Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
Identifieur interne : 000017 ( Pmc/Curation ); précédent : 000016; suivant : 000018Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
Auteurs : Marie-Hélène Canron [France] ; Martine Perret [France] ; Anne Vital [France] ; Erwan Bézard [France] ; Benjamin Dehay [France]Source :
- Scientific Reports [ 2045-2322 ] ; 2012.
Abstract
Since age-dependent deposition of Aβ-amyloid has been reported in the
Url:
DOI: 10.1038/srep00910
PubMed: 23205271
PubMed Central: 3510464
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Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bézard">Erwan Bézard</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Univ. de Bordeaux, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>CNRS, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Univ. de Bordeaux, Institut des Maladies 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type="wicri:Area/Pmc/Curation">000017</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000017</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Age-dependent α-synuclein aggregation in the <italic>Microcebus murinus</italic> lemur primate</title><author><name sortKey="Canron, Marie Helene" sort="Canron, Marie Helene" uniqKey="Canron M" first="Marie-Hélène" last="Canron">Marie-Hélène Canron</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Univ. de Bordeaux, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>CNRS, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Perret, Martine" sort="Perret, Martine" uniqKey="Perret M" first="Martine" last="Perret">Martine Perret</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>CNRS UMR 7179, MNHN, Département Ecologie et gestion de la biodiversité</institution>, Brunoy, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, Brunoy</wicri:regionArea></affiliation></author><author><name sortKey="Vital, Anne" sort="Vital, Anne" uniqKey="Vital A" first="Anne" last="Vital">Anne Vital</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Univ. de Bordeaux, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>CNRS, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bézard">Erwan Bézard</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Univ. de Bordeaux, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>CNRS, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Univ. de Bordeaux, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>CNRS, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Since age-dependent deposition of Aβ-amyloid has been reported in the <italic>Microcebus</italic><italic>murinus</italic>, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of <italic>Microcebus</italic><italic>murinus</italic> aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. <italic>Microcebus murinus</italic> may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moore, D J" uniqKey="Moore D">D. J. Moore</name></author><author><name sortKey="Dawson, T M" uniqKey="Dawson T">T. M. Dawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenner, P" uniqKey="Jenner P">P. Jenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meredith, G E" uniqKey="Meredith G">G. E. Meredith</name></author><author><name sortKey="Sonsalla, P K" uniqKey="Sonsalla P">P. K. Sonsalla</name></author><author><name sortKey="Chesselet, M F" uniqKey="Chesselet M">M. F. Chesselet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dehay, B" uniqKey="Dehay B">B. Dehay</name></author><author><name sortKey="Bezard, E" uniqKey="Bezard E">E. Bezard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bezard, E" uniqKey="Bezard E">E. Bezard</name></author><author><name sortKey="Yue, Z" uniqKey="Yue Z">Z. Yue</name></author><author><name sortKey="Kirik, D" uniqKey="Kirik D">D. Kirik</name></author><author><name sortKey="Spillantini, M G" uniqKey="Spillantini M">M. G. Spillantini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Austad, S N" uniqKey="Austad S">S. N. Austad</name></author><author><name sortKey="Fischer, K E" uniqKey="Fischer K">K. E. Fischer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Languille, S" uniqKey="Languille S">S. Languille</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bons, N" uniqKey="Bons N">N. Bons</name></author><author><name sortKey="Rieger, F" uniqKey="Rieger F">F. Rieger</name></author><author><name sortKey="Prudhomme, D" uniqKey="Prudhomme D">D. Prudhomme</name></author><author><name sortKey="Fisher, A" uniqKey="Fisher A">A. Fisher</name></author><author><name sortKey="Krause, K H" uniqKey="Krause K">K. H. Krause</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bons, N" uniqKey="Bons N">N. Bons</name></author><author><name sortKey="Mestre, N" uniqKey="Mestre N">N. Mestre</name></author><author><name sortKey="Petter, A" uniqKey="Petter A">A. Petter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bons, N" uniqKey="Bons N">N. Bons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kraska, A" uniqKey="Kraska A">A. Kraska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Picq, J L" uniqKey="Picq J">J. L. Picq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dhenain, M" uniqKey="Dhenain M">M. Dhenain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dhenain, M" uniqKey="Dhenain M">M. Dhenain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oueslati, A" uniqKey="Oueslati A">A. Oueslati</name></author><author><name sortKey="Fournier, M" uniqKey="Fournier M">M. Fournier</name></author><author><name sortKey="Lashuel, H A" uniqKey="Lashuel H">H. A. Lashuel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, J P" uniqKey="Anderson J">J. P. Anderson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id><journal-title-group><journal-title>Scientific Reports</journal-title></journal-title-group><issn pub-type="epub">2045-2322</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23205271</article-id><article-id pub-id-type="pmc">3510464</article-id><article-id pub-id-type="pii">srep00910</article-id><article-id pub-id-type="doi">10.1038/srep00910</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Age-dependent α-synuclein aggregation in the <italic>Microcebus murinus</italic> lemur primate</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Canron</surname><given-names>Marie-Hélène</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Perret</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="a3">3</xref></contrib><contrib contrib-type="author"><name><surname>Vital</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bézard</surname><given-names>Erwan</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dehay</surname><given-names>Benjamin</given-names></name><xref ref-type="corresp" rid="c1">a</xref><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref></contrib><aff id="a1"><label>1</label><institution>Univ. de Bordeaux, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</aff><aff id="a2"><label>2</label><institution>CNRS, Institut des Maladies Neurodégénératives</institution>, UMR 5293, F-33000 Bordeaux, France</aff><aff id="a3"><label>3</label><institution>CNRS UMR 7179, MNHN, Département Ecologie et gestion de la biodiversité</institution>, Brunoy, France</aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email>benjamin.dehay@u-bordeaux2.fr</email></corresp></author-notes><pub-date pub-type="epub"><day>30</day><month>11</month><year>2012</year></pub-date><pub-date pub-type="collection"><year>2012</year></pub-date><volume>2</volume><elocation-id>910</elocation-id><history><date date-type="received"><day>31</day><month>07</month><year>2012</year></date><date date-type="accepted"><day>01</day><month>11</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2012, Macmillan Publishers Limited. All rights reserved</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>Macmillan Publishers Limited. All rights reserved</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/">http://creativecommons.org/licenses/by-nc-nd/3.0/</ext-link></license-p></license></permissions><abstract><p>Since age-dependent deposition of Aβ-amyloid has been reported in the <italic>Microcebus</italic><italic>murinus</italic>, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of <italic>Microcebus</italic><italic>murinus</italic> aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. <italic>Microcebus murinus</italic> may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.</p></abstract></article-meta></front><floats-group><fig id="f1"><label>Figure 1</label><caption><title>Distribution of synuclein and amyloid pathology in mouse lemur brains.</title><p>(A) Sagittal section of mouse lemur stained with Mayer's hemalum showing midbrain and forebrain regions. Scale bar = 2 mm. (B) Sagittal section of mouse lemur stained with Mayer's hemalun showing distribution of βA4 (purple stars), α-synuclein (pink stars), Phospho-Ser129 α-synuclein (orange stars) immunoreactive regions. (C–H) Magnifications of selected α-synuclein positive regions in young and old animals boxed in A: cortex (C–D), SNpc (E–F), striatum (G–H). (I–N) Magnifications of selected Phospho-Ser129 α-synuclein positive regions in young and old animals boxed in A: cortex (I–J), SNpc (K–L), striatum (M–N). (O–T) Magnifications of selected βA4 positive regions in young and old animals boxed in A: cortex (O–P), SNpc (Q–R), striatum (S–T); Scale bar = 10 µm.</p></caption><graphic xlink:href="srep00910-f1"></graphic></fig><fig id="f2"><label>Figure 2</label><caption><title>Phosphorylated and nitrated α-synuclein immunoreactivity is enhanced in the substantia nigra of old (n = 4) as compared with young (n = 3) mouse lemur.</title><p>(A) Representative midbrain sections from young and old mouse lemur co-immunostained with tyrosine hydroxylase (TH, red) and an anti-phosphorylated α-synuclein (P-Ser129 α-synuclein, green). The merged image shows colabeling within a nigral neuron. (B) Double immunofluorescence for nitrated α-synuclein (green) in TH-positive neurons (red) in young and old animals. The merged image shows coimmunoreactivity within a nigral neuron. Scale bar for panels A and B = 10 µm.</p></caption><graphic xlink:href="srep00910-f2"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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