Sleepiness in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease
Identifieur interne : 000052 ( Pmc/Curation ); précédent : 000051; suivant : 000053Sleepiness in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease
Auteurs : Isabelle Arnulf [France] ; Dulce Neutel [France] ; Bastien Herlin [France] ; Jean-Louis Golmard [France] ; Smaranda Leu-Semenescu [France] ; Valérie Cochen De Cock [France] ; Marie Vidailhet [France]Source :
- Sleep [ 0161-8105 ] ; 2015.
Abstract
To determine whether patients with idiopathic and symptomatic RBD were sleepier than controls, and if sleepiness in idiopathic RBD predicted earlier conversion to Parkinson disease.
The Epworth Sleepiness Scale (ESS) and its determinants were compared at the time of a video-polysomnography for an RBD diagnosis in patients with idiopathic RBD, in patients with Parkinson disease, and in controls. Whether sleepiness at time of RBD diagnosis predicted an earlier conversion to neurodegenerative diseases was retrospectively analyzed in the followed-up patients.
The 75 patients with idiopathic RBD were sleepier (ESS: 7.8 ± 4.6) at the time of RBD diagnosis than 74 age- and sex-matched controls (ESS: 5.0 ± 3.6, P < 0.0001). They reached the levels of 114 patients with Parkinson disease (ESS: 8.7 ± 4.8), whether they had (n = 78) or did not have (n = 36) concomitant RBD. The severity of sleepiness in idiopathic RBD correlated with younger age, but not with sleep measures. Among the 69 patients with idiopathic RBD who were followed up for a median 3 years (1–15 years), 16 (23.2%) developed parkinsonism (n = 6), dementia (n = 6), dementia plus parkinsonism (n = 2), and multiple system atrophy (n = 2). An ESS greater than 8 at time of RBD diagnosis predicted a shorter time to phenoconversion to parkinsonism and dementia, from RBD onset, and from RBD diagnosis (when adjusted for age and time between RBD onset and diagnosis).
Sleepiness is associated with idiopathic REM sleep behavior disorder and predicts more rapid conversion to parkinsonism and dementia, suggesting it is an early marker of neuronal loss in brainstem arousal systems.
Arnulf I, Neutel D, Herlin B, Golmard JL, Leu-Semenescu S, Cochen de Cock V, Vidailhet M. Sleepiness in idiopathic REM sleep behavior disorder and Parkinson disease.
Url:
DOI: 10.5665/sleep.5040
PubMed: 26085299
PubMed Central: 4576326
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UPMC-Paris6), Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Brain Research Institute (CRICM - UPMC-Paris6), Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Neutel, Dulce" sort="Neutel, Dulce" uniqKey="Neutel D" first="Dulce" last="Neutel">Dulce Neutel</name><affiliation wicri:level="1"><nlm:aff id="aff3">Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Herlin, Bastien" sort="Herlin, Bastien" uniqKey="Herlin B" first="Bastien" last="Herlin">Bastien Herlin</name><affiliation wicri:level="1"><nlm:aff id="aff3">Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Golmard, Jean Louis" sort="Golmard, Jean Louis" uniqKey="Golmard J" first="Jean-Louis" last="Golmard">Jean-Louis Golmard</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Biostatistics, Salpêtrière Hospital, ER4, Sorbonne Universites, UPMC Univ Paris 06, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics, Salpêtrière Hospital, ER4, Sorbonne Universites, UPMC Univ Paris 06, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Leu Semenescu, Smaranda" sort="Leu Semenescu, Smaranda" uniqKey="Leu Semenescu S" first="Smaranda" last="Leu-Semenescu">Smaranda Leu-Semenescu</name><affiliation wicri:level="1"><nlm:aff id="aff2">Brain Research Institute (CRICM - UPMC-Paris6), Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Brain Research Institute (CRICM - UPMC-Paris6), Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Cochen De Cock, Valerie" sort="Cochen De Cock, Valerie" uniqKey="Cochen De Cock V" first="Valérie" last="Cochen De Cock">Valérie Cochen De Cock</name><affiliation wicri:level="1"><nlm:aff id="aff3">Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><affiliation wicri:level="1"><nlm:aff id="aff1">Sorbonne Universities, UPMC Univ Paris 06, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universities, UPMC Univ Paris 06, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Brain Research Institute (CRICM - UPMC-Paris6), Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Brain Research Institute (CRICM - UPMC-Paris6), Paris</wicri:regionArea></affiliation></author></analytic><series><title level="j">Sleep</title><idno type="ISSN">0161-8105</idno><idno type="eISSN">1550-9109</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To determine whether patients with idiopathic and symptomatic RBD were sleepier than controls, and if sleepiness in idiopathic RBD predicted earlier conversion to Parkinson disease.</p></sec><sec><title>Methods:</title><p>The Epworth Sleepiness Scale (ESS) and its determinants were compared at the time of a video-polysomnography for an RBD diagnosis in patients with idiopathic RBD, in patients with Parkinson disease, and in controls. Whether sleepiness at time of RBD diagnosis predicted an earlier conversion to neurodegenerative diseases was retrospectively analyzed in the followed-up patients.</p></sec><sec><title>Results:</title><p>The 75 patients with idiopathic RBD were sleepier (ESS: 7.8 ± 4.6) at the time of RBD diagnosis than 74 age- and sex-matched controls (ESS: 5.0 ± 3.6, P < 0.0001). They reached the levels of 114 patients with Parkinson disease (ESS: 8.7 ± 4.8), whether they had (n = 78) or did not have (n = 36) concomitant RBD. The severity of sleepiness in idiopathic RBD correlated with younger age, but not with sleep measures. Among the 69 patients with idiopathic RBD who were followed up for a median 3 years (1–15 years), 16 (23.2%) developed parkinsonism (n = 6), dementia (n = 6), dementia plus parkinsonism (n = 2), and multiple system atrophy (n = 2). An ESS greater than 8 at time of RBD diagnosis predicted a shorter time to phenoconversion to parkinsonism and dementia, from RBD onset, and from RBD diagnosis (when adjusted for age and time between RBD onset and diagnosis).</p></sec><sec><title>Conclusions:</title><p>Sleepiness is associated with idiopathic REM sleep behavior disorder and predicts more rapid conversion to parkinsonism and dementia, suggesting it is an early marker of neuronal loss in brainstem arousal systems.</p></sec><sec><title>Citation:</title><p>Arnulf I, Neutel D, Herlin B, Golmard JL, Leu-Semenescu S, Cochen de Cock V, Vidailhet M. Sleepiness in idiopathic REM sleep behavior disorder and Parkinson disease. <italic>SLEEP</italic> 2015;38(10):1529–1535.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id><journal-id journal-id-type="iso-abbrev">Sleep</journal-id><journal-id journal-id-type="publisher-id">Sleep</journal-id><journal-title-group><journal-title>Sleep</journal-title></journal-title-group><issn pub-type="ppub">0161-8105</issn><issn pub-type="epub">1550-9109</issn><publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26085299</article-id><article-id pub-id-type="pmc">4576326</article-id><article-id pub-id-type="publisher-id">sp-00663-14</article-id><article-id pub-id-type="doi">10.5665/sleep.5040</article-id><article-categories><subj-group subj-group-type="heading"><subject>Sleepiness in Idiopathic RBD and Parkinson Disease</subject></subj-group></article-categories><title-group><article-title>Sleepiness in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Arnulf</surname><given-names>Isabelle</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Neutel</surname><given-names>Dulce</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Herlin</surname><given-names>Bastien</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Golmard</surname><given-names>Jean-Louis</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Leu-Semenescu</surname><given-names>Smaranda</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cochen de Cock</surname><given-names>Valérie</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vidailhet</surname><given-names>Marie</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><aff id="aff1"><label>1</label>Sorbonne Universities, UPMC Univ Paris 06, Paris, France</aff><aff id="aff2"><label>2</label>Brain Research Institute (CRICM - UPMC-Paris6), Paris, France</aff><aff id="aff3"><label>3</label>Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris, France</aff><aff id="aff4"><label>4</label>Department of Biostatistics, Salpêtrière Hospital, ER4, Sorbonne Universites, UPMC Univ Paris 06, Paris, France</aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to: Isabelle Arnulf, <addr-line>Service des Pathologies du Sommeil, Hôpital Pitié Salpêtrière, 47-83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France</addr-line><phone>+33 1 42 16 77 02</phone><fax>+33 1 42 16 77 00</fax><email>isabelle.arnulf@aphp.fr</email></corresp></author-notes><pub-date pub-type="epub"><day>1</day><month>10</month><year>2015</year></pub-date><volume>38</volume><issue>10</issue><fpage>1529</fpage><lpage>1535</lpage><history><date date-type="received"><month>10</month><year>2014</year></date><date date-type="rev-recd"><month>3</month><year>2015</year></date><date date-type="accepted"><month>4</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 Associated Professional Sleep Societies, LLC.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><sec><title>Objective:</title><p>To determine whether patients with idiopathic and symptomatic RBD were sleepier than controls, and if sleepiness in idiopathic RBD predicted earlier conversion to Parkinson disease.</p></sec><sec><title>Methods:</title><p>The Epworth Sleepiness Scale (ESS) and its determinants were compared at the time of a video-polysomnography for an RBD diagnosis in patients with idiopathic RBD, in patients with Parkinson disease, and in controls. Whether sleepiness at time of RBD diagnosis predicted an earlier conversion to neurodegenerative diseases was retrospectively analyzed in the followed-up patients.</p></sec><sec><title>Results:</title><p>The 75 patients with idiopathic RBD were sleepier (ESS: 7.8 ± 4.6) at the time of RBD diagnosis than 74 age- and sex-matched controls (ESS: 5.0 ± 3.6, P < 0.0001). They reached the levels of 114 patients with Parkinson disease (ESS: 8.7 ± 4.8), whether they had (n = 78) or did not have (n = 36) concomitant RBD. The severity of sleepiness in idiopathic RBD correlated with younger age, but not with sleep measures. Among the 69 patients with idiopathic RBD who were followed up for a median 3 years (1–15 years), 16 (23.2%) developed parkinsonism (n = 6), dementia (n = 6), dementia plus parkinsonism (n = 2), and multiple system atrophy (n = 2). An ESS greater than 8 at time of RBD diagnosis predicted a shorter time to phenoconversion to parkinsonism and dementia, from RBD onset, and from RBD diagnosis (when adjusted for age and time between RBD onset and diagnosis).</p></sec><sec><title>Conclusions:</title><p>Sleepiness is associated with idiopathic REM sleep behavior disorder and predicts more rapid conversion to parkinsonism and dementia, suggesting it is an early marker of neuronal loss in brainstem arousal systems.</p></sec><sec><title>Citation:</title><p>Arnulf I, Neutel D, Herlin B, Golmard JL, Leu-Semenescu S, Cochen de Cock V, Vidailhet M. Sleepiness in idiopathic REM sleep behavior disorder and Parkinson disease. <italic>SLEEP</italic> 2015;38(10):1529–1535.</p></sec></abstract><kwd-group><kwd>hypersomnolence</kwd><kwd>synucleinopathy</kwd><kwd>dementia</kwd><kwd>parkinsonism</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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