disease suggest a noninfectious origin influenced by genetic and metabolic factors.
Url:
DOI: 10.3201/eid1505.081119
PubMed: 19402956
PubMed Central: 2687017
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title>Emerging Infectious Diseases</journal-title><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19402956</article-id><article-id pub-id-type="pmc">2687017</article-id><article-id pub-id-type="publisher-id">08-1119</article-id><article-id pub-id-type="doi">10.3201/eid1505.081119</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>A Case–Control Study on the Origin of Atypical Scrapie in Sheep, France </article-title><alt-title alt-title-type="running-head">Origin of Atypical Scrapie in Sheep, France</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Fediaevsky</surname><given-names>Alexandre</given-names></name></contrib><contrib contrib-type="author"><name><surname>Morignat</surname><given-names>Eric</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ducrot</surname><given-names>Christian</given-names></name></contrib><contrib contrib-type="author"><name><surname>Calavas</surname><given-names>Didier</given-names></name></contrib><aff id="aff1">Agence Française de Sécurité Sanitaire des Aliments, Lyon, France (A. Fediaevsky, E. Morignat, D. Calavas)</aff><aff id="aff2">Institut National de la Recherche Agronomique, Clermont-Theix, France (A. Fediaevsky, C, Ducrot)</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Alexandre Fediaevsky, Unité d’Épidémiologie Animale, Institut National de la Recherche Agronomique, Unité de Recherche 346, F-63122 Saint-Genès-Champanelle, France; email: <email xlink:href="afediaevsky@clermont.inra.fr">afediaevsky@clermont.inra.fr</email></corresp></author-notes><pub-date pub-type="ppub"><month>5</month><year>2009</year></pub-date><volume>15</volume><issue>5</issue><fpage>710</fpage><lpage>718</lpage><abstract abstract-type="toc"><p>Risk factors for this disease suggest a noninfectious origin influenced by genetic and metabolic factors.</p></abstract><abstract><p>A matched case–control study (95 cases and 220 controls) was designed to study risk factors for atypical scrapie in sheep in France. We analyzed contacts with animals from other flocks, lambing and feeding practices, and exposure to toxic substances. Data on the <italic>prnp</italic> genotype were collected for some case and control animals and included in a complementary analysis. Sheep dairy farms had a higher risk for scrapie (odds ratio [OR] 15.1, 95% confidence interval [CI] 3.3–69.7). Lower risk was associated with organic farms (OR 0.15, 95% CI 0.02–1.26), feeding corn silage (OR 0.16, 95% CI 0.05–0.53), and feeding vitamin and mineral supplements (OR 0.6, 95% CI 0.32–1.14). Genetic effects were quantitatively important but only marginally changed estimates of other variables. We did not find any risk factor associated with an infectious origin of scrapie. Atypical scrapie could be a spontaneous disease influenced by genetic and metabolic factors.</p></abstract><kwd-group kwd-group-type="author" xml:lang="EN"><title>Keywords: </title><kwd>Prions and related diseases</kwd><kwd>scrapie</kwd><kwd>transmissible spongiform encephalopathy</kwd><kwd>case–control study</kwd><kwd>sheep</kwd><kwd>epidemiology</kwd><kwd>France</kwd><kwd>research</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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