Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease
Identifieur interne : 000087 ( Pmc/Curation ); précédent : 000086; suivant : 000088Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease
Auteurs : Nicolas Maurice [France] ; Thierry Deltheil [France] ; Christophe Melon [France] ; Bertrand Degos [France] ; Christiane Mourre [France] ; Marianne Amalric [France] ; Lydia Kerkerian-Le Goff [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Recent evidence points to a neuroprotective action of bee venom on nigral dopamine neurons in animal models of Parkinson’s disease (PD). Here we examined whether bee venom also displays a symptomatic action by acting on the pathological functioning of the basal ganglia in rat PD models. Bee venom effects were assessed by combining motor behavior analyses and
Url:
DOI: 10.1371/journal.pone.0142838
PubMed: 26571268
PubMed Central: 4646345
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000087
Links to Exploration step
PMC:4646345Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease</title>
<author><name sortKey="Maurice, Nicolas" sort="Maurice, Nicolas" uniqKey="Maurice N" first="Nicolas" last="Maurice">Nicolas Maurice</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deltheil, Thierry" sort="Deltheil, Thierry" uniqKey="Deltheil T" first="Thierry" last="Deltheil">Thierry Deltheil</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Melon, Christophe" sort="Melon, Christophe" uniqKey="Melon C" first="Christophe" last="Melon">Christophe Melon</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Degos, Bertrand" sort="Degos, Bertrand" uniqKey="Degos B" first="Bertrand" last="Degos">Bertrand Degos</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>INSERM, CNRS, Collège de France, CIRB UMR 7241 U-1050, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, CNRS, Collège de France, CIRB UMR 7241 U-1050, Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>APHP, Département des Maladies du Système Nerveux, Centre Expert Inter-Régional Ile de France de la Maladie de Parkinson, Hôpital Pitié-Salpêtrière, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>APHP, Département des Maladies du Système Nerveux, Centre Expert Inter-Régional Ile de France de la Maladie de Parkinson, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mourre, Christiane" sort="Mourre, Christiane" uniqKey="Mourre C" first="Christiane" last="Mourre">Christiane Mourre</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Amalric, Marianne" sort="Amalric, Marianne" uniqKey="Amalric M" first="Marianne" last="Amalric">Marianne Amalric</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kerkerian Le Goff, Lydia" sort="Kerkerian Le Goff, Lydia" uniqKey="Kerkerian Le Goff L" first="Lydia" last="Kerkerian-Le Goff">Lydia Kerkerian-Le Goff</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26571268</idno>
<idno type="pmc">4646345</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646345</idno>
<idno type="RBID">PMC:4646345</idno>
<idno type="doi">10.1371/journal.pone.0142838</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000087</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000087</idno>
<idno type="wicri:Area/Pmc/Curation">000087</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000087</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease</title>
<author><name sortKey="Maurice, Nicolas" sort="Maurice, Nicolas" uniqKey="Maurice N" first="Nicolas" last="Maurice">Nicolas Maurice</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deltheil, Thierry" sort="Deltheil, Thierry" uniqKey="Deltheil T" first="Thierry" last="Deltheil">Thierry Deltheil</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Melon, Christophe" sort="Melon, Christophe" uniqKey="Melon C" first="Christophe" last="Melon">Christophe Melon</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Degos, Bertrand" sort="Degos, Bertrand" uniqKey="Degos B" first="Bertrand" last="Degos">Bertrand Degos</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>INSERM, CNRS, Collège de France, CIRB UMR 7241 U-1050, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, CNRS, Collège de France, CIRB UMR 7241 U-1050, Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>APHP, Département des Maladies du Système Nerveux, Centre Expert Inter-Régional Ile de France de la Maladie de Parkinson, Hôpital Pitié-Salpêtrière, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>APHP, Département des Maladies du Système Nerveux, Centre Expert Inter-Régional Ile de France de la Maladie de Parkinson, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mourre, Christiane" sort="Mourre, Christiane" uniqKey="Mourre C" first="Christiane" last="Mourre">Christiane Mourre</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Amalric, Marianne" sort="Amalric, Marianne" uniqKey="Amalric M" first="Marianne" last="Amalric">Marianne Amalric</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kerkerian Le Goff, Lydia" sort="Kerkerian Le Goff, Lydia" uniqKey="Kerkerian Le Goff L" first="Lydia" last="Kerkerian-Le Goff">Lydia Kerkerian-Le Goff</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Recent evidence points to a neuroprotective action of bee venom on nigral dopamine neurons in animal models of Parkinson’s disease (PD). Here we examined whether bee venom also displays a symptomatic action by acting on the pathological functioning of the basal ganglia in rat PD models. Bee venom effects were assessed by combining motor behavior analyses and <italic>in vivo</italic>
electrophysiological recordings in the substantia nigra pars reticulata (SNr, basal ganglia output structure) in pharmacological (neuroleptic treatment) and lesional (unilateral intranigral 6-hydroxydopamine injection) PD models. In the hemi-parkinsonian 6-hydroxydopamine lesion model, subchronic bee venom treatment significantly alleviates contralateral forelimb akinesia and apomorphine-induced rotations. Moreover, a single injection of bee venom reverses haloperidol-induced catalepsy, a pharmacological model reminiscent of parkinsonian akinetic deficit. This effect is mimicked by apamin, a blocker of small conductance Ca2+-activated K+ (SK) channels, and blocked by CyPPA, a positive modulator of these channels, suggesting the involvement of SK channels in the bee venom antiparkinsonian action. <italic>In vivo</italic>
electrophysiological recordings in the substantia nigra pars reticulata (basal ganglia output structure) showed no significant effect of BV on the mean neuronal discharge frequency or pathological bursting activity. In contrast, analyses of the neuronal responses evoked by motor cortex stimulation show that bee venom reverses the 6-OHDA- and neuroleptic-induced biases in the influence exerted by the direct inhibitory and indirect excitatory striatonigral circuits. These data provide the first evidence for a beneficial action of bee venom on the pathological functioning of the cortico-basal ganglia circuits underlying motor PD symptoms with potential relevance to the symptomatic treatment of this disease.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wichmann, T" uniqKey="Wichmann T">T Wichmann</name>
</author>
<author><name sortKey="Delong, Mr" uniqKey="Delong M">MR DeLong</name>
</author>
<author><name sortKey="Guridi, J" uniqKey="Guridi J">J Guridi</name>
</author>
<author><name sortKey="Obeso, Ja" uniqKey="Obeso J">JA Obeso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Albin, Rl" uniqKey="Albin R">RL Albin</name>
</author>
<author><name sortKey="Young, Ab" uniqKey="Young A">AB Young</name>
</author>
<author><name sortKey="Penney, Jb" uniqKey="Penney J">JB Penney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pollak, P" uniqKey="Pollak P">P Pollak</name>
</author>
<author><name sortKey="Fraix, V" uniqKey="Fraix V">V Fraix</name>
</author>
<author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name>
</author>
<author><name sortKey="Moro, E" uniqKey="Moro E">E Moro</name>
</author>
<author><name sortKey="Mendes, A" uniqKey="Mendes A">A Mendes</name>
</author>
<author><name sortKey="Chabardes, S" uniqKey="Chabardes S">S Chabardes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name>
</author>
<author><name sortKey="Lozano, A" uniqKey="Lozano A">A Lozano</name>
</author>
<author><name sortKey="Stern, M" uniqKey="Stern M">M Stern</name>
</author>
<author><name sortKey="Poewe, W" uniqKey="Poewe W">W Poewe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lindvall, O" uniqKey="Lindvall O">O Lindvall</name>
</author>
<author><name sortKey="Bjorklund, A" uniqKey="Bjorklund A">A Björklund</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hickey, P" uniqKey="Hickey P">P Hickey</name>
</author>
<author><name sortKey="Stacy, M" uniqKey="Stacy M">M Stacy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harris, H" uniqKey="Harris H">H Harris</name>
</author>
<author><name sortKey="Rubinsztein, Dc" uniqKey="Rubinsztein D">DC Rubinsztein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salthun Lassalle, B" uniqKey="Salthun Lassalle B">B Salthun-Lassalle</name>
</author>
<author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name>
</author>
<author><name sortKey="Wolfart, J" uniqKey="Wolfart J">J Wolfart</name>
</author>
<author><name sortKey="Ruberg, M" uniqKey="Ruberg M">M Ruberg</name>
</author>
<author><name sortKey="Michel, Pp" uniqKey="Michel P">PP Michel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doo, Ar" uniqKey="Doo A">AR Doo</name>
</author>
<author><name sortKey="Kim, St" uniqKey="Kim S">ST Kim</name>
</author>
<author><name sortKey="Kim, Sn" uniqKey="Kim S">SN Kim</name>
</author>
<author><name sortKey="Moon, W" uniqKey="Moon W">W Moon</name>
</author>
<author><name sortKey="Yin, Cs" uniqKey="Yin C">CS Yin</name>
</author>
<author><name sortKey="Chae, Y" uniqKey="Chae Y">Y Chae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doo, Ar" uniqKey="Doo A">AR Doo</name>
</author>
<author><name sortKey="Kim, Sn" uniqKey="Kim S">SN Kim</name>
</author>
<author><name sortKey="Kim, St" uniqKey="Kim S">ST Kim</name>
</author>
<author><name sortKey="Park, Jy" uniqKey="Park J">JY Park</name>
</author>
<author><name sortKey="Chung, Sh" uniqKey="Chung S">SH Chung</name>
</author>
<author><name sortKey="Choe, By" uniqKey="Choe B">BY Choe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Ji" uniqKey="Kim J">JI Kim</name>
</author>
<author><name sortKey="Yang, Ej" uniqKey="Yang E">EJ Yang</name>
</author>
<author><name sortKey="Lee, Ms" uniqKey="Lee M">MS Lee</name>
</author>
<author><name sortKey="Kim, Ys" uniqKey="Kim Y">YS Kim</name>
</author>
<author><name sortKey="Huh, Y" uniqKey="Huh Y">Y Huh</name>
</author>
<author><name sortKey="Cho, Ih" uniqKey="Cho I">IH Cho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alvarez Fischer, D" uniqKey="Alvarez Fischer D">D Alvarez-Fischer</name>
</author>
<author><name sortKey="Noelker, C" uniqKey="Noelker C">C Noelker</name>
</author>
<author><name sortKey="Vulinovi, F" uniqKey="Vulinovi F">F Vulinović</name>
</author>
<author><name sortKey="Grunewald, A" uniqKey="Grunewald A">A Grünewald</name>
</author>
<author><name sortKey="Chevarin, C" uniqKey="Chevarin C">C Chevarin</name>
</author>
<author><name sortKey="Klein, C" uniqKey="Klein C">C Klein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khalil, Wkb" uniqKey="Khalil W">WKB Khalil</name>
</author>
<author><name sortKey="Assaf, N" uniqKey="Assaf N">N Assaf</name>
</author>
<author><name sortKey="Elshebiney, Sa" uniqKey="Elshebiney S">SA ElShebiney</name>
</author>
<author><name sortKey="Salem, Na" uniqKey="Salem N">NA Salem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Ej" uniqKey="Yang E">EJ Yang</name>
</author>
<author><name sortKey="Jiang, Jh" uniqKey="Jiang J">JH Jiang</name>
</author>
<author><name sortKey="Lee, Sm" uniqKey="Lee S">SM Lee</name>
</author>
<author><name sortKey="Yang, Sc" uniqKey="Yang S">SC Yang</name>
</author>
<author><name sortKey="Hwang, Hs" uniqKey="Hwang H">HS Hwang</name>
</author>
<author><name sortKey="Lee, Ms" uniqKey="Lee M">MS Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aumann, Td" uniqKey="Aumann T">TD Aumann</name>
</author>
<author><name sortKey="Gantois, I" uniqKey="Gantois I">I Gantois</name>
</author>
<author><name sortKey="Egan, K" uniqKey="Egan K">K Egan</name>
</author>
<author><name sortKey="Vais, A" uniqKey="Vais A">A Vais</name>
</author>
<author><name sortKey="Tomas, D" uniqKey="Tomas D">D Tomas</name>
</author>
<author><name sortKey="Drago, J" uniqKey="Drago J">J Drago</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benitez, Ba" uniqKey="Benitez B">BA Benítez</name>
</author>
<author><name sortKey="Belalcazar, Hm" uniqKey="Belalcazar H">HM Belálcazar</name>
</author>
<author><name sortKey="Anastasia, A" uniqKey="Anastasia A">A Anastasía</name>
</author>
<author><name sortKey="Mamah, Dt" uniqKey="Mamah D">DT Mamah</name>
</author>
<author><name sortKey="Zorumski, Cf" uniqKey="Zorumski C">CF Zorumski</name>
</author>
<author><name sortKey="Masc, Dh" uniqKey="Masc D">DH Mascó</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wulff, H" uniqKey="Wulff H">H Wulff</name>
</author>
<author><name sortKey="Kolski Andreaco, A" uniqKey="Kolski Andreaco A">A Kolski-Andreaco</name>
</author>
<author><name sortKey="Sankaranarayanan, A" uniqKey="Sankaranarayanan A">A Sankaranarayanan</name>
</author>
<author><name sortKey="Sabatier, J M" uniqKey="Sabatier J">J-M Sabatier</name>
</author>
<author><name sortKey="Shakkottai, V" uniqKey="Shakkottai V">V Shakkottai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
<author><name sortKey="Zeng, J" uniqKey="Zeng J">J Zeng</name>
</author>
<author><name sortKey="Ren, R" uniqKey="Ren R">R Ren</name>
</author>
<author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Faber, Esl" uniqKey="Faber E">ESL Faber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Deltheil, T" uniqKey="Deltheil T">T Deltheil</name>
</author>
<author><name sortKey="Turle Lorenzo, N" uniqKey="Turle Lorenzo N">N Turle-Lorenzo</name>
</author>
<author><name sortKey="Liberge, M" uniqKey="Liberge M">M Liberge</name>
</author>
<author><name sortKey="Rosier, C" uniqKey="Rosier C">C Rosier</name>
</author>
<author><name sortKey="Watabe, I" uniqKey="Watabe I">I Watabe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Groot, J" uniqKey="De Groot J">J De Groot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salin, P" uniqKey="Salin P">P Salin</name>
</author>
<author><name sortKey="Manrique, C" uniqKey="Manrique C">C Manrique</name>
</author>
<author><name sortKey="Forni, C" uniqKey="Forni C">C Forni</name>
</author>
<author><name sortKey="Kerkerian Le Goff, L" uniqKey="Kerkerian Le Goff L">L Kerkerian-Le Goff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schallert, T" uniqKey="Schallert T">T Schallert</name>
</author>
<author><name sortKey="Fleming, Sm" uniqKey="Fleming S">SM Fleming</name>
</author>
<author><name sortKey="Leasure, Jl" uniqKey="Leasure J">JL Leasure</name>
</author>
<author><name sortKey="Tillerson, Jl" uniqKey="Tillerson J">JL Tillerson</name>
</author>
<author><name sortKey="Bland, St" uniqKey="Bland S">ST Bland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paxinos, G" uniqKey="Paxinos G">G Paxinos</name>
</author>
<author><name sortKey="Watson, C" uniqKey="Watson C">C Watson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deniau, Jm" uniqKey="Deniau J">JM Deniau</name>
</author>
<author><name sortKey="Menetrey, A" uniqKey="Menetrey A">A Menetrey</name>
</author>
<author><name sortKey="Charpier, S" uniqKey="Charpier S">S Charpier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maurice, N" uniqKey="Maurice N">N Maurice</name>
</author>
<author><name sortKey="Deniau, Jm" uniqKey="Deniau J">JM Deniau</name>
</author>
<author><name sortKey="Glowinski, J" uniqKey="Glowinski J">J Glowinski</name>
</author>
<author><name sortKey="Thierry, Am" uniqKey="Thierry A">AM Thierry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deniau, Jm" uniqKey="Deniau J">JM Deniau</name>
</author>
<author><name sortKey="Hammond, C" uniqKey="Hammond C">C Hammond</name>
</author>
<author><name sortKey="Riszk, A" uniqKey="Riszk A">A Riszk</name>
</author>
<author><name sortKey="Feger, J" uniqKey="Feger J">J Féger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bunney, Bs" uniqKey="Bunney B">BS Bunney</name>
</author>
<author><name sortKey="Walters, Jr" uniqKey="Walters J">JR Walters</name>
</author>
<author><name sortKey="Roth, Rh" uniqKey="Roth R">RH Roth</name>
</author>
<author><name sortKey="Aghajanian, Gk" uniqKey="Aghajanian G">GK Aghajanian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Robin, K" uniqKey="Robin K">K Robin</name>
</author>
<author><name sortKey="Maurice, N" uniqKey="Maurice N">N Maurice</name>
</author>
<author><name sortKey="Degos, B" uniqKey="Degos B">B Degos</name>
</author>
<author><name sortKey="Deniau, Jm" uniqKey="Deniau J">JM Deniau</name>
</author>
<author><name sortKey="Martinerie, J" uniqKey="Martinerie J">J Martinerie</name>
</author>
<author><name sortKey="Pezard, L" uniqKey="Pezard L">L Pezard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Legendy, Cr" uniqKey="Legendy C">CR Legéndy</name>
</author>
<author><name sortKey="Salcman, M" uniqKey="Salcman M">M Salcman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kolomiets, Bp" uniqKey="Kolomiets B">BP Kolomiets</name>
</author>
<author><name sortKey="Deniau, Jm" uniqKey="Deniau J">JM Deniau</name>
</author>
<author><name sortKey="Glowinski, J" uniqKey="Glowinski J">J Glowinski</name>
</author>
<author><name sortKey="Thierry, Am" uniqKey="Thierry A">AM Thierry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beyeler, A" uniqKey="Beyeler A">A Beyeler</name>
</author>
<author><name sortKey="Kadiri, N" uniqKey="Kadiri N">N Kadiri</name>
</author>
<author><name sortKey="Navailles, S" uniqKey="Navailles S">S Navailles</name>
</author>
<author><name sortKey="Boujema, M Ben" uniqKey="Boujema M">M Ben Boujema</name>
</author>
<author><name sortKey="Gonon, F" uniqKey="Gonon F">F Gonon</name>
</author>
<author><name sortKey="Moine, C Le" uniqKey="Moine C">C Le Moine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Degos, B" uniqKey="Degos B">B Degos</name>
</author>
<author><name sortKey="Deniau, Jm" uniqKey="Deniau J">JM Deniau</name>
</author>
<author><name sortKey="Thierry, Am" uniqKey="Thierry A">AM Thierry</name>
</author>
<author><name sortKey="Glowinski, J" uniqKey="Glowinski J">J Glowinski</name>
</author>
<author><name sortKey="Pezard, L" uniqKey="Pezard L">L Pezard</name>
</author>
<author><name sortKey="Maurice, N" uniqKey="Maurice N">N Maurice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inoue, K" uniqKey="Inoue K">K Inoue</name>
</author>
<author><name sortKey="Koketsu, D" uniqKey="Koketsu D">D Koketsu</name>
</author>
<author><name sortKey="Kato, S" uniqKey="Kato S">S Kato</name>
</author>
<author><name sortKey="Kobayashi, K" uniqKey="Kobayashi K">K Kobayashi</name>
</author>
<author><name sortKey="Nambu, A" uniqKey="Nambu A">A Nambu</name>
</author>
<author><name sortKey="Takada, M" uniqKey="Takada M">M Takada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nishibayashi, H" uniqKey="Nishibayashi H">H Nishibayashi</name>
</author>
<author><name sortKey="Ogura, M" uniqKey="Ogura M">M Ogura</name>
</author>
<author><name sortKey="Kakishita, K" uniqKey="Kakishita K">K Kakishita</name>
</author>
<author><name sortKey="Tanaka, S" uniqKey="Tanaka S">S Tanaka</name>
</author>
<author><name sortKey="Tachibana, Y" uniqKey="Tachibana Y">Y Tachibana</name>
</author>
<author><name sortKey="Nambu, A" uniqKey="Nambu A">A Nambu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gerlach, M" uniqKey="Gerlach M">M Gerlach</name>
</author>
<author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stansfeld, Ce" uniqKey="Stansfeld C">CE Stansfeld</name>
</author>
<author><name sortKey="Marsh, Sj" uniqKey="Marsh S">SJ Marsh</name>
</author>
<author><name sortKey="Parcej, Dn" uniqKey="Parcej D">DN Parcej</name>
</author>
<author><name sortKey="Dolly, Jo" uniqKey="Dolly J">JO Dolly</name>
</author>
<author><name sortKey="Brown, Da" uniqKey="Brown D">DA Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Ej" uniqKey="Yang E">EJ Yang</name>
</author>
<author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name>
</author>
<author><name sortKey="Yang, Sc" uniqKey="Yang S">SC Yang</name>
</author>
<author><name sortKey="Lee, Sm" uniqKey="Lee S">SM Lee</name>
</author>
<author><name sortKey="Choi, S M" uniqKey="Choi S">S-M Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Habermann, E" uniqKey="Habermann E">E Habermann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kokot, Zj" uniqKey="Kokot Z">ZJ Kokot</name>
</author>
<author><name sortKey="Matysiak, J" uniqKey="Matysiak J">J Matysiak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herrik, Kf" uniqKey="Herrik K">KF Herrik</name>
</author>
<author><name sortKey="Redrobe, Jp" uniqKey="Redrobe J">JP Redrobe</name>
</author>
<author><name sortKey="Holst, D" uniqKey="Holst D">D Holst</name>
</author>
<author><name sortKey="Hougaard, C" uniqKey="Hougaard C">C Hougaard</name>
</author>
<author><name sortKey="Sandager Nielsen, K" uniqKey="Sandager Nielsen K">K Sandager-Nielsen</name>
</author>
<author><name sortKey="Nielsen, An" uniqKey="Nielsen A">AN Nielsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steketee, Jd" uniqKey="Steketee J">JD Steketee</name>
</author>
<author><name sortKey="Kalivas, Pw" uniqKey="Kalivas P">PW Kalivas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stocker, M" uniqKey="Stocker M">M Stocker</name>
</author>
<author><name sortKey="Pedarzani, P" uniqKey="Pedarzani P">P Pedarzani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sailer, Ca" uniqKey="Sailer C">CA Sailer</name>
</author>
<author><name sortKey="Kaufmann, Wa" uniqKey="Kaufmann W">WA Kaufmann</name>
</author>
<author><name sortKey="Marksteiner, J" uniqKey="Marksteiner J">J Marksteiner</name>
</author>
<author><name sortKey="Knaus, Hg" uniqKey="Knaus H">HG Knaus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sarpal, D" uniqKey="Sarpal D">D Sarpal</name>
</author>
<author><name sortKey="Koenig, Ji" uniqKey="Koenig J">JI Koenig</name>
</author>
<author><name sortKey="Adelman, Jp" uniqKey="Adelman J">JP Adelman</name>
</author>
<author><name sortKey="Brady, D" uniqKey="Brady D">D Brady</name>
</author>
<author><name sortKey="Prendeville, Lc" uniqKey="Prendeville L">LC Prendeville</name>
</author>
<author><name sortKey="Shepard, Pd" uniqKey="Shepard P">PD Shepard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maltete, D" uniqKey="Maltete D">D Maltête</name>
</author>
<author><name sortKey="Jodoin, N" uniqKey="Jodoin N">N Jodoin</name>
</author>
<author><name sortKey="Karachi, C" uniqKey="Karachi C">C Karachi</name>
</author>
<author><name sortKey="Houeto, Jl" uniqKey="Houeto J">JL Houeto</name>
</author>
<author><name sortKey="Navarro, S" uniqKey="Navarro S">S Navarro</name>
</author>
<author><name sortKey="Cornu, P" uniqKey="Cornu P">P Cornu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wichmann, T" uniqKey="Wichmann T">T Wichmann</name>
</author>
<author><name sortKey="Bergman, H" uniqKey="Bergman H">H Bergman</name>
</author>
<author><name sortKey="Starr, Pa" uniqKey="Starr P">PA Starr</name>
</author>
<author><name sortKey="Subramanian, T" uniqKey="Subramanian T">T Subramanian</name>
</author>
<author><name sortKey="Watts, Rl" uniqKey="Watts R">RL Watts</name>
</author>
<author><name sortKey="Delong, Mr" uniqKey="Delong M">MR DeLong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boraud, T" uniqKey="Boraud T">T Boraud</name>
</author>
<author><name sortKey="Bezard, E" uniqKey="Bezard E">E Bezard</name>
</author>
<author><name sortKey="Bioulac, B" uniqKey="Bioulac B">B Bioulac</name>
</author>
<author><name sortKey="Gross, Ce" uniqKey="Gross C">CE Gross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tai, Ch" uniqKey="Tai C">CH Tai</name>
</author>
<author><name sortKey="Boraud, T" uniqKey="Boraud T">T Boraud</name>
</author>
<author><name sortKey="Bezard, E" uniqKey="Bezard E">E Bezard</name>
</author>
<author><name sortKey="Bioulac, B" uniqKey="Bioulac B">B Bioulac</name>
</author>
<author><name sortKey="Gross, C" uniqKey="Gross C">C Gross</name>
</author>
<author><name sortKey="Benazzouz, A" uniqKey="Benazzouz A">A Benazzouz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sano, H" uniqKey="Sano H">H Sano</name>
</author>
<author><name sortKey="Yasoshima, Y" uniqKey="Yasoshima Y">Y Yasoshima</name>
</author>
<author><name sortKey="Matsushita, N" uniqKey="Matsushita N">N Matsushita</name>
</author>
<author><name sortKey="Kaneko, T" uniqKey="Kaneko T">T Kaneko</name>
</author>
<author><name sortKey="Kohno, K" uniqKey="Kohno K">K Kohno</name>
</author>
<author><name sortKey="Pastan, I" uniqKey="Pastan I">I Pastan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tachibana, Y" uniqKey="Tachibana Y">Y Tachibana</name>
</author>
<author><name sortKey="Kita, H" uniqKey="Kita H">H Kita</name>
</author>
<author><name sortKey="Chiken, S" uniqKey="Chiken S">S Chiken</name>
</author>
<author><name sortKey="Takada, M" uniqKey="Takada M">M Takada</name>
</author>
<author><name sortKey="Nambu, A" uniqKey="Nambu A">A Nambu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Missale, C" uniqKey="Missale C">C Missale</name>
</author>
<author><name sortKey="Nash, Sr" uniqKey="Nash S">SR Nash</name>
</author>
<author><name sortKey="Robinson, Sw" uniqKey="Robinson S">SW Robinson</name>
</author>
<author><name sortKey="Jaber, M" uniqKey="Jaber M">M Jaber</name>
</author>
<author><name sortKey="Caron, Mg" uniqKey="Caron M">MG Caron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Angulo, Ja" uniqKey="Angulo J">JA Angulo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Konieczny, J" uniqKey="Konieczny J">J Konieczny</name>
</author>
<author><name sortKey="Wardas, J" uniqKey="Wardas J">J Wardas</name>
</author>
<author><name sortKey="Kuter, K" uniqKey="Kuter K">K Kuter</name>
</author>
<author><name sortKey="Pilc, A" uniqKey="Pilc A">A Pilc</name>
</author>
<author><name sortKey="Ossowska, K" uniqKey="Ossowska K">K Ossowska</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drew, Kl" uniqKey="Drew K">KL Drew</name>
</author>
<author><name sortKey="Wt, O Onnor" uniqKey="Wt O">O’Connor WT</name>
</author>
<author><name sortKey="Kehr, J" uniqKey="Kehr J">J Kehr</name>
</author>
<author><name sortKey="Ungerstedt, U" uniqKey="Ungerstedt U">U Ungerstedt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chapman, Ma" uniqKey="Chapman M">MA Chapman</name>
</author>
<author><name sortKey="See, Re" uniqKey="See R">RE See</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arias Garcia, Ma" uniqKey="Arias Garcia M">MA Arias-García</name>
</author>
<author><name sortKey="Tapia, D" uniqKey="Tapia D">D Tapia</name>
</author>
<author><name sortKey="Flores Barrera, E" uniqKey="Flores Barrera E">E Flores-Barrera</name>
</author>
<author><name sortKey="Perez Ortega, Je" uniqKey="Perez Ortega J">JE Pérez-Ortega</name>
</author>
<author><name sortKey="Bargas, J" uniqKey="Bargas J">J Bargas</name>
</author>
<author><name sortKey="Galarraga, E" uniqKey="Galarraga E">E Galarraga</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26571268</article-id>
<article-id pub-id-type="pmc">4646345</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0142838</article-id>
<article-id pub-id-type="publisher-id">PONE-D-15-32902</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease</article-title>
<alt-title alt-title-type="running-head">Bee Venom for Parkinson's Disease</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Maurice</surname>
<given-names>Nicolas</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref rid="cor001" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Deltheil</surname>
<given-names>Thierry</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Melon</surname>
<given-names>Christophe</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Degos</surname>
<given-names>Bertrand</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mourre</surname>
<given-names>Christiane</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Amalric</surname>
<given-names>Marianne</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Kerkerian-Le Goff</surname>
<given-names>Lydia</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Aix Marseille Université, CNRS, IBDM UMR 7288, Marseille, France</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Aix Marseille Université, CNRS, LNC UMR 7291, Marseille, France</addr-line>
</aff>
<aff id="aff003"><label>3</label>
<addr-line>INSERM, CNRS, Collège de France, CIRB UMR 7241 U-1050, Paris, France</addr-line>
</aff>
<aff id="aff004"><label>4</label>
<addr-line>APHP, Département des Maladies du Système Nerveux, Centre Expert Inter-Régional Ile de France de la Maladie de Parkinson, Hôpital Pitié-Salpêtrière, Paris, France</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Aumann</surname>
<given-names>Tim Douglas</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Florey Institute of Neuroscience & Mental Health, AUSTRALIA</addr-line>
</aff>
<author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: NM BD MA LKLG. Performed the experiments: NM TD C. Melon BD. Analyzed the data: NM C. Melon. Wrote the paper: NM C. Mourre MA LKLG.</p>
</fn>
<corresp id="cor001">* E-mail: <email>nicolas.maurice@univ-amu.fr</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>16</day>
<month>11</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>10</volume>
<issue>11</issue>
<elocation-id>e0142838</elocation-id>
<history><date date-type="received"><day>27</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>27</day>
<month>10</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-year>2015</copyright-year>
<copyright-holder>Maurice et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0142838.pdf"></self-uri>
<abstract><p>Recent evidence points to a neuroprotective action of bee venom on nigral dopamine neurons in animal models of Parkinson’s disease (PD). Here we examined whether bee venom also displays a symptomatic action by acting on the pathological functioning of the basal ganglia in rat PD models. Bee venom effects were assessed by combining motor behavior analyses and <italic>in vivo</italic>
electrophysiological recordings in the substantia nigra pars reticulata (SNr, basal ganglia output structure) in pharmacological (neuroleptic treatment) and lesional (unilateral intranigral 6-hydroxydopamine injection) PD models. In the hemi-parkinsonian 6-hydroxydopamine lesion model, subchronic bee venom treatment significantly alleviates contralateral forelimb akinesia and apomorphine-induced rotations. Moreover, a single injection of bee venom reverses haloperidol-induced catalepsy, a pharmacological model reminiscent of parkinsonian akinetic deficit. This effect is mimicked by apamin, a blocker of small conductance Ca2+-activated K+ (SK) channels, and blocked by CyPPA, a positive modulator of these channels, suggesting the involvement of SK channels in the bee venom antiparkinsonian action. <italic>In vivo</italic>
electrophysiological recordings in the substantia nigra pars reticulata (basal ganglia output structure) showed no significant effect of BV on the mean neuronal discharge frequency or pathological bursting activity. In contrast, analyses of the neuronal responses evoked by motor cortex stimulation show that bee venom reverses the 6-OHDA- and neuroleptic-induced biases in the influence exerted by the direct inhibitory and indirect excitatory striatonigral circuits. These data provide the first evidence for a beneficial action of bee venom on the pathological functioning of the cortico-basal ganglia circuits underlying motor PD symptoms with potential relevance to the symptomatic treatment of this disease.</p>
</abstract>
<funding-group><funding-statement>This work was supported by the Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU) and by a grant from Association France Parkinson (Grand Appel d’Offre 2011). This work has been carried out within the context of the DHUNE project thanks to the support of the A*MIDEX project (n° ANR-11-IDEX-0001-02) funded by the « Investissements d’Avenir » French Government program, managed by the French National Research Agency (ANR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="6"></fig-count>
<table-count count="2"></table-count>
<page-count count="18"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper.</p>
</notes>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000087 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000087 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:4646345 |texte= Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26571268" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |