Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lessons from the analysis of nonhuman primates for understanding human aging and neurodegenerative diseases</title><author><name sortKey="Verdier, Jean Michel" sort="Verdier, Jean Michel" uniqKey="Verdier J" first="Jean-Michel" last="Verdier">Jean-Michel Verdier</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Acquatella, Isabelle" sort="Acquatella, Isabelle" uniqKey="Acquatella I" first="Isabelle" last="Acquatella">Isabelle Acquatella</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Lautier, Corinne" sort="Lautier, Corinne" uniqKey="Lautier C" first="Corinne" last="Lautier">Corinne Lautier</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Devau, Gina" sort="Devau, Gina" uniqKey="Devau G" first="Gina" last="Devau">Gina Devau</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Trouche, Stephanie" sort="Trouche, Stephanie" uniqKey="Trouche S" first="Stéphanie" last="Trouche">Stéphanie Trouche</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Lasbleiz, Christelle" sort="Lasbleiz, Christelle" uniqKey="Lasbleiz C" first="Christelle" last="Lasbleiz">Christelle Lasbleiz</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Mestre Frances, Nadine" sort="Mestre Frances, Nadine" uniqKey="Mestre Frances N" first="Nadine" last="Mestre-Francés">Nadine Mestre-Francés</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25788873</idno><idno type="pmc">4349082</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349082</idno><idno type="RBID">PMC:4349082</idno><idno type="doi">10.3389/fnins.2015.00064</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000953</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000953</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lessons from the analysis of nonhuman primates for understanding human aging and neurodegenerative diseases</title><author><name sortKey="Verdier, Jean Michel" sort="Verdier, Jean Michel" uniqKey="Verdier J" first="Jean-Michel" last="Verdier">Jean-Michel Verdier</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Acquatella, Isabelle" sort="Acquatella, Isabelle" uniqKey="Acquatella I" first="Isabelle" last="Acquatella">Isabelle Acquatella</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Lautier, Corinne" sort="Lautier, Corinne" uniqKey="Lautier C" first="Corinne" last="Lautier">Corinne Lautier</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Devau, Gina" sort="Devau, Gina" uniqKey="Devau G" first="Gina" last="Devau">Gina Devau</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Trouche, Stephanie" sort="Trouche, Stephanie" uniqKey="Trouche S" first="Stéphanie" last="Trouche">Stéphanie Trouche</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Lasbleiz, Christelle" sort="Lasbleiz, Christelle" uniqKey="Lasbleiz C" first="Christelle" last="Lasbleiz">Christelle Lasbleiz</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author><author><name sortKey="Mestre Frances, Nadine" sort="Mestre Frances, Nadine" uniqKey="Mestre Frances N" first="Nadine" last="Mestre-Francés">Nadine Mestre-Francés</name><affiliation><nlm:aff id="aff1"><institution>Université de Montpellier</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in Neuroscience</title><idno type="ISSN">1662-4548</idno><idno type="eISSN">1662-453X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Animal models are necessary tools for solving the most serious challenges facing medical research. In aging and neurodegenerative disease studies, rodents occupy a place of choice. However, the most challenging questions about longevity, the complexity and functioning of brain networks or social intelligence can almost only be investigated in nonhuman primates. Beside the fact that their brain structure is much closer to that of humans, they develop highly complex cognitive strategies and they are visually-oriented like humans. For these reasons, they deserve consideration, although their management and care are more complicated and the related costs much higher. Despite these caveats, considerable scientific advances have been possible using nonhuman primates. This review concisely summarizes their role in the study of aging and of the mechanisms involved in neurodegenerative disorders associated mainly with cognitive dysfunctions (Alzheimer's and prion diseases) or motor deficits (Parkinson's and related diseases).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abdel Rassoul, R" uniqKey="Abdel Rassoul R">R. Abdel Rassoul</name></author><author><name sortKey="Alves, S" uniqKey="Alves S">S. Alves</name></author><author><name sortKey="Pantesco, V" uniqKey="Pantesco V">V. Pantesco</name></author><author><name sortKey="De Vos, J" uniqKey="De Vos J">J. De Vos</name></author><author><name sortKey="Michel, B" uniqKey="Michel B">B. Michel</name></author><author><name sortKey="Perret, M" uniqKey="Perret M">M. Perret</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abildgaard, C F" uniqKey="Abildgaard C">C. F. Abildgaard</name></author><author><name sortKey="Harrison, J" uniqKey="Harrison J">J. Harrison</name></author><author><name sortKey="Johnson, C A" uniqKey="Johnson C">C. A. Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Austad, S N" uniqKey="Austad S">S. N. Austad</name></author><author><name sortKey="Fischer, K E" uniqKey="Fischer K">K. E. Fischer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baron, M S" uniqKey="Baron M">M. S. Baron</name></author><author><name sortKey="Wichmann, T" uniqKey="Wichmann T">T. Wichmann</name></author><author><name sortKey="Ma, D" uniqKey="Ma D">D. Ma</name></author><author><name sortKey="Delong, M R" uniqKey="Delong M">M. R. DeLong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beltran, W A" uniqKey="Beltran W">W. A. Beltran</name></author><author><name sortKey="Vanore, M" uniqKey="Vanore M">M. Vanore</name></author><author><name sortKey="Ollivet, F" uniqKey="Ollivet F">F. Ollivet</name></author><author><name sortKey="Nemoz Bertholet, F" uniqKey="Nemoz Bertholet F">F. Nemoz-Bertholet</name></author><author><name sortKey="Aujard, F" uniqKey="Aujard F">F. Aujard</name></author><author><name sortKey="Clerc, B" uniqKey="Clerc B">B. Clerc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergman, H" uniqKey="Bergman H">H. Bergman</name></author><author><name sortKey="Wichmann, T" uniqKey="Wichmann T">T. Wichmann</name></author><author><name sortKey="Delong, M R" uniqKey="Delong M">M. R. DeLong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bihaqi, S W" uniqKey="Bihaqi S">S. W. Bihaqi</name></author><author><name sortKey="Zawia, N H" uniqKey="Zawia N">N. H. Zawia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bons, N" uniqKey="Bons N">N. Bons</name></author><author><name sortKey="Jallageas, V" uniqKey="Jallageas V">V. Jallageas</name></author><author><name sortKey="Silhol, S" uniqKey="Silhol S">S. Silhol</name></author><author><name sortKey="Mestre Frances, N" uniqKey="Mestre Frances N">N. Mestre-Frances</name></author><author><name sortKey="Petter, A" uniqKey="Petter A">A. Petter</name></author><author><name sortKey="Delacourte, A" uniqKey="Delacourte A">A. Delacourte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buse, E" uniqKey="Buse E">E. Buse</name></author><author><name sortKey="Habermann, G" uniqKey="Habermann G">G. Habermann</name></author><author><name sortKey="Osterburg, I" uniqKey="Osterburg I">I. Osterburg</name></author><author><name sortKey="Korte, R" uniqKey="Korte R">R. Korte</name></author><author><name sortKey="Weinbauer, G F" uniqKey="Weinbauer G">G. F. Weinbauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Capitanio, J P" uniqKey="Capitanio J">J. P. Capitanio</name></author><author><name sortKey="Emborg, M E" uniqKey="Emborg M">M. E. Emborg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chellman, G J" uniqKey="Chellman G">G. J. Chellman</name></author><author><name sortKey="Bussiere, J L" uniqKey="Bussiere J">J. L. Bussiere</name></author><author><name sortKey="Makori, N" uniqKey="Makori N">N. Makori</name></author><author><name sortKey="Martin, P L" uniqKey="Martin P">P. L. Martin</name></author><author><name sortKey="Ooshima, Y" uniqKey="Ooshima Y">Y. Ooshima</name></author><author><name sortKey="Weinbauer, G F" uniqKey="Weinbauer G">G. F. Weinbauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corr, J" uniqKey="Corr J">J. Corr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Courtine, G" uniqKey="Courtine G">G. Courtine</name></author><author><name sortKey="Bunge, M B" uniqKey="Bunge M">M. B. Bunge</name></author><author><name sortKey="Fawcett, J W" uniqKey="Fawcett J">J. W. Fawcett</name></author><author><name sortKey="Grossman, R G" uniqKey="Grossman R">R. G. Grossman</name></author><author><name sortKey="Kaas, J H" uniqKey="Kaas J">J. H. Kaas</name></author><author><name sortKey="Lemon, R" uniqKey="Lemon R">R. Lemon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curths, C" uniqKey="Curths C">C. Curths</name></author><author><name sortKey="Knauf, S" uniqKey="Knauf S">S. Knauf</name></author><author><name sortKey="Kaup, F J" uniqKey="Kaup F">F.-J. Kaup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darusman, H S" uniqKey="Darusman H">H. S. Darusman</name></author><author><name sortKey="Pandelaki, J" uniqKey="Pandelaki J">J. Pandelaki</name></author><author><name sortKey="Mulyadi, R" uniqKey="Mulyadi R">R. Mulyadi</name></author><author><name sortKey="Sajuthi, D" uniqKey="Sajuthi D">D. Sajuthi</name></author><author><name sortKey="Putri, I A" uniqKey="Putri I">I. A. Putri</name></author><author><name sortKey="Kalliokoski, O H" uniqKey="Kalliokoski O">O. H. Kalliokoski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delong, M R" uniqKey="Delong M">M. R. DeLong</name></author><author><name sortKey="Benabid, A L" uniqKey="Benabid A">A.-L. Benabid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finch, C E" uniqKey="Finch C">C. E. Finch</name></author><author><name sortKey="Austad, S N" uniqKey="Austad S">S. N. Austad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, S H" uniqKey="Fox S">S. H. Fox</name></author><author><name sortKey="Brotchie, J M" uniqKey="Brotchie J">J. M. Brotchie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fraser, P E" uniqKey="Fraser P">P. E. Fraser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frost, J L" uniqKey="Frost J">J. L. Frost</name></author><author><name sortKey="Le, K X" uniqKey="Le K">K. X. Le</name></author><author><name sortKey="Cynis, H" uniqKey="Cynis H">H. Cynis</name></author><author><name sortKey="Ekpo, E" uniqKey="Ekpo E">E. Ekpo</name></author><author><name sortKey="Kleinschmidt, M" uniqKey="Kleinschmidt M">M. Kleinschmidt</name></author><author><name sortKey="Palmour, R M" uniqKey="Palmour R">R. M. Palmour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gama Sosa, M A" uniqKey="Gama Sosa M">M. A. Gama Sosa</name></author><author><name sortKey="De Gasperi, R" uniqKey="De Gasperi R">R. De Gasperi</name></author><author><name sortKey="Elder, G A" uniqKey="Elder G">G. A. Elder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardner, M B" uniqKey="Gardner M">M. B. Gardner</name></author><author><name sortKey="Luciw, P A" uniqKey="Luciw P">P. A. Luciw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibbs, C J" uniqKey="Gibbs C">C. J. Gibbs</name></author><author><name sortKey="Amyx, H L" uniqKey="Amyx H">H. L. Amyx</name></author><author><name sortKey="Bacote, A" uniqKey="Bacote A">A. Bacote</name></author><author><name sortKey="Masters, C L" uniqKey="Masters C">C. L. Masters</name></author><author><name sortKey="Gajdusek, D C" uniqKey="Gajdusek D">D. C. Gajdusek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilman, S" uniqKey="Gilman S">S. Gilman</name></author><author><name sortKey="Koller, M" uniqKey="Koller M">M. Koller</name></author><author><name sortKey="Black, R S" uniqKey="Black R">R. S. Black</name></author><author><name sortKey="Jenkins, L" uniqKey="Jenkins L">L. Jenkins</name></author><author><name sortKey="Griffith, S G" uniqKey="Griffith S">S. G. Griffith</name></author><author><name sortKey="Fox, N C" uniqKey="Fox N">N. C. Fox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodall, J" uniqKey="Goodall J">J. Goodall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herculano Houzel, S" uniqKey="Herculano Houzel S">S. Herculano-Houzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herculano Houzel, S" uniqKey="Herculano Houzel S">S. Herculano-Houzel</name></author><author><name sortKey="Mota, B" uniqKey="Mota B">B. Mota</name></author><author><name sortKey="Wong, P" uniqKey="Wong P">P. Wong</name></author><author><name sortKey="Kaas, J H" uniqKey="Kaas J">J. H. Kaas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herzog, C" uniqKey="Herzog C">C. Herzog</name></author><author><name sortKey="Sales, N" uniqKey="Sales N">N. Salès</name></author><author><name sortKey="Etchegaray, N" uniqKey="Etchegaray N">N. Etchegaray</name></author><author><name sortKey="Charbonnier, A" uniqKey="Charbonnier A">A. Charbonnier</name></author><author><name sortKey="Freire, S" uniqKey="Freire S">S. Freire</name></author><author><name sortKey="Dormont, D" uniqKey="Dormont D">D. Dormont</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heuer, E" uniqKey="Heuer E">E. Heuer</name></author><author><name sortKey="Rosen, R F" uniqKey="Rosen R">R. F. Rosen</name></author><author><name sortKey="Cintron, A" uniqKey="Cintron A">A. Cintron</name></author><author><name sortKey="Walker, L C" uniqKey="Walker L">L. C. Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heydecke, H" uniqKey="Heydecke H">H. Heydecke</name></author><author><name sortKey="Schwibe, M" uniqKey="Schwibe M">M. Schwibe</name></author><author><name sortKey="Kaumanns, W" uniqKey="Kaumanns W">W. Kaumanns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huffmann, M A" uniqKey="Huffmann M">M. A. Huffmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joly, M" uniqKey="Joly M">M. Joly</name></author><author><name sortKey="Ammersdorfer, S" uniqKey="Ammersdorfer S">S. Ammersdörfer</name></author><author><name sortKey="Schmidtke, D" uniqKey="Schmidtke D">D. Schmidtke</name></author><author><name sortKey="Zimmermann, E" uniqKey="Zimmermann E">E. Zimmermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joly, M" uniqKey="Joly M">M. Joly</name></author><author><name sortKey="Deputte, B" uniqKey="Deputte B">B. Deputte</name></author><author><name sortKey="Verdier, J M" uniqKey="Verdier J">J. M. Verdier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joseph Mathurin, N" uniqKey="Joseph Mathurin N">N. Joseph-Mathurin</name></author><author><name sortKey="Dorieux, O" uniqKey="Dorieux O">O. Dorieux</name></author><author><name sortKey="Trouche, S G" uniqKey="Trouche S">S. G. Trouche</name></author><author><name sortKey="Boutajangout, A" uniqKey="Boutajangout A">A. Boutajangout</name></author><author><name sortKey="Kraska, A" uniqKey="Kraska A">A. Kraska</name></author><author><name sortKey="Fontes, P" uniqKey="Fontes P">P. Fontes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalinin, S" uniqKey="Kalinin S">S. Kalinin</name></author><author><name sortKey="Willard, S L" uniqKey="Willard S">S. L. Willard</name></author><author><name sortKey="Shively, C A" uniqKey="Shively C">C. A. Shively</name></author><author><name sortKey="Kaplan, J R" uniqKey="Kaplan J">J. R. Kaplan</name></author><author><name sortKey="Register, T C" uniqKey="Register T">T. C. Register</name></author><author><name sortKey="Jorgensen, M J" uniqKey="Jorgensen M">M. J. Jorgensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krasemann, S" uniqKey="Krasemann S">S. Krasemann</name></author><author><name sortKey="Sikorska, B" uniqKey="Sikorska B">B. Sikorska</name></author><author><name sortKey="Liberski, P P" uniqKey="Liberski P">P. P. Liberski</name></author><author><name sortKey="Glatzel, M" uniqKey="Glatzel M">M. Glatzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name></author><author><name sortKey="Hedges, S B" uniqKey="Hedges S">S. B. Hedges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Languille, S" uniqKey="Languille S">S. Languille</name></author><author><name sortKey="Blanc, S" uniqKey="Blanc S">S. Blanc</name></author><author><name sortKey="Blin, O" uniqKey="Blin O">O. Blin</name></author><author><name sortKey="Canale, C I" uniqKey="Canale C">C. I. Canale</name></author><author><name sortKey="Dal Pan, A" uniqKey="Dal Pan A">A. Dal-Pan</name></author><author><name sortKey="Devau, G" uniqKey="Devau G">G. Devau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lasmezas, C I" uniqKey="Lasmezas C">C. I. Lasmezas</name></author><author><name sortKey="Comoy, E" uniqKey="Comoy E">E. Comoy</name></author><author><name sortKey="Hawkins, S" uniqKey="Hawkins S">S. Hawkins</name></author><author><name sortKey="Herzog, C" uniqKey="Herzog C">C. Herzog</name></author><author><name sortKey="Mouthon, F" uniqKey="Mouthon F">F. Mouthon</name></author><author><name sortKey="Konold, T" uniqKey="Konold T">T. Konold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lebrec, H N" uniqKey="Lebrec H">H. N. Lebrec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemere, C A" uniqKey="Lemere C">C. A. Lemere</name></author><author><name sortKey="Beierschmitt, A" uniqKey="Beierschmitt A">A. Beierschmitt</name></author><author><name sortKey="Iglesias, M" uniqKey="Iglesias M">M. Iglesias</name></author><author><name sortKey="Spooner, E T" uniqKey="Spooner E">E. T. Spooner</name></author><author><name sortKey="Bloom, J K" uniqKey="Bloom J">J. K. Bloom</name></author><author><name sortKey="Leverone, J F" uniqKey="Leverone J">J. F. Leverone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemere, C A" uniqKey="Lemere C">C. A. Lemere</name></author><author><name sortKey="Oh, J" uniqKey="Oh J">J. Oh</name></author><author><name sortKey="Stanish, H A" uniqKey="Stanish H">H. A. Stanish</name></author><author><name sortKey="Peng, Y" uniqKey="Peng Y">Y. Peng</name></author><author><name sortKey="Pepivani, I" uniqKey="Pepivani I">I. Pepivani</name></author><author><name sortKey="Fagan, A M" uniqKey="Fagan A">A. M. Fagan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, J H" uniqKey="Lewis J">J. H. Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loerch, P M" uniqKey="Loerch P">P. M. Loerch</name></author><author><name sortKey="Lu, T" uniqKey="Lu T">T. Lu</name></author><author><name sortKey="Dakin, K A" uniqKey="Dakin K">K. A. Dakin</name></author><author><name sortKey="Vann, J M" uniqKey="Vann J">J. M. Vann</name></author><author><name sortKey="Isaacs, A" uniqKey="Isaacs A">A. Isaacs</name></author><author><name sortKey="Geula, C" uniqKey="Geula C">C. Geula</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marvanova, M" uniqKey="Marvanova M">M. Marvanová</name></author><author><name sortKey="Menager, J" uniqKey="Menager J">J. Ménager</name></author><author><name sortKey="Bezard, E" uniqKey="Bezard E">E. Bezard</name></author><author><name sortKey="Bontrop, R E" uniqKey="Bontrop R">R. E. Bontrop</name></author><author><name sortKey="Pradier, L" uniqKey="Pradier L">L. Pradier</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maryanski, A" uniqKey="Maryanski A">A. Maryanski</name></author><author><name sortKey="Turner, J H" uniqKey="Turner J">J. H. Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messaoudi, I" uniqKey="Messaoudi I">I. Messaoudi</name></author><author><name sortKey="Ingram, D K" uniqKey="Ingram D">D. K. Ingram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mestre Frances, N" uniqKey="Mestre Frances N">N. Mestre-Frances</name></author><author><name sortKey="Keller, E" uniqKey="Keller E">E. Keller</name></author><author><name sortKey="Calenda, A" uniqKey="Calenda A">A. Calenda</name></author><author><name sortKey="Barelli, H" uniqKey="Barelli H">H. Barelli</name></author><author><name sortKey="Checler, F" uniqKey="Checler F">F. Checler</name></author><author><name sortKey="Bons, N" uniqKey="Bons N">N. Bons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mestre Frances, N" uniqKey="Mestre Frances N">N. Mestre-Frances</name></author><author><name sortKey="Nicot, S" uniqKey="Nicot S">S. Nicot</name></author><author><name sortKey="Rouland, S" uniqKey="Rouland S">S. Rouland</name></author><author><name sortKey="Biacabe, A G" uniqKey="Biacabe A">A. G. Biacabe</name></author><author><name sortKey="Quadrio, I" uniqKey="Quadrio I">I. Quadrio</name></author><author><name sortKey="Perret Liaudet, A" uniqKey="Perret Liaudet A">A. Perret-Liaudet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nader, M A" uniqKey="Nader M">M. A. Nader</name></author><author><name sortKey="Banks, M L" uniqKey="Banks M">M. L. Banks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagahara, A H" uniqKey="Nagahara A">A. H. Nagahara</name></author><author><name sortKey="Bernot, T" uniqKey="Bernot T">T. Bernot</name></author><author><name sortKey="Tuszynski, M H" uniqKey="Tuszynski M">M. H. Tuszynski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamura, S" uniqKey="Nakamura S">S. Nakamura</name></author><author><name sortKey="Nakayama, H" uniqKey="Nakayama H">H. Nakayama</name></author><author><name sortKey="Goto, N" uniqKey="Goto N">N. Goto</name></author><author><name sortKey="Ono, F" uniqKey="Ono F">F. Ono</name></author><author><name sortKey="Sakakibara, I" uniqKey="Sakakibara I">I. Sakakibara</name></author><author><name sortKey="Yoshikawa, Y" uniqKey="Yoshikawa Y">Y. Yoshikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nemoz Bertholet, F" uniqKey="Nemoz Bertholet F">F. Nemoz-Bertholet</name></author><author><name sortKey="Aujard, F" uniqKey="Aujard F">F. Aujard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orgogozo, J M" uniqKey="Orgogozo J">J. M. Orgogozo</name></author><author><name sortKey="Gilman, S" uniqKey="Gilman S">S. Gilman</name></author><author><name sortKey="Dartigues, J F" uniqKey="Dartigues J">J. F. Dartigues</name></author><author><name sortKey="Laurent, B" uniqKey="Laurent B">B. Laurent</name></author><author><name sortKey="Puel, M" uniqKey="Puel M">M. Puel</name></author><author><name sortKey="Kirby, L C" uniqKey="Kirby L">L. C. Kirby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Passingham, R E" uniqKey="Passingham R">R. E. Passingham</name></author><author><name sortKey="Wise, S P" uniqKey="Wise S">S. P. Wise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perret, M" uniqKey="Perret M">M. Perret</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Philippens, I H" uniqKey="Philippens I">I. H. Philippens</name></author><author><name sortKey=" Hart, B A" uniqKey=" Hart B">B. A. ‘t Hart</name></author><author><name sortKey="Torres, G" uniqKey="Torres G">G. Torres</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Picq, J L" uniqKey="Picq J">J. L. Picq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Picq, J L" uniqKey="Picq J">J. L. Picq</name></author><author><name sortKey="Aujard, F" uniqKey="Aujard F">F. Aujard</name></author><author><name sortKey="Volk, A" uniqKey="Volk A">A. Volk</name></author><author><name sortKey="Dhenain, M" uniqKey="Dhenain M">M. Dhenain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rathbun, W B" uniqKey="Rathbun W">W. B. Rathbun</name></author><author><name sortKey="Holleschau, A M" uniqKey="Holleschau A">A. M. Holleschau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robine, J M" uniqKey="Robine J">J. M. Robine</name></author><author><name sortKey="Michel, J P" uniqKey="Michel J">J. P. Michel</name></author><author><name sortKey="Herrmann, F R" uniqKey="Herrmann F">F. R. Herrmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosen, R F" uniqKey="Rosen R">R. F. Rosen</name></author><author><name sortKey="Farberg, A S" uniqKey="Farberg A">A. S. Farberg</name></author><author><name sortKey="Gearing, M" uniqKey="Gearing M">M. Gearing</name></author><author><name sortKey="Dooyema, J" uniqKey="Dooyema J">J. Dooyema</name></author><author><name sortKey="Long, P M" uniqKey="Long P">P. M. Long</name></author><author><name sortKey="Anderson, D C" uniqKey="Anderson D">D. C. Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schenk, D" uniqKey="Schenk D">D. Schenk</name></author><author><name sortKey="Barbour, R" uniqKey="Barbour R">R. Barbour</name></author><author><name sortKey="Dunn, W" uniqKey="Dunn W">W. Dunn</name></author><author><name sortKey="Gordon, G" uniqKey="Gordon G">G. Gordon</name></author><author><name sortKey="Grajeda, H" uniqKey="Grajeda H">H. Grajeda</name></author><author><name sortKey="Guido, T" uniqKey="Guido T">T. Guido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoenemann, P T" uniqKey="Schoenemann P">P. T. Schoenemann</name></author><author><name sortKey="Sheehan, M J" uniqKey="Sheehan M">M. J. Sheehan</name></author><author><name sortKey="Glotzer, L D" uniqKey="Glotzer L">L. D. Glotzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sigurdsson, E M" uniqKey="Sigurdsson E">E. M. Sigurdsson</name></author><author><name sortKey="Scholtzova, H" uniqKey="Scholtzova H">H. Scholtzova</name></author><author><name sortKey="Mehta, P D" uniqKey="Mehta P">P. D. Mehta</name></author><author><name sortKey="Frangione, B" uniqKey="Frangione B">B. Frangione</name></author><author><name sortKey="Wisniewski, T" uniqKey="Wisniewski T">T. Wisniewski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, D E" uniqKey="Smith D">D. E. Smith</name></author><author><name sortKey="Roberts, J" uniqKey="Roberts J">J. Roberts</name></author><author><name sortKey="Gage, F H" uniqKey="Gage F">F. H. Gage</name></author><author><name sortKey="Tuszynski, M H" uniqKey="Tuszynski M">M. H. Tuszynski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, J" uniqKey="Stone J">J. Stone</name></author><author><name sortKey="Johnston, E" uniqKey="Johnston E">E. Johnston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sutcliffe, J" uniqKey="Sutcliffe J">J. Sutcliffe</name></author><author><name sortKey="Hutcheson, D" uniqKey="Hutcheson D">D. Hutcheson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torrent, J" uniqKey="Torrent J">J. Torrent</name></author><author><name sortKey="Soukkarieh, C" uniqKey="Soukkarieh C">C. Soukkarieh</name></author><author><name sortKey="Lenaers, G" uniqKey="Lenaers G">G. Lenaers</name></author><author><name sortKey="Arndt, C" uniqKey="Arndt C">C. Arndt</name></author><author><name sortKey="Forster, V" uniqKey="Forster V">V. Forster</name></author><author><name sortKey="Picaud, S" uniqKey="Picaud S">S. Picaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trouche, S G" uniqKey="Trouche S">S. G. Trouche</name></author><author><name sortKey="Asuni, A" uniqKey="Asuni A">A. Asuni</name></author><author><name sortKey="Rouland, S" uniqKey="Rouland S">S. Rouland</name></author><author><name sortKey="Wisniewski, T" uniqKey="Wisniewski T">T. Wisniewski</name></author><author><name sortKey="Frangione, B" uniqKey="Frangione B">B. Frangione</name></author><author><name sortKey="Verdier, J M" uniqKey="Verdier J">J. M. Verdier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uchida, A" uniqKey="Uchida A">A. Uchida</name></author><author><name sortKey="Sasaguri, H" uniqKey="Sasaguri H">H. Sasaguri</name></author><author><name sortKey="Kimura, N" uniqKey="Kimura N">N. Kimura</name></author><author><name sortKey="Tajiri, M" uniqKey="Tajiri M">M. Tajiri</name></author><author><name sortKey="Ohkubo, T" uniqKey="Ohkubo T">T. Ohkubo</name></author><author><name sortKey="Ono, F" uniqKey="Ono F">F. Ono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uno, H" uniqKey="Uno H">H. Uno</name></author><author><name sortKey="Walker, L C" uniqKey="Walker L">L. C. Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Someren, E J" uniqKey="Van Someren E">E. J. Van Someren</name></author><author><name sortKey="Riemersma Van Der Lek, R F" uniqKey="Riemersma Van Der Lek R">R. F. Riemersma-Van Der Lek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vezoli, J" uniqKey="Vezoli J">J. Vezoli</name></author><author><name sortKey="Fifel, K" uniqKey="Fifel K">K. Fifel</name></author><author><name sortKey="Leviel, V" uniqKey="Leviel V">V. Leviel</name></author><author><name sortKey="Dehay, C" uniqKey="Dehay C">C. Dehay</name></author><author><name sortKey="Kennedy, H" uniqKey="Kennedy H">H. Kennedy</name></author><author><name sortKey="Cooper, H M" uniqKey="Cooper H">H. M. Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, L C" uniqKey="Walker L">L. C. Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, H" uniqKey="Weber H">H. Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinbauer, G F" uniqKey="Weinbauer G">G. F. Weinbauer</name></author><author><name sortKey="Frings, W" uniqKey="Frings W">W. Frings</name></author><author><name sortKey="Fuchs, A" uniqKey="Fuchs A">A. Fuchs</name></author><author><name sortKey="Osterburg, I" uniqKey="Osterburg I">I. Osterburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winkelmann, C J" uniqKey="Winkelmann C">C. J. Winkelmann</name></author><author><name sortKey="Krause, S M" uniqKey="Krause S">S. M. Krause</name></author><author><name sortKey="Mccracken, P J" uniqKey="Mccracken P">P. J. McCracken</name></author><author><name sortKey="Brammer, D W" uniqKey="Brammer D">D. W. Brammer</name></author><author><name sortKey="Gelovani, J G" uniqKey="Gelovani J">J. G. Gelovani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zurcher, N R" uniqKey="Zurcher N">N. R. Zürcher</name></author><author><name sortKey="Rodriguez, J S" uniqKey="Rodriguez J">J. S. Rodriguez</name></author><author><name sortKey="Jenkins, S L" uniqKey="Jenkins S">S. L. Jenkins</name></author><author><name sortKey="Keenan, K" uniqKey="Keenan K">K. Keenan</name></author><author><name sortKey="Bartlett, T Q" uniqKey="Bartlett T">T. Q. Bartlett</name></author><author><name sortKey="Mcdonald, T J" uniqKey="Mcdonald T">T. J. McDonald</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">Front Neurosci</journal-id><journal-id journal-id-type="publisher-id">Front. Neurosci.</journal-id><journal-title-group><journal-title>Frontiers in Neuroscience</journal-title></journal-title-group><issn pub-type="ppub">1662-4548</issn><issn pub-type="epub">1662-453X</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25788873</article-id><article-id pub-id-type="pmc">4349082</article-id><article-id pub-id-type="doi">10.3389/fnins.2015.00064</article-id><article-categories><subj-group subj-group-type="heading"><subject>Psychiatry</subject><subj-group><subject>Mini Review Article</subject></subj-group></subj-group></article-categories><title-group><article-title>Lessons from the analysis of nonhuman primates for understanding human aging and neurodegenerative diseases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Verdier</surname><given-names>Jean-Michel</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/9561"></uri></contrib><contrib contrib-type="author"><name><surname>Acquatella</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lautier</surname><given-names>Corinne</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/214136"></uri></contrib><contrib contrib-type="author"><name><surname>Devau</surname><given-names>Gina</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/214850"></uri></contrib><contrib contrib-type="author"><name><surname>Trouche</surname><given-names>Stéphanie</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/214780"></uri></contrib><contrib contrib-type="author"><name><surname>Lasbleiz</surname><given-names>Christelle</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/214776"></uri></contrib><contrib contrib-type="author"><name><surname>Mestre-Francés</surname><given-names>Nadine</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/14288"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Université de Montpellier</institution><country>Montpellier, France</country></aff><aff id="aff2"><sup>2</sup><institution>Institut National de la Santé et de la Recherche Médicale, U1198</institution><country>Montpellier, France</country></aff><aff id="aff3"><sup>3</sup><institution>Ecole Pratique des Hautes Etudes</institution><country>Paris, France</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Patrick Lewis, University of Reading, UK</p></fn><fn fn-type="edited-by"><p>Reviewed by: Ricardo Insausti, University of Castilla -la Mancha, Spain; Varun Kesherwani, University of Nebraska Medical Center, USA</p></fn><corresp id="fn001">*Correspondence: Jean-Michel Verdier, University of Montpellier, Place Eugène Bataillon, CC105, 34095 Montpellier, France e-mail: <email xlink:type="simple">jean-michel.verdier@univ-montp2.fr</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience.</p></fn></author-notes><pub-date pub-type="epub"><day>04</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>9</volume><elocation-id>64</elocation-id><history><date date-type="received"><day>14</day><month>10</month><year>2014</year></date><date date-type="accepted"><day>13</day><month>2</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Verdier, Acquatella, Lautier, Devau, Trouche, Lasbleiz and Mestre-Francés.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Animal models are necessary tools for solving the most serious challenges facing medical research. In aging and neurodegenerative disease studies, rodents occupy a place of choice. However, the most challenging questions about longevity, the complexity and functioning of brain networks or social intelligence can almost only be investigated in nonhuman primates. Beside the fact that their brain structure is much closer to that of humans, they develop highly complex cognitive strategies and they are visually-oriented like humans. For these reasons, they deserve consideration, although their management and care are more complicated and the related costs much higher. Despite these caveats, considerable scientific advances have been possible using nonhuman primates. This review concisely summarizes their role in the study of aging and of the mechanisms involved in neurodegenerative disorders associated mainly with cognitive dysfunctions (Alzheimer's and prion diseases) or motor deficits (Parkinson's and related diseases).</p></abstract><kwd-group><kwd>neuroscience</kwd><kwd>brain</kwd><kwd>aging</kwd><kwd>neurodegenerative diseases</kwd><kwd>nonhuman primate</kwd></kwd-group><counts><fig-count count="0"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="79"></ref-count><page-count count="6"></page-count><word-count count="5660"></word-count></counts></article-meta></front><body><sec><title>Why do we need animal models?</title><p>The simplest answer to this question is to increase our general knowledge, to experimentally test theories. Animal model usefulness is manifold, from the study of physiological processes to the identification of disease-causing mechanisms. Indeed, physiopathological studies are of the utmost importance for developing diagnostic and therapeutic approaches based on the discovery of new, more sensitive and specific biomarkers, the identification of the mechanism of action of drugs, the establishment of pharmacodynamics and pharmacokinetic parameters, the toxicity analysis of new compounds or the assessment of clinical drug regimens.</p><p>Many different animal models, ranging from unicellular organisms (bacteria, yeast) to invertebrates (the roundworm <italic>Caenorhabditis elegans</italic> or the fruit fly <italic>Drosophila melanogaster</italic>) and vertebrates (fish and mammals), are currently used for research on aging and neurodegenerative disorders. They are all of interest and importance, but they also show limitations and drawbacks. Most studies on neurodegenerative diseases have been done in transgenic animals (Gama Sosa et al., <xref rid="B21" ref-type="bibr">2012</xref>), particularly in mice. Indeed, as the production and handling of transgenic mice is currently quite easy, they have played and continue to play a very important role in biomedical research. Nevertheless, fundamental differences between rodents and humans exist. Conversely, nonhuman primates (NHPs) share many structural and functional features with humans. NHPs diverged from humans and formed various lineages: Great Apes (our closest relatives, <italic>Hominidae—</italic>e.g., chimpanzees), Old World monkeys (<italic>Cercopithecidae—</italic>e.g., baboons, macaques), New World monkeys (<italic>Parvorder Platyrrhini—</italic>e.g., marmosets) and Prosimians (our most distant relatives, the Suborder <italic>Strepsirrhini</italic> and Infraorder <italic>Tarsiiformes—</italic>e.g., lemurs). Therefore, NHPs are genetically the closest species to humans (Kumar and Hedges, <xref rid="B37" ref-type="bibr">1998</xref>; Finch and Austad, <xref rid="B17" ref-type="bibr">2012</xref>). The purpose of this review is to explain why the use of NHPs in aging and neurodegenerative studies brings additional, sometimes unique information compared to other animal models.</p></sec><sec><title>The primate brain advantage</title><p>In neuroscience, the global understanding of how brain works in physiological and pathophysiological conditions represents a major challenge. Brain evolution is characterized by a complex pattern of species similarities and differences. The neocortex, also called the “thinking” brain, represents the latest evolutionary stage and brings the capacity, for instance, of planning complex cognitive behaviors, personality expression, decision-making and moderating social behavior. These observations suggest a more complex circuitry that favors local connectivity (Herculano-Houzel et al., <xref rid="B27" ref-type="bibr">2010</xref>) with cognitive consequences (Herculano-Houzel, <xref rid="B26" ref-type="bibr">2012</xref>). Another important point is the important role played by the primate prefrontal cortex in “higher” brain functions, such as reasoning, judgment or social intelligence. Although the total prefrontal cortex volume is larger in humans than in other primates, suggesting that humans have more connections among prefrontal cortex neurons and consequently greater communication (Schoenemann et al., <xref rid="B64" ref-type="bibr">2005</xref>), many of the genes expressed in human prefrontal cortex are also detected in the prefrontal cortex of NHPs (Marvanová et al., <xref rid="B45" ref-type="bibr">2003</xref>). In rodents, the existence of the prefrontal cortex is still debated. However, it is clear that they lack functional areas involved in overall planning, such as the prefrontal granular cortex (Passingham and Wise, <xref rid="B55" ref-type="bibr">2012</xref>). Moreover, rodents rely primarily on the use of their nose and whiskers for orientation, because their hearing and vision are much weaker than in NHPs. Conversely, NHPs are visually-oriented, like humans. They perceive the world first with their eyes, showing that their visual system is the main sense responsible for behavior. Spatial information is received through visual sensations (Maryanski and Turner, <xref rid="B46" ref-type="bibr">1993</xref>). It is also possible to test NHP cognitive functions by using sophisticated go/no go procedures, such as automated cognitive test batteries, which are similar to those used in human studies on aging and Alzheimer's disease (Nagahara et al., <xref rid="B51" ref-type="bibr">2010</xref>; Zürcher et al., <xref rid="B79" ref-type="bibr">2010</xref>; Joly et al., <xref rid="B32" ref-type="bibr">2014</xref>). These similarities between NHP and human brain in terms of anatomy, gene expression, neural circuitry, functional and cognitive abilities make of NHPs unique, valuable models for neuroscience research. They provide a more direct approach that can be translated to human diseases as they allow investigating higher intellectual functions with comparative endpoints (Sutcliffe and Hutcheson, <xref rid="B68" ref-type="bibr">2012</xref>).</p></sec><sec><title>Nonhuman primate models matter because they fill the gap between rodents and humans</title><p>Nonanimal experimental approaches play an important role in the identification/selection of candidate drugs; however, animal-based methods are required for toxicity testing. In addition, the safety of pharmaceuticals must be assessed using nonrodent models because these tests are carried out with the aim of protecting human patients in clinical trials. In Europe, all classes of pharmaceuticals must be tested in NHPs because NHP pharmacodynamic responses are close to those of humans. We will illustrate this point with four examples:
<list list-type="order"><list-item><p>Developmental and reproductive toxicology effects are tested in NHPs (Chellman et al., <xref rid="B11" ref-type="bibr">2009</xref>), most frequently in cynomolgus macaque (<italic>Macaca fascicularis</italic>) (Buse et al., <xref rid="B9" ref-type="bibr">2003</xref>; Weinbauer et al., <xref rid="B77" ref-type="bibr">2008</xref>) but also in rhesus macaques and marmosets, because of the similar pharmacological responses in NHPs and humans;</p></list-item><list-item><p>NHP retina has unique features (for instance, both NHPs and humans have a macula lutea/fovea) not found in other mammals (Stone and Johnston, <xref rid="B67" ref-type="bibr">1981</xref>);</p></list-item><list-item><p>NHP blood coagulation system is more similar to that of humans than any other species (Abildgaard et al., <xref rid="B2" ref-type="bibr">1971</xref>; Lewis, <xref rid="B43" ref-type="bibr">1996</xref>);</p></list-item><list-item><p>NHPs are less susceptible to vomiting than other animal models (Weber, <xref rid="B76" ref-type="bibr">2005</xref>). Therefore, in NHPs, vomiting will not decrease the exposure to the tested compound and will not confound the assessment of the early effects of a compound.</p></list-item></list></p><p>Another important phenomenon associated with drug testing in NHPs, although very difficult to deal with, is the inter-individual variability. This variability can be observed for instance in behavioral studies using the gray mouse lemur (Joly et al., <xref rid="B33" ref-type="bibr">2006</xref>), in the response to treatments for Parkinson's disease in monkeys (Vezoli et al., <xref rid="B74" ref-type="bibr">2011</xref>), and also in immune functions (Lebrec, <xref rid="B40" ref-type="bibr">2013</xref>). NHP inter-individual variability poses real problems in terms of statistical evaluation of outcomes. However, it mimics what happens in humans and therefore helps us to better understand the variability within human populations.</p></sec><sec><title>NHPs grow old like humans</title><p>NHPs have also significantly contributed to understanding aging and neurodegenerative diseases. Aging NHPs show striking similarities with elderly humans. Like in humans, age-related changes in the glutathione metabolic pathway have been observed in Old World simians (Rathbun and Holleschau, <xref rid="B60" ref-type="bibr">1992</xref>) and in the gray mouse lemur, in which glutathione-synthase activity decreases and glutathione-peroxidase activity increases in the lens with age (reviewed in Languille et al., <xref rid="B38" ref-type="bibr">2012</xref>). Aging gray mouse lemurs also present changes of the sensorial system, especially high susceptibility to cataract (the most frequent ocular lesions observed) (Beltran et al., <xref rid="B5" ref-type="bibr">2007</xref>), alterations of the biological rhythms and of the endocrine system (Van Someren and Riemersma-Van Der Lek, <xref rid="B73" ref-type="bibr">2007</xref>) and a progressive decrease of their motor capacities (Nemoz-Bertholet and Aujard, <xref rid="B53" ref-type="bibr">2003</xref>). Interestingly, acceleration of seasonal rhythms (i.e., an annual cycle takes place in 8 months rather than 1 year by alternating long and short photoperiods) affects survival and longevity (Perret, <xref rid="B56" ref-type="bibr">1997</xref>). This result suggests that longevity could be correlated with the succession of seasonal cycles rather than with a fixed biological age. This hypothesis is very interesting and it might apply also to human populations. Indeed, it has been reported that the accumulation of harsh winters may be responsible for a decrease in longevity (Robine et al., <xref rid="B61" ref-type="bibr">2012</xref>).</p><p>Social interactions are fundamental in primates. For instance, Picq (<xref rid="B58" ref-type="bibr">1992</xref>) suggested that older gray mouse lemur females are less interested in social contacts than younger females. In rhesus monkeys, a decrease in social interactions with age has been observed (Heydecke et al., <xref rid="B30" ref-type="bibr">1986</xref>). In chimpanzees, Goodall (<xref rid="B25" ref-type="bibr">1986</xref>) and Huffmann (<xref rid="B31" ref-type="bibr">1990</xref>) reported withdrawal from social interactions in older individuals. Sex-based differences in social interactions, social roles and social networks have also been observed in aging rhesus macaques (Corr, <xref rid="B12" ref-type="bibr">2003</xref>). Altogether, these examples show that social interactions are of the utmost importance for aging studies in NHPs and should be used as clear readouts.</p></sec><sec><title>The aging NHP and human brain transcriptomes are similar</title><p>Most of our understanding on the biological changes observed during aging comes from studies in rodents because they present clear advantages (short life span, fully characterized genetic aspects, easy genetic manipulation…). However, rodents and humans diverged much earlier than humans and NHPs, and this is likely to have led to fundamental differences in their aging processes (Messaoudi and Ingram, <xref rid="B47" ref-type="bibr">2012</xref>). In a pioneering work, Loerch et al. (<xref rid="B44" ref-type="bibr">2008</xref>) compared the transcriptome of the cerebral cortex in aging mice, rhesus macaques and humans, providing a broad view of the evolution of aging mammalian brain. They found that only a small subset of age-related gene expression changes are conserved from mouse to human brain, whereas such changes are highly conserved in rhesus macaques and humans. Similarly, Marvanová et al. (<xref rid="B45" ref-type="bibr">2003</xref>) showed that more than 80% of genes detected in the human prefrontal cortex have similar expression profiles also in NHPs. Moreover, the study by Loerch et al. revealed that the major distinguishing feature is the dramatic, age-related increase in neuronal gene expression down-regulation, particularly of genes involved in neurotransmission, in humans compared to mice (Loerch et al., <xref rid="B44" ref-type="bibr">2008</xref>). These major evolutionary changes in the primate cortex are potentially relevant when studying age-related changes in cognition and vulnerability to neurodegeneration. These observations have been recently corroborated by a transcriptomic analysis, using human DNA chips (Abdel Rassoul et al., <xref rid="B1" ref-type="bibr">2010</xref>), of the gene expression profiles in the temporal cortex of young adults, healthy old animals and “Alzheimer's disease-like” (“AD-like”) gray mouse lemurs that naturally present the pathognomonic lesions of Alzheimer's disease. The temporal cortex was chosen because this region is connected to the hippocampus and to the frontal cortex, two structures that are critical for learning and memory and are altered in Alzheimer's disease. This study identified 47 genes that discriminated young from healthy old and “AD-like” animals. Functional categorization showed that most of the genes that were up-regulated in healthy old animals and down-regulated in “AD-like” animals belonged to metabolic pathways, particularly protein synthesis. These data suggest the existence of compensatory mechanisms during physiological brain aging that disappear in “AD-like” animals (Abdel Rassoul et al., <xref rid="B1" ref-type="bibr">2010</xref>).</p></sec><sec><title>Nonhuman primates naturally display Alzheimer's disease lesions such as amyloid plaques and aggregated hyperphosphorylated tau protein</title><p>All NHPs naturally display, to various extents depending on the species, the main pathognomonic lesions of Alzheimer's disease (AD): amyloid-beta (Aβ deposits, tau aggregation (reviewed in Heuer et al., <xref rid="B29" ref-type="bibr">2012</xref>) and also cortical atrophy. For instance, Aβ plaques and/or tau aggregation have been found in rhesus monkeys (Uno and Walker, <xref rid="B72" ref-type="bibr">1993</xref>; Walker, <xref rid="B75" ref-type="bibr">1997</xref>; Bihaqi and Zawia, <xref rid="B7" ref-type="bibr">2013</xref>), cynomolgus monkeys (Nakamura et al., <xref rid="B52" ref-type="bibr">1998</xref>), great apes (Rosen et al., <xref rid="B62" ref-type="bibr">2008</xref>), vervet monkeys (Kalinin et al., <xref rid="B35" ref-type="bibr">2013</xref>), tamarins (Lemere et al., <xref rid="B42" ref-type="bibr">2008</xref>) and gray mouse lemurs (Bons et al., <xref rid="B8" ref-type="bibr">1995</xref>; Mestre-Frances et al., <xref rid="B48" ref-type="bibr">2000</xref>). A N-terminal variant called pyroglutamate-3 Aβ, which is thought to play an early role in AD pathogenesis, has been detected in the brain of 13–32 year/old Caribbean vervets (Frost et al., <xref rid="B20" ref-type="bibr">2013</xref>). In addition, based on neuron counting of the subcortical cholinergic basal forebrain regions (Smith et al., <xref rid="B66" ref-type="bibr">1999</xref>) or imaging studies (Winkelmann et al., <xref rid="B78" ref-type="bibr">2012</xref>), NHPs show cerebral atrophy and this feature has been linked to cognitive decline. For instance, in gray mouse lemurs, age-related decrease in spatial memory performance is related to atrophy of the hippocampus and entorhinal cortex (Picq et al., <xref rid="B59" ref-type="bibr">2012</xref>), the two regions primarily affected in AD. Very recently, Darusman et al. (<xref rid="B15" ref-type="bibr">2014</xref>) found in aged cynomolgus monkeys a correlation between poor performances in memory tasks and hippocampus atrophy.</p><p>NHPs could also be useful to test new AD therapeutic approaches, for instance anti-amyloid beta (Aβ) immunotherapy. The idea is to combat AD by injecting the Aβ peptide, which is considered to play a central role in AD neuropathology, to trigger an immune response that eventually leads to the production of antibodies against Aβ. The first attempts in an AD transgenic mouse model showed that immunization with Aβ42 markedly reduced the AD-like pathology (Aβ plaque formation, neuritic dystrophy and astrogliosis) (Schenk et al., <xref rid="B63" ref-type="bibr">1999</xref>). In a follow-up study in five aged Caribbean vervets, Lemere et al. (<xref rid="B41" ref-type="bibr">2004</xref>) validated this paradigm, showing a reduction of cerebral Aβ and gliosis. This major result generated a great deal of enthusiasm. However, administration of full-length Aβ self-antigen in humans (Elan/Wyeth AN-1792 trial) resulted in brain and spinal cord inflammation and possible micro-hemorrhages (Orgogozo et al., <xref rid="B54" ref-type="bibr">2003</xref>; Gilman et al., <xref rid="B24" ref-type="bibr">2005</xref>). As a consequence, less toxic Aβ derivatives have been developed in Tg2576 transgenic mice (Sigurdsson et al., <xref rid="B65" ref-type="bibr">2001</xref>). We found that these Aβ derivatives elicit a substantial antibody response in gray mouse lemurs and, importantly, that this effect is reversible, thus enhancing the safety profile of this approach (Trouche et al., <xref rid="B70" ref-type="bibr">2009</xref>). We have also shown iron accumulation in the choroid plexus with aging by MRI. This accumulation could be worsened by Aβ-immunization, and this observation should be a side effect that may be monitored in therapeutic trials (Joseph-Mathurin et al., <xref rid="B34" ref-type="bibr">2013</xref>).</p></sec><sec><title>Breakthroughs in prion research thanks to the use of NHPs</title><p>Prion diseases are fatal neurodegenerative diseases that affect humans and animals. Prion diseases are thought to be caused by transmissible pathogenic agents (“prions”) that can convert a normal cellular protein (called PrP<sup>c</sup>) into the pathogenic, transmissible form called PrP<sup>Sc</sup> (reviewed in Fraser, <xref rid="B19" ref-type="bibr">2014</xref>). Among the different forms of prion diseases, variant Creutzfeldt-Jakob Disease (vCJD) received considerable attention in the late 20th century because humans can be infected through oral consumption of animals infected by the bovine spongiform encephalopathy (BSE) prion strain. NHP-based studies have much contributed to advancing our knowledge on this disease (reviewed in Krasemann et al., <xref rid="B36" ref-type="bibr">2012</xref>). For instance, the risk and the mechanisms associated with oral transmission have been studied using squirrel monkeys (Gibbs et al., <xref rid="B23" ref-type="bibr">1980</xref>), cynomolgus macaques (Herzog et al., <xref rid="B28" ref-type="bibr">2004</xref>; Lasmezas et al., <xref rid="B39" ref-type="bibr">2005</xref>) and gray mouse lemurs (Mestre-Frances et al., <xref rid="B49" ref-type="bibr">2012</xref>). These studies led to three major conclusions:
<list list-type="order"><list-item><p>The asymptomatic incubation period may be extremely long (several years), much longer than in the case of intravenous or intracerebral infection;</p></list-item><list-item><p>The spectrum of tissues harboring BSE infectivity includes not only brain, but also the lymphoreticular system (spleen, lymph nodes, appendix, tonsils)</p></list-item><list-item><p>It is possible to estimate the food exposure risk.</p></list-item></list></p><p>These results highlighted the necessity of rapidly introducing health policy measures to prevent BSE transmission to humans. Furthermore, the use of NHPs not only improved our knowledge on the transmissibility of prion strains, but also allowed studying the fine molecular mechanisms involved. For instance, visual impairment, associated with retinal damage, is one of the first clinical signs of prion disease in <italic>Microcebus murinus</italic>. We have, therefore, developed an experimental model system based on the analysis of the retina of gray mouse lemurs to rapidly test prion-related neurotoxicity and to develop new therapeutic approaches (Torrent et al., <xref rid="B69" ref-type="bibr">2010</xref>).</p></sec><sec><title>The MPTP NHP models of neurodegeneration and the renaissance of Parkinson's disease research</title><p>Based on the observation of early-onset parkinsonism in users of a synthetic opioid, 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP), a compound with similar neurotoxic properties, was further developed. Studies in squirrel monkeys, rhesus macaques and marmosets showed that MPTP injections leads to dopamine depletion in the <italic>substantia nigra pars compacta</italic> followed by drastic cell loss, resting tremor, rigidity and bradykinesia, like in humans with Parkinson's disease (reviewed in Fox and Brotchie, <xref rid="B18" ref-type="bibr">2010</xref>). Conversely, rodents are not sensitive to MPTP (Capitanio and Emborg, <xref rid="B10" ref-type="bibr">2008</xref>) and MPTP injections do not lead to the full spectrum of Parkinson's symptoms in these animals. Importantly, the MPTP NHP models allowed the identification of the neural circuits affected in Parkinson's disease, specifically the role of excessive activity in the subthalamic nuclei (Bergman et al., <xref rid="B6" ref-type="bibr">1990</xref>), leading to the development of ablative procedures (Baron et al., <xref rid="B4" ref-type="bibr">2002</xref>) and of deep-brain stimulation of these nuclei (DeLong and Benabid, <xref rid="B16" ref-type="bibr">2014</xref>). This latter experiments would not have been developed without knowing the physiology of the basal ganglia in nonhuman primates (Baron et al., <xref rid="B4" ref-type="bibr">2002</xref>). The MPTP NHP models are also used to discover neuroprotective compounds for Parkinson's and other diseases associated with motor deficits, such as Huntington disease or Amyotrophic Lateral Sclerosis (Philippens et al., <xref rid="B57" ref-type="bibr">2010</xref>; Uchida et al., <xref rid="B71" ref-type="bibr">2012</xref>).</p></sec><sec><title>Conclusion and perspectives</title><p>Due to their genetic proximity to humans and their highly developed social skills, NHPs are extremely valuable as experimental animal models. However, as the number of available animals is restricted for ethical reasons and also because of the high cost and large space required for breeding colonies, NHPs should only be used when no other suitable method is available to fill the gap of our knowledge. Developing the use of small and relatively short-lived NHPs, as proposed by Austad and Fischer (<xref rid="B3" ref-type="bibr">2011</xref>), could lower the costs per animal and facilitate the colony management and growth. They could be used in preclinical studies with clear reachable endpoints or in long-term follow-up studies (equivalent to phase IV in clinical trials) (Lemere et al., <xref rid="B41" ref-type="bibr">2004</xref>; Trouche et al., <xref rid="B70" ref-type="bibr">2009</xref>). NHP unique contribution to aging and neuroscience research is well exemplified (Capitanio and Emborg, <xref rid="B10" ref-type="bibr">2008</xref>; Austad and Fischer, <xref rid="B3" ref-type="bibr">2011</xref>; Bihaqi and Zawia, <xref rid="B7" ref-type="bibr">2013</xref>); however, they are also extremely valuable for studying other diseases, such as spinal cord injury (Courtine et al., <xref rid="B13" ref-type="bibr">2007</xref>), infectious diseases (reviewed in Gardner and Luciw, <xref rid="B22" ref-type="bibr">2008</xref>), respiratory diseases (Curths et al., <xref rid="B14" ref-type="bibr">2014</xref>), and also for pharmacological studies (Nader and Banks, <xref rid="B50" ref-type="bibr">2014</xref>) because their pharmacodynamic and pharmacokinetic parameters are closely related to those of humans.</p><p>In any case, rodent (or other small animal models) and primate experimental models need to be used in parallel in order to obtain robust and complementary information. Alongside other models, nonhuman primates should have a unique place in the overall aging and neurodegenerative research strategy.</p><sec><title>Conflict of interest statement</title><p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec></sec></body><back><ack><p>This study is part of a project that has received funding from the European Community's 7th Framework Program (FP7/2007-2013) under grant agreement N<sup>br</sup> 278486 (acronym “DEVELAGE”), from the Fonds Unique Interministériel and Région Languedoc-Roussillon under grant agreement N<sup>br</sup> 110284 (acronym “DiaTrAl”), and from the Fondation Plan Alzheimer (acronym PRADNET). We thank the animal keepers, Sylvie Rouland, Elisabeth Huetter and Joël Cuoq for animal husbandry.</p></ack><ref-list><title>References</title><ref id="B1"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Abdel Rassoul</surname><given-names>R.</given-names></name><name><surname>Alves</surname><given-names>S.</given-names></name><name><surname>Pantesco</surname><given-names>V.</given-names></name><name><surname>De Vos</surname><given-names>J.</given-names></name><name><surname>Michel</surname><given-names>B.</given-names></name><name><surname>Perret</surname><given-names>M.</given-names></name><etal></etal></person-group>. (<year>2010</year>). <article-title>Distinct transcriptome expression of the temporal cortex of the primate <italic>Microcebus murinus</italic> during brain aging versus Alzheimer's disease-like pathology</article-title>. <source>PLoS ONE</source><volume>5</volume>:<fpage>e12770</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0012770</pub-id><pub-id pub-id-type="pmid">20862281</pub-id></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Abildgaard</surname><given-names>C. F.</given-names></name><name><surname>Harrison</surname><given-names>J.</given-names></name><name><surname>Johnson</surname><given-names>C. A.</given-names></name></person-group> (<year>1971</year>). <article-title>Comparative study of blood coagulation in nonhuman primates</article-title>. <source>J. Appl. Physiol</source>. <volume>30</volume>, <fpage>400</fpage>–<lpage>405</lpage>. <pub-id pub-id-type="pmid">5544120</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Austad</surname><given-names>S. N.</given-names></name><name><surname>Fischer</surname><given-names>K. E.</given-names></name></person-group> (<year>2011</year>). <article-title>The development of small primate models for aging research</article-title>. <source>ILAR J. Natl. Res. Counc. Inst. Lab. Anim. Resour</source>. <volume>52</volume>, <fpage>78</fpage>–<lpage>88</lpage>. <pub-id pub-id-type="doi">10.1093/ilar.52.1.78</pub-id><pub-id pub-id-type="pmid">21411860</pub-id></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baron</surname><given-names>M. S.</given-names></name><name><surname>Wichmann</surname><given-names>T.</given-names></name><name><surname>Ma</surname><given-names>D.</given-names></name><name><surname>DeLong</surname><given-names>M. R.</given-names></name></person-group> (<year>2002</year>). <article-title>Effects of transient focal inactivation of the basal ganglia in Parkinsonian primates</article-title>. <source>J. Neurosci</source>. <volume>22</volume>, <fpage>592</fpage>–<lpage>599</lpage>. <pub-id pub-id-type="pmid">11784807</pub-id></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Beltran</surname><given-names>W. A.</given-names></name><name><surname>Vanore</surname><given-names>M.</given-names></name><name><surname>Ollivet</surname><given-names>F.</given-names></name><name><surname>Nemoz-Bertholet</surname><given-names>F.</given-names></name><name><surname>Aujard</surname><given-names>F.</given-names></name><name><surname>Clerc</surname><given-names>B.</given-names></name><etal></etal></person-group>. (<year>2007</year>). <article-title>Ocular findings in two colonies of gray mouse lemurs (<italic>Microcebus murinus</italic>)</article-title>. <source>Vet. Ophthalmol</source>. <volume>10</volume>, <fpage>43</fpage>–<lpage>49</lpage>. <pub-id pub-id-type="doi">10.1111/j.1463-5224.2007.00491.x</pub-id><pub-id pub-id-type="pmid">17204127</pub-id></mixed-citation></ref><ref id="B6"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bergman</surname><given-names>H.</given-names></name><name><surname>Wichmann</surname><given-names>T.</given-names></name><name><surname>DeLong</surname><given-names>M. R.</given-names></name></person-group> (<year>1990</year>). <article-title>Reversal of experimental parkinsonism by lesions of the subthalamic nucleus</article-title>. <source>Science</source><volume>249</volume>, <fpage>1436</fpage>–<lpage>1438</lpage>. <pub-id pub-id-type="doi">10.1126/science.2402638</pub-id><pub-id pub-id-type="pmid">2402638</pub-id></mixed-citation></ref><ref id="B7"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bihaqi</surname><given-names>S. W.</given-names></name><name><surname>Zawia</surname><given-names>N. H.</given-names></name></person-group> (<year>2013</year>). <article-title>Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb)</article-title>. <source>Neurotoxicology</source><volume>39</volume>, <fpage>95</fpage>–<lpage>101</lpage>. <pub-id pub-id-type="doi">10.1016/j.neuro.2013.07.010</pub-id><pub-id pub-id-type="pmid">23973560</pub-id></mixed-citation></ref><ref id="B8"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bons</surname><given-names>N.</given-names></name><name><surname>Jallageas</surname><given-names>V.</given-names></name><name><surname>Silhol</surname><given-names>S.</given-names></name><name><surname>Mestre-Frances</surname><given-names>N.</given-names></name><name><surname>Petter</surname><given-names>A.</given-names></name><name><surname>Delacourte</surname><given-names>A.</given-names></name></person-group> (<year>1995</year>). <article-title>Immunocytochemical characterization of Tau proteins during cerebral aging of the lemurian primate <italic>Microcebus murinus</italic></article-title>. <source>C. R. Acad. Sci. III</source><volume>318</volume>, <fpage>741</fpage>–<lpage>747</lpage>.<pub-id pub-id-type="pmid">7583762</pub-id></mixed-citation></ref><ref id="B9"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Buse</surname><given-names>E.</given-names></name><name><surname>Habermann</surname><given-names>G.</given-names></name><name><surname>Osterburg</surname><given-names>I.</given-names></name><name><surname>Korte</surname><given-names>R.</given-names></name><name><surname>Weinbauer</surname><given-names>G. F.</given-names></name></person-group> (<year>2003</year>). <article-title>Reproductive/developmental toxicity and immunotoxicity assessment in the nonhuman primate model</article-title>. <source>Toxicology</source><volume>185</volume>, <fpage>221</fpage>–<lpage>227</lpage>. <pub-id pub-id-type="doi">10.1016/S0300-483X(02)00614-5</pub-id><pub-id pub-id-type="pmid">12581697</pub-id></mixed-citation></ref><ref id="B10"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Capitanio</surname><given-names>J. P.</given-names></name><name><surname>Emborg</surname><given-names>M. E.</given-names></name></person-group> (<year>2008</year>). <article-title>Contributions of non-human primates to neuroscience research</article-title>. <source>Lancet</source><volume>371</volume>, <fpage>1126</fpage>–<lpage>1135</lpage>. <pub-id pub-id-type="doi">10.1016/S0140-6736(08)60489-4</pub-id><pub-id pub-id-type="pmid">18374844</pub-id></mixed-citation></ref><ref id="B11"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chellman</surname><given-names>G. J.</given-names></name><name><surname>Bussiere</surname><given-names>J. L.</given-names></name><name><surname>Makori</surname><given-names>N.</given-names></name><name><surname>Martin</surname><given-names>P. L.</given-names></name><name><surname>Ooshima</surname><given-names>Y.</given-names></name><name><surname>Weinbauer</surname><given-names>G. F.</given-names></name></person-group> (<year>2009</year>). <article-title>Developmental and reproductive toxicology studies in nonhuman primates</article-title>. <source>Birth Defects Res. B. Dev. Reprod. Toxicol</source>. <volume>86</volume>, <fpage>446</fpage>–<lpage>462</lpage>. <pub-id pub-id-type="doi">10.1002/bdrb.20216</pub-id><pub-id pub-id-type="pmid">20025046</pub-id></mixed-citation></ref><ref id="B12"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Corr</surname><given-names>J.</given-names></name></person-group> (<year>2003</year>). <article-title>Social behavior in aged rhesus macaques</article-title>. <source>Coll. Antropol</source>. <volume>27</volume>, <fpage>87</fpage>–<lpage>94</lpage>. <pub-id pub-id-type="pmid">12974136</pub-id></mixed-citation></ref><ref id="B13"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Courtine</surname><given-names>G.</given-names></name><name><surname>Bunge</surname><given-names>M. B.</given-names></name><name><surname>Fawcett</surname><given-names>J. W.</given-names></name><name><surname>Grossman</surname><given-names>R. G.</given-names></name><name><surname>Kaas</surname><given-names>J. H.</given-names></name><name><surname>Lemon</surname><given-names>R.</given-names></name><etal></etal></person-group>. (<year>2007</year>). <article-title>Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?</article-title><source>Nat. Med</source>. <volume>13</volume>, <fpage>561</fpage>–<lpage>566</lpage>. <pub-id pub-id-type="doi">10.1038/nm1595</pub-id><pub-id pub-id-type="pmid">17479102</pub-id></mixed-citation></ref><ref id="B14"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Curths</surname><given-names>C.</given-names></name><name><surname>Knauf</surname><given-names>S.</given-names></name><name><surname>Kaup</surname><given-names>F.-J.</given-names></name></person-group> (<year>2014</year>). <article-title>Respiratory animal models in the common marmoset (<italic>Callithrix jacchus</italic>)</article-title>. <source>Vet. Sci</source>. <volume>1</volume>, <fpage>63</fpage>–<lpage>76</lpage><pub-id pub-id-type="doi">10.3390/vetsci1010063</pub-id></mixed-citation></ref><ref id="B15"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Darusman</surname><given-names>H. S.</given-names></name><name><surname>Pandelaki</surname><given-names>J.</given-names></name><name><surname>Mulyadi</surname><given-names>R.</given-names></name><name><surname>Sajuthi</surname><given-names>D.</given-names></name><name><surname>Putri</surname><given-names>I. A.</given-names></name><name><surname>Kalliokoski</surname><given-names>O. H.</given-names></name><etal></etal></person-group>. (<year>2014</year>). <article-title>Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid</article-title>. <source>In Vivo</source><volume>28</volume>, <fpage>173</fpage>–<lpage>184</lpage>. <pub-id pub-id-type="pmid">24632970</pub-id></mixed-citation></ref><ref id="B16"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>DeLong</surname><given-names>M. R.</given-names></name><name><surname>Benabid</surname><given-names>A.-L.</given-names></name></person-group> (<year>2014</year>). <article-title>Discovery of high-frequency deep brain stimulation for treatment of Parkinson disease: 2014 lasker award</article-title>. <source>J. Am. Med. Assoc</source>. <volume>312</volume>, <fpage>1093</fpage>–<lpage>1094</lpage>. <pub-id pub-id-type="doi">10.1001/jama.2014.11132</pub-id><pub-id pub-id-type="pmid">25198255</pub-id></mixed-citation></ref><ref id="B17"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Finch</surname><given-names>C. E.</given-names></name><name><surname>Austad</surname><given-names>S. N.</given-names></name></person-group> (<year>2012</year>). <article-title>Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging</article-title>. <source>Age Dordr. Neth</source>. <volume>34</volume>, <fpage>1075</fpage>–<lpage>1091</lpage>. <pub-id pub-id-type="doi">10.1007/s11357-011-9355-9</pub-id><pub-id pub-id-type="pmid">22218781</pub-id></mixed-citation></ref><ref id="B18"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Fox</surname><given-names>S. H.</given-names></name><name><surname>Brotchie</surname><given-names>J. M.</given-names></name></person-group> (<year>2010</year>). <article-title>Chapter 7—the MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future</article-title>, in <source>Progress in Brain Research</source>, eds <person-group person-group-type="editor"><name><surname>Björklund</surname><given-names>A.</given-names></name><name><surname>Angela Cenci</surname><given-names>M.</given-names></name></person-group> (<publisher-loc>London</publisher-loc>: <publisher-name>Elsevier</publisher-name>), <fpage>133</fpage>–<lpage>157</lpage>.</mixed-citation></ref><ref id="B19"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fraser</surname><given-names>P. E.</given-names></name></person-group> (<year>2014</year>). <article-title>Prions and prion-like proteins</article-title>. <source>J. Biol. Chem</source>. <volume>289</volume>, <fpage>19839</fpage>–<lpage>19840</lpage>. <pub-id pub-id-type="doi">10.1074/jbc.R114.583492</pub-id><pub-id pub-id-type="pmid">24860092</pub-id></mixed-citation></ref><ref id="B20"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Frost</surname><given-names>J. L.</given-names></name><name><surname>Le</surname><given-names>K. X.</given-names></name><name><surname>Cynis</surname><given-names>H.</given-names></name><name><surname>Ekpo</surname><given-names>E.</given-names></name><name><surname>Kleinschmidt</surname><given-names>M.</given-names></name><name><surname>Palmour</surname><given-names>R. M.</given-names></name><etal></etal></person-group>. (<year>2013</year>). <article-title>Pyroglutamate-3 amyloid-' deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models</article-title>. <source>Am. J. Pathol</source>. <volume>183</volume>, <fpage>369</fpage>–<lpage>381</lpage>. <pub-id pub-id-type="doi">10.1016/j.ajpath.2013.05.005</pub-id><pub-id pub-id-type="pmid">23747948</pub-id></mixed-citation></ref><ref id="B21"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gama Sosa</surname><given-names>M. A.</given-names></name><name><surname>De Gasperi</surname><given-names>R.</given-names></name><name><surname>Elder</surname><given-names>G. A.</given-names></name></person-group> (<year>2012</year>). <article-title>Modeling human neurodegenerative diseases in transgenic systems</article-title>. <source>Hum. Genet</source>. <volume>131</volume>, <fpage>535</fpage>–<lpage>563</lpage>. <pub-id pub-id-type="doi">10.1007/s00439-011-1119-1</pub-id><pub-id pub-id-type="pmid">22167414</pub-id></mixed-citation></ref><ref id="B22"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gardner</surname><given-names>M. B.</given-names></name><name><surname>Luciw</surname><given-names>P. A.</given-names></name></person-group> (<year>2008</year>). <article-title>Macaque models of human infectious disease</article-title>. <source>ILAR J</source>. <volume>49</volume>, <fpage>220</fpage>–<lpage>255</lpage>. <pub-id pub-id-type="doi">10.1093/ilar.49.2.220</pub-id><pub-id pub-id-type="pmid">18323583</pub-id></mixed-citation></ref><ref id="B23"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gibbs</surname><given-names>C. J.</given-names></name><name><surname>Amyx</surname><given-names>H. L.</given-names></name><name><surname>Bacote</surname><given-names>A.</given-names></name><name><surname>Masters</surname><given-names>C. L.</given-names></name><name><surname>Gajdusek</surname><given-names>D. C.</given-names></name></person-group> (<year>1980</year>). <article-title>Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates</article-title>. <source>J. Infect. Dis</source>. <volume>142</volume>, <fpage>205</fpage>–<lpage>208</lpage>. <pub-id pub-id-type="doi">10.1093/infdis/142.2.205</pub-id><pub-id pub-id-type="pmid">6997404</pub-id></mixed-citation></ref><ref id="B24"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gilman</surname><given-names>S.</given-names></name><name><surname>Koller</surname><given-names>M.</given-names></name><name><surname>Black</surname><given-names>R. S.</given-names></name><name><surname>Jenkins</surname><given-names>L.</given-names></name><name><surname>Griffith</surname><given-names>S. G.</given-names></name><name><surname>Fox</surname><given-names>N. C.</given-names></name><etal></etal></person-group>. (<year>2005</year>). <article-title>Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial</article-title>. <source>Neurology</source><volume>64</volume>, <fpage>1553</fpage>–<lpage>1562</lpage>. <pub-id pub-id-type="doi">10.1212/01.WNL.0000159740.16984.3C</pub-id><pub-id pub-id-type="pmid">15883316</pub-id></mixed-citation></ref><ref id="B25"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Goodall</surname><given-names>J.</given-names></name></person-group> (<year>1986</year>). <source>The Chimpanzees of Gombe: Patterns of Behavior</source>. <publisher-loc>Cambridge</publisher-loc>: <publisher-name>Belknap Press</publisher-name>.</mixed-citation></ref><ref id="B26"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Herculano-Houzel</surname><given-names>S.</given-names></name></person-group> (<year>2012</year>). <article-title>Neuronal scaling rules for primate brains: the primate advantage</article-title>. <source>Prog. Brain Res</source>. <volume>195</volume>, <fpage>325</fpage>–<lpage>340</lpage>. <pub-id pub-id-type="doi">10.1016/B978-0-444-53860-4.00015-5</pub-id><pub-id pub-id-type="pmid">22230634</pub-id></mixed-citation></ref><ref id="B27"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Herculano-Houzel</surname><given-names>S.</given-names></name><name><surname>Mota</surname><given-names>B.</given-names></name><name><surname>Wong</surname><given-names>P.</given-names></name><name><surname>Kaas</surname><given-names>J. H.</given-names></name></person-group> (<year>2010</year>). <article-title>Connectivity-driven white matter scaling and folding in primate cerebral cortex</article-title>. <source>Proc. Natl. Acad. Sci. U.S.A</source>. <volume>107</volume>, <fpage>19008</fpage>–<lpage>19013</lpage>. <pub-id pub-id-type="doi">10.1073/pnas.1012590107</pub-id><pub-id pub-id-type="pmid">20956290</pub-id></mixed-citation></ref><ref id="B28"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Herzog</surname><given-names>C.</given-names></name><name><surname>Salès</surname><given-names>N.</given-names></name><name><surname>Etchegaray</surname><given-names>N.</given-names></name><name><surname>Charbonnier</surname><given-names>A.</given-names></name><name><surname>Freire</surname><given-names>S.</given-names></name><name><surname>Dormont</surname><given-names>D.</given-names></name><etal></etal></person-group>. (<year>2004</year>). <article-title>Tissue distribution of bovine spongiform encephalopathy agent in primates after intravenous or oral infection</article-title>. <source>Lancet</source><volume>363</volume>, <fpage>422</fpage>–<lpage>428</lpage>. <pub-id pub-id-type="doi">10.1016/S0140-6736(04)15487-1</pub-id><pub-id pub-id-type="pmid">14962521</pub-id></mixed-citation></ref><ref id="B29"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heuer</surname><given-names>E.</given-names></name><name><surname>Rosen</surname><given-names>R. F.</given-names></name><name><surname>Cintron</surname><given-names>A.</given-names></name><name><surname>Walker</surname><given-names>L. C.</given-names></name></person-group> (<year>2012</year>). <article-title>Nonhuman primate models of Alzheimer-like cerebral proteopathy</article-title>. <source>Curr. Pharm. Des</source>. <volume>18</volume>, <fpage>1159</fpage>–<lpage>1169</lpage>. <pub-id pub-id-type="doi">10.2174/138161212799315885</pub-id><pub-id pub-id-type="pmid">22288403</pub-id></mixed-citation></ref><ref id="B30"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heydecke</surname><given-names>H.</given-names></name><name><surname>Schwibe</surname><given-names>M.</given-names></name><name><surname>Kaumanns</surname><given-names>W.</given-names></name></person-group> (<year>1986</year>). <article-title>Studies on social behaviour of aging rhesus monkeys (Macamulatta)</article-title>. <source>Primate Rep</source>. <volume>15</volume>, <fpage>41</fpage>–<lpage>59</lpage>.</mixed-citation></ref><ref id="B31"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Huffmann</surname><given-names>M. A.</given-names></name></person-group> (<year>1990</year>). <article-title>Some socio-behavioral manifestations of the old age</article-title>, in <source>The Chimpanzees of the Mahale Mountains: Sexual and Life History Strategies</source>, ed <person-group person-group-type="editor"><name><surname>Nishida</surname><given-names>T.</given-names></name></person-group> (<publisher-loc>Tokyo</publisher-loc>: <publisher-name>University of Tokyo Press</publisher-name>), <fpage>237</fpage>–<lpage>255</lpage>.</mixed-citation></ref><ref id="B32"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Joly</surname><given-names>M.</given-names></name><name><surname>Ammersdörfer</surname><given-names>S.</given-names></name><name><surname>Schmidtke</surname><given-names>D.</given-names></name><name><surname>Zimmermann</surname><given-names>E.</given-names></name></person-group> (<year>2014</year>). <article-title>Touchscreen-based cognitive tasks reveal age-related impairment in a primate aging model, the grey mouse lemur (<italic>Microcebus murinus</italic>)</article-title>. <source>PLoS ONE</source><volume>9</volume>:<fpage>e109393</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0109393</pub-id><pub-id pub-id-type="pmid">25299046</pub-id></mixed-citation></ref><ref id="B33"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Joly</surname><given-names>M.</given-names></name><name><surname>Deputte</surname><given-names>B.</given-names></name><name><surname>Verdier</surname><given-names>J. M.</given-names></name></person-group> (<year>2006</year>). <article-title>Age effect on olfactory discrimination in a non-human primate, <italic>Microcebus murinus</italic></article-title>. <source>Neurobiol. Aging</source><volume>27</volume>, <fpage>1045</fpage>–<lpage>1049</lpage>. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2005.05.001</pub-id><pub-id pub-id-type="pmid">15955599</pub-id></mixed-citation></ref><ref id="B34"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Joseph-Mathurin</surname><given-names>N.</given-names></name><name><surname>Dorieux</surname><given-names>O.</given-names></name><name><surname>Trouche</surname><given-names>S. G.</given-names></name><name><surname>Boutajangout</surname><given-names>A.</given-names></name><name><surname>Kraska</surname><given-names>A.</given-names></name><name><surname>Fontes</surname><given-names>P.</given-names></name><etal></etal></person-group>. (<year>2013</year>). <article-title>Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds</article-title>. <source>Neurobiol. Aging</source><volume>34</volume>, <fpage>2613</fpage>–<lpage>2622</lpage>. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2013.05.013</pub-id><pub-id pub-id-type="pmid">23796662</pub-id></mixed-citation></ref><ref id="B35"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kalinin</surname><given-names>S.</given-names></name><name><surname>Willard</surname><given-names>S. L.</given-names></name><name><surname>Shively</surname><given-names>C. A.</given-names></name><name><surname>Kaplan</surname><given-names>J. R.</given-names></name><name><surname>Register</surname><given-names>T. C.</given-names></name><name><surname>Jorgensen</surname><given-names>M. J.</given-names></name><etal></etal></person-group>. (<year>2013</year>). <article-title>Development of amyloid burden in African Green monkeys</article-title>. <source>Neurobiol. Aging</source><volume>34</volume>, <fpage>2361</fpage>–<lpage>2369</lpage>. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2013.03.023</pub-id><pub-id pub-id-type="pmid">23601810</pub-id></mixed-citation></ref><ref id="B36"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Krasemann</surname><given-names>S.</given-names></name><name><surname>Sikorska</surname><given-names>B.</given-names></name><name><surname>Liberski</surname><given-names>P. P.</given-names></name><name><surname>Glatzel</surname><given-names>M.</given-names></name></person-group> (<year>2012</year>). <article-title>Non-human primates in prion research</article-title>. <source>Folia Neuropathol</source>. <volume>50</volume>, <fpage>57</fpage>–<lpage>67</lpage>. <pub-id pub-id-type="pmid">22505364</pub-id></mixed-citation></ref><ref id="B37"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kumar</surname><given-names>S.</given-names></name><name><surname>Hedges</surname><given-names>S. B.</given-names></name></person-group> (<year>1998</year>). <article-title>A molecular timescale for vertebrate evolution</article-title>. <source>Nature</source><volume>392</volume>, <fpage>917</fpage>–<lpage>920</lpage>. <pub-id pub-id-type="doi">10.1038/31927</pub-id><pub-id pub-id-type="pmid">9582070</pub-id></mixed-citation></ref><ref id="B38"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Languille</surname><given-names>S.</given-names></name><name><surname>Blanc</surname><given-names>S.</given-names></name><name><surname>Blin</surname><given-names>O.</given-names></name><name><surname>Canale</surname><given-names>C. I.</given-names></name><name><surname>Dal-Pan</surname><given-names>A.</given-names></name><name><surname>Devau</surname><given-names>G.</given-names></name><etal></etal></person-group>. (<year>2012</year>). <article-title>The grey mouse lemur: a non-human primate model for ageing studies</article-title>. <source>Ageing Res. Rev</source>. <volume>11</volume>, <fpage>150</fpage>–<lpage>162</lpage>. <pub-id pub-id-type="doi">10.1016/j.arr.2011.07.001</pub-id><pub-id pub-id-type="pmid">21802530</pub-id></mixed-citation></ref><ref id="B39"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lasmezas</surname><given-names>C. I.</given-names></name><name><surname>Comoy</surname><given-names>E.</given-names></name><name><surname>Hawkins</surname><given-names>S.</given-names></name><name><surname>Herzog</surname><given-names>C.</given-names></name><name><surname>Mouthon</surname><given-names>F.</given-names></name><name><surname>Konold</surname><given-names>T.</given-names></name><etal></etal></person-group>. (<year>2005</year>). <article-title>Risk of oral infection with bovine spongiform encephalopathy agent in primates</article-title>. <source>Lancet</source><volume>365</volume>, <fpage>781</fpage>–<lpage>783</lpage>. <pub-id pub-id-type="doi">10.1016/S0140-6736(05)17985-9</pub-id><pub-id pub-id-type="pmid">15733719</pub-id></mixed-citation></ref><ref id="B40"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lebrec</surname><given-names>H. N.</given-names></name></person-group> (<year>2013</year>). <article-title>Regulatory forum opinion piece<sup>*</sup>: immunotoxicology assessments in nonhuman primates—challenges and opportunities</article-title>. <source>Toxicol. Pathol</source>. <volume>41</volume>, <fpage>548</fpage>–<lpage>551</lpage>. <pub-id pub-id-type="doi">10.1177/0192623312455526</pub-id><pub-id pub-id-type="pmid">22886347</pub-id></mixed-citation></ref><ref id="B41"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lemere</surname><given-names>C. A.</given-names></name><name><surname>Beierschmitt</surname><given-names>A.</given-names></name><name><surname>Iglesias</surname><given-names>M.</given-names></name><name><surname>Spooner</surname><given-names>E. T.</given-names></name><name><surname>Bloom</surname><given-names>J. K.</given-names></name><name><surname>Leverone</surname><given-names>J. F.</given-names></name><etal></etal></person-group>. (<year>2004</year>). <article-title>Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet</article-title>. <source>Am. J. Pathol</source>. <volume>165</volume>, <fpage>283</fpage>–<lpage>297</lpage>. <pub-id pub-id-type="doi">10.1016/S0002-9440(10)63296-8</pub-id><pub-id pub-id-type="pmid">15215183</pub-id></mixed-citation></ref><ref id="B42"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lemere</surname><given-names>C. A.</given-names></name><name><surname>Oh</surname><given-names>J.</given-names></name><name><surname>Stanish</surname><given-names>H. A.</given-names></name><name><surname>Peng</surname><given-names>Y.</given-names></name><name><surname>Pepivani</surname><given-names>I.</given-names></name><name><surname>Fagan</surname><given-names>A. M.</given-names></name><etal></etal></person-group>. (<year>2008</year>). <article-title>Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease?</article-title><source>Rejuvenation Res</source>. <volume>11</volume>, <fpage>321</fpage>–<lpage>332</lpage>. <pub-id pub-id-type="doi">10.1089/rej.2008.0677</pub-id><pub-id pub-id-type="pmid">18341428</pub-id></mixed-citation></ref><ref id="B43"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Lewis</surname><given-names>J. H.</given-names></name></person-group> (<year>1996</year>). <article-title>Chapter 14: The Primates</article-title>, in <source>Comparative Hemostasis in Vertebrates</source>, ed <person-group person-group-type="editor"><name><surname>Lewis</surname><given-names>J. H.</given-names></name></person-group> (<publisher-loc>New York, NY</publisher-loc>: <publisher-name>Springer Science'Business Media</publisher-name>), <fpage>153</fpage>–<lpage>176</lpage>.</mixed-citation></ref><ref id="B44"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Loerch</surname><given-names>P. M.</given-names></name><name><surname>Lu</surname><given-names>T.</given-names></name><name><surname>Dakin</surname><given-names>K. A.</given-names></name><name><surname>Vann</surname><given-names>J. M.</given-names></name><name><surname>Isaacs</surname><given-names>A.</given-names></name><name><surname>Geula</surname><given-names>C.</given-names></name><etal></etal></person-group>. (<year>2008</year>). <article-title>Evolution of the aging brain transcriptome and synaptic regulation</article-title>. <source>PLoS ONE</source><volume>3</volume>:<fpage>e3329</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0003329</pub-id><pub-id pub-id-type="pmid">18830410</pub-id></mixed-citation></ref><ref id="B45"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marvanová</surname><given-names>M.</given-names></name><name><surname>Ménager</surname><given-names>J.</given-names></name><name><surname>Bezard</surname><given-names>E.</given-names></name><name><surname>Bontrop</surname><given-names>R. E.</given-names></name><name><surname>Pradier</surname><given-names>L.</given-names></name><name><surname>Wong</surname><given-names>G.</given-names></name></person-group> (<year>2003</year>). <article-title>Microarray analysis of nonhuman primates: validation of experimental models in neurological disorders</article-title>. <source>FASEB J</source>. <volume>17</volume>, <fpage>929</fpage>–<lpage>931</lpage>. <pub-id pub-id-type="doi">10.1096/fj.02-0681fje</pub-id><pub-id pub-id-type="pmid">12626435</pub-id></mixed-citation></ref><ref id="B46"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Maryanski</surname><given-names>A.</given-names></name><name><surname>Turner</surname><given-names>J. H.</given-names></name></person-group> (<year>1993</year>). <source>The Origin of Human Culture</source>. <publisher-loc>Stanford</publisher-loc>: <publisher-name>Stanford University Press</publisher-name>, <fpage>58</fpage>–<lpage>60</lpage>.</mixed-citation></ref><ref id="B47"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Messaoudi</surname><given-names>I.</given-names></name><name><surname>Ingram</surname><given-names>D. K.</given-names></name></person-group> (<year>2012</year>). <article-title>Overview of aging research using nonhuman primate models</article-title>. <source>Age Dordr. Neth</source>. <volume>34</volume>, <fpage>1047</fpage>–<lpage>1049</lpage>. <pub-id pub-id-type="doi">10.1007/s11357-011-9370-x</pub-id><pub-id pub-id-type="pmid">22207280</pub-id></mixed-citation></ref><ref id="B48"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mestre-Frances</surname><given-names>N.</given-names></name><name><surname>Keller</surname><given-names>E.</given-names></name><name><surname>Calenda</surname><given-names>A.</given-names></name><name><surname>Barelli</surname><given-names>H.</given-names></name><name><surname>Checler</surname><given-names>F.</given-names></name><name><surname>Bons</surname><given-names>N.</given-names></name></person-group> (<year>2000</year>). <article-title>Immunohistochemical analysis of cerebral cortical and vascular lesions in the primate <italic>Microcebus murinus</italic> reveal distinct amyloid beta1-42 and beta1-40 immunoreactivity profiles</article-title>. <source>Neurobiol. Dis</source>. <volume>7</volume>, <fpage>1</fpage>–<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1006/nbdi.1999.0270</pub-id><pub-id pub-id-type="pmid">10671318</pub-id></mixed-citation></ref><ref id="B49"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mestre-Frances</surname><given-names>N.</given-names></name><name><surname>Nicot</surname><given-names>S.</given-names></name><name><surname>Rouland</surname><given-names>S.</given-names></name><name><surname>Biacabe</surname><given-names>A. G.</given-names></name><name><surname>Quadrio</surname><given-names>I.</given-names></name><name><surname>Perret-Liaudet</surname><given-names>A.</given-names></name><etal></etal></person-group>. (<year>2012</year>). <article-title>Oral transmission of L-type bovine spongiform encephalopathy in primate model</article-title>. <source>Emerg. Infect. Dis</source>. <volume>18</volume>, <fpage>142</fpage>–<lpage>145</lpage>. <pub-id pub-id-type="doi">10.3201/eid1801.111092</pub-id><pub-id pub-id-type="pmid">22261009</pub-id></mixed-citation></ref><ref id="B50"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nader</surname><given-names>M. A.</given-names></name><name><surname>Banks</surname><given-names>M. L.</given-names></name></person-group> (<year>2014</year>). <article-title>Environmental modulation of drug taking: nonhuman primate models of cocaine abuse and PET neuroimaging</article-title>. <source>Neuropharmacology</source><volume>76(Pt B)</volume>, <fpage>510</fpage>–<lpage>517</lpage>. <pub-id pub-id-type="doi">10.1016/j.neuropharm.2013.05.044</pub-id><pub-id pub-id-type="pmid">23748095</pub-id></mixed-citation></ref><ref id="B51"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nagahara</surname><given-names>A. H.</given-names></name><name><surname>Bernot</surname><given-names>T.</given-names></name><name><surname>Tuszynski</surname><given-names>M. H.</given-names></name></person-group> (<year>2010</year>). <article-title>Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery</article-title>. <source>Neurobiol. Aging</source><volume>31</volume>, <fpage>1020</fpage>–<lpage>1031</lpage>. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2008.07.007</pub-id><pub-id pub-id-type="pmid">18760505</pub-id></mixed-citation></ref><ref id="B52"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nakamura</surname><given-names>S.</given-names></name><name><surname>Nakayama</surname><given-names>H.</given-names></name><name><surname>Goto</surname><given-names>N.</given-names></name><name><surname>Ono</surname><given-names>F.</given-names></name><name><surname>Sakakibara</surname><given-names>I.</given-names></name><name><surname>Yoshikawa</surname><given-names>Y.</given-names></name></person-group> (<year>1998</year>). <article-title>Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys</article-title>. <source>J. Med. Primatol</source>. <volume>27</volume>, <fpage>244</fpage>–<lpage>252</lpage>. <pub-id pub-id-type="doi">10.1111/j.1600-0684.1998.tb00244.x</pub-id><pub-id pub-id-type="pmid">9926980</pub-id></mixed-citation></ref><ref id="B53"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nemoz-Bertholet</surname><given-names>F.</given-names></name><name><surname>Aujard</surname><given-names>F.</given-names></name></person-group> (<year>2003</year>). <article-title>Physical activity and balance performance as a function of age in a prosimian primate (<italic>Microcebus murinus</italic>)</article-title>. <source>Exp. Gerontol</source>. <volume>38</volume>, <fpage>407</fpage>–<lpage>414</lpage>. <pub-id pub-id-type="doi">10.1016/S0531-5565(02)00244-9</pub-id><pub-id pub-id-type="pmid">12670627</pub-id></mixed-citation></ref><ref id="B54"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Orgogozo</surname><given-names>J. M.</given-names></name><name><surname>Gilman</surname><given-names>S.</given-names></name><name><surname>Dartigues</surname><given-names>J. F.</given-names></name><name><surname>Laurent</surname><given-names>B.</given-names></name><name><surname>Puel</surname><given-names>M.</given-names></name><name><surname>Kirby</surname><given-names>L. C.</given-names></name><etal></etal></person-group>. (<year>2003</year>). <article-title>Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization</article-title>. <source>Neurology</source><volume>61</volume>, <fpage>46</fpage>–<lpage>54</lpage>. <pub-id pub-id-type="doi">10.1212/01.WNL.0000073623.84147.A8</pub-id><pub-id pub-id-type="pmid">12847155</pub-id></mixed-citation></ref><ref id="B55"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Passingham</surname><given-names>R. E.</given-names></name><name><surname>Wise</surname><given-names>S. P.</given-names></name></person-group> (<year>2012</year>). <article-title>Chapter 2. Evolution of the primate prefrontal cortex</article-title>, in <source>The Neurobiology of the Prefrontal Cortex: Anatomy, Evolution, and the Origin of Insight, Oxford Psychology Series</source>, eds <person-group person-group-type="editor"><name><surname>Esposito</surname><given-names>M. D'</given-names></name><name><surname>Schacter</surname><given-names>D.</given-names></name><name><surname>Driver</surname><given-names>J.</given-names></name><name><surname>Treisman</surname><given-names>A.</given-names></name><name><surname>Robbins</surname><given-names>T.</given-names></name><name><surname>Weiskrantz</surname><given-names>L.</given-names></name></person-group> (<publisher-loc>Oxford</publisher-loc>: <publisher-name>Oxford University Press</publisher-name>), <fpage>28</fpage>–<lpage>64</lpage>.</mixed-citation></ref><ref id="B56"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Perret</surname><given-names>M.</given-names></name></person-group> (<year>1997</year>). <article-title>Change in photoperiodic cycle affects life span in a prosimian primate (<italic>Microcebus murinus</italic>)</article-title>. <source>J. Biol. Rhythms</source>. <volume>12</volume>, <fpage>136</fpage>–<lpage>145</lpage>. <pub-id pub-id-type="doi">10.1177/074873049701200205</pub-id><pub-id pub-id-type="pmid">9090567</pub-id></mixed-citation></ref><ref id="B57"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Philippens</surname><given-names>I. H.</given-names></name><name><surname>‘t Hart</surname><given-names>B. A.</given-names></name><name><surname>Torres</surname><given-names>G.</given-names></name></person-group> (<year>2010</year>). <article-title>The MPTP marmoset model of parkinsonism: a multi-purpose non-human primate model for neurodegenerative diseases</article-title>. <source>Drug Discov. Today</source><volume>15</volume>, <fpage>985</fpage>–<lpage>990</lpage>. <pub-id pub-id-type="doi">10.1016/j.drudis.2010.08.009</pub-id><pub-id pub-id-type="pmid">20732446</pub-id></mixed-citation></ref><ref id="B58"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Picq</surname><given-names>J. L.</given-names></name></person-group> (<year>1992</year>). <article-title>Aging and social behaviour in captivity in <italic>Microcebus murinus</italic></article-title>. <source>Folia Primatol. Basel</source><volume>59</volume>, <fpage>217</fpage>–<lpage>220</lpage>. <pub-id pub-id-type="doi">10.1159/000156664</pub-id><pub-id pub-id-type="pmid">1307078</pub-id></mixed-citation></ref><ref id="B59"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Picq</surname><given-names>J. L.</given-names></name><name><surname>Aujard</surname><given-names>F.</given-names></name><name><surname>Volk</surname><given-names>A.</given-names></name><name><surname>Dhenain</surname><given-names>M.</given-names></name></person-group> (<year>2012</year>). <article-title>Age-related cerebral atrophy in nonhuman primates predicts cognitive impairments</article-title>. <source>Neurobiol. Aging</source><volume>33</volume>, <fpage>1096</fpage>–<lpage>1109</lpage>. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2010.09.009</pub-id><pub-id pub-id-type="pmid">20970891</pub-id></mixed-citation></ref><ref id="B60"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rathbun</surname><given-names>W. B.</given-names></name><name><surname>Holleschau</surname><given-names>A. M.</given-names></name></person-group> (<year>1992</year>). <article-title>The effects of age on glutathione synthesis enzymes in lenses of Old World simians and prosimians</article-title>. <source>Curr. Eye Res</source>. <volume>11</volume>, <fpage>601</fpage>–<lpage>607</lpage>. <pub-id pub-id-type="doi">10.3109/02713689209000733</pub-id><pub-id pub-id-type="pmid">1355706</pub-id></mixed-citation></ref><ref id="B61"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Robine</surname><given-names>J. M.</given-names></name><name><surname>Michel</surname><given-names>J. P.</given-names></name><name><surname>Herrmann</surname><given-names>F. R.</given-names></name></person-group> (<year>2012</year>). <article-title>Excess male mortality and age-specific mortality trajectories under different mortality conditions: a lesson from the heat wave of summer 2003</article-title>. <source>Mech. Ageing Dev</source>. <volume>133</volume>, <fpage>378</fpage>–<lpage>386</lpage>. <pub-id pub-id-type="doi">10.1016/j.mad.2012.04.004</pub-id><pub-id pub-id-type="pmid">22564660</pub-id></mixed-citation></ref><ref id="B62"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rosen</surname><given-names>R. F.</given-names></name><name><surname>Farberg</surname><given-names>A. S.</given-names></name><name><surname>Gearing</surname><given-names>M.</given-names></name><name><surname>Dooyema</surname><given-names>J.</given-names></name><name><surname>Long</surname><given-names>P. M.</given-names></name><name><surname>Anderson</surname><given-names>D. C.</given-names></name><etal></etal></person-group>. (<year>2008</year>). <article-title>Tauopathy with paired helical filaments in an aged chimpanzee</article-title>. <source>J. Comp. Neurol</source>. <volume>509</volume>, <fpage>259</fpage>–<lpage>270</lpage>. <pub-id pub-id-type="doi">10.1002/cne.21744</pub-id><pub-id pub-id-type="pmid">18481275</pub-id></mixed-citation></ref><ref id="B63"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schenk</surname><given-names>D.</given-names></name><name><surname>Barbour</surname><given-names>R.</given-names></name><name><surname>Dunn</surname><given-names>W.</given-names></name><name><surname>Gordon</surname><given-names>G.</given-names></name><name><surname>Grajeda</surname><given-names>H.</given-names></name><name><surname>Guido</surname><given-names>T.</given-names></name><etal></etal></person-group>. (<year>1999</year>). <article-title>Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse</article-title>. <source>Nature</source><volume>400</volume>, <fpage>173</fpage>–<lpage>177</lpage>. <pub-id pub-id-type="doi">10.1038/22124</pub-id><pub-id pub-id-type="pmid">10408445</pub-id></mixed-citation></ref><ref id="B64"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schoenemann</surname><given-names>P. T.</given-names></name><name><surname>Sheehan</surname><given-names>M. J.</given-names></name><name><surname>Glotzer</surname><given-names>L. D.</given-names></name></person-group> (<year>2005</year>). <article-title>Prefrontal white matter volume is disproportionately larger in humans than in other primates</article-title>. <source>Nat. Neurosci</source>. <volume>8</volume>, <fpage>242</fpage>–<lpage>252</lpage>. <pub-id pub-id-type="doi">10.1038/nn1394</pub-id><pub-id pub-id-type="pmid">15665874</pub-id></mixed-citation></ref><ref id="B65"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sigurdsson</surname><given-names>E. M.</given-names></name><name><surname>Scholtzova</surname><given-names>H.</given-names></name><name><surname>Mehta</surname><given-names>P. D.</given-names></name><name><surname>Frangione</surname><given-names>B.</given-names></name><name><surname>Wisniewski</surname><given-names>T.</given-names></name></person-group> (<year>2001</year>). <article-title>Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice</article-title>. <source>Am. J. Pathol</source>. <volume>159</volume>, <fpage>439</fpage>–<lpage>447</lpage>. <pub-id pub-id-type="doi">10.1016/S0002-9440(10)61715-4</pub-id><pub-id pub-id-type="pmid">11485902</pub-id></mixed-citation></ref><ref id="B66"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname><given-names>D. E.</given-names></name><name><surname>Roberts</surname><given-names>J.</given-names></name><name><surname>Gage</surname><given-names>F. H.</given-names></name><name><surname>Tuszynski</surname><given-names>M. H.</given-names></name></person-group> (<year>1999</year>). <article-title>Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy</article-title>. <source>Proc. Natl. Acad. Sci. U.S.A</source>. <volume>96</volume>, <fpage>10893</fpage>–<lpage>10898</lpage>. <pub-id pub-id-type="doi">10.1073/pnas.96.19.10893</pub-id><pub-id pub-id-type="pmid">10485922</pub-id></mixed-citation></ref><ref id="B67"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stone</surname><given-names>J.</given-names></name><name><surname>Johnston</surname><given-names>E.</given-names></name></person-group> (<year>1981</year>). <article-title>The topography of primate retina: a study of the human, bushbaby, and new- and old-world monkeys</article-title>. <source>J. Comp. Neurol</source>. <volume>196</volume>, <fpage>205</fpage>–<lpage>223</lpage>. <pub-id pub-id-type="doi">10.1002/cne.901960204</pub-id><pub-id pub-id-type="pmid">7217355</pub-id></mixed-citation></ref><ref id="B68"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Sutcliffe</surname><given-names>J.</given-names></name><name><surname>Hutcheson</surname><given-names>D.</given-names></name></person-group> (<year>2012</year>). <article-title>Perspectives on the non-human primate touch-screen self ordered spatial search paradigm</article-title>, in <source>8th International Conference on Methods and Techniques in Behavioral Research</source>, eds <person-group person-group-type="editor"><name><surname>Spink</surname><given-names>A. J.</given-names></name><name><surname>Grieco</surname><given-names>F.</given-names></name><name><surname>Krips</surname><given-names>O. E.</given-names></name><name><surname>Loijens</surname><given-names>L. W. S.</given-names></name><name><surname>Noldus</surname><given-names>L. P. J. J.</given-names></name><name><surname>Zimmerman</surname><given-names>P. H.</given-names></name></person-group> (<publisher-loc>Wageningen</publisher-loc>: <publisher-name>Measuring Behavior Conferences</publisher-name>), <fpage>182</fpage>–<lpage>185</lpage>.</mixed-citation></ref><ref id="B69"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Torrent</surname><given-names>J.</given-names></name><name><surname>Soukkarieh</surname><given-names>C.</given-names></name><name><surname>Lenaers</surname><given-names>G.</given-names></name><name><surname>Arndt</surname><given-names>C.</given-names></name><name><surname>Forster</surname><given-names>V.</given-names></name><name><surname>Picaud</surname><given-names>S.</given-names></name><etal></etal></person-group>. (<year>2010</year>). <article-title><italic>Microcebus murinus</italic> retina: a new model to assess prion-related neurotoxicity in primates</article-title>. <source>Neurobiol. Dis</source>. <volume>39</volume>, <fpage>211</fpage>–<lpage>220</lpage>. <pub-id pub-id-type="doi">10.1016/j.nbd.2010.04.010</pub-id><pub-id pub-id-type="pmid">20399858</pub-id></mixed-citation></ref><ref id="B70"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Trouche</surname><given-names>S. G.</given-names></name><name><surname>Asuni</surname><given-names>A.</given-names></name><name><surname>Rouland</surname><given-names>S.</given-names></name><name><surname>Wisniewski</surname><given-names>T.</given-names></name><name><surname>Frangione</surname><given-names>B.</given-names></name><name><surname>Verdier</surname><given-names>J. M.</given-names></name><etal></etal></person-group>. (<year>2009</year>). <article-title>Antibody response and plasma Abeta1-40 levels in young <italic>Microcebus murinus</italic> primates immunized with Abeta1-42 and its derivatives</article-title>. <source>Vaccine</source><volume>27</volume>, <fpage>957</fpage>–<lpage>964</lpage>. <pub-id pub-id-type="doi">10.1016/j.vaccine.2008.12.012</pub-id><pub-id pub-id-type="pmid">19114076</pub-id></mixed-citation></ref><ref id="B71"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Uchida</surname><given-names>A.</given-names></name><name><surname>Sasaguri</surname><given-names>H.</given-names></name><name><surname>Kimura</surname><given-names>N.</given-names></name><name><surname>Tajiri</surname><given-names>M.</given-names></name><name><surname>Ohkubo</surname><given-names>T.</given-names></name><name><surname>Ono</surname><given-names>F.</given-names></name><etal></etal></person-group>. (<year>2012</year>). <article-title>Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43</article-title>. <source>Brain J. Neurol</source>. <volume>135</volume>, <fpage>833</fpage>–<lpage>846</lpage>. <pub-id pub-id-type="doi">10.1093/brain/awr348</pub-id><pub-id pub-id-type="pmid">22252998</pub-id></mixed-citation></ref><ref id="B72"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Uno</surname><given-names>H.</given-names></name><name><surname>Walker</surname><given-names>L. C.</given-names></name></person-group> (<year>1993</year>). <article-title>The age of biosenescence and the incidence of cerebral beta-amyloidosis in aged captive rhesus monkeys</article-title>. <source>Ann. N.Y. Acad. Sci</source>. <volume>695</volume>, <fpage>232</fpage>–<lpage>235</lpage>. <pub-id pub-id-type="doi">10.1111/j.1749-6632.1993.tb23058.x</pub-id><pub-id pub-id-type="pmid">8239288</pub-id></mixed-citation></ref><ref id="B73"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Van Someren</surname><given-names>E. J.</given-names></name><name><surname>Riemersma-Van Der Lek</surname><given-names>R. F.</given-names></name></person-group> (<year>2007</year>). <article-title>Live to the rhythm, slave to the rhythm</article-title>. <source>Sleep Med. Rev</source>. <volume>11</volume>, <fpage>465</fpage>–<lpage>484</lpage>. <pub-id pub-id-type="doi">10.1016/j.smrv.2007.07.003</pub-id><pub-id pub-id-type="pmid">18021942</pub-id></mixed-citation></ref><ref id="B74"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vezoli</surname><given-names>J.</given-names></name><name><surname>Fifel</surname><given-names>K.</given-names></name><name><surname>Leviel</surname><given-names>V.</given-names></name><name><surname>Dehay</surname><given-names>C.</given-names></name><name><surname>Kennedy</surname><given-names>H.</given-names></name><name><surname>Cooper</surname><given-names>H. M.</given-names></name><etal></etal></person-group>. (<year>2011</year>). <article-title>Early presymptomatic and long-term changes of rest activity cycles and cognitive behavior in a MPTP-monkey model of Parkinson's disease</article-title>. <source>PLoS ONE</source><volume>6</volume>:<fpage>e23952</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0023952</pub-id><pub-id pub-id-type="pmid">21887350</pub-id></mixed-citation></ref><ref id="B75"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Walker</surname><given-names>L. C.</given-names></name></person-group> (<year>1997</year>). <article-title>Animal models of cerebral beta-amyloid angiopathy</article-title>. <source>Brain Res. Brain Res. Rev</source>. <volume>25</volume>, <fpage>70</fpage>–<lpage>84</lpage>. <pub-id pub-id-type="doi">10.1016/S0165-0173(97)00017-9</pub-id><pub-id pub-id-type="pmid">9370051</pub-id></mixed-citation></ref><ref id="B76"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Weber</surname><given-names>H.</given-names></name></person-group> (<year>2005</year>). <article-title>Factors affecting the choice of species</article-title>, in <source>The Laboratory Primate</source>, ed <person-group person-group-type="editor"><name><surname>Wolfe-Coote</surname><given-names>S.</given-names></name></person-group> (<publisher-loc>Cape Town</publisher-loc>), <fpage>259</fpage>–<lpage>272</lpage>.</mixed-citation></ref><ref id="B77"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Weinbauer</surname><given-names>G. F.</given-names></name><name><surname>Frings</surname><given-names>W.</given-names></name><name><surname>Fuchs</surname><given-names>A.</given-names></name><name><surname>Osterburg</surname><given-names>I.</given-names></name></person-group> (<year>2008</year>). <article-title>Reproductive/developmental toxicity assessment of biopharmaceuticals in nonhuman primates</article-title>, in <source>Preclinical Safety Evaluation of Biopharmaceuticals, A Science-Based Approach to Facilitating Clinical Trials</source> (<publisher-loc>Hoboken, NJ</publisher-loc>: <publisher-name>John Wiley and Sons</publisher-name>), <fpage>379</fpage>–<lpage>397</lpage>.</mixed-citation></ref><ref id="B78"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Winkelmann</surname><given-names>C. J.</given-names></name><name><surname>Krause</surname><given-names>S. M.</given-names></name><name><surname>McCracken</surname><given-names>P. J.</given-names></name><name><surname>Brammer</surname><given-names>D. W.</given-names></name><name><surname>Gelovani</surname><given-names>J. G.</given-names></name></person-group> (<year>2012</year>). <article-title>Imaging in research using nonhuman primates</article-title>, in <source>Nonhuman Primates in Biomedical Research: Diseases</source>, eds <person-group person-group-type="editor"><name><surname>Abee</surname><given-names>C. R.</given-names></name><name><surname>Mansfield</surname><given-names>K.</given-names></name><name><surname>Tardif</surname><given-names>S. D.</given-names></name></person-group> (<publisher-loc>London</publisher-loc>: <publisher-name>Timothy Morris</publisher-name>), <fpage>795</fpage>–<lpage>815</lpage>.</mixed-citation></ref><ref id="B79"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zürcher</surname><given-names>N. R.</given-names></name><name><surname>Rodriguez</surname><given-names>J. S.</given-names></name><name><surname>Jenkins</surname><given-names>S. L.</given-names></name><name><surname>Keenan</surname><given-names>K.</given-names></name><name><surname>Bartlett</surname><given-names>T. Q.</given-names></name><name><surname>McDonald</surname><given-names>T. J.</given-names></name><etal></etal></person-group>. (<year>2010</year>). <article-title>Performance of juvenile baboons on neuropsychological tests assessing associative learning, motivation and attention</article-title>. <source>J. Neurosci. Methods</source><volume>188</volume>, <fpage>219</fpage>–<lpage>225</lpage>. <pub-id pub-id-type="doi">10.1016/j.jneumeth.2010.02.011</pub-id><pub-id pub-id-type="pmid">20170676</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0009531 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0009531 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.29. |  |